İhsan Bağlı, Mehmet Sait Bakır, Yasemin Doğan, Selami Erdem, Cuma Taşın, Neslihan Uğur Demirel, Mehmet İrfan Kulahçıoğlu
OBJECTIVES: The study aims to evaluate the success rate of suction curettage (SC) as a first line treatment with or without use of foley balloon tamponade for cesarean scar pregnancy (CSP) and to determine the risk factors for failure of treatment. STUDY DESIGN: The study was retrospective and included 36 CSP cases who underwent SC for treatment. Presence of pain with active bleeding and > 10 weeks of gestation were taken as the exclusion criterion. The procedure was performed under sonographic guidance...
January 6, 2021: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Francesco Secchi, Giulia Lastella, Caterina Beatrice Monti, Ugo Barbaro, Davide Capra, Moreno Zanardo, Francesco Sardanelli
PURPOSE: The aim of this study is to review the literature concerning myocardial late gadolinium enhancement (LGE) with cardiac magnetic resonance in patients with Tetralogy of Fallot (ToF), with regards to its prevalence, characteristics and clinical relevance. METHODS: We performed a systematic search, aiming to retrieve original articles that evaluated LGE in ToF, running a search string on MEDLINE and EMBASE in November 2019 and November 2020. Papers were then selected by two independent, blinded readers based on title and abstract, and then on full-text reading, and articles which did not include LGE evaluation were excluded...
January 6, 2021: European Journal of Radiology
Marlene S Williams, Sammy Zakaria, Michelle D'Alessandro, Susan Kraeuter, Heather Hicks
No abstract text is available yet for this article.
January 9, 2021: Heart & Lung: the Journal of Critical Care
Patrizia Amadio, Benedetta Porro, Viviana Cavalca, Silvia Stella Barbieri, Sonia Eligini, Susanna Fiorelli, Alessandro Di Minno, Alessandra Gorini, Mattia Giuliani, Josè Pablo Werba, Nicola Cosentino, Paolo Olivares, Simone Barbieri, Fabrizio Veglia, Elena Tremoli, Daniela Trabattoni
BACKGROUND: Takotsubo (TTS) syndrome is an acute cardiac condition characterized by transient and reversible left ventricle dysfunction that mainly affects postmenopausal women. Catecholamine burst is the most accredited mechanism underpinning TTS onset and leading to endothelial dysfunction and platelet activation. Even if the use of low dose acetylsalycilic acid (ASA) in this clinical setting is based on both clinical presentation and unfavorable long-term prognosis, its efficacy has been recently challenged...
January 12, 2021: Biomedicine & Pharmacotherapy
Aleksandra Paterek, Barbara Sochanowicz, Marta Oknińska, Witold Śmigielski, Marcin Kruszewski, Urszula Mackiewicz, Michał Mączewski, Przemysław Leszek
BACKGROUND: Exacerbations of chronic heart failure (CHF) are often treated with catecholamines to provide short term inotropic support, but this strategy is associated with long-term detrimental hemodynamic effects and increased ventricular arrhythmias (VA), possibly related to increased heart rate (HR). We hypothesized that ivabradine may prevent adverse effects of short-term dopamine treatment in CHF. METHODS: Rats with post-myocardial infarction CHF received 2-week infusion of saline, dopamine(D), ivabradine(I) or D&I; cardiac function was assessed using echocardiography and pressure-volume loops while VA were assessed using telemetric ECG recording...
January 12, 2021: Biomedicine & Pharmacotherapy
Maciej Zacharski, Alicja Tomaszek, Liliana Kiczak, Maciej Ugorski, Jacek Bania, Urszula Pasławska, Ilona Rybinska, Ewa Anita Jankowska, Adrian Janiszewski, Piotr Ponikowski
BACKGROUND: Steroid hormones play an important role in heart failure (HF) pathogenesis, and clinical data has revealed disordered steroidogenesis in male HF patients. However, there is still a lack of studies on steroid hormones and their receptors during HF progression. Therefore, a porcine model of tachycardia-induced cardiomyopathy corresponding to HF was used to assess steroid hormone concentrations in serum and their nuclear receptor levels in heart tissue during the consecutive stages of HF...
January 12, 2021: Journal of Cardiac Failure
Gaurav Gulati, Robin Ruthazer, David DeNofrio, Amanda R Vest, David Kent, Michael S Kiernan
BACKGROUND: Elevated PVR is common in patients with advanced heart failure. PVR generally improves after LVAD implantation, but the rate of decrease has not been quantified and the patient characteristics most strongly associated with this improvement are unknown. METHODS AND RESULTS: We analyzed 1581 patients from the INTERMACS registry that received a primary continuous-flow LVAD, had baseline PVR ≥ 3 Wood units (WU), and had PVR measured at least once postoperatively...
