Adam D Farmer, Ahmed Albusoda, Gehanjali Amarasinghe, James K Ruffle, Heather E Fitzke, Ruqaya Idrees, Ron Fried, Christina Brock, Qasim Aziz
BACKGROUND: The vagus nerve exerts an anti-nociceptive effect in the viscera. AIMS: To investigate whether transcutaneous vagal nerve stimulation (t-VNS) prevents the development and/or reverses established visceral hypersensitivity in a validated model of acid-induced oesophageal pain. METHODS: Before and after a 30-minute infusion of 0.15M hydrochloric acid into the distal oesophagus, pain thresholds to electrical stimulation were determined in the proximal non-acid exposed oesophagus...
August 7, 2020: Alimentary Pharmacology & Therapeutics
Frank Weber, Bharat K Rashmi, Gülhan Karaoz-Bulut, Jaap Dogger, Iris J de Heer, Christopher Prasser
BACKGROUND: In children the preoperative hydration status is an important part of the overall clinical assessment. The assumed preoperative fluid deficit is often routinely replaced during induction without knowing the child's actual fluid status. AIM: We investigated the predictive value of the Pleth Variability Index as a measure of fluid responsiveness in spontaneously breathing anesthetized children. METHODS: Pleth Variability Index, stroke volume and cardiac index, measured by electrovelocimetry, mean blood pressure and heart rate were recorded during anesthesia induction in 50 pediatric patients < 6 years...
August 7, 2020: Paediatric Anaesthesia
Marco Baron Toaldo, Chiara Mazzoldi, Giovanni Romito, Helen Poser, Barbara Contiero, Mario Cipone, Carlo Guglielmini
BACKGROUND: Atrial fibrillation (AF) occurs in dogs with myxomatous mitral valve disease (MMVD) as a consequence of left atrial (LA) dilatation, and it affects survival and quality of life. OBJECTIVES: To evaluate the usefulness of echocardiography in predicting the first occurrence of AF in dogs with MMVD. ANIMALS: Forty-four client-owned dogs with MMVD, 22 dogs that developed AF, and 22 dogs that maintained sinus rhythm. METHODS: Retrospective observational study...
August 7, 2020: Journal of Veterinary Internal Medicine
Samit Shah, Yulanka Castro-Dominguez, Tanush Gupta, Robert Attaran, Kip Byrum, Adam Taleb, Amanda Pettyjohn, Robert C Bartel, Molly Szerlip, Timothy D Henry, Ehtisham Mahmud, Robert J Applegate
OBJECTIVES: We sought to determine the effect of COVID-19 related reduction in elective cardiac procedures and acute coronary syndrome presentations on interventional cardiology (IC) training. BACKGROUND: The COVID-19 pandemic has significantly disrupted healthcare in the United States, including cardiovascular services. The impact of COVID-19 on IC fellow training in the United States has not been assessed. METHODS: The Society for Cardiovascular Angiography and Interventions (SCAI) surveyed IC fellows training in both accredited and advanced non-accredited programs, as well as their program directors (PD)...
August 7, 2020: Catheterization and Cardiovascular Interventions
Elise Rouault, Corinne Ghnassia, Emmanuelle Filippi-Codaccioni, Nicolas Maillard
Digifab® is indicated for digoxin poisoning. One vial contains 40 mg of digoxin-specific antibody fragments (Fab) for intravenous administration. In cases of pharmaceutical digoxin poisoning, the necessary dose for complete neutralization is obtained by defined calculation. An empirical dose of 20 vials can be used in case of life-threatening poisoning without available serum digoxin level or estimation of amount ingested. Administration of initially 10 vials followed by 10 further vials is possible to avoid febrile reactions [1]...
