keyword
https://read.qxmd.com/read/33073840/mirna-1183-targeted-regulation-of-bcl-2-contributes-to-the-pathogenesis-of-rheumatic-heart-disease
#1
Ni Li, Linwen Zhu, Hua Zhou, Dawei Zheng, Guodong Xu, Lebo Sun, Jianqing Gao, Guofeng Shao
To determine whether up-regulation of miR-1183 targeting the gene for anti-apoptotic factor, B cell lymphoma-2 (BCL-2) contributes to apoptosis in patients with rheumatic heart disease (RHD). Peripheral blood samples were isolated for miR-1183 characterization. The function of miRNA-1183 in RHD using miRNA mimic on PBMCs and THP-1 cell models. The binding of miR-1183 and Bcl-2 gene was confirmed by luciferase activity test.We also measured expression levels of BCL-2 in heart valve tissue from patients with RHD using ELISA and immunohistochemistry...
October 19, 2020: Bioscience Reports
https://read.qxmd.com/read/33073669/more-than-meets-the-heart-systolic-amplification-of-different-emotional-faces-is-task-dependent
#2
Mateo Leganes-Fonteneau, Jennifer F Buckman, Keisuke Suzuki, Anthony Pawlak, Marsha E Bates
Interoceptive processes emanating from baroreceptor signals support emotional functioning. Previous research suggests a unique link to fear: fearful faces, presented in synchrony with systolic baroreceptor firing draw more attention and are rated as more intense than those presented at diastole. This study examines whether this effect is unique to fearful faces or can be observed in other emotional faces. Participants ( n  = 71) completed an emotional visual search task (VST) in which fearful, happy, disgust and sad faces were presented during systolic and diastolic phases of the cardiac cycle...
October 19, 2020: Cognition & Emotion
https://read.qxmd.com/read/33073623/heat-shock-protein-70-expression-protects-against-sepsis-associated-cardiomyopathy-by-inhibiting-autophagy
#3
Xiaofeng Wang, Yan Zhu, Qiuxiang Zhou, Yueyue Yan, Jinlong Qu, Hongwei Ye
OBJECTIVES: Increasing evidence suggests that heat shock protein 70 (Hsp70) has a protective effect in sepsis-induced cardiomyopathy; however, the protective mechanism remains unclear. METHODS: Previous studies have also implicated autophagy in sepsis-induced cardiomyopathy. The aim of the current study was to reveal the protective mechanisms of Hsp70 in sepsis-induced cardiomyopathy using a cecal ligation and puncture (CLP) rat sepsis model. The roles of Hsp70 and autophagy in sepsis-induced cardiomyopathy were investigated by pretreating rats with the Hsp70 inhibitor quercetin or the autophagy inhibitor 3-methyladenine (3-Ma) before CLP...
October 19, 2020: Human & Experimental Toxicology
https://read.qxmd.com/read/33073614/primary-results-from-the-understanding-outcomes-with-the-s-icd-in-primary-prevention-patients-with-low-ejection-fraction-untouched-trial
#4
Michael R Gold, Pier D Lambiase, Mikhael F El-Chami, Reinoud E Knops, Johan D Aasbo, Maria Grazia Bongiorni, Andrea M Russo, Jean Claude Deharo, Martin C Burke, Jay Dinerman, Craig S Barr, Naushad Shaik, Nathan Carter, Thomas Stoltz, Kenneth M Stein, Amy J Brisben, Lucas V Boersma
Background: The Subcutaneous ICD (S-ICD) is safe and effective for sudden cardiac death prevention. However, patients in previous S-ICD studies had fewer comorbidities, less left ventricular dysfunction and received more inappropriate shocks (IAS) than in typical transvenous (TV)-ICD trials. The UNTOUCHED trial was designed to evaluate the IAS rate in a more typical, contemporary ICD patient population implanted with the S-ICD using standardized programming and enhanced discrimination algorithms. Methods: Primary prevention patients with left ventricular ejection fraction (LVEF) ≤ 35% and no pacing indications were included...
October 19, 2020: Circulation
https://read.qxmd.com/read/33073610/exercise-training-induced-repolarization-abnormalities-masquerading-as-congenital-long-qt-syndrome
#5
Federica Dagradi, Carla Spazzolini, Silvia Castelletti, Matteo Pedrazzini, Maria-Christina Kotta, Lia Crotti, Peter J Schwartz
Background: The diagnosis of long QT syndrome (LQTS) is rather straightforward. We were surprised by realizing that, despite long-standing experience, we were making occasional diagnostic errors by considering as affected subjects that, over time, resulted as not affected. These individuals were all actively practicing sports, an observation which helped to design our study. Methods: We focused on subjects referred to our Center by Sports Medicine doctors with a suspicion of LQTS because of marked repolarization abnormalities on the ECG performed during the mandatory medical visit necessary in Italy to obtain the certificate of eligibility to practice sports...
