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Ophthalmology and Therapy

Hamed Momeni-Moghaddam, Nasim Maddah, James S Wolffsohn, Mohammad Etezad-Razavi, Siamak Zarei-Ghanavati, Amir Akhavan Rezayat, Majid Moshirfar
INTRODUCTION: To evaluate the effects of cycloplegia on the biometric components and anterior segment parameters of the eye. METHODS: In this cross-sectional study, changes to axial length (AL), anterior chamber depth (ACD) lens thickness, anterior chamber angle (ACA) and volume, corneal thickness in the pupil center (PC), corneal curvature (CC) and white-to-white (WTW) following cycloplegia induced by tropicamide 1% in 42 eyes of patients aged 23-58 years were assessed...
May 3, 2019: Ophthalmology and Therapy
Jianjun Gu, Yuying Zhang, Jiajie Zhai, Zhancong Ou, Jiaqi Chen
INTRODUCTION: The purpose of this study was to describe the results using the Nd:YAG laser to reopen blocked glaucoma tube shunts in three ocular chemical burn patients with Boston keratoprostesis type I (KPro) implantation. METHODS: The medical records of the three patients at Zhongshan Ophthalmic Centre were reviewed. RESULTS: Patient 1, who had glaucoma secondary to KPro implantation, had undergone Ahmed glaucoma valve (AGV) implantation to control an elevated intraocular pressure (IOP)...
April 29, 2019: Ophthalmology and Therapy
Josef Guber, Ioana Pereni, Hendrik P N Scholl, Ivo Guber, Richard J Haynes
INTRODUCTION: The aim of this study was to assess the incidence of persistent postoperative cystoid macular edema (pCME) in patients undergoing pars plana vitrectomy with epiretinal membrane peel (ERM) only versus those with ERM peel combined with internal limiting membrane peel (ILM). Secondary endpoints of the study were to review both the central macular thickness (CMT) and visual acuity. METHODS: The patients were divided in two groups, one group in which only the ERM was peeled (n = 36 patients) and another group in which both the ERM and the ILM were removed (n = 62 patients)...
April 19, 2019: Ophthalmology and Therapy
Maria Eleftheriadou, Luke Nicholson, Giulia D'Alonzo, Peter K F Addison
INTRODUCTION: To report the 52-week treatment outcomes with intravitreal injections of aflibercept using a treat-and-extend regimen for treating macular edema secondary to central retinal vein occlusion (CRVO). METHODS: A retrospective analysis of patients newly diagnosed with CRVO was performed. Patients receiving aflibercept between 1 December 2016 and 31 March 2017 were included in the analysis. Data on age, gender, visual acuity measured on Early Treatment of Diabetic Retinopathy Study charts, presence of macular and peripheral ischemia, anatomical changes observed on spectral domain-optical coherence tomography examination and the number of injections needed were recorded...
April 10, 2019: Ophthalmology and Therapy
Valentina De Luca, Adriano Carnevali, Giovanna Carnovale Scalzo, Gabriele Piccoli, Donatella Bruzzichessi, Vincenzo Scorcia
INTRODUCTION: A novel treatment for posterior blepharitis which involves the use of disposable wet wipes imbibed with a solution of terpinen-4-ol and hyaluronic acid (Hy-Ter® ) as well as aloe, natural anti-inflammatories and antiseptics (Blephapad Combo; Novelty Technology Care, Milan, Italy) has been proposed. The aim of this study was to compare the efficacy and safety of treatment with Blephapad Combo with standard treatment. METHODS: We conducted 4-week, open-label, randomized controlled study with a closed sequential design at the Magna Graecia University of Catanzaro, Italy in which patients aged > 40 years with symmetrical bilateral posterior blepharitis were enrolled...
March 30, 2019: Ophthalmology and Therapy
Ninel Z Gregori, Jose J Echegaray, Harry W Flynn
We report localized opacification of a sclera-fixated Akreos® hydrophilic acrylic intraocular lens after successful repair of rhegmatogenous retinal detachment with silicone oil tamponade in a nondiabetic patient. No intraoperative lens opacification during air-fluid exchange or lens dislocation was encountered. Granular opacities within the optic were noted at 5 months after surgery, and did not relent to scrubbing with a vitrector during oil removal. Akreos lens opacification under silicone oil is not well documented in the literature...
March 28, 2019: Ophthalmology and Therapy
Vance M Thompson, Tanner J Ferguson, Iqbal Ike K Ahmed, Thomas W Samuelson, Russell J Swan, Mitch Ibach, John P Berdahl
INTRODUCTION: Prospective, open-label, non-randomized, single site study to assess the safety and tolerability of a multi-pressure dial. METHODS: 30 healthy subjects received application of negative pressure (-15 mmHg) in one eye for 30 minutes and ambient atmospheric pressure in the contralateral eye. To evaluate safety, the primary outcome measures included best corrected visual acuity (BCVA), intraocular pressure (IOP) changes from baseline, slit-lamp and dilated fundus examination findings, and rate of adverse events...
