Alba Farré Mariné, Luisa De Risio, Joan Mascort, Manuel Jiménez Peláez, Marta López, Fabio Stabile, Alejandro Luján Feliu-Pascual
OBJECTIVE:  The aim of this study was to describe the surgical technique and outcomes of dogs with congenital thoracic vertebral body malformations (CTVBM) treated with unilateral vertebral distraction and stabilization with monocortical screws and polymethylmethacrylate (PMMA). STUDY DESIGN:  Medical records of 10 client-owned dogs with CTVBM were retrospectively searched for signalment, history, neurological examination, neurological grade based on the modified Frankel scale (MFS), diagnostic method, CTVBM location, Cobb's angle, and vertebral canal angle (VCA), surgical procedure, complications and long-term follow-up...
July 22, 2021: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Venkata R Latha Gullapudi, Kelly White, Jill Stewart, Paul Stewart, Mohammed T Eldehni, Maarten W Taal, Nicholas M Selby
BACKGROUND: Higher beat-to-beat blood pressure (BP) variation during haemodialysis (HD) has been shown to be associated with elevated cardiac damage markers and white matter ischaemic changes in the brain suggesting relevance to end-organ perfusion. We aimed to characterize individual patterns of BP variation and associated haemodynamic responses to HD. METHODS: Fifty participants underwent continuous non-invasive haemodynamic monitoring during HD and BP variation were assessed using extrema point (EP) frequency analysis...
July 22, 2021: Blood Purification
Qiaozi Wang, Yanan Song, Jing Chen, Qiyu Li, Jinfeng Gao, Haipeng Tan, Yuefei Zhu, Zhengmin Wang, Minghui Li, Hongbo Yang, Ning Zhang, Xiaomin Li, Juying Qian, Zhiqing Pang, Zheyong Huang, Junbo Ge
microRNA-mediated direct cardiac reprogramming, directly converts fibroblasts into induced cardiomyocyte-like cells (iCMs), which holds great promise in cardiac regeneration therapy. However, effective approaches to deliver therapeutic microRNA into cardiac fibroblasts (CFs) to induce in vivo cardiac reprogramming remain to be explored. Herein, a non-viral biomimetic system to directly reprogram CFs for cardiac regeneration after myocardial injury was developed by coating FH peptide-modified neutrophil-mimicking membranes on mesoporous silicon nanoparticles (MSNs) loaded with microRNA1, 133, 208, and 499 (miR Combo)...
July 15, 2021: Biomaterials
Jinmeng Li, Gaoyi Yang, Qingshan Cai, Yu Wang, Yingying Xu, Ruoying Zhang, Yazhen Lang, Xinjun Cai
OBJECTIVES: To determine the safety and efficacy of bedaquiline for Chinese multidrug-resistant tuberculosis patients based on serum concentration monitoring and identify factors associated with QTc prolongation occurring during treatment. METHODS: We collected data from 35 patients who received treatment regimens containing bedaquiline for multidrug-resistant tuberculosis (MDR-TB) from May 2018 to December 2020. Blood samples were collected, and serum concentrations of bedaquiline were measured using high-performance liquid chromatography-mass spectrometry...
July 19, 2021: International Journal of Infectious Diseases: IJID
Nisha Bansal, Leila Zelnick, Christie Ballantyne, Paulo Chaves, Robert Christenson, Joseph Coresh, Chris deFilippi, James de Lemos, Lori Daniels, Alan S Go, Jiang He, Susan Heydati, Kuni Matsushita, Vijay Nambi, Michael Shlipak, Jonathan Taliercio, Stephen Seliger
RATIONALE & OBJECTIVE: The utility of conventional upper reference limits (URL) for N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hsTnT) in chronic kidney disease (CKD) remains debated. We analyzed the distribution of hsTnT and NT-proBNP in people with CKD in ambulatory settings to examine the diagnostic value of conventional URL in this population. STUDY DESIGN: Observational study. SETTING & PARTICIPANTS: We studied participants of the Chronic Renal Insufficiency Cohort with CKD and no self-reported history of cardiovascular disease (CVD)...
July 19, 2021: American Journal of Kidney Diseases
Connor Lantz, Amanda Becker, Edward B Thorp
While largely appreciated for their antimicrobial and repair functions, macrophages have emerged as indispensable for the development, homeostasis, and regeneration of tissue, including regeneration of the neonatal heart. Upon activation, mammalian neonatal macrophages express and secrete factors that coordinate angiogenesis, resolution of inflammation, and ultimately cardiomyocyte proliferation. This is contrary to adult macrophages in the adult heart, which are incapable of inducing significant levels of cardiac regeneration...
July 20, 2021: Journal of Molecular and Cellular Cardiology
Puneeta Tandon, Corey R Tomczak, Calvin Kruger, Cynthia Tsien, Mark J Haykowsky, Richard Thompson
Reduced exercise tolerance (whole body peak oxygen uptake, VO2 ) is a hallmark feature of both heart failure (HF) and cirrhosis1,2 . By the Fick equation, whole body peak VO2 is the product of cardiac output (central component) and O2 extraction (i.e., the arteriovenous O2 difference, peripheral component). In HF, multiple studies have described the important contributions of central and peripheral components to reduced peak VO2 3,4 .