October 19, 2020: Circulation
https://read.qxmd.com/read/33073523/stratified-treatment-of-heart-failure-with-preserved-ejection-fraction-rationale-and-design-of-the-stadia-hfpef-trial
#6
Mariëlle Scheffer, Annet Driessen-Waaijer, Nazha Hamdani, Jochem W D Landzaat, Nini H Jonkman, Walter J Paulus, Loek van Heerebeek
AIMS: High myocardial stiffness in heart failure with preserved ejection fraction (HFpEF) is attributed to comorbidity-induced structural and functional remodelling through inflammation and oxidative stress affecting coronary microvascular endothelial cells and cardiomyocytes, which augments interstitial fibrosis and cardiomyocyte stiffness. In murine and human HFpEF myocardium, sodium glucose co-transporter 2 (SGLT2) inhibition ameliorates cardiac microvascular endothelial cell and cardiomyocyte oxidative stress, while enhancing myocardial protein kinase G activity and lowering titin-based cardiomyocyte stiffness...
October 19, 2020: ESC Heart Failure
https://read.qxmd.com/read/33073484/preoperative-echocardiographic-parameters-predict-primary-graft-dysfunction-following-pediatric-lung-transplantation
#7
Adam S Himebauch, Wai Wong, Yan Wang, Francis X McGowan, Robert A Berg, Christopher E Mascio, Todd J Kilbaugh, Kimberly Y Lin, Samuel B Goldfarb, Steven M Kawut, Laura Mercer-Rosa, Nadir Yehya
The importance of preoperative cardiac function in pediatric lung transplantation is unknown. We hypothesized that worse preoperative right ventricular (RV) systolic and worse left ventricular (LV) diastolic function would be associated with a higher risk of primary graft dysfunction grade 3 (PGD 3) between 48 and 72 hours. We performed a single center, retrospective pilot study of children (<18 years) who had echocardiograms <1 year prior to lung transplantation between 2006 and 2019. Conventional and strain echocardiography parameters were measured, and PGD was graded...
October 19, 2020: Pediatric Transplantation
https://read.qxmd.com/read/33073482/the-chromogranin-a-1-373-fragment-reveals-how-a-single-change-in-the-protein-sequence-exerts-strong-cardioregulatory-effects-by-engaging-neuropilin-1
#8
Carmine Rocca, Fedora Grande, Maria Concetta Granieri, Barbara Colombo, Anna De Bartolo, Francesca Giordano, Vittoria Rago, Nicola Amodio, Bruno Tota, Maria Carmela Cerra, Bruno Rizzuti, Angelo Corti, Tommaso Angelone, Teresa Pasqua
AIM: Chromogranin A (CgA), a 439-residue long protein, is an important cardiovascular regulator and a precursor of various bio-active fragments. Under stressful/pathological conditions, CgA cleavage generates the CgA1-373 proangiogenic fragment. The present work investigated the possibility that human CgA1-373 influences the mammalian cardiac performance, evaluating the role of its C-terminal sequence. METHODS: Hemodynamic assessment was performed on an ex vivo Langendorff rat heart model, while mechanistic studies were performed using perfused hearts, H9c2 cardiomyocytes, and in silico...
October 18, 2020: Acta Physiologica
https://read.qxmd.com/read/33073454/incorporating-sensitive-cardiac-substructure-sparing-into-radiation-therapy-planning
#9
Eric D Morris, Kate Aldridge, Ahmed I Ghanem, Simeng Zhu, Carri K Glide-Hurst
PURPOSE: Rising evidence suggests that cardiac substructures are highly radiosensitive. However, they are not routinely considered in treatment planning as they are not readily visualized on treatment planning CTs (TPCTs). This work integrated the soft tissue contrast provided by low-field MRIs acquired on an MR-linac via image registration to further enable cardiac substructure sparing on TPCTs. METHODS: Sixteen upper thoracic patients treated at various breathing states (7 end-exhalation, 7 end-inhalation, 2 free-breathing) on a 0...
