Laurent Kodjikian, Cécile Delcourt, Catherine Creuzot-Garcher, Pascale Massin, John Conrath, Marie-Ève Velard, Thibaut Lassalle, Sybil Pinchinat, Laure Dupont-Benjamin
INTRODUCTION: To evaluate real-world efficacy, safety, and treatment patterns with the dexamethasone intravitreal implant (DEX) in diabetic macular edema (DME) in France. METHODS: In this prospective, multicenter, observational, noncomparative, post-reimbursement study, consecutively enrolled patients with DME had a baseline evaluation on day 0. Those treated with DEX on day 0 were to be reevaluated at week 6 and months 6, 12, 18, and 24. DEX retreatment and/or alternative therapies were allowed during follow-up...
March 26, 2023: Ophthalmology and Therapy
Vasileios Karampatakis, Diamantis Almaliotis, Persefoni Talimtzi, Stavroula Almpanidou
INTRODUCTION: Visual acuity (VA) testing is a critical screening examination for the assessment of visual function. This study describes the development and validation of a smartphone-based VA test: the K-VA test. METHODS: A total of 171 patients with various ocular diseases were examined in our outpatient unit at Aristotle University of Thessaloniki, School of Medicine in Greece. Participants underwent VA examination using the standard Early Treatment Diabetic Retinopathy Study (ETDRS) charts and the K-VA smartphone-based test...
March 24, 2023: Ophthalmology and Therapy
Benoît Paganelli, Marwan Sahyoun, Eric Gabison
INTRODUCTION: The purpose of this study is to compare the "real-life" effectiveness of amniotic membrane graft (AMG) and conjunctival (CAT) or limbal conjunctival (LCA) autograft in the management of primary pterygium. METHODS: Human-based studies on primary pterygium surgery that were published between 1993 and 2022 with at least 3 months of follow-up were identified, and only those that were retrospective were included. The global recurrence rate of pterygium was assessed for each surgical technique separately...
March 24, 2023: Ophthalmology and Therapy
Tetsuro Oshika, Hiroyuki Arai, Yasushi Inoue, Yoshifumi Fujita
INTRODUCTION: This study assessed 5-year results of rotationally asymmetric multifocal intraocular lens (IOL) with +1.5 diopters (D) near addition (Lentis Comfort LS-313 MF15, Teleon Surgical B.V., Spankeren, Netherlands). METHODS: In 38 eyes of 20 patients (76.8 ± 4.6 years) who were examined at both 1 and 5 years after surgery, clinical data were retrospectively collected. RESULTS: Corrected and uncorrected distance visual acuity (5 m) and uncorrected and distance-corrected intermediate visual acuity (70 cm) were excellent, with no significant differences between 1 and 5 years after surgery...
March 22, 2023: Ophthalmology and Therapy
Claudio Iovino, Clemente Maria Iodice, Danila Pisani, Andrea Rosolia, Francesco Testa, Giuseppe Giannaccare, Jay Chhablani, Francesca Simonelli
Yellow subthreshold micropulse laser (YSML) is a retinal laser capable of inducing a biologic response without causing thermal damage to the targeted tissue. The 577-nm YSML is delivered to the retina abiding by different protocols in which wavelength, power, duration, spot size and number of spots can be properly set to achieve the most effective and safe treatment response in various chorioretinal disorders. The ultrashort trains of power modulate the activation of the retinal pigment epithelium cells and intraretinal cells, such as Müller cells, causing no visible retinal scars...
March 18, 2023: Ophthalmology and Therapy
Stylianos A Kandarakis, Konstantina A Togka, Leonidas Doumazos, Ioanna Mylona, Andreas Katsimpris, Petros Petrou, George Kymionis
Corneal endothelium is a single cell layer that is mainly responsible for maintaining corneal clarity. Endothelial damage secondary to toxicity, stress, or genetic predisposition are common and in conjunction with the low regenerative ability of the cells, making their preservation critical for maintaining visual acuity. Patients with glaucoma, who are estimated to be close to 80 million worldwide, have a plethora of reasons for developing endothelial damage, being exposed to a spectrum that extends from various medical and surgical interventions to the disease itself...
March 17, 2023: Ophthalmology and Therapy
Jaekyoung Lee, Dong Cheol Lee
INTRODUCTION: The aim of this study was to investigate changes in the Clinical Activity Score, serum thyroid-stimulating hormone receptor antibody and thyroid-stimulating immunoglobulin levels, chorioretinal blood vessels, and extraocular muscle thickness in patients with thyroid eye disease following systemic steroid treatment. METHODS: This prospective observational study enrolled 57 patients with active thyroid eye disease who received systemic intravenous glucocorticoids for 12 weeks...
