journal
https://read.qxmd.com/read/38907092/pre-clinical-studies-of-a-novel-bispecific-fusion-protein-targeting-c3b-and-vegf-in-neovascular-and-nonexudative-amd-models
#1
JOURNAL ARTICLE
Yeri Lee, Donggeon Kim, Philip E D Chung, Minkyeong Lee, Nahmju Kim, Jihoon Chang, Byoung Chul Lee
INTRODUCTION: KNP-301 is a bi-specific fragment crystallizable region (Fc) fusion protein, which inhibits both C3b and vascular endothelial growth factor (VEGF) simultaneously for patients with late-stage age-related macular degeneration (AMD). The present study evaluated in vitro potency, in vivo efficacy, intravitreal pharmacokinetics (IVT PK), and injectability of KNP-301. METHODS: C3b and VEGF binding of KNP-301 were assessed by surface plasmon resonance (SPR) and enzyme-linked immunosorbent assay (ELISA), and cellular bioassays...
June 21, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38907091/ten-year-effectiveness-and-safety-of-trabecular-micro-bypass%C3%A2-stent%C3%A2-implantation-with-cataract-surgery-in-patients-with-glaucoma-or-ocular-hypertension
#2
JOURNAL ARTICLE
Tobias H Neuhann, Raphael T Neuhann, Dana M Hornbeak
INTRODUCTION: This study evaluated 10-year results of implanting one iStent trabecular micro-bypass stent during cataract surgery in eyes with open-angle glaucoma (OAG) or ocular hypertension. METHODS: This retrospective, non-randomized study examined 10-year outcomes of iStent trabecular micro-bypass stent implantation with cataract surgery by one surgeon in eyes with OAG [including primary OAG (POAG) and pseudoexfoliative glaucoma (PXG)] or ocular hypertension at a multi-specialty German ophthalmology center...
June 21, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38879718/vectored-thermal-pulsation-as-a-treatment-for-meibomian-gland-dysfunction-a-review-spanning-15-years
#3
REVIEW
Caroline A Blackie, David Murakami, Eric Donnenfeld, Heather S Oliff
The LipiFlow Thermal Pulsation System received its first marketing clearance for the treatment of meibomian gland dysfunction (MGD) 13 years ago. Since then, the evidence evaluating the effectiveness and safety of LipiFlow as a treatment for MGD has grown significantly. The objective of this comprehensive review was to summarize all clinical reports evaluating the effectiveness and safety of LipiFlow over the past 15 years. The literature was systematically reviewed, and 55 unique articles had subjective (patient-reported outcomes) and objective (meibomian gland function, tear production, and ocular staining) outcomes for extraction...
June 15, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38878130/analytical-characterization-for-similarity-assessment-between-an-aflibercept-biosimilar-sb15-and-reference-product-eylea-%C3%A2
#4
JOURNAL ARTICLE
Hangyeore Lee, Jongcheol Huh, Dayoung Kim, Soye Lee, Jaeil Lee, Jungmin Lee, Beom Chan Kim, Jinsu Song
INTRODUCTION: SB15 is a proposed biosimilar product of reference aflibercept (Eylea® ), an approved biological drug product for retinal diseases including neovascular age-related macular degeneration (nAMD). This study aimed to assess the analytical similarity between SB15 and its commercially available reference product (RP) sourced from the United States (US-aflibercept) and European Union (EU-aflibercept) in terms of structural, physicochemical, and biological properties. METHODS: A panel of state-of-the-art analytical methods was used for the comprehensive characterization of SB15 and US/EU-aflibercept...
June 15, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38874887/evaluation-of-the-accuracy-of-intraocular-lens-power-calculation-formulas-in-phacovitrectomy
#5
JOURNAL ARTICLE
Yuichiro Tanaka, Kazutaka Kamiya, Akihito Igarahi, Nobuyuki Shoji, Hiroshi Tsuchiya, Shinya Takahashi, Eri Ishikawa, Tadahiko Kozawa
INTRODUCTION: The aim of this study was to evaluate the refractive error in patients undergoing combined phacovitrectomy with and without gas tamponade. METHODS: This was a retrospective chart review including patients undergoing phacoemulsification alone (Group 1), combined phacovitrectomy for epiretinal membrane (Group 2), and combined phacovitrectomy with gas tamponade for rhegmatogenous retinal detachment (RRD) (Group 3). Axial length and keratometry were measured using an optical biometric system (Argos, Alcon Laboratories...
