journal
https://read.qxmd.com/read/36444881/cannabis-impaired-driving-ethical-considerations-for-the-primary-care-practitioner
#1
REVIEW
Katherine Huerne, Carolyn Ells, Roland Grad, Kristian B Filion, Mark J Eisenberg
Background: Widespread cannabis consumption and recreational cannabis legalization is thought to have led to an increase in motor vehicle accidents, although there currently lacks ethical guidance for primary care practitioners on cannabis-impaired driving. Objective: The aim was to develop an ethical framework for primary care providers on cannabis-impaired driving. Methods: An ethical analysis in the form of a critical interpretive review was undertaken, using a systematic approach to determine the appropriate action to a given situation with evidence to substantiate its claims...
December 2023: Annals of Medicine
https://read.qxmd.com/read/36444856/covid-19-subphenotypes-at-hospital-admission-are-associated-with-mortality-a-cross-sectional-study
#2
JOURNAL ARTICLE
Kathryn Dubowski, Giovanna T Braganza, Anne Bozack, Elena Colicino, Nicholas DeFelice, Laura McGuinn, Duncan Maru, Alison G Lee
BACKGROUND: We have an incomplete understanding of COVID-19 characteristics at hospital presentation and whether underlying subphenotypes are associated with clinical outcomes and therapeutic responses. METHODS: For this cross-sectional study, we extracted electronic health data from adults hospitalized between 1 March and 30 August 2020 with a PCR-confirmed diagnosis of COVID-19 at five New York City Hospitals. We obtained clinical and laboratory data from the first 24 h of the patient's hospitalization...
December 2023: Annals of Medicine
https://read.qxmd.com/read/36426680/country-specific-reference-values-for-promis-%C3%A2-pain-physical-function-and-participation-measures-compared-to-us-reference-values
#3
JOURNAL ARTICLE
Caroline B Terwee, Leo D Roorda
INTRODUCTION: Patient-Reported Outcomes Measurement Information System (PROMIS® ) is commonly used across medical conditions. To facilitate interpretation of scores across countries, we calculated Dutch reference values for PROMIS Physical Function (PROMIS-PF), Pain Interference (PROMIS-PI), Pain Behavior (PROMIS-PB), Ability to Participate in Social Roles and Activities (PROMIS-APSRA), and Satisfaction with Social Roles and Activities (PROMIS-SSRA), as compared to US reference values...
December 2023: Annals of Medicine
https://read.qxmd.com/read/36453635/different-treatment-response-to-systemic-corticosteroids-according-to-white-blood-cell-counts-in-severe-covid-19-patients
#4
JOURNAL ARTICLE
Kwang Yong Choi, Dong Hyun Kim, Kwang Nam Jin, Hyo Jin Lee, Tae Yun Park, Borim Ryu, Jung-Kyu Lee, Eun Young Heo, Deog Kyeom Kim, Hyun Woo Lee
BACKGROUND: Limited data are available in COVID-19 patients on the prediction of treatment response to systemic corticosteroid therapy based on systemic inflammatory markers. There is a concern whether the response to systemic corticosteroid is different according to white blood cell (WBC) counts in COVID-19 patients. We aimed to assess whether WBC count is related with the clinical outcomes after treatment with systemic corticosteroids in severe COVID-19. METHODS: We conducted a retrospective cohort study and analysed the patients hospitalised for severe COVID-19 and received systemic corticosteroids between July 2020 and June 2021...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36420822/using-texture-and-colour-enhancement-imaging-to-evaluate-gastrointestinal-diseases-in-clinical-practice-a-review
#5
REVIEW
Mitsushige Sugimoto, Yohei Koyama, Takao Itoi, Takashi Kawai
White light imaging (WLI) is the most common endoscopic technique used for screening of gastrointestinal diseases. However, despite the advent of a new processor that offers sufficient clear illumination and other advanced developments in endoscopic instrumentation, WLI alone is inadequate for detecting all gastrointestinal diseases with abnormalities in mucosal discoloration and morphological changes to the mucosal surface. The recent development of image-enhanced endoscopy (IEE) has dramatically improved the detection of gastrointestinal diseases...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36411732/psychiatric-diseases-and-dementia-and-their-association-with-open-angle-glaucoma-in-the-total-population-of-stockholm
