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A. Baumannii

Aušra Čiginskienė, Asta Dambrauskienė, Jordi Rello, Dalia Adukauskienė
Background and objectives: High mortality and healthcare costs area associated with ventilator-associated pneumonia (VAP) due to Acinetobacter baumannii ( A. baumannii ). The data concerning the link between multidrug-resistance of A. baumannii strains and outcomes remains controversial. Therefore, we aimed to identify the relation of risk factors for ventilator-associated pneumonia (VAP) and mortality with the drug resistance profiles of Acinetobacter baumannii ( A. baumannii ) and independent predictors of in-hospital mortality...
February 13, 2019: Medicina
Ahmed O H El-Nezhawy, Majed Alrobaian, Ahmed Khames, Mohamed F El-Badawy, Sayed F Abdelwahab
A general strategy towards total synthesis of (-)-codonopsinine, (-)-codonopsine and codonopsinine analogues has been developed from (D)-tartaric acid via the intermediate (3S,4R)-1-methyl-2-oxo-5-(2,2,2-trichloroacetamido)pyrrolidinediacetate (7). α-amidoalkylation studies of 7 with electron rich benzene derivative 8a-g as C-nucleophiles afforded (aryl derivatives) 9a-g. The target compounds 1, 2 and 13c-g were readily obtained from 10a-gvia Grignard addition to the homochiral lactam which was produced by deoxygenation using Lewis-acid followed by deacetylation...
February 13, 2019: Bioorganic & Medicinal Chemistry
Mariam ALfadli, Eman M El-Sehsah, Moustapha Ahmed-Maher Ramadan
Introduction: Patients with burn wounds are more susceptible to develop healthcare associated (HA) infection. Bacterial isolates from HA burn wound infection vary from one place to the other and also differ in terms of antimicrobial susceptibility pattern. The aim of our study was to assess the incidence of HA burn wound infection, risk factors and to determine the microbiological profile and antimicrobial susceptibility pattern of isolated pathogens. Methods: This was a one-year retrospective descriptive study conducted between January 2017 and December 2017, in Al-Babtain Burn and Plastic Surgery center, Kuwait...
December 2018: Germs
Sabine Zeidler, Volker Müller
Multidrug resistant (MDR) pathogens are one of the most pressing challenges of contemporary health care. Acinetobacter baumannii takes a predominant position, emphasized in 2017 by the World Health Organization. The increasing emergence of MDR strains strengthens the demand for new antimicrobials. Possible targets for such compounds might be proteins involved in resistance against low water activity environments, since A. baumannii is known for its pronounced resistance against desiccation stress. Despite the importance of desiccation resistance for persistence of this pathogen in hospitals, comparable studies and precise data on this topic are rare and the mechanisms involved are largely unknown...
February 17, 2019: Environmental Microbiology
Sajjad Yazdansetad, Ehsan Najari, Ezzat Allah Ghaemi, Naemeh Javid, Ali Hashemi, Abdollah Ardebili
OBJECTIVES: Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a serious challenge and poses a threat to public health worldwide. This study aimed to determine drug susceptibility of A. baumannii, and then, investigate oxacillinase-encoding determinants and their association with ISAba1 sequence in CRAB isolates. METHODS: This study was performed on A. baumannii isolates recovered from patients with burn wound infections during 2013. All isolates were evaluated for antimicrobial susceptibility by disc agar diffusion method...
February 11, 2019: Journal of Global Antimicrobial Resistance
P Malaka De Silva, Ayush Kumar
Acinetobacter baumannii is a notorious pathogen in health care settings around the world, primarily due to high resistance to antibiotics. A. baumannii also shows an impressive capability to adapt to harsh conditions in clinical settings, which contributes to its persistence in such conditions. Following their traditional role, the T wo C omponent S ystems (TCSs) present in A. baumannii play a crucial role in sensing and adapting to the changing environmental conditions. This provides A. baumannii with a greater chance of survival even in unfavorable conditions...
2019: Frontiers in Microbiology
Xiaoxian Song, Ruxia Tu, Xiaoli Mei, Silan Wu, Bo Lan, Li Zhang, Xianqin Luo, Jianyi Liu, Minghe Luo
Mycophenolic acid (MPA) is a group of metabolite derived from several species of Penicillium, which shows potent bioactivity. In this study, a new derivative of MPA compound named penicacid D (1), was isolated from the marine derived fungus Penicillium sp. SCSIO sof101, along with seven known compounds (2-8). Their structures were elucidated based on the HR-ESI-MS and NMR data. Moreover, the 1 H and 13 C NMR data of compound 2 and the 13 C NMR data of compound 3 are reported. Compounds 1, 4 and 6 exhibited weak activities against Escherichia coli (clinical isolation number 100385570) and Acinetobacter baumannii (clinical isolation number 100069)...
