journal
Journals International Journal of Clini...

International Journal of Clinical and Experimental Pathology

https://read.qxmd.com/read/38859920/characterization-of-blood-inflammatory-markers-in-patients-with-non-small-cell-lung-cancer
#1
JOURNAL ARTICLE
Yinggang Zhai, Jinqiang Wu, Chunrong Tang, Binghua Huang, Qinyu Bi, Shiguan Luo
OBJECTIVE: To investigate the differences and correlation between blood inflammatory indexes such as monocytes (MONO), lymphocytes (LYM), haemoglobin (HGB), neutrophils (NEU), platelets (PLT), ultrasensitive C-reactive protein, albumin and platelet/lymphocyte ratio (PLR), NEU/LYM ratio (NLR), MONO/LYM ratio (MLR) and clinicopathologic characteristics of patients with non-small cell lung cancer (NSCLC). METHODS: 187 patients with NSCLC who were first diagnosed in 2017-2023 and 102 with healthy check-ups during the same period (control group) were retrospectively selected as study subjects to compare the differences in inflammatory indexes between the two groups and the levels of inflammatory indexes in NSCLC patients with different clinicopathologic characteristics...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38859919/targeted-biopsy-added-to-systematic-biopsy-improves-cancer-detection-in-prostate-cancer-screening
#2
JOURNAL ARTICLE
Peizi Li, Pu Ni, Faruk Erdem Kombak, Emily Wolters, George Kenneth Haines, Qiusheng Si
BACKGROUND: Magnetic resonance imaging (MRI)/ultrasound targeted biopsy has frequently been used together with a 12-core systematic biopsy for prostate cancer screening in the past few years. However, the efficacy of targeted biopsy compared to systematic biopsy, as well as its clinical-histologic correlation, has been assessed by a limited number of studies and is further investigated in this study. DESIGN: We collected 960 cases with both targeted and systematic prostate biopsies from 04/2019 to 04/2022 (Table 1)...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38716353/mir-34b-5p-suppresses-the-epithelial-mesenchymal-transition-and-metastasis-in-endometrial-cancer-an3ca-cells-by-targeting-zeb1
#3
JOURNAL ARTICLE
Lulu Shi, Dan Yang, Hui Dong, Xueyu Zhang, Caihong Yang
OBJECTIVES: Tumor metastasis is a primary cause of recurrence and mortality in endometrial cancer. miR-34b-5p is abnormally expressed in various cancers and participates in tumor cell progression and metastasis. The objective of this study was to elucidate the biological functions and molecular mechanisms of miR-34b-5p in regulating the epithelial-mesenchymal transition (EMT) and metastasis in AN3CA endometrial cancer cells. METHODS: The expression levels of miR-34b-5p and zinc finger E-box-binding homeobox 1 (ZEB1) in endometrial cancer cells were analyzed by qRT-PCR, and ZEB1 expression in endometrial cancer tissues was examined by immunohistochemistry...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38716352/newly-designed-nanoparticle-drug-delivery-systems-against-staphylococcus-aureus-infection-a-systematic-review
#4
REVIEW
Farideh Kamarehei, Goran Noori Saleh, Jaber Hemmati, Saeedeh Gohari
A nanoparticle-drug delivery system against Staphylococcus aureus , especially Methicillin-resistant staphylococcus aureus , has been recently proposed as an alternative pathway therapy. Methicillin-resistant staphylococcus aureus is resistance to many antibiotics, making it a a threat to human life, especially for older and immunocompromised people. Treatment of Multidrug-resistant staphylococcus aureus is considered an urgent need. A variety of kinds of nanoparticle-drug delivery systems with different compositions, and biological properties have been extensively investigated against Staphylococcus aureus ...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38716351/thyroid-cancer-prognostic-biomarker-arl4a-and-its-relationship-with-immune-infiltration
#5
JOURNAL ARTICLE
Xiaoyong Han, Jianping Liao, Yaoping Zhou, Xiaohua Hu, Haishan Wu
BACKGROUND: Thyroid cancer (THCA) is a prevalent form of cancer with high rates of morbidity and mortality. The small GTPase ADP-ribosylation factor-like 4A (ARL4A) is integral to various cellular processes, including cytoskeletal restructuring, vesicular transport, cell migration, and neuronal development. However, the role of ARL4A as a clinical predictor, particularly its relation to immune cell infiltration in THCA, remains unclear. METHODS: A combination of experimental studies and analysis of online databases was employed to investigate ARL4A expression in THCA...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38716350/the-regulation-of-intestinal-flora-on-host-s-genes-may-play-an-essential-role-in-the-development-of-endometrial-hyperplastic-processes-in-yang-deficiency-individuals
