Journals International Journal of Clini...

International Journal of Clinical and Experimental Pathology
Michael Liew, Leslie Rowe, Kristina Moore, Emily Aston, Kathryn O'Brien, Maria Longhurst, Jason Kenney, Marshall Priest, Wenhua Zhou, Diane Wilcock, Anton Rets, Rodney Miles
OBJECTIVE: Detection of gene rearrangements in MYC (a family of regulator genes and proto-oncogenes) and human B-cell lymphoma 6 ( BCL6 ) using fluorescence in situ hybridization (FISH) are important in the evaluation of lymphomas, in particular diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma. Our current clinical MYC and BCL6 FISH workflow involves an overnight hybridization of probes with digital analysis using the GenASIs Scan and Analysis instrument (Applied Spectral Imaging)...
2023: International Journal of Clinical and Experimental Pathology
Si-Qi Zhang, Jun Zhang, Yang Yu, Miao-Mei Yu, Jiang Wei, Yan-Hong Tang
OBJECTIVE: Cervical cancer is one of the leading fatal diseases in women, and the role of Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B) in cervical cancer is uncertain. METHODS: Four Gene Expression Omnibus (GEO) mRNA microarray datasets were analyzed to identify differentially expressed genes (DEGs) between cervical cancer and normal cervical tissues. The results were validated using a The Cancer Genome Atlas (TCGA)-cervical cancer (CESC) dataset...
2023: International Journal of Clinical and Experimental Pathology
Feng Liu, Li Fan, Lifang Lu, Hongyi Guo, Jie Nan, Fei Han
Salivary duct carcinoma (SDC) is a rare malignant tumor of the salivary gland and is most commonly found in the parotid gland, followed by the submandibular gland. Due to its rarity, there is no consensus on its treatment. Surgical resection is currently the only curative treatment. Considering its high degree of malignancy, extensive tumor resection and postoperative adjuvant radiotherapy are recommended. We report a rare case of SDC of the submandibular gland. A 62-year-old man presented to our hospital with complaints of swelling in the right submaxillary area for 4 months, rapidly growing, with pain for 10 days...
2023: International Journal of Clinical and Experimental Pathology
Xue-Zheng Wang, Lei Chen, Hao Sun, Xiao-Qian Li, Hu Wang, Xiao-Peng Zhang, Jiang-Bin Sun, Hai-Yong Wang
OBJECTIVE: Myocardial infarction (MI) has gained widespread interest due to its high death and disability rate worldwide. Some miRNAs are markers of heart disease. Therefore, it is necessary to understand the mechanism for repairing MI injury. METHODS: Here, we evaluated the relative expression levels of miR-199a-3p in mouse and human myocardial cell models of injury, and its effect on myocardial cells viability using Cell Counting Kit-8 (CCK-8) assay, 5-ethynyl-2'-deoxyuridline (EdU) assay, and flow cytometry assay as well as western blot in vitro...
2023: International Journal of Clinical and Experimental Pathology
Hui Pan, Joshua Byers, Hong Yin, Heather Rytting, Suzanna Logan, Mai He, Zhongxin Yu, Dehua Wang, Shamlal Mangray, Shengmei Zhou
OBJECTIVES: Diagnosis of angiomatoid fibrous histiocytoma (AFH) can be challenging due to its variable histologic features and a lack of highly sensitive and/or specific immunohistochemical markers. The utility of TLE1 and BCOR as immunohistochemical markers for AFH is not known. METHODS: We examined the spectrum of histologic features of 36 AFHs, and studied the expression of both TLE1 and BCOR in AFH and its mimics by immunohistochemical staining. Positive nuclear expression was scored semiquantitatively...
2023: International Journal of Clinical and Experimental Pathology
Yong Zhang, Jie Wu, Wei Huang, Ying Wang, Lidys Rivera Galvis, Tiane Chen, Bing Han
OBJECTIVES: Breast conservation therapy (BCT) or lumpectomy followed by radiation has been established as a preferred treatment for most patients with early-stage invasive breast cancer. About 20-40% of patients after initial lumpectomy will have to undergo re-excision due to a positive margin. METHODS: To determine the factors predicting higher risk of positive resection margin, we retrospectively analyzed 409 patients who underwent initial lumpectomy for invasive breast cancer from January 2019 through November 2022...
