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JOURNAL ARTICLE
Lin-Zi Long, Ling Tan, Feng-Qin Xu, Wen-Wen Yang, Hong-Zheng Li, Jian-Gang Liu, Ke Wang, Zhi-Ru Zhao, Yue-Qi Wang, Chao-Ju Wang, Yi-Chao Wen, Ming-Yan Huang, Hua Qu, Chang-Geng Fu, Ke-Ji Chen
OBJECTIVE: To assess the efficacy of Qingda Granule (QDG) in ameliorating hypertension-induced cardiac damage and investigate the underlying mechanisms involved. METHODS: Twenty spontaneously hypertensive rats (SHRs) were used to develope a hypertension-induced cardiac damage model. Another 10 Wistar Kyoto (WKY) rats were used as normotension group. Rats were administrated intragastrically QDG [0.9 g/(kg•d)] or an equivalent volume of pure water for 8 weeks...
September 7, 2024: Chinese Journal of Integrative Medicine
#2
JOURNAL ARTICLE
Teiichi Yamane, Tetsuo Sasano, Hirofumi Tomita, Daisetsu Aoyama, Shinsuke Miyazaki, Masateru Takigawa, Masaomi Kimura, Taihei Itoh, Seigo Yamashita, Jada M Selma, Jeffrey Cerkvenik, Atul Verma, Hiroshi Tada
BACKGROUND: Pulsed field ablation (PFA), a novel treatment for atrial fibrillation (AF), has yet to be evaluated in a Japanese cohort. METHODS: In this sub-analysis of the PULSED AF trial, 12-month outcomes of paroxysmal AF (PAF) and persistent AF (PsAF) patients treated with PFA in four Japan centers were assessed. After a 90-day blanking period, primary efficacy was determined via freedom from a composite endpoint of acute procedural failure, arrhythmia recurrence, or antiarrhythmic drug escalation over 1 year...
September 7, 2024: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
#3
JOURNAL ARTICLE
Anne M Beukers, Anoek L I van Leeuwen, Roselique Ibelings, Anita M Tuip-de Boer, Carolien S E Bulte, Susanne Eberl, Charissa E van den Brom
BACKGROUND: Endothelial disorders with edema formation and microcirculatory perfusion disturbances are common in cardiac surgery with cardiopulmonary bypass (CPB) and contribute to disturbed tissue oxygenation resulting in organ dysfunction. Albumin is protective for the endothelium and could be a useful additive to CPB circuit priming. Therefore, this study aimed to compare organ edema and microcirculatory perfusion in rats on CPB primed with lactated Ringers, albumin and mannitol (LR/albumin/mannitol) compared to 6% hydroxyethyl starch (HES)...
September 7, 2024: Intensive Care Medicine Experimental
#4
JOURNAL ARTICLE
Martin Aguilar, Laurent Macle, Sewanou H Honfo, Paul Khairy, Julia Cadrin-Tourigny, Marc W Deyell, Nathaniel Hawkins, Richard G Bennett, Jason G Andrade
No abstract text is available yet for this article.
August 10, 2024: JACC. Clinical Electrophysiology
#5
JOURNAL ARTICLE
Hao Wu, Weilin Chen, Jiabo Shen, Longfu Jiang
No abstract text is available yet for this article.
August 12, 2024: JACC. Clinical Electrophysiology
#6
JOURNAL ARTICLE
Daehoon Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y H Lip, Jung-Hoon Sung, Boyoung Joung
BACKGROUND: Atrial fibrillation (AF) is associated with impaired renal function and chronic kidney disease (CKD). OBJECTIVES: This study assessed the effects of rhythm control on renal function compared with rate control among patients recently diagnosed with AF. METHODS: A total of 20,886 patients with AF and available baseline estimated glomerular filtration rate (eGFR) data undergoing rhythm control (antiarrhythmic drugs or ablation) or rate control therapy, initiated within 1 year of AF diagnosis in 2005 to 2015, were identified from the Korean National Health Insurance Service database...