#6
JOURNAL ARTICLE
Hui-Xiang Zhang, Xiao-Ling Zhao, Hong-Xiang Wu, Zhan-Qin Luo, Li-Mei Wang, Si-Rui Lv, Xue-Rong Huang, Nan Dong, Dai-Zhu Li, Chan Bao, Liang-Di Su, Ying-Xiu Liu, Hui-Qiong Hu, Zi-Xian Bu, Hao-Ran Zhang, Ying Liu, Shu-Jie Chang, Zheng-Yuan He, Liang Sai, Hua-Wei Wang, Hui-Ming Guo, Xue-Hui Huang, Xue Cao
UNLABELLED: Yang-deficiency constitution (YADC) is linked to a higher vulnerability to various diseases, such as cold coagulation and blood stasis (CCBS) syndrome and infertility. Endometrial hyperplastic processes (EHPs) are a leading cause of infertility in women and are characterized by CCBS. However, it remains unclear whether YADC is related to the development of EHPs. METHODS: We recruited 202 EHPs patients including 147 with YADC (YEH group) and 55 with non-YADC (NYEH group)...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38716349/protective-effect-of-ischaemic-preconditioning-on-acute-and-chronic-renal-damage-following-ischaemia-reperfusion-injury-characterisation-of-fibrosis-development-after-inflammation-resolution
#7
JOURNAL ARTICLE
Charlotte Vm Brown, Gilda Pino-Chavez, Aeliya Zaidi, Irina Grigorieva, Emma Woods, Robert Steadman, Rafael Chavez, Soma Meran, Usman Khalid
OBJECTIVES: Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD) are increasingly recognised as one disease continuum, rather than distinct entities, and are associated with a huge burden to healthcare services. The leading cause of AKI worldwide is Ischaemia Reperfusion Injury (IRI), most commonly seen in clinical settings of sepsis-driven hypotension. Ischaemic Preconditioning (IPC) is a strategy aimed at reducing the deleterious effects of IRI. The objectives of this study were to demonstrate an efficacious in vivo model of Kidney IRI, and the protective influence of IPC in attenuating AKI and development of renal fibrosis...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38577698/intracardiac-leakage-of-cement-during-artificial-femoral-head-replacement-a-case-report-and-review
#8
Jin Li, Yanqing Zhang, Hongmei Zhang, Shanyun Jiang, Xindong Wu
Bone cement leakage from the femoral medullary cavity is a rare complication following hip replacement. Currently, there are no reports of bone cement leakage into the heart. Here, we report an 81-year-old female patient with right femoral neck fracture. A thorough preoperative examination showed that bone cement had leaked into the heart during right femoral head replacement, leading to the death of the patient that night. Postoperative cardiac ultrasound showed that bone cement entered the vascular system through the femoral medullary cavity and subsequently entered the heart...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38577697/prognostic-impact-of-tumor-associated-neutrophils-in-breast-cancer
#9
JOURNAL ARTICLE
Akinari Kakumoto, Tsengelmaa Jamiyan, Hajime Kuroda, Oi Harada, Tomomi Yamaguchi-Isochi, Shogo Baba, Yasutaka Kato, Hiroshi Nishihara, Hiroyuki Kawami
OBJECTIVES: Neutrophils are the most common type of leukocyte in mammals and play an essential role in the innate immune system and anti-cancer responses. However, recent studies identified the presence of tumor-associated neutrophils (TANs) as a poor prognostic factor. The present study investigated whether relationships exist between TANs and the clinicopathological factors and genetic status of breast cancer. METHODS: A total of 196 breast cancer patients with sufficient biopsy, breast-conserving surgery, or mastectomy specimens between 2014 and 2021 in Hokuto Hospital were included...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38577696/spondylodiscitis-after-sacral-colpopexy-diagnose-early-to-treat-earlier
#10
REVIEW
Andrea Tinelli, Murat Yassa, Giuseppe Marzo, Daniela Romualdi, Matteo Frigerio, Alessio Melcarne, Giovanni Scambia, Giovanni Pecorella, Andrea Morciano