March 27, 2019: Ophthalmology and Therapy
Mania Horani, Sajjad Mahmood, Tariq M Aslam
INTRODUCTION: The purpose of this review was to explore the potential link between macular atrophy (MA) of the retinal pigment epithelium in patients with neovascular age-related macular degeneration (nAMD) with the disease characteristics and morphological features. METHODS: To this end, we performed a search of peer-reviewed articles published on the PubMed database and included all relevant papers. We then examined these papers for possible risk factors for MA development in the context of nAMD treated with anti-vascular endothelial growth factor drugs, as well as possible protective factors...
March 25, 2019: Ophthalmology and Therapy
Keisuke Shinno, Kazuya Kurokawa, Seiko Kozai, Akio Kawamura, Katsuhiro Inada, Hideki Tokushige
INTRODUCTION: Brimonidine bioavailability in the aqueous humor depends on the solution pH following topical administration. The purpose of this study was to investigate the effect of solution pH on brimonidine distribution in the posterior ocular tissues in pigmented rabbits. METHODS: The anterior retina/choroid, posterior retina/choroid, and vitreous body of pigmented rabbits were collected 0.67, 1.5, 3, 6, 12, 24, 168, and 360 h after the administration of a single topical dose of 0...
March 20, 2019: Ophthalmology and Therapy
Rodolfo A Perez-Grossmann, Daniel E Grigera, Alan Wenger
INTRODUCTION: The aim of this study was to evaluate the efficacy of trabeculectomy with suprachoroidal derivation in eyes with uncontrolled glaucoma after a 24-month follow-up period. METHODS: This was a prospective uncontrolled non-randomized case series. All patients scheduled for a trabeculectomy due to uncontrolled glaucoma at the "Instituto de Glaucoma y Catarata" (Lima, Peru) between 2011 and 2014 were included. Thee patients underwent trabeculectomy with mitomycin C and suprachoroidal derivation with two autologous scleral flaps...
March 16, 2019: Ophthalmology and Therapy
Evdokia Sfiniadaki, Ioanna Tsiara, Panagiotis Theodossiadis, Irini Chatziralli
Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune disease of unknown etiology that is characterized by granulomatous inflammation, tissue necrosis, and vasculitis in small- and medium-sized vessels. Ocular and orbital manifestations are common in almost half of patients with GPA, affecting every structure of the eye, from the eyelid and orbit to the retina, the choroid, and the optic nerve, with a wide range of severity. Since imaging findings are not always specific for the diagnosis of GPA, biopsy is useful to confirm the diagnosis...
March 15, 2019: Ophthalmology and Therapy
Melissa M Toyos
AIM: Randomized pilot study comparing clinical outcomes with bromfenac ophthalmic solution 0.07% versus nepafenac 0.3% ophthalmic suspension administered as identical dosing regimens in patients undergoing uncomplicated phacoemulsification with intraocular lens implantation. METHODS: Forty-nine subjects were treated with bromfenac (n = 25) or nepafenac (n = 24) once daily starting 3 days before cataract surgery, continued on the day of surgery, and for 21 days following surgery, in addition to standard of care...
March 13, 2019: Ophthalmology and Therapy
Enrico Borrelli, SriniVas R Sadda, Akihito Uji, Giuseppe Querques
Optical coherence tomography angiography (OCTA) has significantly expanded our knowledge of the ocular vasculature. Furthermore, this imaging modality has been widely adopted to investigate different ocular and systemic diseases. In this review, a discussion of the fundamental principles of OCTA is followed by the application of this imaging modality to study the retinal and choroidal vessels. A proper comprehension of this imaging modality is essential for the interpretation of OCTA imaging applications in retinal and choroidal disorders...
March 13, 2019: Ophthalmology and Therapy
Mukhtar Bizrah, Ammar Yusuf, Sajjad Ahmad
INTRODUCTION: To investigate the demographics, acute management and compliance rates of severe chemical eye burn cases that presented to the largest eye hospital in the United Kingdom (UK). METHODS: All patients presenting to the Moorfields Eye Hospital emergency department are registered on the electronic patient administration system (PAS). A search of the PAS for patients assigned a preset diagnosis of 'chemical injury' was performed for the period from 1 January to 31 March 2016...