July 22, 2021: Liver Transplantation
John W Stokes, James M Katsis, Whitney D Gannon, Todd W Rice, Robert J Lentz, Otis B Rickman, Sameer K Avasarala, Clayne Benson, Matthew Bacchetta, Fabien Maldonado
OBJECTIVES: Practice patterns for the use of extracorporeal membrane oxygenation (ECMO) during high-risk airway interventions vary, and data are limited. We aim to characterize our recent experience using ECMO for procedural support during whole-lung lavage (WLL) and high-risk bronchoscopy for central airway obstruction (CAO). METHODS: We performed a retrospective cohort study of adults who received ECMO during WLL and high-risk bronchoscopy from 1 July 2018 to 30 March 2020...
July 19, 2021: Interactive Cardiovascular and Thoracic Surgery
Dimitrios E Magouliotis, Maria P Fergadi, Gregory Christodoulidis, Alexis A Svokos, Konstantina A Svokos, Metaxia Bareka, Thanos Athanasiou
OBJECTIVES: Thoracic aortic aneurysm (TAA) is characterized by the dilation of the aorta and is associated with poor prognosis if not diagnosed and treated early. In this context, the identification of biomarkers regarding the TAA diagnosis, monitoring and prognosis is crucial. The purpose of the current study was to investigate the differential gene expression profile of the cadherin 5 (CDH5 or VE-Cadherin) gene network in patients with TAA, to propose novel biomarkers. METHODS: In silico techniques were used to construct the interactome of the CDH5 network, identify the differentially expressed genes (DEGs) in TAA as compared to healthy controls, and uncover the related molecular functions and the regulating miRNAs...
July 19, 2021: European Journal of Cardio-thoracic Surgery
Youcef Lounes, Lucien Chassin-Trubert, Thomas Gandet, Baris Ata Ozdemir, Pierre-Antoine Peyron, Mariama Akodad, Pierre Alric, Ludovic Canaud
No abstract text is available yet for this article.
July 19, 2021: Interactive Cardiovascular and Thoracic Surgery
Dirk De Bacquer, Felicity Astin, Kornelia Kotseva, Nana Pogosova, Delphine De Smedt, Guy De Backer, Lars Rydén, David Wood, Catriona Jennings
AIMS : Despite the high use of cardioprotective medications, the risk factor control in patients with coronary heart disease (CHD) is still inadequate. Guidelines identify healthy lifestyles as equally important in secondary prevention as pharmacotherapy. Here, we describe reasons for poor lifestyle adherence from the patient's perspective. METHODS AND RESULTS : In the EUROASPIRE IV and V surveys, 16 259 CHD patients were examined and interviewed during a study visit ≥6 months after hospital discharge...
July 19, 2021: European Journal of Preventive Cardiology
Xin Xia, Yonghua Cai, Xiaoli Zhu, Yingying Zhu, Le Shen, Yalin Zhou, Wenwen Diao, Xingming Chen
OBJECTIVES: The aim of this study was to present surgical techniques and evaluate outcomes of a sternocleidomastoid muscle (SCM) myoperiosteal flap used for the reconstruction of tracheal or laryngotracheal defects after the radical resection of invasive thyroid carcinoma. METHODS: A retrospective study was performed for patients at Peking Union Medical College Hospital from January 2008 to December 2018 of papillary thyroid carcinoma with tracheal or laryngotracheal invasion...
July 19, 2021: Interactive Cardiovascular and Thoracic Surgery
Zeyi Cheng, Luchen Wang, Yingqiang Guo
No abstract text is available yet for this article.
July 22, 2021: European Journal of Cardio-thoracic Surgery
Brian Zenger, T Jared Bunch
No abstract text is available yet for this article.
July 22, 2021: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Hector I Michelena, Alessandro Della Corte, Arturo Evangelista, Joseph J Maleszewski, William D Edwards, Mary J Roman, Richard B Devereux, Borja Fernández, Federico M Asch, Alex J Barker, Lilia M Sierra-Galan, Laurent De Kerchove, Susan M Fernandes, Paul W M Fedak, Evaldas Girdauskas, Victoria Delgado, Suhny Abbara, Emmanuel Lansac, Siddharth K Prakash, Malenka M Bissell, Bogdan A Popescu, Michael D Hope, Marta Sitges, Vinod H Thourani, Phillippe Pibarot, Krishnaswamy Chandrasekaran, Patrizio Lancellotti, Michael A Borger, John K Forrest, John Webb, Dianna M Milewicz, Raj Makkar, Martin B Leon, Stephen P Sanders, Michael Markl, Victor A Ferrari, William C Roberts, Jae-Kwan Song, Philipp Blanke, Charles S White, Samuel Siu, Lars G Svensson, Alan C Braverman, Joseph Bavaria, Thoralf M Sundt, Gebrine El Khoury, Ruggero De Paulis, Maurice Enriquez-Sarano, Jeroen J Bax, Catherine M Otto, Hans-Joachim Schäfers
This International Consensus Classification and Nomenclature for the congenital bicuspid aortic valve condition recognizes 3 types of bicuspid valves: 1. The fused type (right-left cusp fusion, right-non-coronary cusp fusion and left-non-coronary cusp fusion phenotypes); 2. The 2-sinus type (latero-lateral and antero-posterior phenotypes); and 3. The partial-fusion (forme fruste) type. The presence of raphe and the symmetry of the fused type phenotypes are critical aspects to describe. The International Consensus also recognizes 3 types of bicuspid valve-associated aortopathy: 1...