August 7, 2020: Basic & Clinical Pharmacology & Toxicology
Santiago Garcia, Larissa Stanberry, Christian Schmidt, Scott Sharkey, Michael Megaly, Mazen S Albaghdadi, Perwaiz M Meraj, Ross Garberich, Farouc A Jaffer, Ada C Stefanescu Schmidt, Simon R Dixon, Jeffrey J Rade, Timothy Smith, Mark Tannenbaum, Jenny Chambers, Frank Aguirre, Paul P Huang, Dharam J Kumbhani, Thomas Koshy, Dmitriy N Feldman, Jay Giri, Prashant Kaul, Craig Thompson, Houman Khalili, Brij Maini, Keshav R Nayak, Mauricio G Cohen, Sripal Bangalore, Binita Shah, Timothy D Henry
OBJECTIVE: To evaluate the impact of COVID-19 pandemic migitation measures on of ST-elevation myocardial infarction (STEMI) care. BACKGROUND: We previously reported a 38% decline in cardiac catheterization activations during the early phase of the COVID-19 pandemic mitigation measures. This study extends our early observations using a larger sample of STEMI programs representative of different US regions with the inclusion of more contemporary data. METHODS: Data from 18 hospitals or healthcare systems in the US from January 2019 to April 2020 were collecting including number activations for STEMI, the number of activations leading to angiography and primary percutaneous coronary intervention (PPCI), and average door to balloon (D2B) times...
August 7, 2020: Catheterization and Cardiovascular Interventions
Tiina Heliö, Perry Elliott, Juha W Koskenvuo, Juan R Gimeno, Luigi Tavazzi, Michal Tendera, Juan Pablo Kaski, Nicolas Mansencal, Zofia Bilińska, Gerry Carr-White, Thibaud Damy, Andrea Frustaci, Ingrid Kindermann, Tomas Ripoll-Vera, Jelena Čelutkienė, Anna Axelsson, Massimiliano Lorenzini, Aly Saad, Aldo P Maggioni, Cécile Laroche, Alida L P Caforio, Philippe Charron
AIMS: Cardiomyopathies comprise a heterogeneous group of diseases, often of genetic origin. We assessed the current practice of genetic counselling and testing in the prospective European Society of Cardiology EURObservational Research Programme Cardiomyopathy Registry. METHODS AND RESULTS: A total of 3208 adult patients from 69 centres in 18 countries were enrolled. Genetic counselling was performed in 60.8% of all patients [75.4% in hypertrophic cardiomyopathy (HCM), 39...
August 7, 2020: ESC Heart Failure
Fausto Biancari, Jouni Pykäri, Mikko Savontaus, Mika Laine, Annastiina Husso, Marko Virtanen, Pasi Maaranen, Matti Niemelä, Timo Mäkikallio, Tuomas Tauriainen, Markku Eskola, Peter Raivio, Antti Valtola, Tatu Juvonen, Juhani Airaksinen
BACKGROUND: Conduction defects requiring permanent pacemaker (PPM) implantation are frequent complications occurring after surgical (SAVR) and transcatheter aortic valve replacement (TAVR). METHODS: Patients who underwent TAVR or SAVR with a bioprosthesis from the nationwide FinnValve registry were the subjects of this study. Patients with prior PPM, who received a sutureless prosthesis, or required cardiac resynchronization therapy or implantable cardioverter defibrillator were excluded from this analysis...
August 7, 2020: Catheterization and Cardiovascular Interventions
Delio Tedeschi, Andrea Rizzi, Simone Biscaglia, Carlo Tumscitz
This is a case report of a 60-year-old male, without any cardiovascular risk factor and no cardiac history admitted to hospital with a diagnosis of interstitial pneumonia caused by coronavirus disease 2019 (COVID-19). After 7 days, the blood tests showed a significant rise of inflammatory and procoagulant markers, along with a relevant elevation of high-sensitivity Troponin I. Electrocardiogram and transthoracic echocardiogram (TTE) were consistent with a diagnosis of infero-posterolateral acute myocardial infarction and the patient was transferred to the isolated Cath Lab for primary percutaneous coronary intervention (PCI)...