#6
JOURNAL ARTICLE
Per E Wändell, Gunnar Ljunggren, Lars Wahlström, Axel Carl Carlsson
OBJECTIVE: Association between some somatic diseases and primary open-angle glaucoma (POAG) are well-known. We aimed to study psychiatric diseases and dementia and their association with POAG in the total population of Region Stockholm. METHODS: All living individuals above 18 years of age who resided in Stockholm County, Sweden, on 1 January 2017 ( N  = 1,703,675) were included. Data were obtained from administrative regional data. We identified individuals with specified psychiatric disorders in the years 2010-2019, and further identified those with an incident diagnosis of POAG during 2012-2018...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36411721/virtual-residency-recruitment-future-directions-in-the-new-era
#7
JOURNAL ARTICLE
Daniel Breitkopf, Cheryll Albold, Jonathan Barlow, Venkatesh Bellamkonda, Claire Dorcent, Annie Sadosty, Michelle Clarke, Daniel Cabrera
INTRODUCTION: The COVID-19 pandemic led to many changes in healthcare including graduate medical education (GME). Residency and fellowship programs halted in-person recruitment and pivoted to virtual models. Residency selection and recruitment were practices ripe for redesign, as they relied on in-person interviewing as the major point of contact prior to match list creation. In this commentary, we review the state of virtual interviewing and propose a future state where virtual interactions are commonplace and integrated into a comprehensive recruitment process...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36411680/thematic-analysis-comparing-stressors-for-pediatric-residents-and-subspecialty-fellows-at-a-large-children-s-hospital
#8
JOURNAL ARTICLE
Nimisha Bajaj, Suzanne M Reed
INTRODUCTION: Pediatric residents and subspecialty fellows experience a significant number of stressors during training, but they have rarely been self-reported or compared between groups. This qualitative study aimed to identify and compare themes of stressors experienced by pediatric residents and subspecialty fellows at a single large children's hospital. MATERIALS AND METHODS: Using an open-ended survey at single time point for each group, we asked residents and fellows to list the stressors they face in training...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36411585/diagnostic-accuracy-of-linked-colour-imaging-versus-white-light-imaging-for-early-gastric-cancers-a-prospective-multicentre-randomized-controlled-trial-study
#9
JOURNAL ARTICLE
Min Min, Xiaotian Sun, Jianying Bai, Qinsheng Zhang, Xiaocui Yang, Qiang Guo, Rong Wang, Bangmao Wang, Zhiwu Lv, Jie Pan, Chunmeng Jiang, Duanmin Hu, Bing Nong, Enqiang Linghu, Yan Liu
BACKGROUND: Linked colour imaging (LCI) is a novel new image-enhanced endoscopy (IEE) technology that produces bright and vivid images. The aim of this study was to assess the ability of LCI to improve the diagnostic accuracy of early gastric cancer (EGC) relative to white light imaging (WLI). MATERIALS AND METHODS: We performed this study on patients undergoing screening endoscopy from 12 medical institutions in China. Patients were randomly assigned to receive WLI followed by LCI or LCI followed by WLI...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36411543/clinical-characteristics-and-mutation-spectrum-in-33-chinese-families-with-familial-exudative-vitreoretinopathy
#10
JOURNAL ARTICLE
Jianbo Mao, Yijing Chen, Yuyan Fang, Yirun Shao, Ziyi Xiang, Hanxiao Li, Shixin Zhao, Yiqi Chen, Lijun Shen
OBJECTIVE: To explore the clinical manifestations and search for the variants of six related genes ( LRP5 , FZD4 , TSPAN12 , NDP , KIF11 and ZNF408 ) in Chinese patients with familial exudative vitreoretinopathy (FEVR), and investigate the correlation between the genetic variants and the clinical characteristics. PATIENTS AND METHODS: Clinical data, including the retinal artery angle, acquired from wide-field fundus imaging, structural and microvascular features of the retina obtained from optical coherence tomography (OCT) and OCT angiography (OCTA) were collected from 33 pedigrees...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36399108/the-role-of-hepatic-microenvironment-in-hepatic-fibrosis-development
#11
