Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Ana Luisa Corona-Nakamura, Martha Judith Arias-Merino, Eleazar Iván Ávila-Esparza, María de Lourdes Tolentino-Corona, César Cuauhtémoc Cañedo-Castañeda, Héctor Enrique Flores-Salinas, Juan Fernando Corona-Macías, Martha Elena Vázquez-Arias
INTRODUCTION: Nosocomial infectious ventriculitis caused by multidrug-resistant (MDR) Gram-negative bacilli associated with external ventricular drainage (EVD) placement poses a significant mortality burden and hospital costs. OBJECTIVES: This study aims to analyze the characteristics, ventriculitis evolution, treatment, and outcomes of patients with ventriculitis due to MDR Gram-negative bacilli associated with EVD placement. METHODS: A retrospective cohort study focusing on patients with nosocomial infection caused by MDR Gram-negative bacilli while on EVD was conducted from 2019 to 2022...
2024: Frontiers in Neurology
#2
JOURNAL ARTICLE
Zhitao Wang, Xue Yang, Hui Wang, Shuxian Wang, Ren Fang, Xiaotian Li, Jiayin Xing, Qianqian Wu, Zhaoli Li, Ningning Song
Carbapenem-resistant Acinetobacter baumannii (CRAB) has become a new threat in recent years, owing to its rapidly increasing resistance to antibiotics and new effective therapies are needed to combat this pathogen. Phage therapy is considered to be the most promising alternative for treating CRAB infections. In this study, a novel phage, Ab_WF01, which can lyse clinical CRAB, was isolated and characterized from hospital sewage. The multiplicity of infection, morphology, one-step growth curve, stability, sensitivity, and lytic activity of the phage were also investigated...
2024: Frontiers in Cellular and Infection Microbiology
#3
JOURNAL ARTICLE
Rahul A Pandit, P C Vijayakumar, Mehul Shah, Simant Jha, Bhagyashri Patil, Arpita Dwivedy, Kiran Patil, R B Nerli, Amol Kulkarni, N K Vinod, Anand Nikalje, Anand Jain, Vidhyadhara Gajanana Lakkappan, Rajendra K Parakh, Deodatta S Chafekar
INTRODUCTION: A survey-based approach to managing antibiotic-resistant infections in the intensive care unit (ICU) setting, with a focus on carbapenem-resistant Enterobacteriaceae (CRE) cases, was conducted. Among CRE, New Delhi metallo-β-lactamase 1 (NDM-1) is a carbapenemase that is resistant to β-lactam antibiotics and has a broader spectrum of antimicrobial resistance than other carbapenemase types. The article explains that healthcare-associated infections (HAIs) are a significant problem, particularly in low- and middle-income countries, and that carbapenem in combination with other antibiotics are the most potent class of antimicrobial agents effective in treating life-threatening bacterial infections, including those caused by resistant strains...
January 2024: Journal of the Association of Physicians of India
#4
JOURNAL ARTICLE
Sarah M McLeod, Nicole M Carter, Patricia A Bradford, Alita A Miller
Combinations of the β-lactam/β-lactamase inhibitor sulbactam-durlobactam and seventeen antimicrobial agents were tested against strains of Acinetobacter baumannii in checkerboard assays. Most combinations resulted in indifference with no instances of antagonism. These results suggest sulbactam-durlobactam antibacterial activity against A. baumannii is unlikely to be affected if co-dosed with other antimicrobial agents.
May 9, 2024: Diagnostic Microbiology and Infectious Disease
#5
REVIEW
Razique Anwer
The aim of this study was to go through the molecular methods used for typing of carbapenem-resistant Acientobacter baumannii (CRAB) isolates for investigating the molecular epidemiology all over the world. Multiple typing techniques are required to understand the source and nature of outbreaks caused by Acientobacter baumannii ( A. baumannii ) and acquired resistance to antimicrobials. Nowadays, there is gradual shift from traditional typing methods to modern molecular methods to study molecular epidemiology and infection control...