August 10, 2024: JACC. Clinical Electrophysiology
#7
REVIEW
Guram Imnadze, Thomas Fink, Thomas Eitz, Yuri Bocchini, Lilit Antonyan, Karen Harutyunyan, Valérian Valiton, Maxim Didenko, Philipp Sommer, Haran Burri
The authors report for the first time to their knowledge, implantation of a standard implantable cardioverter-defibrillator lead for permanent delivery of left bundle branch area pacing. Implantation was successful and safe in 11 of 12 patients, with adequate defibrillation testing, good electrical and electrocardiographic parameters, and uneventful device-related short-term follow-up.
August 12, 2024: JACC. Clinical Electrophysiology
#8
JOURNAL ARTICLE
Majd A El-Harasis, Zachary T Yoneda, Katherine C Anderson, Fei Ye, Joseph A Quintana, J Roberto Martinez-Parachini, Gregory G Jackson, Bibin T Varghese, Diane M Crawford, Lili Sun, Hollie L Williams, Matthew J O'Neill, Giovanni E Davogustto, James L Laws, Brittany S Murphy, Kelsey Tomasek, Yan Ru Su, Emily McQuillen, Emma Metz, Carly Smith, Doug Stubbs, Dakota D Grauherr, Quinn S Wells, Gregory F Michaud, Pablo Saavedra, Juan Carlos Estrada, Travis D Richardson, Sharon T Shen, Arvindh N Kanagasundram, Jay A Montgomery, Harikrishna Tandri, Christopher R Ellis, George H Crossley, Prince J Kannankeril, Lynne W Stevenson, William G Stevenson, Steven A Lubitz, Patrick T Ellinor, Dan M Roden, M Benjamin Shoemaker
BACKGROUND: Patients with rare, pathogenic cardiomyopathy (CM) and arrhythmia variants can present with atrial fibrillation (AF). The efficacy of AF ablation in these patients is unknown. OBJECTIVE: This study tested the hypotheses that: 1) patients with a pathogenic variant in any CM or arrhythmia gene have increased recurrence following AF ablation; and 2) patients with a pathogenic variant associated with a specific gene group (arrhythmogenic left ventricular CM [ALVC], arrhythmogenic right ventricular CM, dilated CM, hypertrophic CM, or a channelopathy) have increased recurrence...
August 20, 2024: JACC. Clinical Electrophysiology
#9
JOURNAL ARTICLE
Kensuke Sakata, Ryan P Bradley, Adityo Prakosa, Carolyna A P Yamamoto, Syed Yusuf Ali, Shane Loeffler, Eugene G Kholmovski, Sunil Kumar Sinha, Joseph E Marine, Hugh Calkins, David D Spragg, Natalia A Trayanova
BACKGROUND: Although targeting atrial fibrillation (AF) drivers and substrates has been used as an effective adjunctive ablation strategy for patients with persistent AF (PsAF), it can result in iatrogenic scar-related atrial tachycardia (iAT) requiring additional ablation. Personalized atrial digital twins (DTs) have been used preprocedurally to devise ablation targeting that eliminate the fibrotic substrate arrhythmogenic propensity and could potentially be used to predict and prevent postablation iAT...
August 6, 2024: JACC. Clinical Electrophysiology
#10
JOURNAL ARTICLE
Vardhmaan Jain, Abdul Mannan Khan Minhas, Birju Rao, Stacy Westerman, Neal K Bhatia, Mikhael F El-Chami, Kamala P Tamirisa, Faisal M Merchant
No abstract text is available yet for this article.