Spondylodiscitis following sacral colpopexy for Pelvic Organ Prolapse (POP) represents a rare complication with severe consequences. Authors performed a literature search, from 2000 to 2022, to set a narrative review of literature. Spondylodiscitis is an uncommon but dangerous side effect of a routine surgical treatment that needs to be identified and treated right away to prevent worsening clinical consequences. Suboptimal dissection of the sacral promontory and/or site infection are associated with spondylodiscitis...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38577695/multifocal-lower-limb-hemangioendothelioma-in-a-young-female-a-case-report-and-review-of-the-literature
#11
Sandeep Kumar Yadav, Ashraf Jamal, Prabodh Kantiwal, Abhay Elhence, Poonam Elhence, Balamurugan Thirunavukkarasu, Suvinay Saxena
A 26-year-old female presented with pain and swelling of distal thigh and distal leg. She was diagnosed with multifocal epitheloid hemangioendothelioma (EHE) and was successfully treated with wide resection of femoral and tibial lesions followed by their reconstruction using vascularised fibular graft and local bone grafting. One year into follow-up, the patient remained asymptomatic with full Range Of Motion (ROM) and full weight bearing walking. This case illustrates a unique multifocal presentation of hemangioendothelioma and early surgical intervention leading to complete recovery, highlighting the importance of early diagnosis and intervention to help improve prognosis and quality of life of the patient...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38577694/post-therapeutic-squamous-cell-transformation-of-a-metastatic-prostate-adenocarcinoma-with-comparison-of-molecular-profiles-a-case-report-and-review-of-the-literature
#12
Peizi Li, George K Haines, Qiusheng Si, Brett Baskovich
Transformation of primary prostate adenocarcinoma to squamous cell carcinoma after initial treatment with chemotherapy and hormonal therapy is extremely rare and typically results in rapid treatment-refractory disease progression and death. Here, we present a case of a 64-year-old man who was initially diagnosed with metastatic prostate adenocarcinoma (positive PSA and NKX3.1 stains, total PSA 747.2 ng/ml) to the thoracic spine (T8) in 2019. The patient received androgen deprivation therapy and chemotherapy with good response (PSA 2...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38577693/unique-immunohistochemical-profiles-of-muc5ac-muc6-p53-and-ki67-in-gastric-atypical-hyperplasia-and-dysplasia
#13
JOURNAL ARTICLE
Lanfang Miao, Yuanyuan Sun, Mei Guo, Haijun Yang, Xianjuan Du, Junkuo Li, Jingwei Shen, Xiaomin Wang, Ruixue Lei
OBJECTIVES: Differentiating gastric atypical hyperplasia (AH) from dysplasia, including low-grade dysplasia (LGD) and high-grade dysplasia (HGD), poses significant challenges in small biopsies and specimens with technical artifacts. This study aims to establish objective diagnostic criteria for these conditions through combined morphologic and immunohistochemical (IHC) analyses. METHODS: Between January 2018 and September 2020, a total of 123 gastric mucosa biopsy specimens were collected at Anyang Tumor Hospital...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38455508/revolutionizing-patient-care-the-harmonious-blend-of-artificial-intelligence-and-surgical-tradition
#14
JOURNAL ARTICLE
Michael Stark, Ospan Mynbaev, Antonio Malvasi, Andrea Tinelli
Surgery has undergone remarkable evolution over the past decades, propelled by unprecedented technological advancement. Despite these changes, the role of surgeons and their irreplaceable qualities remains pivotal. This article delves into the intersection of surgery and artificial intelligence (AI), underscoring the enduring significance of human expertise and values. The potential of AI to learn and improve over time holds great promise for enhancing various facets of surgery, including diagnostics, personalized treatment, preoperative planning, real-time support in the operating room, and comprehensive postoperative analytics of the outcome...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38455507/survivin-expression-is-associated-with-lymph-node-metastasis-and-short-survival-in-patients-with-colorectal-adenocarcinoma
#15
JOURNAL ARTICLE
Haneen Al-Maghrabi, Zuhoor Al-Mansouri, Jaudah Al-Maghrabi