March 13, 2023: Ophthalmology and Therapy
Anna Hillenmayer, Christian M Wertheimer, Maximilian-Joachim Gerhard, Siegfried G Priglinger, Andreas Ohlmann, Armin Wolf
INTRODUCTION: Amniotic membrane (AM) is a popular treatment for external ocular diseases. First intraocular implantations in other diseases reported promising results. Here, we review three cases of intravitreal epiretinal human AM (iehAM) transplantation as an adjunct treatment for complicated retinal detachment and analyze clinical safety. Possible cellular rejection reactions against the explanted iehAM were evaluated and its influence was assessed on three retinal cell lines in vitro...
March 11, 2023: Ophthalmology and Therapy
Weijia Yan, Gerd U Auffarth, Ramin Khoramnia, Grzegorz Łabuz
INTRODUCTION: This study was performed to compare the optical performance of a multizonal presbyopia-correcting intraocular lens (IOL) and a conventional trifocal model. METHODS: The optical quality and simulated visual acuity (VA) of 570 Precizon Presbyopic NVA (OPHTEC BV) and AcrySof IQ PanOptix (Alcon) were compared. The Precizon features a refractive design consisting of alternating optical zones that converge the incident light into two principal foci and a transitional zone for intermediate vision...
March 8, 2023: Ophthalmology and Therapy
Zhe Xu, Jia Xu, Ce Shi, Wen Xu, Xiuming Jin, Wei Han, Kai Jin, Andrzej Grzybowski, Ke Yao
Artificial intelligence (AI) technology is promising in the field of healthcare. With the developments of big data and image-based analysis, AI shows potential value in ophthalmology applications. Recently, machine learning and deep learning algorithms have made significant progress. Emerging evidence has demonstrated the capability of AI in the diagnosis and management of anterior segment diseases. In this review, we provide an overview of AI applications and potential future applications in anterior segment diseases, focusing on cornea, refractive surgery, cataract, anterior chamber angle detection, and refractive error prediction...
March 8, 2023: Ophthalmology and Therapy
Lina Guan, Jiayu Chen, Yu Tang, Zhaolin Lu, Zhengpei Zhang, Sujuan Ji, Meili Li, Yalu Liu, Suyan Li, Haiyang Liu
INTRODUCTION: Pars plana vitrectomy (PPV) is a primary strategy to restore vision for patients who have rhegmatogenous retinal detachment (RRD). Perfluorocarbon liquid (PFCL) is frequently used during PPV surgery. However, the unintended intraocular retention of PFCL may cause retina toxicity and thus lead to possible postoperative complications. In this paper, the experiences and surgical outcomes of a NGENUITY 3D Visualization System-assisted PPV are shown to evaluate the possibility of excluding the application of PFCL...
March 4, 2023: Ophthalmology and Therapy
Rui Ning, Xiaomin Huang, Yili Jin, Chak Seng Lei, Xindi Ma, Shuoyu Xu, Jinxuan Xiahou, Giacomo Savini, Domenico Schiano-Lomoriello, Xiaoying Wang, Xingtao Zhou, Jinhai Huang
INTRODUCTION: The aim of this study was to evaluate the measurements of corneal higher-order aberrations (HOAs) obtained by a new anterior segment optical coherence tomography (OCT) technique combined with a Placido topographer (the MS-39 device) in eyes with prior small-incision lenticule extraction (SMILE) and compare them to the measurements obtained by a Scheimpflug camera combined with a Placido topographer (the Sirius device). METHODS: A total of 56 eyes (56 patients) were included in this prospective study...
March 2, 2023: Ophthalmology and Therapy
Andrzej Grzybowski, Panisa Singhanetr, Onnisa Nanegrungsunk, Paisan Ruamviboonsuk
Diabetic retinopathy (DR), a leading cause of preventable blindness, is expected to remain a growing health burden worldwide. Screening to detect early sight-threatening lesions of DR can reduce the burden of vision loss; nevertheless, the process requires intensive manual labor and extensive resources to accommodate the increasing number of patients with diabetes. Artificial intelligence (AI) has been shown to be an effective tool which can potentially lower the burden of screening DR and vision loss. In this article, we review the use of AI for DR screening on color retinal photographs in different phases of application, ranging from development to deployment...
March 2, 2023: Ophthalmology and Therapy
Getasew Alemu Mersha, Destaye Shiferaw Alemu, Meneberesibhat Getie Ferede, Melkamu Temeselew Tegegn, Mikias Mered Tilahun, Merkineh Markos Lorato, Biruk Lelisa Eticha, Asamere Tsegaw Woredekal
No abstract text is available yet for this article.