2023: International Journal of Clinical and Experimental Pathology
Xuekun Huang, Zhiwei Weng, Shuting Zhang, Xuerong Li, Shaohu Zhou, Jingyao Liang
OBJECTIVES: How chronic pelvic inflammatory disease (CPID), the most common cause of infertility, affects metabolic profiles of follicular fluid (FF) remains unknown. This study aimed to identify candidate biomarkers in FF of infertile women with CPID. METHOD: FF samples were collected from infertile women with CPID (n = 8) and healthy controls (n = 8) at the time of oocyte retrieval. Untargeted metabolomic profiling of FF samples was conducted using the liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
2023: International Journal of Clinical and Experimental Pathology
Subhashini Ramamoorthy, Bheemanathi Hanuman Srinivas, Bhawana Ashok Badhe, Sreerekha Jinkala, Rajesh Nachiappa Ganesh
BACKGROUND: Coexistent malignancy and tuberculosis (TB) are rarely encountered. Cancer patients are a highly vulnerable subgroup during this Covid crisis. Delayed treatment for malignancy because of COVID-19 pandemic leads to higher chances to get infections. PURPOSE: The present study aimed to present the clinicopathologic profile of the patients with coexistent carcinoma and TB during the COVID-19 pandemic in a tertiary care center. MATERIALS AND METHODS: This was a retrospective study conducted during the COVID-19 pandemic between April 2020 to May 2021 in the Department of Pathology of our Institute...
2023: International Journal of Clinical and Experimental Pathology
Qing Zhu, Hongkai Zhang
Occult primary non-small cell lung cancer (OP-NSCLC) is a relatively rare entity that brings difficulties in diagnosis and treatment. Accurate diagnosis depends on biopsy specimens. Often, repeated biopsies are required. Here we report a patient who underwent 3 rounds of biopsy of her cervical superficial enlarged lymph nodes to get a final diagnosis of occult metastatic lung cancer. There was no evidence of primary lesions in the lung. The patient was treated with targeted chemotherapy and survived 4 years...
2023: International Journal of Clinical and Experimental Pathology
Qi Cheng, Xian Zhou, Jie Fan, Weimin Jiang
A 60-year-old Chinese female patient was admitted to the hospital with complaint of intermittent fever for more than seven months. The main clinical manifestations were acute kidney injury and nephrotic syndrome which developed into a hemophagocytic syndrome. The symptoms did not improve with antibiotics. Moreover, prednisone could only reduce the fever. Finally, a kidney biopsy showed many CD20-positive cells in the glomerulus and some in the peritubular capillaries. This led to a diagnosis of renal intravascular large B-cell lymphoma...
2023: International Journal of Clinical and Experimental Pathology
Hongli Xia, Guoli Liu, Ansen Wu, Rong Zhao, Shihuan Li, Suqin Li, Qiaofeng Zhou, Zhi Zeng, Ling Chen, Mincai Li
Soft tissue sarcomas are mesenchymal tumors that account for about 1% of all malignancies. We retrospectively analyzed a rare case of a painful intra-muscular extraskeletal myxoid chondrosarcoma in the thigh of a 35-year-old man, that had undergone excision. Histological and immunohistochemical analysis of the mass revealed extraskeletal myxoid chondrosarcoma. The patient proceeded to radiotherapy and chemotherapy after curative surgery and had a good outcome.
2022: International Journal of Clinical and Experimental Pathology
Yinpeng Huang, Lei Zhou, Xiangli Meng, Boqiang Yu, Huaitao Wang, Yifan Yang, Yunhao Wu, Xiaodong Tan
[This corrects the article on p. 5185 in vol. 11, PMID: 31949598.].
2022: International Journal of Clinical and Experimental Pathology
Garima Vijayvergiya, Ashwani Tandon, Anshul Rai, Ujjawal Khurana, Deepti Joshi, Jai Chaurasia, Tanya Sharma, Garima Goel, Hemlata Panwar, Neelkamal Kapoor
Odontogenic tumors have the potential for the development of malformations of the teeth as well as the surrounding tissue. Sound knowledge of various types of jaw lesions and their characteristics will help the clinician with timely measures and management. Our main aim was to study the histopathological nature of various jaw lesions retrieved from biopsies and resected specimens. Consecutive 60 cases of jaw lesions were analyzed. Odontogenic cyst, odontogenic tumor, fibro-osseous lesions, and giant cell lesions were included in this study...
