Samuel M S Cheng, Jonathan J Lau, Leo C H Tsang, Kathy Leung, Cheuk Kwong Lee, Asmaa Hachim, Niloufar Kavian, Sara Chaothai, Ricky W K Wong, Jennifer K M Yu, Zacary Y H Chai, Masashi Mori, Chao Wu, Karen Yiu, David S C Hui, Gaya K Amarasinghe, Leo L M Poon, Joseph T Wu, Sophie A Valkenburg, Malik Peiris
BACKGROUND: Natural SARS-CoV-2 infection may elicit antibodies to a range of viral proteins including non-structural protein ORF8. RNA, adenovirus vectored and sub-unit vaccines expressing SARS-CoV-2 spike would be only expected to elicit S-antibodies and antibodies to distinct domains of nucleocapsid (N) protein may reliably differentiate infection from vaccine-elicited antibody. However, inactivated whole virus vaccines may potentially elicit antibody to wider range of viral proteins, including N protein...
December 1, 2023: Journal of Clinical Virology