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Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Protective Efficacy of Lyophilized Vesicular Stomatitis Virus-Based Vaccines in Animal Model.
Emerging Infectious Diseases 2024 May
We evaluated the in vitro effects of lyophilization for 2 vesicular stomatitis virus-based vaccines by using 3 stabilizing formulations and demonstrated protective immunity of lyophilized/reconstituted vaccine in guinea pigs. Lyophilization increased stability of the vaccines, but specific vesicular stomatitis virus-based vaccines will each require extensive analysis to optimize stabilizing formulations.
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