Huanhuan Lu, Jinbo Xiao, Yang Song, Dongmei Yan, Shuangli Zhu, Qian Yang, Tianjiao Ji, Zhenzhi Han, Jichen Li, Ruyi Cong, Ying Liu, Haiyan Wei, Qiong Ge, Dajin Xiao, Yingying Liu, Xiaofang Zhou, Wei Huang, Hanri Zeng, Leilei Wei, Renqing Li, Likun Lv, Jun Guo, Yong Zhang
BACKGROUND: The increasing incidence of hand, foot, and mouth disease (HFMD) associated with Coxsackievirus A6 (CVA6) has become a very significant public health problem. The aim of this study is to investigate the recombination, geographic transmission, and evolutionary characteristics of the global CVA6. METHODS: From 2019 to 2022, 73 full-length CVA6 sequences were obtained from HFMD patients in China and analyzed in combination with 1032 published whole genome sequences...
May 11, 2024: Journal of Clinical Virology
Alessandra Pierangeli, Fabio Midulla, Antonio Piralla, Guglielmo Ferrari, Raffaella Nenna, Antonino Maria Guglielmo Pitrolo, Amelia Licari, Gian Luigi Marseglia, Dario Abruzzese, Laura Pellegrinelli, Cristina Galli, Sandro Binda, Danilo Cereda, Matteo Fracella, Giuseppe Oliveto, Roberta Campagna, Laura Petrarca, Elena Pariani, Guido Antonelli, Fausto Baldanti
BACKGROUND: Following the pandemic restrictions, the epidemiology of respiratory syncytial virus (RSV) has changed, leading to intense hospitalization peaks. OBJECTIVES: This study, conducted at multiple sites in Italy, aimed to describe the temporal dynamics of two post-COVID-19 RSV epidemics. Additionally, the circulating RSV-A and -B lineages were characterized and compared to those found in 2018 and 2019. STUDY DESIGN: Respiratory specimens and data were collected from RSV-positive patients, both inpatients, and outpatients, of all ages at three sites in north-central Italy...
May 10, 2024: Journal of Clinical Virology
Cindy Lee, Younmin Lim, Deborah Saintine, N Esther Babady
BACKGROUND: Epstein-Barr Virus (EBV) viral loads in hematopoietic stem cell transplant (HSCT) recipients are typically monitored using quantitative molecular assays. The Cobas EBV test (Roche Molecular, Pleasanton, CA) has recently been FDA-cleared for the monitoring of EBV viral loads in plasma samples of transplant patients. In this study, we compared the viral loads obtained by a laboratory-developed test (EBV LDT) using Altona Analyte specific reagents (ASR) to those obtained on the Cobas EBV test...
April 29, 2024: Journal of Clinical Virology
Danlei Chen, Qingyi Shao, Xuanwen Ru, Simiao Chen, Dongqing Cheng, Qing Ye
OBJECTIVE: Norovirus (NoV) is an important human pathogen that can cause severe gastroenteritis in vulnerable populations. This study aimed to analyze the epidemiological and genetic characteristics of 2021-2023 NoV in Hangzhou, China. METHODS: This study enrolled patients aged 0-18 years who underwent NoV RNA detection in the hospital between January 2021 and October 2023 and analyzed the epidemiological characteristics of NoV. Polymerase chain reaction (PCR) was used to detect NoV RNA...
April 23, 2024: Journal of Clinical Virology
Priya S Verghese, Michael D Evans, Amy Hanson, Justina Hathi, Srinath Chinnakotla, Arthur Matas, Henry H Balfour
BACKGROUND: Valganciclovir (valG), a cytomegalovirus (CMV) prophylactic agent, has dose-limiting side effects. The tolerability and effectiveness of valacyclovir (valA) as CMV prophylaxis is unknown. METHODS: We conducted a randomized, open-label, single-center trial of valA versus valG for all posttransplant CMV prophylaxis in adult and pediatric kidney recipients. Participants were randomly assigned to receive valA or valG. Primary endpoints were the incidence of CMV viremia and side-effect related drug reduction with secondary assessment of incidence of EBV viremia...