October 18, 2020: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/33073384/candida-spp-infective-endocarditis-characteristics-and-outcomes-of-twenty-patients-with-a-focus-on-injection-drug-use-as-a-predisposing-risk-factor
#10
Morgan K Morelli, Michael P Veve, William Lorson, Mahmoud A Shorman
BACKGROUND: Candida spp. infective endocarditis (CIE) although rare is associated with high morbidity and mortality. Risk factors include prosthetic heart valves and injection drug use (IDU). We reviewed all cases of CIE at our institution to describe the microbiology, treatment, and outcomes of patients focusing on IDU as a predisposing factor. METHODS: Retrospective cohort of patients with definite CIE between 2013-2019 at a university hospital was analyzed. Demographic data collected included IDU, microbiologic, treatment, and mortality...
October 18, 2020: Mycoses
https://read.qxmd.com/read/33073372/ginsenoside-rb2-alleviates-myocardial-ischemia-reperfusion-injury-in-rats-through-sirt1-activation
#11
Yan Xue, Wenwen Fu, Yanzhe Liu, Ping Yu, Mingyang Sun, Xin Li, Xiaofeng Yu, Dayun Sui
The cardioprotective effects of ginsenoside Rb2 on oxidative stress, which is induced by hydrogen peroxide and myocardial ischemia/reperfusion (MI/R) injury, have been studied. The mechanisms were associated with the inhibition of cardiomyocyte apoptosis, a high concentration of antioxidant defense enzymes, and scavenging oxidative stress products. Because of the association with oxidative reaction and cardioprotection, sirtuin-1 (SIRT1) was selected as a promising target for investigating whether MI/R injury can be alleviated by ginsenoside Rb2 pretreatment through SIRT1 activation...
October 18, 2020: Journal of Food Science
https://read.qxmd.com/read/33073361/admission-fasting-plasma-glucose-is-an-independent-risk-factor-for-28-day-mortality-in-patients-with-covid-19
#12
Ping Yang, Nan Wang, Jingjing Wang, Ailin Luo, Feng Gao, Ye Tu
Hyperglycemia commonly occurred in severe cases with COVID-19. In this study, we explored the associations between admission fasting plasma glucose (FPG) and 28-day mortality in COVID-19 patients. In this single centre retrospective study, 263 adult patients with COVID-19 were included. Demographic and clinical information were collected and compared between patients with and without diabetes. Cox regression analyses was used to investigate the risk factors of 28-day mortality in hospital. Of 263 patients, 161 (61...
October 19, 2020: Journal of Medical Virology
https://read.qxmd.com/read/33073350/occurrence-of-pulsus-alternans-during-anaesthesia-of-two-dogs-and-one-cat-and-its-treatment
#13
D Nicholls, C Adami, P Monticelli
The authors report the occurrence of pulsus alternans, a condition characterised by the alternance of pulses of higher and lower amplitude, in two dogs and one cat under general anaesthesia. The presence of an underlying cardiac disease was confirmed in the cat but not in either dog, which - based on history and clinical findings - had presumably normal cardiovascular function before the anaesthetic. Possible mechanisms, including negative inotropy and haemodynamic and Frank-Starling effects, as well as the role of general anaesthesia as the potential triggering factor, are discussed in this report...
October 19, 2020: Australian Veterinary Journal
https://read.qxmd.com/read/33073318/dpp-4-inhibitor-induces-fgf21-expression-via-sirtuin-1-signaling-and-improves-myocardial-energy-metabolism
#14
Nozomi Furukawa, Norimichi Koitabashi, Hiroki Matsui, Hiroaki Sunaga, Yogi Umbarawan, Mas Rizky A A Syamsunarno, Aiko Yamaguchi, Masaru Obokata, Hirofumi Hanaoka, Tomoyuki Yokoyama, Masahiko Kurabayashi
Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used incretin-based therapy for the treatment of type 2 diabetes. We investigated the cardioprotective effect of a DPP-4 inhibitor, vildagliptin (vilda), on myocardial metabolism and cardiac performance under pressure overload. Mice were treated with either vehicle or vilda, followed by transverse aortic constriction (TAC). After 3 weeks of TAC, cardiac hypertrophy and impairment of systolic function were attenuated in vilda-treated mice. Pressure-volume analysis showed that vilda treatment significantly improved left-ventricular contractile efficiency in TAC heart...
October 18, 2020: Heart and Vessels
https://read.qxmd.com/read/33073249/diuretic-dose-and-nyha-functional-class-are-independent-predictors-of-mortality-in-patients-with-transthyretin-cardiac-amyloidosis
#15
Richard K Cheng, Wayne C Levy, Alexi Vasbinder, Sergio Teruya, Jeffeny De Los Santos, Douglas Leedy, Mathew S Maurer
BACKGROUND: With increasing diagnoses and available treatment options for transthyretin amyloidosis cardiomyopathy (ATTR-CM), risk stratification of ATTR-CM patients is imperative. OBJECTIVES: We hypothesized that diuretic dose and New York Heart Association (NYHA) functional class are independent predictors of mortality in ATTR-CM and would be incrementally additive to existent risk scores. METHODS: Consecutive ATTR-CM patients referred to a single center were identified...