January 12, 2021: Journal of Cardiac Failure
Thimo Marcin, Lukas D Trachsel, Michelle Dysli, Jean Paul Schmid, Prisca Eser, Matthias Wilhelm
BACKGROUND: Whether high-intensity interval training (HIIT) is more efficient than moderate-intensity continuous exercise (MICE) to increase cardiorespiratory fitness in patients with acute coronary syndrome at moderate-to-high cardiovascular risk is controversial. The best approach to guide training intensity remains to be determined. OBJECTIVE: We aimed to assess intensities achieved with self-tailored HIIT and MICE according to perceived exertion and to compare the effect on cardiorespiratory fitness in patients early after ST-elevation myocardial infarction (STEMI)...
January 12, 2021: Annals of Physical and Rehabilitation Medicine
Kenneth E Mah, Jeffrey A Alten, Timothy T Cornell, David T Selewski, David Askenazi, Julie C Fitzgerald, Alexis Topjian, Kent Page, Richard Holubkov, Beth S Slomine, James R Christensen, J Michael Dean, Frank W Moler
AIM: Determine 1) frequency and risk factors for acute kidney injury (AKI) after in-hospital cardiac arrest (IHCA) in the Therapeutic Hypothermia after Pediatric Cardiac Arrest In-Hospital (THAPCA-IH) trial and associated outcomes; 2) impact of temperature management on post-IHCA AKI. METHODS: Secondary analysis of THAPCA-IH; a randomized controlled multi-national trial at 37 children's hospitals. ELIGIBILITY: Serum creatinine (Cr) within 24 h of randomization...
January 12, 2021: Resuscitation
Michel-Pierre Coll, Hannah Hobson, Geoffrey Bird, Jennifer Murphy
The Heartbeat Evoked Potential (HEP) has been proposed as a neurophysiological marker of interoceptive processing. Despite its use to validate interoceptive measures and to assess interoceptive functioning in clinical groups, the empirical evidence for a relationship between HEP amplitude and interoceptive processing, including measures of such processing, is scattered across several studies with varied designs. The aim of this systematic review and meta-analysis was to examine the body of HEP-interoception research, and consider the associations the HEP shows with various direct and indirect measures of interoception, and how it is affected by manipulations of interoceptive processing...
January 12, 2021: Neuroscience and Biobehavioral Reviews
Tatsuki Asai, Naruhiko Adachi, Toshio Moriya, Hideyuki Oki, Takamitsu Maru, Masato Kawasaki, Kano Suzuki, Sisi Chen, Ryohei Ishii, Kazuko Yonemori, Shigeru Igaki, Satoshi Yasuda, Satoshi Ogasawara, Toshiya Senda, Takeshi Murata
The hERG channel is a voltage-gated potassium channel involved in cardiac repolarization. Off-target hERG inhibition by drugs has become a critical issue in the pharmaceutical industry. The three-dimensional structure of the hERG channel was recently reported at 3.8-Å resolution using cryogenic electron microscopy (cryo-EM). However, the drug inhibition mechanism remains unclear because of the scarce structural information regarding the drug- and potassium-bound hERG channels. In this study, we obtained the cryo-EM density map of potassium-bound hERG channel complexed with astemizole, a well-known hERG inhibitor that increases risk of potentially fatal arrhythmia, at 3...
December 30, 2020: Structure
Yugeesh R Lankadeva, Yahya Shehabi, Adam M Deane, Mark P Plummer, Rinaldo Bellomo, Clive N May
Alpha2 -adrenoceptor agonists are increasingly being used for the provision of comfort, sedation and the management of delirium in critically ill patients with and without sepsis. In this context, increased sympathetic and inflammatory activity are common pathophysiological features linked to multi-organ dysfunction, particularly in patients with sepsis or those undergoing cardiac surgery requiring cardiopulmonary bypass. Experimental and clinical studies support the notion that the alpha2 -adrenoceptor agonists, dexmedetomidine and clonidine, mitigate sympathetic and inflammatory overactivity in sepsis and cardiac surgery requiring cardiopulmonary bypass...
January 15, 2021: British Journal of Pharmacology
Melina Lopez, Pedro F Malacarne, Anna Gajos-Draus, Xinxin Ding, Andreas Daiber, Jon O Lundberg, Stefan Offermanns, Ralf P Brandes, Flávia Rezende
BACKGROUND AND PURPOSE: Organic nitrates like nitroglycerin (NTG) or pentaerythritol tetranitrate (PETN) have been used for over a century in the treatment of angina or ischemic heart disease. These compounds are prodrugs which release their nitro-vasodilators upon enzymatic bioactivation by aldehyde dehydrogenase (ALDH2) or cytochromes P450 (CYP). Whereas ALDH2 is known to directly activate organic nitrates in vessels, the contribution of vascular CYPs is unknown and was studied here...