February 13, 2019: Natural Product Research
Eun Seon Chung, Kwan Soo Ko
Objectives: Persister cells following antibiotic exposure may cause failure of antibiotic treatment. The synergistic effects of antibiotic combinations with respect to eliminating persister cells were investigated based on their characteristics. Methods: For Acinetobacter baumannii clinical isolates, persister assays were performed using colistin, amikacin, imipenem and ciprofloxacin in various ways, including exposure to antibiotics in combination and sequentially...
February 12, 2019: Journal of Antimicrobial Chemotherapy
Yan Zhu, Jinxin Zhao, Mohd Hafidz Mahamad Maifiah, Tony Velkov, Falk Schreiber, Jian Li
Multidrug-resistant (MDR) Acinetobacter baumannii has emerged as a very problematic pathogen over the past decades, with a high incidence in nosocomial infections. Discovered in the late 1940s but abandoned in the 1970s, polymyxins (i.e., polymyxin B and colistin) have been revived as the last-line therapy against Gram-negative "superbugs," including MDR A. baumannii. Worryingly, resistance to polymyxins in A. baumannii has been increasingly reported, urging the development of novel antimicrobial therapies to rescue this last-line class of antibiotics...
January 2019: MSystems
Xingchen Bian, Xiaofen Liu, Yuancheng Chen, Daijie Chen, Jian Li, Jing Zhang
Background: Colistin-based combination therapy has become an important strategy to combat the carbapenem-resistant Acinetobacter baumannii (CRAB). However, the optimal dosage regimen selection for the combination with the maximum efficacy is challenging. Method: Checkerboard assay was employed to evaluate the synergy of colistin in combination with meropenem, rifampicin, fosfomycin and minocycline against nine carbapenem-resistant A. baumannii (Minimum inhibitory concentration of meropenem [MICMEM ]≥32 mg/L) isolated from Chinese hospital-acquired pneumonia (HAP) patients...
February 11, 2019: Antimicrobial Agents and Chemotherapy
Htut Htut Htoo, Lauren Brumage, Vorrapon Chaikeeratisak, Hannah Tsunemoto, Joseph Sugie, Chanwit Tribuddharat, Joe Pogliano, Poochit Nonejuie
An increasing number of multidrug-resistant Acinetobacter baumannii (MDR- AB ) infections have been reported worldwide, posing a threat to public health. The establishment of methods to elucidate the mechanism of action (MOA) of A. baumannii -specific antibiotics is needed to develop novel antimicrobial therapeutics with activity against MDR- AB We previously developed bacterial cytological profiling (BCP) to understand the MOA of compounds in E. coli and B. subtilis Given how distantly related A. baumannii is to these species, it was unclear to what extent it could be applied...
February 11, 2019: Antimicrobial Agents and Chemotherapy
Toby L Bartholomew, Timothy J Kidd, Joana Sá Pessoa, Raquel Conde Álvarez, José A Bengoechea
Acinetobacter baumannii causes a wide range of nosocomial infections. This pathogen is considered a threat to human health due to the increasing isolation of multidrug resistant strains. There is a major gap in knowledge on the infection biology of A. baumannii , and only few virulence factors have been characterized including the lipopolysaccharide. The lipid A expressed by A. baumannii is hepta-acylated and contains 2-hydroxylaurate. The late acyltransferases controlling the acylation of the lipid A have been already characterized...
February 11, 2019: Infection and Immunity
Hervé Nicoloff, Karin Hjort, Bruce R Levin, Dan I Andersson
When choosing antibiotics to treat bacterial infections, it is assumed that the susceptibility of the target bacteria to an antibiotic is reflected by laboratory estimates of the minimum inhibitory concentration (MIC) needed to prevent bacterial growth. A caveat of using MIC data for this purpose is heteroresistance, the presence of a resistant subpopulation in a main population of susceptible cells. We investigated the prevalence and mechanisms of heteroresistance in 41 clinical isolates of the pathogens Escherichia coli, Salmonella enterica, Klebsiella pneumoniae and Acinetobacter baumannii against 28 different antibiotics...
February 11, 2019: Nature Microbiology
Corinne Sadlowski, Bora Park, Clarissa Araújo, Subhamoy Das, D Lucas Kerr, Maomao He, Hesong Han, Lee Riley, Niren Murthy
The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant Acinetobacter baumannii, and Pseudomonas aeruginosa.