August 7, 2020: Catheterization and Cardiovascular Interventions
Beatrice Besche, Thomas Blondel, Emilie Guillot, Catherine Garelli-Paar, Mark A Oyama
BACKGROUND: Torasemide is a potent loop diuretic with potential to treat congestive heart failure (CHF) in dogs. OBJECTIVE: Evaluate the efficacy and safety of torasemide compared to furosemide in dogs with first occurrence of CHF caused by degenerative mitral valve disease (DMVD). ANIMALS: Three hundred and nineteen dogs with new onset CHF attributable to DMVD. METHODS: Double-blinded randomized noninferiority study of PO torasemide vs furosemide in addition to standard CHF treatment...
August 7, 2020: Journal of Veterinary Internal Medicine
Jie Zhang, Xijiang Zhang
Ischaemia/reperfusion (I/R) injury can lead to severe arrhythmia and aggravate myocardial damage. Exosomes are small-membrane vesicles that play a protective role in myocardial I/R injury. This study aimed to explore the protective effects of ischaemic preconditioning (IPC)-induced serum exosomes (IPC-Exo) on myocardial I/R injury in rats and its underlying mechanism. Serum exosomes were extracted from IPC rats and quantified using a bicinchoninic acid assay kit. IPC-Exo (50 μg) was injected into the infarcted myocardium immediately after ligation...
August 7, 2020: Cell Biochemistry and Function
Adam O'Riordan, Siobhán Howard, Eoin Brown, Stephen Gallagher
Type D personality has been consistently associated with adverse cardiovascular health with atypical cardiovascular reactions to psychological stress one potential underlying mechanism. As Type D individuals have been noted to report lower social support and greater perceptions of negativity in social interactions, this study examined if the association between Type D personality and cardiovascular reactivity was mediated by these social relationships. A sample of 195 undergraduate students (138 female) participated in this observational study, where they completed measures assessing Type D personality (DS14), social support, and perceptions of negative social relationships (National Institute of Health social relationship scales), before undergoing a traditional cardiovascular reactivity protocol...
August 7, 2020: Psychophysiology
Nils Dennhardt, Frederike-Debora Elfgen-Schiffner, Oliver Keil, Christiane E Beck, Sebastian Heiderich, Robert Sümpelmann, Katja Nickel
BACKGROUND: Neonates and infants with congenital heart disease undergoing general anesthesia have an increased risk for critical cardiovascular events. Etomidate produces very minimal changes in hemodynamic parameters in older children with congenital heart disease. There is a lack of studies evaluating the effect of etomidate on systemic and regional cerebral perfusion in neonates and infants with congenital heart disease. AIM: The aim of this prospective observational study was to evaluate the effect of etomidate on systemic and regional cerebral perfusion in neonates and infants with congenital heart disease...
July 24, 2020: Paediatric Anaesthesia
I A Bukhari, B I Alorainey, A A Al-Motrefi, A Mahmoud, W B Campbell, B D Hammock
OBJECTIVE: This study evaluated the efficacy of the soluble epoxide hydrolase (sEH) inhibitor, TPPU on chronic NG-Nitro L-arginine methyl ester (L-NAME)-induced hypertension in rats and its effects on plasma Angiotensin II (Ang II), cardiac Angiotensin-converting enzyme (ACE) and Angiotensin II receptor type 1 (AT1R) expressions. MATERIALS AND METHODS: Forty Sprague Dawley rats were divided into 5 groups. Two groups served as control and received orally either vehicle or TPPU (3 mg/kg) for five weeks...
August 2020: European Review for Medical and Pharmacological Sciences
E Paszek, K Żmudka, K Plens, J Legutko, T Rajs, W Zajdel
OBJECTIVE: Profilin 1 (Pfn1) is likely to be involved in atherogenesis and myocardial infarction (MI). Clinical data on this subject are very limited. The aim of this study was to search for associations between serum Pfn1 and a number of parameters in MI patients: symptom onset to PCI time (OPT), myocardial necrosis markers, thrombolysis in myocardial infarction (TIMI) flow, antiplatelet drugs, heparin administration and typical atherosclerosis risk factors. PATIENTS AND METHODS: We included patients with type 1 MI (according to the Third Universal Definition of Myocardial Infarction) who were able to precisely determine the time of symptom onset...