January 15, 2021: British Journal of Pharmacology
Mátyás C Földi, Krisztina Pesti, Katalin Zboray, Adam V Toth, Tamás Hegedűs, András Málnási-Csizmadia, Peter Lukacs, Arpad Mike
BACKGROUND AND PURPOSE: Sodium channel inhibitors can be used to treat hyperexcitability-related diseases, including epilepsies, pain syndromes, neuromuscular disorders, and cardiac arrhythmias. The applicability of these drugs is limited by their nonspecific effect on physiological function. They act mainly by sodium channel block and in addition by modulation of channel kinetics. While channel block inhibits healthy and pathological tissue equally, modulation can preferentially inhibit pathological activity...
January 15, 2021: British Journal of Pharmacology
Fabienne Carré, Elisabeth Mamelle, Suzanne Ferrier, Paul Achouh
Hearing loss is a rare complication of cardiac surgery; bilateral profound deafness has never been reported in this setting. A 45-year-old male presented with profound bilateral sudden deafness following arch surgery and frozen elephant trunk. Patient's presentation, surgery details and aetiological mechanisms are discussed.
November 30, 2020: Interactive Cardiovascular and Thoracic Surgery
Sariya Meephat, Patoomporn Prasatthong, Siwayu Rattanakanokchai, Sarawoot Bunbupha, Putcharawipa Maneesai, Poungrat Pakdeechote
Diosmetin, a monomethoxyflavone, is isolated from citrus fruits. The objective of this research was to test the biological role of diosmetin on parameters of metabolic syndrome (MS) and left ventricular (LV) alterations in rats fed with a high-fat (HF) diet. MS was induced by feeding male Sprague-Dawley rats with a HF diet plus 15% fructose in drinking water for 16 weeks. MS rats were given diosmetin (20 or 40 mg per kg per day) or metformin (100 mg per kg per day) for the final four weeks. Diosmetin attenuated signs of MS including, hypertension, hyperglycemia, insulin resistance, and dyslipidemia in rats that received the HF diet (p < 0...
January 15, 2021: Food & Function
Hajime Yoshifuji, Sumika Kagebayashi, Hideyuki Kinoshita, Takao Fujii, Yoshiaki Okano, Masao Katsushima, Tsuneyo Mimori
Pulmonary arterial hypertension (PAH) is a rare complication of ANCA-associated vasculitis (AAV). We report a 37-year-old man with PAH complicated by both AAV and SSc who presented with dyspnea, cardiac enlargement, positive myeloperoxidase (MPO)-ANCA, anti-centromere antibodies, proteinuria, and urinary casts. Elevated pulmonary arterial pressure (58/22/34 mmHg) and low PAWP (2 mmHg) were confirmed by right heart catheterization. Treatment with glucocorticoids (GC) decreased urinary protein and serum MPO-ANCA; however, PAH did not respond to GC...
January 15, 2021: Immunological Medicine
Klaus-Georg Kreitmeier, Daniel Tarnwoski, Maithily S Nanadikar, Maria J Baier, Stefan Wagner, Dörthe Magdalena Katschinski, Lars S Maier, Can Martin Sag
BACKGROUND: CaMKIId is needed for the recovery of Ca2+ transients during acidosis, but also mediates post-acidic arrhythmias. CaMKIId can sustain its activity following oxidation. Increasing intracellular Na+ during acidosis as well as post-acidic pH normalization should result in pro-oxidant conditions within the cell favoring oxidative CaMKIId activation. RATIONALE: We tested whether oxidative CaMKIId activation is needed for the recovery of Ca2+ -transients during acidosis and for cellular arrhythmias post acidosis...
January 15, 2021: American Journal of Physiology. Heart and Circulatory Physiology
Sebastien Chaigne, Guillaume Cardouat, Julien Louradour, Fanny Vaillant, Sabine Charron, Frederic Sacher, Thomas Ducret, Romain Guinamard, Edward Vigmond, Thomas Hof
INTRODUCTION: Transient Receptor Potential Vanilloid 4 (TRPV4) channel is a calcium permeable channel (PCa /PNa ~ 10). Its expression was reported in ventricular myocytes where it is involved in several cardiac pathological mechanisms. In this study, we investigated the implication of TRPV4 in ventricular electrical activity. METHODS AND RESULTS: Left ventricular myocytes were isolated from trpv4+/+ and trpv4-/- mice. TRPV4 membrane expression and its colocalization with Cav 1...
January 15, 2021: American Journal of Physiology. Heart and Circulatory Physiology
Lorenzo R Sewanan, Shi Shen, Stuart G Campbell
Comprehensive functional characterization of cardiac tissue includes investigation of length and load dependence. Such measurements have been slow to develop in engineered heart tissues (EHTs), whose mechanical characterizations have been limited primarily to isometric and near-isometric behaviors. A more realistic assessment of myocardial function would include force-velocity curves to characterize power output and force-length loops mimicking the cardiac cycle to characterize work output. We developed a system that produces force-velocity curves and work loops in human EHTs using an adaptive iterative control scheme...
January 15, 2021: American Journal of Physiology. Heart and Circulatory Physiology
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