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Koshi Akahane, Atsushi Watanabe, Yoshiyuki Furuichi, Shinpei Somazu, Hiroko Oshiro, Kumiko Goi, Kazuo Sakashita, Hideki Muramatsu, Asahito Hama, Yoshiyuki Takahashi, Kenichi Koike, Seiji Kojima, Kanji Sugita, Takeshi Inukai
JMML is an aggressive hematopoietic malignancy of early childhood, and allogeneic HSCT is the only curative treatment for this disease. Umbilical cord blood is one of donor sources for HSCT in JMML patients who do not have an HLA-compatible relative, but engraftment failure remains a major problem. Here, we report two cases of JMML who were successfully rescued by HSCT from an HLA-mismatched parent after development of primary engraftment failure following unrelated CBT. Both patients had severe splenomegaly and underwent unrelated CBT from an HLA-mismatched donor...
February 20, 2019: Pediatric Transplantation
Wenhui Liang, Chuanli Wu, Zhewei Cai, Yujie Sun, Hui Zhang, Ping Wu, Chenxin Cai
We report a facile and new method to tune the electron transport (ETp) band gaps of proteins (bovine serum albumin, BSA) via doping with other molecules (cyanocobalamin, Vb12). The results indicated that doping with Vb12 can enhance the ETp ability of BSA and reduce its conduction band (CB) and valence band (VB) energy levels, thereby achieving the goal of tuning protein ETp band gaps.
February 18, 2019: Chemical Communications: Chem Comm
Jingjing Zhang, Huayun Geng, Ling Liu, Hao Zhang
Background/Aims: Cytotoxicity induced by reactive oxygen species (ROS) is critical for the effectiveness of chemotherapeutic drugs used in the treatment of acute myeloid leukemia (AML). This study aimed to investigate whether ROS contributes to cytotoxicity in AML cells when treated with homoharringtonine (HHT) and etoposide (ETP) in combination. Methods: AML cell lines THP1 and HL60 and primary AML cells from patients were treated with HHT and ETP alone or in combination, and cell viability was determined by trypan blue exclusion test, and apoptosis was analyzed by annexin-V/propidium iodide double staining as well as Western blot for measuring expression of cleaved caspase-9 and cleaved caspase-3...
2019: Cancer Management and Research
Hamed Ghaffari, Jeffrey D Varner, Linda R Petzold
BACKGROUND: Clinical studies have shown that all-trans retinoic acid (RA), which is often used in treatment of cancer patients, improves hemostatic parameters and bleeding complications such as disseminated intravascular coagulation (DIC). However, the mechanisms underlying this improvement have yet to be elucidated. In vitro studies have reported that RA upregulates thrombomodulin (TM) expression on the endothelial cell surface. The objective of this study was to investigate how and to what extent the TM concentration changes after RA treatment in cancer patients, and how this variation influences the blood coagulation cascade...
February 14, 2019: Theoretical Biology & Medical Modelling
Jinglan Feng, Jiahui Zhao, Nannan Xi, Wei Guo, Jianhui Sun
In this study, six alkyl esters of p-hydroxybenzoic acids (parabens) and their metabolite, 4-hydroxybenzoic acid (p-HB) were simultaneously determined in surface water and sediment from the Yellow River and the Huai River in Henan Province, China. Concentrations of ∑parabens in surface water were 3.31-55.2 ng/L in the Yellow River and 15.0-164 ng/L in the Huai River, while in the sediment, concentrations of ∑parabens were 13.3-37.2 ng/g and 16.1-31.6 ng/g, respectively. Compared with other studies, levels of parabens in the studied area were relatively high in the sediments but middle in the surface water...
February 6, 2019: Ecotoxicology and Environmental Safety
Ai Leen Ang, Wan Hui Wong, Jeslyn Tan, Heng Joo Ng, Chuen Wen Tan, Ponnudurai Kuperan, Sally Lam, Hwee Huang Tan, Sze Sze Chua
BACKGROUND/OBJECTIVES: We compared the ex vivo haemostatic capacity of RTFP24 with FFP upon thawing and >24 h post-thaw. We included thrombin generation (TG) as few studies had compared global haemostatic function, and most did not directly compare RTFP24 with FFP >24 h post-thaw. MATERIALS/METHODS: Twenty units each of RTFP24 and FFP were measured for coagulation factors and thrombin generation upon thawing (D0) and 4 days post-thaw (D4). Labile factors were also measured from D1 to D3...
February 7, 2019: Vox Sanguinis
V A Mergulhão, L S de Mendonça, M S de Albuquerque, R Braz
PURPOSE: The purpose of this in vitro study was to evaluate the resistance and patterns of fracture of endodontically treated maxillary premolars (ETPs) restored with different methods. METHODS AND MATERIALS: Mesio-occluso-distal cavities were prepared in 50 extracted caries-free human maxillary premolars after endodontic treatment. The teeth were divided into five groups (n=10), according to the restorative method. G1: intact teeth (control group); G2: conventional composite resin; G3: conventional composite resin with a horizontal glass fiber post inserted between buccal and palatal walls; G4: bulk-fill flowable and bulk-fill restorative composites; and G5: ceramic inlay...