May 2024: Saudi Medical Journal
#6
JOURNAL ARTICLE
Ajit Ramesh Sawant, Sudhakar Pagal, K Prashanth
Acinetobacter baumannii is an important Gram-negative nosocomial pathogen that causes opportunistic infections and employs different mechanisms to survive in the presence of antibiotics in the host. Nutrient limitation is one of the important defense mechanisms of the mammalian immune system to fight against the colonization of pathogens like A. baumannii. The present study describes an NtrC-type Response Regulator (RR) A1S_1978 involved in modulating the metabolism and cell morphology of A. baumannii via a two-component system...
May 9, 2024: Gene
#7
JOURNAL ARTICLE
Hilla Khelwati, Lasse van Geelen, Rainer Kalscheuer, Thomas J J Müller
In this study, a library of 3,7-di(hetero)aryl-substituted 10-(3-trimethylammoniumpropyl)10 H -phenothiazine salts is prepared. These title compounds and their precursors are reversible redox systems with tunable potentials. The Hammett correlation gives a very good correlation of the first oxidation potentials with σp parameters. Furthermore, the title compounds and their precursors are blue to green-blue emissive. Screening of the salts reveals for some derivatives a distinct inhibition of several pathogenic bacterial strains ( Mycobacterium tuberculosis , Staphylococcus aureus , Escherichia coli , Aconetobacter baumannii , and Klebsiella pneumoniae ) in the lower micromolar range...
May 3, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#8
JOURNAL ARTICLE
Biljana Kakaraskoska Boceska, Tuba Vilken, Basil Britto Xavier, Tomislav Kostyanev, Qiang Lin, Christine Lammens, Sally Ellis, Seamus O'Brien, Renata Maria Augusto da Costa, Aislinn Cook, Neal Russell, Julia Bielicki, Amy Riddell, Wolfgang Stohr, Ann Sarah Walker, Eitan Naaman Berezin, Emmanuel Roilides, Maia De Luca, Lorenza Romani, Daynia Ballot, Angela Dramowski, Jeannette Wadula, Sorasak Lochindarat, Suppawat Boonkasidecha, Flavia Namiiro, Hoang Thi Bich Ngoc, Minh Dien Tran, Tim R Cressey, Kanchana Preedisripipat, James A Berkley, Robert Musyimi, Charalampos Zarras, Trusha Nana, Andrew Whitelaw, Cely Barreto da Silva, Prenika Jaglal, Willy Ssengooba, Samir K Saha, Mohammad Shahidul Islam, Marisa Marcia Mussi-Pinhata, Cristina Gardonyi Carvalheiro, Laura J V Piddock, Paul T Heath, Surbhi Malhotra-Kumar, Michael Sharland, Youri Glupczynski, Herman Goossens
Gram-negative bacteria (GNB) are a major cause of neonatal sepsis in low- and middle-income countries (LMICs). Although the World Health Organization (WHO) reports that over 80% of these sepsis deaths could be prevented through improved treatment, the efficacy of the currently recommended first- and second-line treatment regimens for this condition is increasingly affected by high rates of drug resistance. Here we assess three well known antibiotics, fosfomycin, flomoxef and amikacin, in combination as potential antibiotic treatment regimens by investigating the drug resistance and genetic profiles of commonly isolated GNB causing neonatal sepsis in LMICs...
May 10, 2024: Nature Communications
#9
JOURNAL ARTICLE
Bhani Kongkham, P Duraivadivel, P Hariprasad
ETHNOPHARMACOLOGICAL RELEVANCE: India's ancient texts, the Charak Samhita and Sushruta Samhita, make reference to the traditional medicinal usage of Acorus calamus L. In India and China, it has long been used to cure stomach aches, cuts, diarrhea, and skin conditions. This ability of the rhizome is attributed to its antimicrobial properties. Research studies to date have shown its antimicrobial properties. However, scientific evidence on its mode of action is still lacking. AIM OF THE STUDY: Acorus calamus L...