August 2020: European Review for Medical and Pharmacological Sciences
X-J Zhou, X Zhang, J Zhang, L Zhou, T-T Zhou, J-W Zhang
OBJECTIVE: This study aimed to investigate the diagnostic value of growth differentiation factor-15 (GDF-15) and β2-microglobulin (β2-MG) in infants with congenital heart disease (CHD) combined with chronic heart failure and its relationship with cardiac function. PATIENTS AND METHODS: A total of 100 cases of infants diagnosed with CHD combined with chronic heart failure in our hospital from July 2015 to July 2018 were selected as the experimental group, and 80 cases of healthy subjects underwent health examination in our hospital during the same period were selected as the control group...
August 2020: European Review for Medical and Pharmacological Sciences
Jenica N Upshaw
Moderate-level evidence suggests that cardiac troponin and natriuretic peptides are useful for risk stratification and early identification of anthracycline cardiotoxicity; however, many of these studies used older chemotherapy regimens, and thus, the applicability to current anthracycline treatment regimens is uncertain. Further research is needed to determine optimal timing and thresholds for troponin and natriuretic peptides in anthracycline-treated patients and evaluate these and other promising biomarkers for anti-HER2 therapies, thoracic radiation, anti-VEGF therapy, and fluoropyrimidine therapy-related cardiotoxicity...
August 7, 2020: Current Treatment Options in Oncology
Yumei Ye, Yochai Birnbaum, Steven G Widen, Zhaohui Zhang, Shipeng Zhu, Mandeep Bajaj, Huan Chen
PURPOSE: To assess the effects of electro-acupuncture (EA) on glycemic control, myocardial inflammation, and the progression of diabetic cardiomyopathy in mice with type 2 diabetes. METHODS: Db/Db mice received EA at PC6+ST36 (DM-Acu), non-acupoint simulation (DM-Sham), or no treatment (DM). EA was applied for 30 min per day, 5 days a week for 4 weeks. Heart function was assessed by echocardiography. Myocardium was assessed by RT-PCR, immunoblotting, and histology...
August 7, 2020: Cardiovascular Drugs and Therapy
I-Mei Lin, San-Yu Wang, Sheng-Yu Fan, Erik Peper, Sui-Pi Chen, Ching-Yu Huang
Heart rate variability biofeedback (HRV-BF) has been confirmed to increase heart rate variability (HRV) and cardiac outflows by baroreflex in healthy populations and clinical patients. Autogenic training (AT) is common used in the psychological intervention. This study integrates a single-session of HRV-BF and AT into a high-technology mobile application (app), and examines the effects on HRV indices, breathing rates, and subjective relaxation scores. Healthy college students were recruited and assigned to the single-session HRV-BF group or AT group...
August 7, 2020: Applied Psychophysiology and Biofeedback
Juanjuan Lyu, Man Wang, Xinjiang Kang, Huadong Xu, Zhongming Cao, Tao Yu, Keli Huang, Jin Wu, Xinchuan Wei, Qian Lei
Sympathetic neural remodeling, which involves the inflammatory response, plays an important role in ventricular arrhythmias (VAs) after myocardial infarction (MI). Adrenergic receptors on macrophages potentially modulate the inflammatory response. We hypothesized that the increased level of catecholamines activates macrophages and regulates sympathetic neural remodeling after MI. We treated MI mice with either clodronate or metoprolol for 5 days following coronary artery ligation. Mice without treatment after MI and sham-operation mice served as the positive control and negative control, respectively...
August 7, 2020: Basic Research in Cardiology
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