January 2019: Operative Dentistry
Paul Billoir, Thomas Duflot, Marielle Fresel, Marie Hélène Chrétien, Virginie Barbay, Véronique Le Cam Duchez
Factor V Leiden (FVL) mutation is the most common genetic risk factor for venous thromboembolism. In families with a history of thrombosis, FVL can be present in 18%. Thrombin generation test is commonly used as an evaluation tool of thrombotic risk. The objective of this study was to evaluate the thrombogenic potential of FVL in asymptomatic carriers and in patients with personal or familial history of thrombosis. This was a retrospective single center study including 160 patients. Among them, 43 had personal history of thrombosis and 117 had familial history of thrombosis...
January 30, 2019: Journal of Thrombosis and Thrombolysis
Armando Tripodi, Massimo Primignani, Sara Badiali, Fausto de Ruberto, Paola Granelli, Giulia Tosetti, Marigrazia Clerici, Lidia Padovan, Veena Chantarangkul, Erica Scalambrino, Flora Peyvandi
Obesity is a risk factor for cardiovascular diseases. The latter being dependent (at least in part) on plasma procoagulant imbalance (i.e., hypercoagulability). Information on hypercoagulability associated with obesity is scanty and mainly based on global traditional coagulation tests or on the measurement of individual components of coagulation (i.e., pro- and anticoagulants). Plasma from 33 obese subjects was investigated soon before endoscopic balloon placement and after removal (6 months later) by thrombin-generation procedures that are thought to represent much better than any other in vitro test the coagulation process occurring in vivo...
January 30, 2019: Journal of Thrombosis and Thrombolysis
Yoko Inaba, Maiko Hongo, Riki Ninomiya, Akiko Nakazawa, Daijyo Hashimoto
A 68-year-old man who had a history of bone marrow transplantation for acute myeloid leukemia was referred to our hospital due to an abnormal liver function test. Based on the clinical diagnosis of P-NET G2 with multiple livermetastases, pylorus-preserving pancreaticoduodenectomy with combined resection of the portal vein and liver sampling were performed (R2 resection). The resected specimen revealed NET-G2 tumorof the pancreatic head(Ki-67 proliferation index 5.0%)and hepatic metastasis(Ki-67 index 2.2%)...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Pierre Chelle, Aurélie Montmartin, Pauline Damien, Michèle Piot, Michel Cournil, Anne Lienhart, Fabienne Genre-Volot, Hervé Chambost, Claire Morin, Brigitte Tardy-Poncet
The thrombin generation (TG) assay evaluates haemostatic balance, which is influenced by the levels of many coagulation factors and inhibitors. Our objective was to identify the determinant factors of TG in haemophilia A (HA) and haemophilia B (HB) patients and to compare them to those in healthy controls. Coagulation factor and inhibitor levels, and TG, were measured in platelet-poor plasma from 40 patients with HA, 32 patients with HB and 40 healthy subjects. Data were analysed using multiple regression models...
January 28, 2019: Haemophilia: the Official Journal of the World Federation of Hemophilia
I-Hsien Lin, Han-Ting Tsai, Chien-Yung Wang, Chih-Yang Hsu, Tsan-Hon Liou, Yen-Nung Lin
OBJECTIVE: To investigate the effects of various rehabilitative interventions aimed at enhancing poststroke motor recovery by assessing their effectiveness when compared with no treatment or placebo and their superiority when compared with conventional training program (CTP). DATA SOURCE: A literature search was based on 19 Cochrane reviews and 26 other reviews. We also updated the searches in PubMed up to September 30, 2017. STUDY SELECTION: Randomized controlled trials associated with 18 experimented training programs (ETP) were included if they evaluated the effects of the programs on either upper extremity (UE) or lower extremity (LE) motor recovery among adults within 6 months poststroke; included ≥10 participants in each arm; and had an intervention duration of ≥10 consecutive weekdays...
February 2019: Archives of Physical Medicine and Rehabilitation
Yothin Teethaisong, Ismini Nakouti, Katie Evans, Griangsak Eumkeb, Glyn Hobbs
OBJECTIVES: The present study developed Nitro-Carba Test (NCT), a rapid and simple chromogenic method for screening of Carbapenemase-producing Enterobacteriaceae (CPE). METHODS: The NCT was validated with a total of 31 carbapenemase-producing isolates (9 KPCs, 11 MBLs and 11 OXA-48s) and with 56 non-carbapenemase-producing strains. The assay relies on the hydrolysis of nitrocefin in the presence of carbapenems. The carbapenemases were extracted with lysis buffer prior to addition to wells with and without imipenem (IPM), meropenem (MEM) and ertapenem (ETP)...