April 22, 2024: Journal of Clinical Virology
Laura Hughes, Lilli Gard, Monika Fliss, Martijn Bakker, Carin Hazenberg, Xuewei Zhou, Paulien Vierdag, Karin von Eije, Andreas Voss, Mariëtte Lokate, Marjolein Knoester
OBJECTIVES: Parainfluenza virus type 3 (PIV3) outbreaks among hematology patients are associated with high morbidity and mortality. Prompt implementation of infection prevention (IP) measures has proven to be the most efficacious approach for controlling PIV3 outbreaks within this patient population. The most suitable IP measures can vary depending on the mode of virus transmission, which remains unidentified in most outbreaks. We describe the molecular epidemiology of an outbreak of PIV3 among hematology patients and the development of a new method that allows for the differentiation of outbreak and community strains, from which a closed outbreak could be inferred...
April 18, 2024: Journal of Clinical Virology
Christel Barker Jensen, Uffe Vest Schneider, Tina Vasehus Madsen, Xiaohui Chen Nielsen, Chih Man German Ma, Jette Krogh Severinsen, Anne Mette Hoegh, Amanda Bolt Botnen, Ramona Trebbien, Jan Gorm Lisby
BACKGROUND: Rapid and accurate detection of viral respiratory infections is important for infection control measures. This study compares the analytical and clinical performance of the Xpert® Xpress CoV-2/Flu/RSV plus test ("Xpert", Cepheid) and the STANDARD™ M10 Flu/RSV/SARS-CoV-2 test ("M10", SD Biosensor). Both tests are quadruplex RT-PCR assays for rapid diagnosis of SARS-CoV-2, influenza A/B and RSV. STUDY DESIGN: Analytical sensitivities were determined by limit of detection for SARS-CoV-2, influenza A, influenza B and RSV, respectively...
April 16, 2024: Journal of Clinical Virology
Kibum Jeon, Su Kyung Lee, Seri Jeong, Wonkeun Song, Han-Sung Kim, Jae-Seok Kim, Kyu Sung Shin, Hyun Soo Kim
BACKGROUND: Viral gastroenteritis continues to be a leading cause of death in low-income countries. The impact of nonpharmaceutical interventions (NPIs) on the transmission of gastroenteritis-causing viruses during the COVID-19 pandemic is understudied. OBJECTIVES: To investigate the 10-year trends of enteric viruses and estimate the impact of implementing and mitigating NPIs. STUDY DESIGN: Data regarding norovirus, rotavirus, adenovirus, astrovirus, and sapovirus detection were collected from five Korean hospitals between January 2013 and April 2023...
April 12, 2024: Journal of Clinical Virology
Caroline De Coninck, Catherine Donner, Elena Costa, Serine Abbas, Marie-Luce Delforge
BACKGROUND: Congenital CMV infection is the most common congenital infection worldwide and a major cause of neurological impairment and sensorineural hearing loss. Fetal CMV infection is confirmed by a positive PCR test in the amniotic fluid (amniocentesis performed after 18-20 weeks of gestation and at least 8 weeks after maternal infection). However, despite a negative antenatal CMV PCR result, some newborns can be tested positive at birth. Although not widely documented, the prognosis for these babies appears to be good...
April 8, 2024: Journal of Clinical Virology
William Rosenbaum, Erik Bovinder Ylitalo, Guillaume Castel, Andreas Sjödin, Pär Larsson, Julia Wigren Byström, Mattias N E Forsell, Clas Ahlm, Lisa Pettersson, Anne Tuiskunen Bäck
Orthohantaviruses, transmitted primarily by rodents, cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus pulmonary syndrome in the Americas. These viruses, with documented human-to-human transmission, exhibit a wide case-fatality rate, 0.5-40 %, depending on the virus species, and no vaccine or effective treatment for severe Orthohantavirus infections exists. In Europe, the Puumala virus (PUUV), carried by the bank vole Myodes glareolus, causes a milder form of HFRS. Despite the reliance on serology and PCR for diagnosis, the three genomic segments of Swedish wild-type PUUV have yet to be completely sequenced...