August 5, 2024: JACC. Clinical Electrophysiology
#11
JOURNAL ARTICLE
Olivier F Clerc, Shilpa Vijayakumar, Sarah A M Cuddy, Giada Bianchi, Jocelyn Canseco Neri, Alexandra Taylor, Dominik C Benz, Yesh Datar, Marie Foley Kijewski, Andrew J Yee, Frederick L Ruberg, Ronglih Liao, Rodney H Falk, Vaishali Sanchorawala, Sharmila Dorbala
BACKGROUND: In light-chain (AL) amyloidosis, whether functional status and heart failure-related quality of life (HF-QOL) correlate with cardiomyopathy severity, improve with therapy, and are associated with major adverse cardiac events (MACE) beyond validated scores is not well-known. OBJECTIVES: The authors aimed to: 1) correlate functional status and HF-QOL with cardiomyopathy severity; 2) analyze their longitudinal changes; and 3) assess their independent associations with MACE...
August 20, 2024: JACC. Heart Failure
#12
JOURNAL ARTICLE
Kannu Bansal, Mohak Gupta, Mohil Garg, Neel Patel, Alexander G Truesdell, Mir Babar Basir, Syed Tanveer Rab, Tariq Ahmad, Navin K Kapur, Nihar Desai, Saraschandra Vallabhajosyula
BACKGROUND: There are limited data on volume-outcome relationships in acute myocardial infarction (AMI) with cardiogenic shock (CS). OBJECTIVES: In this study, the authors sought to evaluate the association between hospital percutaneous coronary intervention (PCI) volume and readmission after AMI-CS. METHODS: Adult AMI-CS patients were identified from the Nationwide Readmissions Database for 2016-2019 and were categorized into hospital quartiles (Q1 lowest volume to Q4 highest) based on annual inpatient PCI volume...
August 21, 2024: JACC. Heart Failure
#13
JOURNAL ARTICLE
Yuanqi Yong, Julian Giovannucci, Sow Neng Pang, Wei Hong, Donghee Han, Daniel S Berman, Damini Dey, Stephen J Nicholls, Nitesh Nerlekar, Andrew Lin
BACKGROUND: There is increasing evidence that coronary artery calcium (CAC) density is inversely associated with plaque vulnerability and atherosclerotic cardiovascular disease risk. OBJECTIVES: A systematic review and meta-analysis were performed to examine the predictive value of CAC density for future cardiovascular events in asymptomatic individuals undergoing noncontrast CAC scoring computed tomography. METHODS: Electronic databases were searched for studies reporting CAC density and subsequent cardiovascular disease (CVD) or coronary heart disease (CHD) events...
August 25, 2024: JACC. Cardiovascular Imaging
#14
JOURNAL ARTICLE
Mamatha Gowda, Ariharan Krishnaraj, Murugesan Ambalakkuthan, Navya Chinta, Tamil Selvan
OBJECTIVE: To treat the fetus presenting with in utero compromise due to a large vein of Galen malformation (VOGM) using glue embolization. METHODS: The fetus that was referred for termination of pregnancy at 30 weeks of gestation due to severe cardiomegaly, mild pericardial effusion and large VOGM was evaluated using ultrasound. There was reversed end diastolic flow in the umbilical artery Doppler indicating imminent fetal demise in the premature fetus weighing <1200 g...
September 7, 2024: Prenatal Diagnosis
#15
JOURNAL ARTICLE
Nabil V Sayour, Tamás G Gergely, Barnabás Váradi, Viktória É Tóth, Bence Ágg, Tamás Kovács, Dániel Kucsera, Csenger Kovácsházi, Gábor B Brenner, Zoltán Giricz, Péter Ferdinandy, Zoltán V Varga
AIMS: Heart failure with reduced ejection fraction (HFrEF) is a leading cause of death worldwide; thus, therapeutic improvements are needed. In vivo preclinical models are essential to identify molecular drug targets for future therapies. Transverse aortic constriction (TAC) is a well-established model of HFrEF; however, highly experienced personnel are needed for the surgery, and several weeks of follow-up are necessary to develop HFrEF. To this end, we aimed (i) to develop an easy-to-perform mouse model of HFrEF by treating Balb/c mice with angiotensin-II (Ang-II) for 2 weeks by minipump and (ii) to compare its cardiac phenotype and transcriptome to the well-established TAC model of HFrEF in C57BL/6J mice...