January 19, 2019: Journal of Global Antimicrobial Resistance
Christopher A G Booth, Sten Eirik W Jacobsen, Adam J Mead
No abstract text is available yet for this article.
November 2018: Oncoscience
Ansu Kumar, Leylah M Drusbosky, Amy Meacham, Madeleine Turcotte, Priyanka Bhargav, Sumanth Vasista, Shahabuddin Usmani, Anusha Pampana, Kabya Basu, Anuj Tyagi, Deepak Lala, Swaminathan Rajagopalan, Shivgonda C Birajdar, Aftab Alam, Kunal Ghosh Roy, Taher Abbasi, Shireen Vali, Manju Sengar, Girish Chinnaswamy, Bijal D Shah, Christopher R Cogle
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is an aggressive hematological malignancy for which optimal therapeutic approaches are poorly characterized. Using computational biology modeling (CBM) in conjunction with genomic data from cell lines and individual patients, we generated disease-specific protein network maps that were used to identify unique characteristics associated with the mutational profiles of ETP-ALL compared to non-ETP-ALL (T-ALL) cases and simulated cellular responses to a digital library of FDA-approved and investigational agents...
January 7, 2019: Leukemia Research
Sankaran Krishnamoorthy, Premalatha Manickam, Vijayasekaran Muthukaruppan
Treatability of anaerobically digested distillery wastewater is challenging because of its high pollution load of COD up to 40,000 ppm. This research investigates the possibilities of retrofitting the effluent treatment plant (ETP) of a distillery with microalgae treatment step. For this, at first the photobioreactors of capacity 50 L and 500 L were customized for the cultivation of Spirulina sp. under xenon lamp and sunlight. The reactor supported the maximum specific growth rate up to 0.42 ± 0...
January 10, 2019: Journal of Environmental Management
X Y Gong, Y Wang, B C Liu, H Wei, C L Zhou, D Lin, K Q Liu, S N Wei, B F Gong, G J Zhang, Y T Liu, X L Zhao, Y Li, R X Gu, S W Qiu, Y C Mi, J X Wang
Objective: To analyze the clinical, laboratory characteristics and prognosis of adult early T-cell precursor acute lymphoblastic leukemia (ETP-ALL). Methods: The clinical data of 13 adult ETP-ALL patients from January 2009 to March 2017 were retrospectively analyzed and compared with non-ETP ALL patients. Results: 13 ETP-ALL patients (17.3%) were identified in 75 adult T-ALL patients, the median age of the patients was 35 years old (15 to 49 years) and 10 patients were male (76.9%). ETP-ALL patients had lower WBC count, LDH level, blasts in peripheral blood, lower incidence of thymic mass and higher PLT count compared to non-ETP ALL patients...
December 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Adi Elias, Wasseem Rock, Ahmad Odetalla, Gilat Ron, Naama Schwartz, Walid Saliba, Mazen Elias
BACKGROUND: Arterial hypertension is associated with greater risk of cardiovascular diseases and thrombotic complications, suggesting that hypertension is a prothrombotic state. OBJECTIVES: To investigate the relationship between arterial hypertension and thrombin generation, and between blood pressure level and thrombin generation in hypertensive patients. METHODS: A total of 165 hypertensive patients and 47 healthy adults controls were include in the study...
December 13, 2018: Thrombosis Research
Alya Zriwil, Charlotta Böiers, Trine A Kristiansen, Lilian Wittmann, Joan Yuan, Claus Nerlov, Ewa Sitnicka, Sten E W Jacobsen
Given that FLT3 expression is highly restricted on lymphoid progenitors, it is possible that the established role of FLT3 in the regulation of B and T lymphopoiesis reflects its high expression and role in regulation of lymphoid-primed multipotent progenitors (LMPPs) or common lymphoid progenitors (CLPs). We generated a Flt3 conditional knock-out (Flt3fl/fl ) mouse model to address the direct role of FLT3 in regulation of lymphoid-restricted progenitors, subsequent to turning on Rag1 expression, as well as potentially ontogeny-specific roles in B and T lymphopoiesis...
November 2018: British Journal of Haematology
Xiao-Xue Wang, Danyang Wu, Lijun Zhang
RATIONALE: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a small subtype of T-cell acute lymphoblastic leukemia with a typical immune-phenotype: lack of T-lineage cell surface markers CD1a and CD8 expression, weak or absent CD5 expression, at least one of the myeloid or hematopoietic stem cell markers. It is characterized by high rate of induction failure and the effective unified treatment strategies are still indeterminate. We present 2 ETP-ALL cases. PATIENT CONCERNS: A 42-year-old man presented with abnormal hemogram for 4 months, intermittent fever for 2 months and cough for 1 week...
December 2018: Medicine (Baltimore)
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