March 30, 2024: Journal of Clinical Virology
Fabian Eibensteiner, Ines Messner, Phoebe Uhl, Gregor Bond, Elisabeth Puchhammer-Stoeckl, Thomas Mueller-Sacherer, Christoph Aufricht, Krisztina Rusai
BACKGROUND: Long-term allograft and patient survival after kidney transplantation (KTX) depends on the balance between over- and under-immunosuppression (IS). High levels of IS predispose to opportunistic infections. Plasma load of Torque Teno Virus (TTV), a non-pathogenic highly prevalent Annellovirus, is associated with its hosts immune status, especially after solid organ transplantation. OBJECTIVES: To investigate the association of plasma TTV load and opportunistic viral infections after pediatric KTX...
March 26, 2024: Journal of Clinical Virology
Mario Poljak, Anja Oštrbenk Valenčak, Kate Cuschieri, Klara B Bohinc, Marc Arbyn
To suit the needs of the human papillomaviruses (HPV) community comprehensively, a range of commercial HPV tests with different performance characteristics are required. Four periodic inventories of commercial HPV molecular tests present in the global market were published previously in 2010, 2012, 2015 and 2020. For the fifth inventory, data were retrieved from internal files and a detailed search using the main bibliographic databases as well as general internet search without period or language restrictions was performed in December 2023...
March 14, 2024: Journal of Clinical Virology
Carlo Pietrasanta, Andrea Ronchi, Laura Bassi, Agnese De Carli, Luca Caschera, Francesco Maria Lo Russo, Beatrice Letizia Crippa, Silvia Pisoni, Riccardo Crimi, Giacomo Artieri, Laura Pellegrinelli, Robertino Dilena, Giorgio Conte, Fabio Mosca, Monica Fumagalli, Lorenza Pugni
BACKGROUND: Non-polio enteroviruses (EV) and human parechoviruses (HPeV) are known etiological agents of meningoencephalitis in neonates. However, reports of neuroradiological findings and neurodevelopmental outcomes in this population are scarce. OBJECTIVES: to describe clinical characteristics, neuroradiological findings and, in a subset of patients, neurodevelopmental outcomes in a cohort of infants with EV or HPeV meningoencephalitis within 60 days of life. STUDY DESIGN: clinical/laboratory data, neuroradiological findings (cranial ultrasound, cUS, brain magnetic resonance imaging, MRI), and neurodevelopmental outcomes assessed by Ages and Stages Questionnaires - third edition were prospectively collected...
March 5, 2024: Journal of Clinical Virology
Adeline Baron, Alice Moisan, Guillemette Unal, Véronique Lemée, Manuel Etienne, Jean-Christophe Plantier
In the last few years, many manufacturers have developed new kits for plasma HIV-1 RNA quantification. Recently, a solution consisting of the ELITe InGenius® instrument and the HIV1 ELITe MGB®kit has been commercialized worldwide. Our aim was to compare its clinical performance with the Aptima® HIV-1 Quant Dx kit by Hologic, on a panel of HIV-1 group M circulating variants, representative of viral load levels found during the pre- and post-treatment follow-up of patients. The linearity was evaluated on the AcroMetrix® HIV-1 Panel...
March 3, 2024: Journal of Clinical Virology
Daniela Sieghart, Claudia A Hana, Caroline Dürrschmid, Leonhard X Heinz, Helmuth Haslacher, Markus Zlesak, Giulia Piccini, Alessandro Manenti, Emanuele Montomoli, Anselm Jorda, Clemens Fedrizzi, Timothy Hasenoehrl, Andrej Zdravkovic, Karolina Anderle, Ursula Wiedermann, Susanne Drapalik, Helmut Steinbrecher, Felix Bergmann, Christa Firbas, Galateja Jordakieva, Barbara Wagner, Margherita Leonardi, Giulio Pierleoni, Matilde Ballini, Linda Benincasa, Serena Marchi, Claudia Trombetta, Thomas Perkmann, Richard Crevenna, Markus Zeitlinger, Michael Bonelli, Daniel Aletaha, Helga Radner
BACKGROUND: Various SARS-CoV-2 variants of concerns (VOCs) characterized by higher transmissibility and immune evasion have emerged. Despite reduced vaccine efficacy against VOCs, currently available vaccines provide protection. Population-based evidence on the humoral immune response after booster vaccination is crucial to guide future vaccination strategies and in preparation for imminent COVID-19 waves. METHODS: This multicenter, population-based cohort study included 4697 individuals ≥18 years of age who received a booster vaccination...