September 7, 2024: ESC Heart Failure
#16
JOURNAL ARTICLE
Taylor E Savage, Kennedy R Geenen, Melissa C Price, Souheil Y El-Chemaly, Elizabeth P Henske, Amita Sharma, Elizabeth A Thiele
This research aims to compare and assess the clinical and radiological presentations of tuberous sclerosis complex (TSC)-associated lymphangioleiomyomatosis (LAM) and sporadic LAM. A retrospective medical record review was conducted for 90 patients with confirmed LAM diagnoses. Radiologists who were blinded to the LAM type evaluated CT images of the chest and abdomen for the presence of four CT phenotypes: multiple sclerotic bone lesions (SBLs), multifocal micronodular pneumocyte hyperplasia (MMPH), hepatic fat-containing lesions, and cardiac fat-containing lesions...
September 7, 2024: American Journal of Medical Genetics. Part A
#17
JOURNAL ARTICLE
Benjamin Buck, Mahmoud Houmsse
INTRODUCTION: Atrial fibrillation (AF) is the most common arrhythmia with an estimated prevalence of 3.2 million cases in the US. Catheter ablation is a successful rhythm control strategy in paroxysmal AF but it has demonstrated dramatically lower AF-free survival rates in patients with persistent AF. In recent years, myriad novel rhythm control strategies have been developed, each with the promise of improved persistent AF ablation success. AREAS COVERED: This review discusses multiple novel techniques and approaches to catheter ablation for persistent AF...
September 6, 2024: Expert Review of Cardiovascular Therapy
#18
JOURNAL ARTICLE
Koichi Inoue, Michikazu Nakai, Teiichi Yamane, Kengo Kusano, Seiji Takatsuki, Kazuhiro Satomi, Yoshitaka Iwanaga, Koshiro Kanaoka, Reina Tonegawa-Kuji, Yoko Sumita, Misa Takegami, Yoko M Nakao, Akihiko Nogami, Yoshihiro Miyamoto, Wataru Shimizu
BACKGROUND AND AIMS: This study evaluated the safety and efficacy of catheter ablation in treating atrial fibrillation (AF) among the elderly population. METHODS: A total of 170 017 AF ablation procedures prospectively enrolled from 482 facilities between 2017 and 2020 were analysed. They were stratified into six age groups, ranging from < 65 to ≥ 85 years, in 5-year increments. A cut-off of 80 years was set for dividing participants into two groups...
September 6, 2024: European Heart Journal. Quality of Care & Clinical Outcomes
#19
JOURNAL ARTICLE
Fei Sun, Shenglan Zou, Xiaomin Li, Xueya Liu
OBJECTIVE: The purpose of this study was to investigate the diagnostic value of circ_0013958 in acute myocardial infarction (AMI) patients and its influence on the prognosis of AMI patients. METHODS: The GSE160717 dataset was downloaded from the NCBI database and differentially expressed genes were analyzed between the control group and the AMI group. The up-regulated genes included circ_0013958. The expression of circ_0013958 in both groups was further verified by RT-qPCR...
September 6, 2024: Journal of Cardiothoracic Surgery
#20
COMPARATIVE STUDY
Ya Zhang, Yang Yu, Ping Qing, Xiaojie Liu, Yao Ding, Jingcan Wang, Hushan Ao
BACKGROUND: Cardiac etiologies arrest accounts for almost half of all in-hospital cardiac arrest (IHCA), and previous studies have shown that the location of IHCA is an important factor affecting patient outcomes. The aim was to compare the characteristics, causes and outcomes of cardiovascular disease in patients suffering IHCA from different departments of Fuwai hospital in Beijing, China. METHODS: We included patients who were resuscitated after IHCA at Fuwai hospital between March 2017 and August 2022...
September 6, 2024: BMC Cardiovascular Disorders
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