July 22, 2021: European Journal of Cardio-thoracic Surgery
Hidekazu Kondo, Ioannis Akoumianakis, Ileana Badi, Nadia Akawi, Christos P Kotanidis, Murray Polkinghorne, Ilaria Stadiotti, Elena Sommariva, Alexios S Antonopoulos, Maria C Carena, Evangelos K Oikonomou, Elsa Mauricio Reus, Rana Sayeed, George Krasopoulos, Vivek Srivastava, Shakil Farid, Surawee Chuaiphichai, Cheerag Shirodaria, Keith M Channon, Barbara Casadei, Charalambos Antoniades
AIMS: Recent clinical trials indicate that sodium-glucose cotransporter 2 (SGLT2) inhibitors improve cardiovascular outcomes in heart failure patients, but the underlying mechanisms remain unknown. We explored the direct effects of canagliflozin, an SGLT2 inhibitor with mild SGLT1 inhibitory effects, on myocardial redox signalling in humans. METHODS AND RESULTS: Study 1 included 364 patients undergoing cardiac surgery. Right atrial appendage biopsies were harvested to quantify superoxide (O2...
July 19, 2021: European Heart Journal
Fyodor Syomin, Anna Osepyan, Andrey Tsaturyan
A model of myocardial electromechanics is suggested. It combines modified and simplified versions of previously published models of cardiac electrophysiology, excitation-contraction coupling, and mechanics. The mechano-calcium and mechano-electrical feedbacks, including the strain-dependence of the propagation velocity of the action potential, are also accounted for. The model reproduces changes in the twitch amplitude and Ca2+-transients upon changes in muscle strain including the slow response. The model also reproduces the Bowditch effect and changes in the twitch amplitude and duration upon changes in the interstimulus interval, including accelerated relaxation at high stimulation frequency...
2021: PloS One
Ho Bum Cho, Mun Gyu Kim, Sun Young Park, Sanghoon Song, Youn Sil Jang, Suyeon Park, Hyun Keun Lee, Jae Hwa Yoo, Ji Won Chung, Sang Ho Kim
BACKGROUND: To determine whether the anesthetic method of propofol total intravenous anesthesia (TIVA) is associated with postoperative outcome in ESRD patients, we evaluated the incidence of postoperative major adverse cardiac events (MACE), comparing propofol TIVA versus anesthesia with volatile anesthesia in ESRD patients. METHODS: Retrospectively, we identified cases with ESRD patients who underwent surgery under general anesthesia. Patients were divided into those who received only volatile anesthesia (volatile group) and those who received only propofol TIVA (TIVA group)...
2021: PloS One
Shoichiro Nohara, Mai Yamamoto, Hideo Yasukawa, Takanobu Nagata, Jinya Takahashi, Koutatsu Shimozono, Toshiyuki Yanai, Tomoko Sasaki, Kota Okabe, Tatsuhiro Shibata, Daiki Akagaki, Kazutoshi Mawatari, Yoshihiro Fukumoto
Ischemic preconditioning (IPC) is the most powerful endogenous cardioprotective form of cellular adaptation. However, the inhibitory or augmenting mechanism underlying cardioprotection via IPC remains largely unknown. Suppressor of cytokine signaling-3 (SOCS3) is a cytokine-inducible potent negative feedback regulator of the signal transducer and activator of transcription-3 (STAT3) signaling pathway. Here, we aimed to determine whether cardiac SOCS3 deficiency and IPC would synergistically reduce infarct size after myocardial ischemia reperfusion injury...
2021: PloS One
Xiaoliang Wang, Xiuchun Li, Hannah Ong, Tao Tan, Ki Ho Park, Zehua Bian, Xunchang Zou, Erin Haggard, Paul M Janssen, Robert E Merritt, Timothy M Pawlik, Bryan A Whitson, Nahush A Mokadam, Lei Cao, Hua Zhu, Chuanxi Cai, Jianjie Ma
Aging is associated with chronic oxidative stress and inflammation that impact the tissue repair and regeneration capacity. MG53 is a TRIM family protein that facilitates repair of cell membrane injury in a redox-dependent manner. Here we demonstrate that the expression of MG53 is reduced in failing human heart and aging mouse heart, concomitant with elevated NFκB activation. We evaluate the safety and efficacy of longitudinal, systemic administration of recombinant human MG53 (rhMG53) protein in aged mice...
July 22, 2021: JCI Insight
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