February 28, 2024: Journal of Clinical Virology
Yanhong Sun, Wenjian Nie, Dandan Tian, Qing Ye
Monkeypox virus (MPXV) is responsible for causing a zoonotic disease called monkeypox (mpox), which sporadically infects humans in West and Central Africa. It first infected humans in 1970 and, along with the variola virus, belongs to the genus Orthopoxvirus in the poxvirus family. Since the World Health Organization declared the MPXV outbreak a "Public Health Emergency of International Concern" on July 23, 2022, the number of infected patients has increased dramatically. To control this epidemic and address this previously neglected disease, MPXV needs to be better understood and reevaluated...
February 28, 2024: Journal of Clinical Virology
Emel Yilmaz, Carina Eklund, Camilla Lagheden, Karin Dahlin Robertsson, Marina Lilja, Miriam Elfström, Laila Sara Arroyo Mühr, Joakim Dillner
No abstract text is available yet for this article.
February 26, 2024: Journal of Clinical Virology
Merle M Böhmer, Viola C Haring, Barbara Schmidt, Franziska S Saller, Liza Coyer, Lidia Chitimia-Dobler, Gerhard Dobler, Dennis Tappe, Andrea Bonakdar, Arnt Ebinger, Gertrud Knoll, Lisa Eidenschink, Anette Rohrhofer, Hans Helmut Niller, Katharina Katz, Philip Starcky, Martin Beer, Rainer G Ulrich, Dennis Rubbenstroth, Markus Bauswein
BACKGROUND: Zoonotic Borna disease virus 1 (BoDV-1) causes fatal encephalitis in humans and animals. Subsequent to the detection of two paediatric cases in a Bavarian municipality in Germany within three years, we conducted an interdisciplinary One Health investigation. We aimed to explore seroprevalence in a local human population with a risk for BoDV-1 exposure as well as viral presence in environmental samples from local sites and BoDV-1 prevalence within the local small mammal population and its natural reservoir, the bicoloured white-toothed shrew (Crocidura leucodon)...
February 23, 2024: Journal of Clinical Virology
Gregory L Damhorst, Kaleb McLendon, Evelyn Morales, Zianya M Solis, Eric Fitts, Heather B Bowers, Courtney Sabino, Julie Sullivan, Morgan Greenleaf, John D Roback, Jonathan A Colasanti, Anandi N Sheth, Boghuma K Titanji, Greg S Martin, Leda Bassit, Wilbur A Lam, Anuradha Rao
Anorectal and oropharyngeal exposures are implicated in sexual transmission of mpox, but authorized assays in the United States are only validated with cutaneous lesion swabs. Diagnostic assays for anorectal and oropharyngeal swabs are needed to address potential future outbreaks. The Cepheid Xpert® Mpox is the first point-of-care assay to receive FDA emergency use authorization in the United States and would be a valuable tool for evaluating these sample types. Our exploratory study demonstrates 100 % positive agreement with our in-house PCR assay for natural positive anorectal and oropharyngeal specimens and 92 % sensitivity with low-positive spiked specimens...
February 23, 2024: Journal of Clinical Virology
Aurélien Aubry, Baptiste Demey, Sandrine Castelain, François Helle, Etienne Brochot
BK Polyomavirus is of particular concern for kidney transplant recipients, due to their immunosuppression. This problem is exacerbated by the high effectiveness of antirejection therapies, which also compromise the organism's ability to fight viral infections. The long-term risk is loss of graft function through BKPyV-associated nephropathy (BKPyVAN). The assessment of host immunity and its link to the control of viral infections is a major challenge. In terms of humoral immunity, researchers have highlighted the prognostic value of the pre-transplantation anti-BKPyV immunoglobulin G titer...
April 2024: Journal of Clinical Virology
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