June 14, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38856837/letter-to-the-editor-regarding-vivex-a-formula-for-calculating-individual-vitreous-volume-a-new-approach-towards-tailored-patient-dosing-regime-in-intravitreal-therapy
#6
LETTER
Bilgehan Erduran, Nurullah Koçak
No abstract text is available yet for this article.
June 10, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38856836/a-response-to-letter-to-the-editor-regarding-vivex-a-formula-for-calculating-individual-vitreous-volume-a-new-approach-towards-tailored-patient-dosing-regime-in-intravitreal-therapy
#7
LETTER
Andreas F Borkenstein, Eva-Maria Borkenstein, Achim Langenbucher
No abstract text is available yet for this article.
June 10, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38834934/impact-of-online-video-game-based-dichoptic-training-on-binocular-vision-rehabilitation-in-post-surgical-patients-with-intermittent-exotropia
#8
JOURNAL ARTICLE
Xuan Qiu, Yusong Zhou, Xinping Yu, Zhonghao Wang, Tao Shen, Daming Deng, Jingchang Chen, Xiaoming Lin, Heping Wu, Ying Kang, Qingqing Ye, Qiwen Chen, Jianhua Yan, Jinrong Li
INTRODUCTION: Dichoptic training has emerged as a promising rehabilitation approach for improving binocular visual function in patients with strabismus. A prospective observational study design was employed to assess the effectiveness of online video game-based dichoptic training in rehabilitating binocular visual function in patients who had undergone an operation for intermittent exotropia. METHODS: A total of 64 patients who had undergone an operation for intermittent exotropia were recruited and divided into the training group and the control group based on whether they would receive the dichoptic training...
June 5, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38833127/advancements-in-imaging-and-therapeutic-options-for-dry-age-related-macular-degeneration-and-geographic-atrophy
#9
REVIEW
Andrea Servillo, Riccardo Sacconi, Gloria Oldoni, Eugenio Barlocci, Beatrice Tombolini, Marco Battista, Federico Fantaguzzi, Federico Rissotto, Cecilia Mularoni, Mariacristina Parravano, Ilaria Zucchiatti, Lea Querques, Francesco Bandello, Giuseppe Querques
Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly, with dry AMD (d-AMD) leading to geographic atrophy (GA) and significant visual impairment. Multimodal imaging plays a crucial role in d-AMD diagnosis and management, allowing for detailed classification of patient phenotypes and aiding in treatment planning and prognosis determination. Treatment approaches for d-AMD have recently witnessed profound change with the development of specific drugs targeting the complement cascade, with the first anticomplement agents recently approved for GA treatment...
June 4, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38831127/real-world-outcomes-of-a-loading-phase-with-intravitreal-faricimab-in-neovascular-age-related-macular-degeneration-n-amd-and-diabetic-macular-edema-dme
#10
JOURNAL ARTICLE
Ermete Giancipoli, Antonella Guglielmi, Anna Valeria Bux, Giulia Maria Emilia Clima, Francesco Pignatelli, Francesco Boscia, Pasquale Viggiano, Giacomo Boscia, Francesca Fortunato, Gianluca Besozzi, Alfredo Niro, Stefano Dore, Cristiana Iaculli
INTRODUCTION: The aims of this work were to evaluate the real-world efficacy and safety of a loading dose of intravitreal faricimab in eyes with active neovascular age-related macular degeneration (n-AMD) or diabetic macular edema (DME) and to analyze the treatment outcome in relation to specific biomarkers. METHODS: Patients with active n-AMD or DME, treated with four monthly intravitreal injections of faricimab, were enrolled in this retrospective, uncontrolled study...
