Anna Andreasson, Lars Agréus, Nikolaos Mastellos, Grzegorz Bliźniuk, Dorota Waśko-Czopnik, Agapi Angelaki, Eirini Theodosaki, Christos Lionis, Karin Hek, Robert Verheij, Ellen Wright, Stevo Durbaba, Jean Muris, Piotr Bródka, Stanislaw Saganowski, Jean-Francois Ethiér, Vasa Curcin, Brendan Delaney
OBJECTIVES: This study aimed to assess the impact of on-demand versus continuous prescribing of proton pump inhibitors (PPIs) on symptom burden and health-related quality of life in patients with gastroesophageal reflux disease (GERD) presenting to primary care. METHODS: Thirty-six primary care centres across Europe enrolled adult GERD patients from electronic health records. Participants were randomised to on-demand or continuous PPI prescriptions and were followed for 8 weeks...
December 2024: Annals of Medicine