September 2020: JACC. CardioOncology
https://read.qxmd.com/read/33073223/admission-high-sensitivity-cardiac-troponin-versus-a-biochemical-score-for-predicting-mortality-in-patients-with-covid-19
#16
Peter A Kavsak, Shawn E Mondoux, Kerstin de Wit, Bram Rochwerg, Cheryl Main, Deborah Yamamura, Guillaume Paré, Jinhui Ma, Dan Perri, Jonathan Sherbino, Andrew Worster
No abstract text is available yet for this article.
October 14, 2020: CJC open
https://read.qxmd.com/read/33073222/rapid-response-to-cytokine-storm-inhibition-using-anakinra-in-a-patient-with-covid-19-myocarditis
#17
Cvetan Trpkov, Paul MacMullan, Patricia Feuchter, Rahim Kachra, Bobak Heydari, Naeem Merchant, Michael S Bristow, James A White
A 62-year-old female with COVID-19 developed acute respiratory failure and cardiogenic shock in the setting of a systemic hyper-inflammatory state and apparent ST-elevation myocardial infarction. Cardiac magnetic resonance (CMR) imaging showed fulminant acute myocarditis with severe left ventricular dysfunction. Treatment with the recombinant interleukin-1 (IL-1) receptor antagonist anakinra and dexamethasone resulted in rapid clinical improvement, reduction in serum inflammatory markers and a marked recovery in CMR-based markers of inflammation and contractile dysfunction...
October 12, 2020: CJC open
https://read.qxmd.com/read/33073115/electroanalysis-on-an-interdigitated-electrode-for-high-affinity-cardiac-troponin-i-biomarker-detection-by-aptamer-gold-conjugates
#18
Jintao Zhang, Thangavel Lakshmipriya, Subash C B Gopinath
The primary reasons for myocardial infarction (MI) are pericarditis, arrhythmia, and heart failure, causing predominant deaths worldwide. Patients need a potential diagnostic system and treatment before cardiomyocyte damage. Cardiac biomarkers are released from myocytes immediately after a heart attack. Troponin is an efficient biomarker released from dead cells within a few hours. Aptamers are artificial antibodies used effectively in the biosensor field for biomarker detection. Along with aptamers, the application of nanomaterials is also expected to enhance the detection limits of biosensors...
October 13, 2020: ACS Omega
https://read.qxmd.com/read/33072884/protocol-the-lacunar-intervention-trial-2-laci-2-a-trial-of-two-repurposed-licenced-drugs-to-prevent-progression-of-cerebral-small-vessel-disease
#19
Joanna Wardlaw, Philip M W Bath, Fergus Doubal, Anna Heye, Nikola Sprigg, Lisa J Woodhouse, Gordon Blair, Jason Appleton, Vera Cvoro, Timothy England, Ahamad Hassan, David John Werring, Alan Montgomery
Background: Small vessel disease causes a quarter of ischaemic strokes (lacunar subtype), up to 45% of dementia either as vascular or mixed types, cognitive impairment and physical frailty. However, there is no specific treatment to prevent progression of small vessel disease. Aim: We designed the LACunar Intervention Trial-2 (LACI-2) to test feasibility of a large trial testing cilostazol and/or isosorbide mononitrate (ISMN) by demonstrating adequate participant recruitment and retention in follow-up, drug tolerability, safety and confirm outcome event rates required to power a phase 3 trial...
September 2020: European Stroke Journal
https://read.qxmd.com/read/33072729/effect-of-co-culturing-fibroblasts-in-human-skeletal-muscle-cell-sheet-on-angiogenic-cytokine-balance-and-angiogenesis
#20
Parichut Thummarati, Masahiro Kino-Oka
Skeletal muscle comprises a heterogeneous population of myoblasts and fibroblasts. Autologous skeletal muscle myoblasts are transplanted to patients with ischemia to promote cardiac regeneration. In damaged hearts, various cytokines secreted from the skeletal muscle myoblasts promote angiogenesis and consequently the recovery of cardiac functions. However, the effect of skeletal muscle fibroblasts co-cultured with skeletal muscle myoblasts on angiogenic cytokine production and angiogenesis has not been fully understood...
2020: Frontiers in Bioengineering and Biotechnology
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