June 4, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38831126/investigating-the-influence-of-temperature-and-supplementation-timing-on-antifungal-efficacy-in-storage-medium-for-corneal-transplantation
#11
JOURNAL ARTICLE
Hsin-Yu Liu, Pao-Yu Chen, Hsiao-Sang Chu, Ya-Ting Chiu, Yee-Chun Chen, Fung-Rong Hu
INTRODUCTION: Although antifungal supplementation reduces the fungal load in the corneal storage medium, consensus is lacking on the influence of dosing and temperature. The study aims to evaluate the impact of eye bank warming protocol and timing of antifungal supplements on efficacy in Optisol-GS and tissue. METHODS: Corneoscleral rims contaminated with Candida albicans (C. albicans) were incubated in Optisol-GS, either without antifungal agents or with the addition of amphotericin B or voriconazole at various concentrations (2 ×, 5 ×, 10 ×, and 20 × MIC), at different time points, and under various preservation temperatures (2-8 °C versus 2 h-room temperature exposure)...
June 3, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38824471/keratoconus-and-corneal-ectasia-with-relatively-low-keratometry
#12
JOURNAL ARTICLE
Louise Pellegrino G Esporcatte, Marcella Q Salomão, Bernardo T Lopes, Nelson Sena, Aydano P Machado, Paolo Vinciguerra, Riccardo Vinciguerra, Renato Ambrósio
INTRODUCTION: The study aims to demonstrate and estimate the prevalence of clinical corneal ectasia and keratoconus (KC) in patients with relatively low keratometry (low-K KC). METHODS: In a retrospective, analytical, and non-interventionist study, one eye was randomly selected from 1054 patients from the original Tomographic Biomechanical Index (TBIv1) study and the external validation (from Rio de Janeiro, Brazil, and Milan, Italy clinics). Patients were stratified into three groups...
June 2, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38824253/vascular-endothelial-growth-factor%C3%A2-c-and-d-signaling-pathways-as-potential-targets-for-the-treatment-of-neovascular-age-related-macular-degeneration-a-narrative-review
#13
REVIEW
Ian M Leitch, Michael Gerometta, David Eichenbaum, Robert P Finger, Nathan C Steinle, Megan E Baldwin
The development of treatments targeting the vascular endothelial growth factor (VEGF) signaling pathways have traditionally been firstly investigated in oncology and then advanced into retinal disease indications. Members of the VEGF family of endogenous ligands and their respective receptors play a central role in vasculogenesis and angiogenesis during both development and physiological homeostasis. They can also play a pathogenic role in cancer and retinal diseases. Therapeutic approaches have mostly focused on targeting VEGF-A signaling; however, research has shown that VEGF-C and VEGF-D signaling pathways are also important to the disease pathogenesis of tumors and retinal diseases...
June 1, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38822998/association-between-myopia-and-pupil-diameter-in-preschoolers-evidence-from-a-machine-learning-approach-based-on-a-real-world-large-scale-dataset
#14
JOURNAL ARTICLE
Shengsong Xu, Linling Li, Wenjing Han, Yingting Zhu, Yin Hu, Zhidong Li, Zhenbang Ruan, Zhuandi Zhou, Yehong Zhuo, Min Fu, Xiao Yang
INTRODUCTION: Previous studies have explored the connections between various ocular biological parameters with myopia. Our previous study also found that pupil data can predict the myopic progression during the interventions for myopia. However, studies exploring the association between pupil diameter and myopia in preschoolers with myopia were lacking. Hence this study was aimed to investigate the association between pupil diameter and myopia in preschoolers with myopia based on a real-world, large-scale dataset...
June 1, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38822193/visual-pathway-recovery-post-pituitary-adenoma-surgery-insights-from-retinal-structure-vascular-density-and-neural-conduction-analysis
#15
JOURNAL ARTICLE
Yanhua Pang, Quanwen Zhao, Zeguang Huang, Kailun Lu, Fengyan Zhou, Wei Mo, Qianshuo Zhong, Zhi Tan
INTRODUCTION: This study investigates how surgery for pituitary adenoma (PA) affects the visual pathway, examining changes in the retina, blood vessel density, and nerve function. Since PAs often impair vision as a result of their location near visual structures, this research is key to understanding and improving vision recovery after surgery. METHODS: Our study is based on a retrospective analysis of the historical data of 28 patients diagnosed with pituitary adenomas...