May 8, 2024: Journal of Ethnopharmacology
#10
JOURNAL ARTICLE
Zachary L Klamer, Cynthia M June, Zdzislaw Wawrzak, Magdalena A Taracila, Joshua A Grey, Alyssa M I Benn, Christopher P Russell, Robert A Bonomo, Rachel A Powers, David A Leonard, Agnieszka Szarecka
OXA-66 is a member of the OXA-51 subfamily of class D β -lactamases native to the Acinetobacter genus that includes Acinetobacter baumannii, one of the ESKAPE pathogens and a major cause of drug-resistant nosocomial infections. Although both wild type OXA-66 and OXA-51 have low catalytic activity, they are ubiquitous in the Acinetobacter genomes. OXA-51 is also remarkably thermostable. In addition, newly emerging, single and double amino acid variants show increased activity against carbapenems, indicating that the OXA-51 subfamily is growing and gaining clinical significance...
May 8, 2024: Journal of Molecular Biology
#11
JOURNAL ARTICLE
Tongdeng You, Ke Shi
To understand the distribution and antimicrobial resistance (AMR) of pathogens in respiratory samples in Changle District People's Hospital in Fujian Province in recent years, and provide empirical guidance for infection control and clinical treatment in the region. A retrospective analysis was conducted on 5137 isolates of pathogens from respiratory samples collected from 2019 to 2022. The AMR patterns were systematically analyzed. For research purposes, the data was accessed on October 12, 2023. A total of 3517 isolates were included in the study, including 811 (23...
May 10, 2024: Medicine (Baltimore)
#12
JOURNAL ARTICLE
Belinda Candra, Deborah Cook, Janelle Hare
The DNA damage response of the multi-drug-resistant nosocomial pathogen Acinetobacter baumannii possesses multiple features that distinguish it from the commonly used LexA repression system. These include the absence of LexA in this genus, the evolution of a UmuD polymerase manager into the UmuDAb repressor of error-prone polymerases, the use of a corepressor unique to Acinetobacter (DdrR), and an unusually large UmuDAb binding site. We defined cis- and trans-acting factors required for UmuDAb DNA binding and gene repression, and tested whether DdrR directly enhances its DNA binding...
May 10, 2024: Journal of Bacteriology
#13
JOURNAL ARTICLE
Zi Jin Zhao, Xiao Ping Chen, Shao Wei Hua, Feng Yu Li, Meng Zhao, Chen Hao Xing, Jie Wang, Feng Yu Tian, Rui Qing Zhang, Xiao Na Lyu, Zhi Qiang Han, Yu Xin Wang, Hong Yi Li, Xin Xin Shen, Xue Jun Ma, Yan Qing Tie
OBJECTIVE: Recombinase-aided polymerase chain reaction (RAP) is a sensitive, single-tube, two-stage nucleic acid amplification method. This study aimed to develop an assay that can be used for the early diagnosis of three types of bacteremia caused by Staphylococcus aureus (SA), Pseudomonas aeruginosa (PA), and Acinetobacter baumannii (AB) in the bloodstream based on recombinant human mannan-binding lectin protein (M1 protein)-conjugated magnetic bead (M1 bead) enrichment of pathogens combined with RAP...
April 20, 2024: Biomedical and Environmental Sciences: BES
#14
JOURNAL ARTICLE
Mélanie Gonzales, Baptiste Kergaravat, Pauline Jacquet, Raphaël Billot, Damien Grizard, Éric Chabrière, Laure Plener, David Daudé
The development of sustainable alternatives to conventional antimicrobials is needed to address bacterial virulence while avoiding selecting resistant strains in a variety of fields, including human, animal and plant health. Quorum sensing (QS), a bacterial communication system involved in noxious bacterial phenotypes such as virulence, motility and biofilm formation, is of utmost interest. In this study, we harnessed the potential of the lactonase SsoPox to disrupt QS of human, fish, and plant pathogens. Lactonase treatment significantly alters phenotypes including biofilm formation, motility, and infection capacity...
May 9, 2024: Pathogens and Disease
#15
JOURNAL ARTICLE
Yingying An, Xiaomin Guo, Tiantian Yan, Yue Jia, Ruoyan Jiao, Xinyu Cai, Bochuan Deng, Guangjun Bao, Yiping Li, Wenle Yang, Rui Wang, Wangsheng Sun, Junqiu Xie
Antimicrobial peptides (AMPs), which have a low probability of developing resistance, are considered the most promising antimicrobial agents for combating antibiotic resistance. Feleucin-K3 is an amphiphilic cationic AMP that exhibits broad-spectrum antimicrobial activity. In our previous research, the first phenylalanine residue was identified as the critical position affecting its biological activity. Here, a series of Feleucin-K3 analogs containing hydrophobic D-amino acids were developed, leveraging the low sensitivity of proteases to unnatural amino acids and the regulatory effect of hydrophobicity on antimicrobial activity...