REVIEW
Ying Meng, Tong Zhao, Zhengyi Zhang, Dekui Zhang
AIM: Fibrosis is a common pathological feature of most types of chronic liver injuries. There is no specific treatment for liver fibrosis at present. The liver microenvironment, which fosters the survival and activity of liver cells, plays an important role in maintaining the normal structure and physiological function of the liver. The aim of this review is to deeply understand the role of the liver microenvironment in the dynamic and complicated development of liver fibrosis. METHODS: After searching in Elsevier ScienceDirect, PubMed and Web of Science databases using 'liver fibrosis' and 'microenvironment' as keywords, studies related to microenvironment in liver fibrosis was compiled and examined...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36399104/stable-thyroid-function-despite-regular-use-of-povidone-iodine-throat-spray-for-sars-cov-2-prophylaxis
#12
JOURNAL ARTICLE
Amy May Lin Quek, Mei Yen Ng, Ooiean Teng, Nicole-Ann Lim, Geelyn Jeng Lin Ng, Samantha Peiling Yang, Mikael Hartman, Paul Anantharajah Tambyah, Alex R Cook, Raymond Chee Seong Seet
BACKGROUND: It is unclear whether unintentional ingestion of povidone-iodine following its application to the oropharyngeal space could affect thyroid function. OBJECTIVE: To examine thyroid function among individuals who regularly apply povidone-iodine throat spray for SARS-CoV-2 prophylaxis. METHODS: We designed a case-control study to compare thyroid function among participants who received povidone-iodine throat spray three times a day for 42 days ('cases') and those who received vitamin C ('controls')...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36382777/risk-factors-and-foetal-growth-restriction-associated-with-expectant-treatment-of-early-onset-preeclampsia
#13
JOURNAL ARTICLE
Jiao Yi, Lei Chen, Xianglian Meng, Yi Chen
OBJECTIVE: To identify the factors affecting expectant management of early-onset preeclampsia, and evaluate the correlation between expectant treatment and foetal growth restriction. MATERIALS AND METHODS: The retrospective study included 72 women who were admitted for early-onset preeclampsia between February 2018 to April 2021. Data included maternal clinical parameters, demographic and maternal and neonatal outcomes, which were analysed for correlation. RESULTS: Multiple logistic regression analysis demonstrated that the time interval from the onset of 24-h proteinuria to termination of pregnancy showed a strong correlation with the expectant treatment; Univariate logistic analysis confirmed that there was no correlation between expectant treatment and foetal growth restriction...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36382719/the-relationship-between-glucose-intolerance-status-and-risk-of-hospitalization-during-two-decades-of-follow-up-tehran-lipid-and-glucose-study
#14
JOURNAL ARTICLE
Rahele Rasooli, Azra Ramezankhani, Davood Khalili, Maryam Tohidi, Mitra Hasheminia, Fereidoun Azizi, Farzad Hadaegh
OBJECTIVE: To assess the relationship between glucose intolerance statuses at baseline defined as normal glucose tolerance (NGT), pre-diabetes, newly diagnosed (NDM) and known diabetes mellitus (KDM) and all-cause hospitalization among Iranian men and women during 20 years of follow-up. RESEARCH DESIGN AND METHODS: This study included 8,014 individuals (3,836 men) ≥30 years from the cohort of Tehran Lipid and Glucose Study. Incidence rate ratios (IRRs) and (95% confidence interval (95% CI) for three groups of pre-diabetes, NDM and KDM was estimated using the Negative Binomial regression model, considering NGT group as reference group...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36382690/the-efficacy-of-mifepristone-combined-with-methotrexate-for-the-treatment-of-ectopic-pregnancy-a-systematic-review-and-meta-analysis
#15
Qiling Su, Huiyan Feng, Tian Tian, Xiaoqian Liao, Yunhui Li, Xiaomao Li
OBJECTIVE: Systematically evaluate the clinical efficacy of mifepristone combined with methotrexate therapy for ectopic pregnancy (EP), analyze the experimental designs, put forward improvement ideas. METHODS: RCTs of mifepristone combined with mifepristone for EP until January 2022 in six databases were searched. The primary outcome indicator was the cure rate. RevMan 5.4 was used to analyse and the online GRADEpro tool was used to assess the certainty of the evidence...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36382675/cytopenias-following-anti-cd19-chimeric-antigen-receptor-car-t-cell-therapy-a-systematic-analysis-for-contributing-factors