March 13, 2019: Ophthalmology and Therapy
Adriana M Morgan, Livia S Mazzoli, Cristiano Caixeta-Umbelino, Niro Kasahara
INTRODUCTION: White-on-white standard automated perimetry (AP) uses a white round stimulus with 0.43° diameter and 4.0 mm2 area (Goldmann size III). Patients with low vision have difficulty seeing such a small stimulus and are often tested with perimetry using the size V stimulus with 1.72° diameter and 64 mm2 area. We undertook an observational case-control study to compare the performance of patients on AP using two differently sized stimuli. METHODS: Patients with glaucoma and visual acuity worse than 20/100 underwent AP using the standard size III stimulus Swedish Interactive Threshold Algorithm (SITA) standard test and size V stimulus full threshold test...
March 13, 2019: Ophthalmology and Therapy
Majid Moshirfar, Michael S Murri, Tirth J Shah, David F Skanchy, James Q Tuckfield, Yasmyne C Ronquillo, Orry C Birdsong, Daniel Hofstedt, Phillip C Hoopes
The corneal endothelium plays an integral role in regulating corneal hydration and clarity. Endotheliitis, defined as inflammation of the corneal endothelium, may disrupt endothelial function and cause subsequent visual changes. Corneal endotheliitis is characterized by corneal edema, the presence of keratic precipitates, anterior chamber inflammation, and occasionally limbal injection, neovascularization, and co-existing or superimposed uveitis. The disorder is classified into four subgroups: linear, sectoral, disciform, and diffuse...
March 11, 2019: Ophthalmology and Therapy
Alia Z Al-Mousawi, Sam P Gurney, Alice R Lorenzi, Ute Pohl, Margaret Dayan, Susan P Mollan
Improving understanding of the underlying pathophysiology of giant cell arteritis (GCA) is transforming clinical management by identifying novel avenues for targeted therapies. One key area of concern for both clinicians and patients with GCA is glucocorticoid (GC) morbidity. The first randomised controlled trials of targeted treatment to reduce cumulative GC use in GCA have been published, with tocilizumab, an interleukin (IL)-6 receptor inhibitor, now the first ever licensed treatment for GCA. Further potential therapies are emerging owing to our enhanced understanding of the pathophysiology of the disease...
March 1, 2019: Ophthalmology and Therapy
Sobha Sivaprasad, Elizabeth A Tschosik, Robyn H Guymer, Audrey Kapre, Ivan J Suñer, Antonia M Joussen, Paolo Lanzetta, Daniela Ferrara
INTRODUCTION: The specific impact from the patient's perspective of geographic atrophy (GA), an advanced form of age-related macular degeneration (AMD), is not well understood. METHODS: An ethnographic study was conducted to understand the impact of bilateral GA secondary to AMD on daily functioning by observing regular activities performed at home and through semi-structured interviews. Eligible subjects had a definitive GA diagnosis, including presence of drusen, GA lesion size of at least one disc area in the better-seeing eye, and no other confounding ophthalmologic diagnosis...
March 2019: Ophthalmology and Therapy
Panagiotis Georgoudis, Francesco Sabatino, Nora Szentmary, Sotiria Palioura, Eszter Fodor, Samer Hamada, Hendrik P N Scholl, Zisis Gatzioufas
Mucous membrane pemphigoid (MMP) is a systemic cicatrizing autoimmune disease that primarily affects orificial mucous membranes, such as the conjunctiva, the nasal cavity, the oropharynx, and the genitalia. Ocular involvement occurs in about 70% of all MMP cases. Ocular MMP (OcMMP) also encompasses the conditions linear immunoglobulin A disease, mucosal dominated epidermolysis bullosa acquisita, and anti-laminin 332/anti-epiligrin/anti-laminin 5 pemphigoid. It is a complex clinical entity that may lead to ocular surface failure and result in inflammatory and infectious complications, as well as potentially devastating visual loss...
March 2019: Ophthalmology and Therapy
Bertan Cakir, Michael Reich, Stefan Lang, Anima Bühler, Christoph Ehlken, Bastian Grundel, Milena Stech, Sabine Reichl, Andreas Stahl, Daniel Böhringer, Hansjürgen Agostini, Clemens Lange
INTRODUCTION: To quantify optical coherence tomography angiography (OCTA) signal changes at the level of the choriocapillaris (CC) in patients with different stages of central serous chorioretinopathy (CSC) and to explore any correlation between subretinal fluid (SRF) and retinal pigment epithelium (RPE) alterations and the OCTA CC signal. METHODS: One hundred one CSC eyes and 42 healthy control eyes were included in this retrospective study. CSC patients were allocated into four groups: acute, non-resolving, chronic atrophic and inactive CSC...
March 2019: Ophthalmology and Therapy
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