May 7, 2024: Biochemical Pharmacology
#16
JOURNAL ARTICLE
Yichuan Gan, Guowen Zhang, Hengbiao Sun, Xiaoming Lyu
OBJECTIVE: This study aimed to analyze the bacterial composition, distribution, drug sensitivity, and clinical characteristics of COVID-19 patients who develop bacterial co-infections. METHODS: We conducted a retrospective study of 184 COVID-19 patients admitted between December 2022 and January 2023. Data on gender, age, length of hospital stay, pneumonia classification, underlying diseases, invasive surgery, hormone therapy, inflammation indicators, and other relevant information were collected...
May 7, 2024: Journal of Global Antimicrobial Resistance
#17
JOURNAL ARTICLE
Anissa Desmoulin, Loïk Sababadichetty, Laure Kamus, Marion Daniel, Lucie Feletti, Nicolas Allou, Anaïs Potron, Anne-Gaëlle Leroy, Marie-Christine Jaffar-Bandjee, Olivier Belmonte, Thomas Garrigos, Guillaume Miltgen
OBJECTIVES: Determining the best available therapy for carbapenem-resistant Acinetobacter baumannii (CRAB) infections is a challenge. Cefiderocol is an attractive alternative drug effective against many resistance mechanisms in Gram-negative bacteria. However, its place in the treatment of Acinetobacter baumannii infections remains unclear and much debated, with contradictory results. METHODS: We describe here the case of a 37-year-old man with ventilator-associated bacteraemic CRAB pneumonia in an intensive care unit...
May 15, 2024: Heliyon
#18
JOURNAL ARTICLE
Yuhui Yang, Qingling Zeng, Guangyun Hu, Zhenkun Wang, Zongyue Chen, Lang Zhou, Aibo He, Wei Qian, Yu Luo, Gaoming Li
INTRODUCTION: Over the past decade, numerous studies have described the types of pathogens and their antibiotic resistance patterns in patients with burn injuries in China; however, the findings have generally been inconsistent. We conducted a literature search and meta-analysis to summarize the infection spectra and antimicrobial resistance patterns in patients with burn injuries. METHODS: We searched the PubMed, Embase, Web of Science, China National Knowledge Infrastructure, China Biomedical Literature, Wanfang, and Weipu databases for relevant articles published between January 2010 and December 2023...
May 9, 2024: Infectious Diseases and Therapy
#19
JOURNAL ARTICLE
Stella Buchhorn de Freitas, Amilton Clair Pinto Seixas Neto, Luciano Aparecido Panagio, Mauro Pereira Soares, Daiane Drawanz Hartwig
Due to its antimicrobial resistance characteristics, the World Health Organization (WHO) classifies A. baumannii as one of the critical priority pathogens for the development of new therapeutic strategies. Vaccination has been approached as an interesting strategy to overcome the lack of effective antimicrobials and the long time required to develop and approve new drugs. In this study, we aimed to evaluate as a vaccine the hypothetical adhesin protein CAM87009.1 in its recombinant format (rCAM87009.1) associated with aluminum hydroxide (Alhydrogel®) or biogenic silver nanoparticles (bio-AgNP) as adjuvant components against lethal infection by A...
May 7, 2024: Vaccine
#20
JOURNAL ARTICLE
Faye C Morris, Yan Jiang, Ying Fu, Xenia Kostoulias, Gerald L Murray, Yusong Yu, Anton Y Peleg
Acinetobacter baumannii is one of the most prevalent causes of nosocomial infections worldwide. However, a paucity of information exists regarding the connection between metabolic capacity and in vivo bacterial fitness. Elevated lactate is a key marker of severe sepsis. We have previously shown that the putative A. baumannii lactate permease gene, lldP, is upregulated during in vivo infection. Here, we confirm that lldP expression is upregulated in three A. baumannii strains during a mammalian systemic infection...
May 8, 2024: FEMS Microbiology Letters
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