May 31, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38801614/analysis-of-choriocapillaris-reperfusion-topography-following-faricimab-treatment-for-neovascular-age-related-macular-degeneration-in-therapy-na%C3%A3-ve-patients
#16
JOURNAL ARTICLE
Max Brinkmann, Pasquale Viggiano, Giacomo Boscia, Tom Müller, Niccolò Castellino, Jakob Schweighofer, Francesco Boscia, Mario Damiano Toro, Yosuf El-Shabrawi
INTRODUCTION: To assess changes in choriocapillaris (CC) vascular density surrounding macular neovascularization (MNV) in treatment-naïve age-related macular degeneration (AMD) after faricimab application using optical coherence tomography angiography (OCTA). METHODS: Twenty-five eyes of 25 treatment-naïve individuals who underwent intravitreal faricimab injections for neovascular AMD (nAMD) with type 1 MNV were included. Spectral-domain optical coherence tomography (SD-OCT) images and en-face swept-source OCTA images were analyzed, and the percentage of CC flow deficit (FD%), FD average area (FDa) and FD number (FDn) in five progressive 20...
May 27, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38789667/incidence-of-cytomegalovirus-infection-after-repeat-keratoplasty-and-associated-rate-of-graft-failure
#17
JOURNAL ARTICLE
Yunxiao Zang, Yaning Zhao, Rongmei Peng, Gege Xiao, Xiaozhen Liu, Yi Qu, Xuanjun Zhang, Jiaxin Zhang, Jing Hong
INTRODUCTION: The aim of this work was to compare the prognosis and characteristics of patients with Cytomegalovirus (CMV) infection (CMV+) with those of patients without virus infection (Virus-) undergoing repeat keratoplasty. METHODS: This prospective propensity score-matched cohort study enrolled patients who underwent repeat keratoplasty for graft failure at the Peking University Third Hospital between January 2016 and May 2022. Patients with prior viral keratitis before the first keratoplasty were excluded...
May 24, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38775923/correction-to-accuracy-of-toric-intraocular-lens-calculators-with-predicted-and-measured-posterior-corneal-astigmatism-across-different-types-of-astigmatism
#18
Soonwon Yang, Jaehyun Park, Woong Joo Whang, Yong-Soo Byun, Hyun Seung Kim, So-Hyang Chung
No abstract text is available yet for this article.
May 22, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38771462/burden-of-disease-study-of-patients-with-diabetic-macular-oedema-in-spain
#19
JOURNAL ARTICLE
José M Ruiz-Moreno, María Gámez Lechuga, Pilar Calvo, María Merino, Teresa Martín Lorenzo, Paulina Maravilla-Herrera, Beatriz Gil Jiménez, Maximino J Abraldes
INTRODUCTION: Diabetic macular oedema (DMO) is a complication of diabetic retinopathy that can result in vision loss. The disease can impact different spheres of a patient's life, including physical and psychological health, work, and activities of daily living, entailing an important use of healthcare and non-healthcare resources. This study aimed to estimate the socio-economic burden of DMO in Spain. METHODS: The burden of DMO was estimated from a societal perspective, per patient, year of treatment since diagnosis, and type of treatment...
May 21, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38771461/burden-of-disease-study-of-patients-with-neovascular-age-related-macular-degeneration-in-spain
#20
JOURNAL ARTICLE
Maximino J Abraldes, Pilar Calvo, María Gámez Lechuga, María Merino, Teresa Martín Lorenzo, Paulina Maravilla-Herrera, Beatriz Gil Jiménez, José M Ruiz-Moreno
INTRODUCTION: Neovascular age-related macular degeneration (nAMD) is a progressive retinal disease that causes severe and irreversible vision loss. The disease can therefore have a significant impact on the life of patients' and their families. The aim of this study was to evaluate the socio-economic burden of nAMD in Spain. METHODS: The annual cost per patient with nAMD was estimated for the first, second, and third year (or beyond) of treatment since diagnosis...
May 21, 2024: Ophthalmology and Therapy
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