BACKGROUND: Survivin, a protein belonging to the Inhibitor of apoptosis (IAP) family, is the smallest member in terms of size. It works by preventing programmed cell death and regulating the advancement of the cell cycle. Being a part of the group of inhibitors associated with apoptosis, survivin is connected to increased aggression and negative prognosis in different malignancies, including colorectal cancer (CRC). MATERIALS AND METHODS: Pathology tissue blocks of 209 primary tumors, and 44 adenomas, were used in this study, as well as an anti-Survivin antibody...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38455506/rcor1-is-targeted-by-mir-23b-3p-to-modulate-growth-colony-formation-migration-and-invasion-of-prostate-cancer-cells
#16
JOURNAL ARTICLE
Chenli Liu, Zhong Dong, Maozhang Li, Guangwei Bai, Zhixiang Zhao
OBJECTIVES: Prostate cancer holds the second-highest incidence rate among all male malignancies, with a noticeable scarcity of effective treatment approaches. The REST Corepressor 1 (RCOR1) protein exhibits elevated expression across various tumors, acting as an oncogene. Nevertheless, its functions and mechanisms in prostate cancer have yet to be documented. While miR-23 demonstrates reduced expression in prostate cancer, the downstream genes it regulates remain unclear. METHODS: RT-qPCR and Western blotting assays were utilized to elucidate the mRNA and protein levels of miR-23b-3p and RCOR1...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38322176/comprehensive-analysis-of-eml2-as-a-prognostic-biomarker-in-colon-cancer
#17
JOURNAL ARTICLE
Yanjun Sun, Lin Han, Dengqun Sun
BACKGROUND: Echinoderm microtubule-associated protein-like 2 (EML2), a gene located on 19q13.32, is overexpressed in various cancers and has been identified as a prognostic factor. However, the function and carcinogenic mechanism of EML2 in colon cancer is yet to be explored. METHODS: This study aimed to demonstrate the relationship between EML2 expression and colon cancer using The Cancer Genome Atlas (TCGA) database. The EML2 expression, including GSE33113 and GSE39923, was validated in colon cancer in the Gene Expression Omnibus (GEO) database...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38322175/pulmonary-squamous-cell-carcinoma-metastatic-to-the-proximal-interphalangeal-joint-of-the-right-finger-report-of-a-rare-case-and-review-of-the-literature
#18
Rana Naous
Synovial metastasis is a rare condition with only a few cases reported in the literature. Synovial metastasis to the finger or toe joint is different from acrometastasis, which is defined as bone metastasis located distal to the elbow and knee. The most common site of synovial metastasis is the knee joint. Conversely, synovial metastasis to the finger or toe joints has, to our knowledge, been reported in one case only so far. Herein, we report the second case of synovial metastasis to the proximal interphalangeal joint of the right third finger in a patient with metastatic pulmonary squamous cell carcinoma and review the literature on synovial metastasis...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38322174/erratum-overexpression-of-zeb1-and-yap1-is-related-to-poor-prognosis-in-patients-with-gliomas-with-different-idh1-status
#19
Na Miao, Zhi-Qiang Wang, Ning Zhang, Zhi-Ping Ma, Li-Ping Su, Yang-Yang Zhai, Yan-Ran Hu, Wei Sang, Wei Zhang
[This corrects the article on p. 138 in vol. 16, PMID: 37559682.].
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38322173/algorithmic-approach-utilizing-histology-and-immunohistochemistry-for-the-current-classification-of-diffuse-glioma
#20
JOURNAL ARTICLE
Chandni Bhandary Panambur, Subhashini Ramamoorthy, Bheemanathi Hanuman Srinivas, Sree Rekha Jinkala, Surendar Kumar Verma, Gopalakrishnan Madhavan Sasidharan
INTRODUCTION: Diffuse glioma constitutes 28% of primary brain tumors. Until recently morphologic appearance was the only criterion for classifying these tumors. However, WHO 2016 incorporates molecular information in the primary diagnosis of gliomas such as Isocitrate dehydrogenase 1 (IDH1), Alpha thalassemia/mental retardation syndrome X inked (ATRX) as well as 1p/19q codeletion on FISH. In a resource-limited setup where FISH is not available, Alpha internexin (INA) has been suggested as a surrogate IHC marker...
2024: International Journal of Clinical and Experimental Pathology
journal
journal
42120
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.