2022: International Journal of Clinical and Experimental Pathology
Guanyu Su, Wei Wang, Lingjuan Xu, Guigang Li
The epidermal growth factor (EGF) superfamily includes the protein 6 with an epidermal growth factor-like protein (EGFL6). EGFL6 has a signal peptide domain with an amino terminus and a MAM domain with a carboxy terminus. There are four whole EGF-like repeat regions and one partial EGF-like repeat region. Three of these regions include calcium-binding structures and an arg-gly-asp (RGD) integrin interaction motif. The epidermal growth factor-like (EGFL) and EGF domains have identical amino acid residues. Cell division, differentiation, mortality, cell adhesion, and migration are all affected by EGFL6...
2022: International Journal of Clinical and Experimental Pathology
Ani Toklu, Hector Mesa, Katrina Collins
Adrenal hemangiomas are rare lesions often found incidentally during unrelated diagnostic work-up. We report a case of a 67-year-old man with history of hypertension, hyperlipidemia, anemia, arthralgia, joint swelling and unexplained weight loss, which prompted imaging studies. Computed tomography scan revealed a 5.4 cm adrenal mass. The patient had no clinical manifestations of adrenal medullary or cortical hyperfunction. Urine and plasma metanephrines and aldosterone/renin ratio were within normal range. The patient was taking prednisone for hand and ankle swelling, precluding assessment for Cushing syndrome...
2022: International Journal of Clinical and Experimental Pathology
Swati Bhardwaj, George K Haines Iii, Qiusheng Si
Glomus tumors are mesenchymal tumors commonly seen in the extremities, and rarely seen in deep visceral organs. This is due to the lack of glomus bodies in visceral organs. Here, we describe an unusual association between glomus tumor and co-existing papillary renal cell carcinoma, multiple papillary adenomas, and end stage renal disease. We discuss our diagnostic approach and differential diagnoses, along with an extensive review of all reported benign and malignant primary glomus tumors. A 63-year-old male with a known history of a kidney transplant, end-stage renal disease, and previous nephrectomy of his right kidney due to a renal mass (papillary renal cell carcinoma) presented with a renal mass...
2022: International Journal of Clinical and Experimental Pathology
Ze-Zhong Chen, Wen-Peng Wang, Hong-Mei Xue, Yu Liang
OBJECTIVES: The aim of this study was to explore the role of integrin alpha V (ITGAV) and the related long noncoding RNA-microRNA-messenger RNA competing endogenous RNA (lncRNA-miRNA-mRNA ceRNA) network in the development and prognosis of cancers, especially gastric cancer (GC), through bioinformatic analysis. METHODS: Pan-cancer and GC data were collected from the UCSC Xena website, and validation datasets were obtained from the Gene Expression Omnibus (GEO). R (version 3...
2022: International Journal of Clinical and Experimental Pathology
Aleksei S Konstantinov, Olga V Kovaleva, Daria V Samoilova, Ksenya V Shelekhova
The phenotype of tumor-associated macrophages may be critical for tumor immunity, angiogenesis, and clinical disease outcome. Here, we elucidated the prognostic significance of the neovasculature and macrophages in colorectal cancer. We analyzed the effect of M2 macrophage density on the clinical behavior of 151 primary colorectal carcinomas using CD206 as a marker for type 2 macrophages. Triple immunohistochemical staining (ERG, SMA, and podoplanin) was used for microvessel evaluation. We found that M2 macrophages in colorectal cancer did not have a direct association with metastatic behavior...
2022: International Journal of Clinical and Experimental Pathology
Dominique Fonseca Rodrigues Lacet, Cristiano Claudino Oliveira
INTRODUCTION: Classical Hodgkin lymphoma (CHL) has a unique cellular composition, containing a minority of neoplastic cells - Hodgkin and Reed-Sternberg (HRS) cells - in an inflammatory background. Investigations into this microenvironment have been given special importance in scientific hematopathology, playing an important role in elucidating its composition and its relationship to the prognosis of patients. OBJECTIVE: To investigate microenvironment tumor markers in CHL, in order to analyze their interactions with clinical-morphological aspects of interest in onco-hematopathology...
2022: International Journal of Clinical and Experimental Pathology
(no author information available yet)
[This retracts the article on p. 1272 in vol. 12, PMID: 31933941.].
2022: International Journal of Clinical and Experimental Pathology
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