March 1, 2023: Ophthalmology and Therapy
John D Sheppard, Kelly K Nichols
Meibomian gland dysfunction (MGD) is highly prevalent and is the leading cause of evaporative dry eye disease (DED). MGD is characterized by a reduction in meibum secretion and/or a change in meibum composition that results in the disruption of the tear film lipid layer and an increase in the tear film evaporation rate. Excessive evaporation causes tear film instability, desiccation, tear hyperosmolarity, inflammation, and apoptosis of ocular surface cells, resulting in a continuous cycle of DED. The primary treatment goal for DED associated with MGD is to restore the tear film lipid layer and decrease evaporation, thereby reducing ocular signs and symptoms...
March 1, 2023: Ophthalmology and Therapy
Gonzalo Velarde-Rodriguez, Carolina Belda-Para, Miriam Velasco-Ocaña, Juan M Trujillo-Sevilla, Javier Rodríguez-Martin, Ignacio Jiménez-Alfaro, José M Rodriguez-Ramos, Nicolas Alejandre-Alba
INTRODUCTION: This study performs optical aberration assessment in patients using a novel ultra-high-resolution device. The objective of this study is to analyze optical aberrations, especially the very high order wavefront (more than 10th order of Zernike coefficients), and compare between keratoconus and healthy patients. METHODS: In this cross-sectional study, we analyzed 43 eyes from 25 healthy patients and 43 eyes from 27 patients with keratoconus using corneal tomography and a very high-resolution (8...
March 1, 2023: Ophthalmology and Therapy
Louis Tong, Elizabeth Wen Ling Lim, Sharon Wan Jie Yeo, Aihua Hou, Yeh Ching Linn, Aloysius Ho, Hein Than, Jeffrey Kim Siang Quek, William Ying Khee Hwang, Francesca Lorraine Wei Inng Lim, Li Lim
INTRODUCTION: To profile conjunctival T cell populations in allogeneic hematopoietic stem cell transplant (HSCT) patients after instillation of daily topical cyclosporine-A (CsA) 0.1% cationic emulsion (Ikervis), and to evaluate patients' tolerance to these eye drops. METHODS: Nineteen participants were prescribed Ikervis prophylaxis once daily to both eyes from 3-5 weeks pre-HSCT to 12 months post-HSCT. The outcome measure was conjunctival T cell proportions from flow cytometry after impression cytology...
March 1, 2023: Ophthalmology and Therapy
Tianxi Li, Xiaoxia Zuo, Tong Zhang, Lei Liu, Zhongzheng Wang, Lin Han, Hu Liu, Zijin Wang
INTRODUCTION: There is a high prevalence of intermittent exotropia and exophoria in myopic populations, and orthokeratology is one of the effective interventions to control myopia progression in children. However, it is still obscure whether intermittent exotropia and exophoria children could wear orthokeratology without experiencing aggravated lens decentration. METHODS: This was a multi-center, prospective cohort study. A total of 123 myopic participants aged 8-14 years were recruited, where conditions of deviation included intermittent exotropia, exophoria, and orthophoria...
March 1, 2023: Ophthalmology and Therapy
Yalan Wang, Fuman Yang, Xicong Lou, Shuyi Qian, Bin Hu, Yune Zhao, Pingjun Chang
INTRODUCTION: This study analyzed the visual outcome following cataract surgery with toric intraocular lenses (IOLs) in patients older than 80 years with corneal astigmatism. METHODS: A total of 159 patients (159 eyes) older than 80 years with corneal astigmatism (≥ 0.75 D) were included. Fifty-three eyes received Acrysof IQ® toric IOLs (SN6AT2-5), while the others received non-toric IOLs: 51 eyes received Acrysof IQ® IOLs (SN60WF) and 55 eyes received A1-UV IOLs...
March 1, 2023: Ophthalmology and Therapy
M Dominik Fischer, Francesco Patalano, Christel Naujoks, Judit Banhazi, Christine Bouchet, Paul O'Brien, Christine Kay, Jane Green, Todd Durham, Helena Bradley, Nicola Williamson, Melissa Barclay, Joel Sims, Isabelle Audo
INTRODUCTION: Retinitis Pigmentosa (RP) and Leber Congenital Amaurosis (LCA) are rare inherited retinal degenerative disorders. The Visual Symptom and Impact Outcomes patient-reported outcome (ViSIO-PRO) and observer-reported outcome (ViSIO-ObsRO) instruments were developed in this population to assess visual function symptoms and impacts on vision-dependent activities of daily living (ADL) and distal health-related quality of life (HRQoL). This study aimed to explore the psychometric properties of the ViSIO-PRO and ViSIO-ObsRO in RP/LCA...
February 27, 2023: Ophthalmology and Therapy
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