August 1, 2018: Molecular Systems Design & Engineering
Han Sang Lee, Jangsup Moon, Hye-Rim Shin, Seon Jae Ahn, Tae-Joon Kim, Jin-Sun Jun, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Manho Kim, Sang Kun Lee, Kon Chu
Background: Bed-ridden state, dysphagia, altered mental state, or respiratory muscle weakness are common in neurologic patients and increase the risk of pneumonia. The major causes of pneumonia in neurologic patients may differ from those in the general population, resulting in a different pathogen distribution. We investigated the trends of pathogen distribution in culture-positive pneumonia in hospitalized neurologic patients and the related antibiotic resistance in those with hospital-acquired pneumonia (HAP)...
2019: Antimicrobial Resistance and Infection Control
Fen Pan, Wantong Zhao, Hong Zhang
Objective: This study was to investigate the microbiological characteristics and the relationship between the time to positivity (TTP) of blood cultures and different bacterial species and to assess the clinical value of TTP in children with bloodstream infections (BSIs). Methods: The TTP of all the blood cultures from children with suspected BSIs was retrospectively collected in 2016. The microbiological characteristics and the relationship between the TTP of blood cultures and different bacterial species were also analyzed...
2019: Canadian Journal of Infectious Diseases & Medical Microbiology
Khalid Eljaaly, Aisha Alharbi, Samah Alshehri, Jessica K Ortwine, Jason M Pogue
Plazomicin is a novel semisynthetic parenteral aminoglycoside that inhibits bacterial protein synthesis. It was approved by the United States Food and Drug Administration for use in adults with complicated urinary tract infections (cUTI), including pyelonephritis. Plazomicin displays potent in vitro activity against Enterobacteriaceae, including both extended-spectrum β-lactamase-producing and carbapenem-resistant isolates. Plazomicin's enhanced Enterobacteriaceae activity is due to its stability to commonly encountered aminoglycoside-modifying enzymes that compromise the activity of traditional aminoglycosides...
February 6, 2019: Drugs
Jhih-Hang Jiang, Karl A Hassan, Stephanie L Begg, Thusitha W T Rupasinghe, Varsha Naidu, Victoria G Pederick, Marjan Khorvash, Jonathan J Whittall, James C Paton, Ian T Paulsen, Christopher A McDevitt, Anton Y Peleg, Bart A Eijkelkamp
Free fatty acids hold important immune-modulatory roles during infection. However, the host's long-chain polyunsaturated fatty acids, not commonly found in the membranes of bacterial pathogens, also have significant broad-spectrum antibacterial potential. Of these, the omega-6 fatty acid arachidonic acid (AA) and the omega-3 fatty acid decosahexaenoic acid (DHA) are highly abundant; hence, we investigated their effects on the multidrug-resistant human pathogen Acinetobacter baumannii Our analyses reveal that AA and DHA incorporate into the A...
February 5, 2019: MBio
Christine J Boinett, Amy K Cain, Jane Hawkey, Nhu Tran Do Hoang, Nhu Nguyen Thi Khanh, Duy Pham Thanh, Janina Dordel, James I Campbell, Nguyen Phu Huong Lan, Matthew Mayho, Gemma C Langridge, James Hadfield, Nguyen Van Vinh Chau, Guy E Thwaites, Julian Parkhill, Nicholas R Thomson, Kathryn E Holt, Stephen Baker
The increasing incidence and emergence of multi-drug resistant (MDR) Acinetobacter baumannii has become a major global health concern. Colistin is a historic antimicrobial that has become commonly used as a treatment for MDR A. baumannii infections. The increase in colistin usage has been mirrored by an increase in colistin resistance. We aimed to identify the mechanisms associated with colistin resistance in A. baumannii using multiple high-throughput-sequencing technologies, including transposon-directed insertion site sequencing (TraDIS), RNA sequencing (RNAseq) and whole-genome sequencing (WGS) to investigate the genotypic changes of colistin resistance in A...
February 5, 2019: Microbial Genomics
FuMei Chen, Xianyu Deng, Zhanpeng Wang, Li Wang, Ke Wang, Liang Gao
Background: Severe ventriculitis (SV) caused by multidrug-resistant bacteria is associated with high morbidity and mortality in neurosurgical patients. This study assessed the outcomes of patients with SV caused by Acinetobacter baumannii who were treated by intraventricular (IVT) lavage and colistin administration. Methods: This retrospective study included consecutive patients with SV caused by A. baumannii who were admitted at the Neurosurgical Department of Shanghai Tenth People's Hospital from January 2014 to September 2017...
2019: Infection and Drug Resistance
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