#16
Yuan Xia, Jue Zhang, Jing Li, Lina Zhang, Jianyong Li, Lei Fan, Lijuan Chen
BACKGROUND: Cytopenia is one of the most common adverse events following the CAR-T cell infusion, affecting the quality of life and potentially leading to life-threatening bleeding and infection. This study aimed to systematically review the cytopenias following anti-CD19 CAR-T therapy and further analyse the contributing factors. METHODS: Databases including PubMed, MEDLINE, Embase and Cochrane were systematically searched on 8 May 2022. A random-effect meta-analysis was used to estimate the incidence of cytopenia, and subgroup analyses were applied to explore heterogeneity...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36382632/clinical-assessment-of-endothelial-function-in-convalescent-covid-19-patients-a-meta-analysis-with-meta-regressions
#17
Pasquale Ambrosino, Stefano Sanduzzi Zamparelli, Marco Mosella, Roberto Formisano, Antonio Molino, Giorgio Alfredo Spedicato, Antimo Papa, Andrea Motta, Matteo Nicola Dario Di Minno, Mauro Maniscalco
BACKGROUND: Endothelial dysfunction has been proposed to play a key role in the pathogenesis of coronavirus disease 2019 (COVID-19) and its post-acute sequelae. Flow-mediated dilation (FMD) is recognized as an accurate clinical method to assess endothelial function. Thus, we performed a meta-analysis of the studies evaluating FMD in convalescent COVID-19 patients and controls with no history of COVID-19. METHODS: A systematic literature search was conducted in the main scientific databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36382627/network-pharmacology-and-in-vivo-experiment-based-strategy-to-investigate-mechanisms-of-jingfangfuzilizhong-formula-for-ulcerative-colitis
#18
JOURNAL ARTICLE
Mengyuan Wang, Jianan Li, Yuzhang Yin, Liying Liu, Yifei Wang, Ying Qu, Yanqiu Hong, Shuangshuang Ji, Tao Zhang, Nan Wang, Jinlong Liu, Xu Cao, Xiaobin Zao, Shuxin Zhang
BACKGROUND: Ulcerative colitis (UC), a chronic inflammatory disease, often cause carcinogenesis, disability, and intestinal perforation. The JingFangFuZiLiZhong formula (JFFZLZ) shows a good effect against UC in the clinic. Hence, we aim to investigate the mechanisms between JFFZLZ and UC via network pharmacology data mining and in vivo experiments. METHODS: We obtained active constituents and related targets from public databases. The overlapped genes between JFFZLZ and UC targets were further analysed by enrichment analysis...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36373970/increasing-trends-of-colistin-resistance-in-patients-at-high-risk-of-carbapenem-resistant-enterobacteriaceae
#19
JOURNAL ARTICLE
Hadir A El-Mahallawy, Marwa El Swify, Asmaa Abdul Hak, Mai M Zafer
INTRODUCTION: Occurrence of colistin-resistant Enterobacteriaceae in response to the unregulated use of this antibiotic has been documented. This study reports an investigation of colistin resistance rates among carbapenem-resistant enterobacterial clinical isolates. METHODS: A total of 196 multidrug-resistant Enterobacteriaceae isolates ( Klebsiella pneumoniae ( n  = 100), Escherichia coli ( n  = 89) and Enterobacter cloacae ( n  = 7) were selected from Gram-negative isolates over one year...
December 2022: Annals of Medicine
https://read.qxmd.com/read/36371797/audit-of-clinical-and-laboratory-parameters-of-hemoglobin-ss-patients-in-a-nigerian-teaching-hospital
#20
JOURNAL ARTICLE
Titilola Stella Akingbola, Oladapo Wale Aworanti, Sunday Peter Ogundeji
BACKGROUND: The burden of Sickle cell anaemia (SCA) is huge in Sub Sahara Africa as it affects 1-2% of the population. HbSS impacts negatively on the quality of life of the sufferers. The clinical manifestations start between 3 and 5 months of life as a result of reduction in foetal hemoglobin. OBJECTIVES: This study describes the clinical and laboratory characteristics of HbSS patients at presentation in steady state, vaso-occlusive and hemolytic crises states...
December 2022: Annals of Medicine
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