Susana Monge, Carmen Olmedo, Belén Alejos, María Fé Lapeña, María José Sierra, Aurora Limia
We conducted a registries-based cohort study of long-term care facility residents >65 years of age offered vaccination against severe acute respiratory syndrome coronavirus 2 before March 10, 2021, in Spain. Risk for infection in vaccinated and nonvaccinated persons was compared with risk in the same persons in a period before the vaccination campaign, adjusted by daily-varying incidence and reproduction number. We selected 299,209 persons; 99.0% had >1 dose, 92.6% had 2 doses, and 99.8% of vaccines were Pfizer/BioNTech (BNT162b2)...
July 27, 2021: Emerging Infectious Diseases
Patricia C Cheung, A Robin Eisch, Noble Maleque, Derek M Polly, Sara C Auld, Kirk M Druey
We report 2 fatal exacerbations of systemic capillary leak syndrome (SCLS), also known as Clarkson disease, associated with coronavirus disease (COVID-19) in the United States. One patient carried an established diagnosis of SCLS and the other sought treatment for new-onset hypotensive shock, hemoconcentration, and anasarca, classic symptoms indicative of an SCLS flare. Both patients had only mild-to-moderate symptoms of COVID-19. This clinical picture suggests that these patients succumbed to complications of SCLS induced by infection with severe acute respiratory syndrome coronavirus 2...
July 27, 2021: Emerging Infectious Diseases
Daniele Focosi, Federica Novazzi, Angelo Genoni, Francesco Dentali, Daniela Dalla Gasperina, Andreina Baj, Fabrizio Maggi
We report in vivo selection of a severe acute respiratory syndrome coronavirus 2 spike mutation (Q493R) conferring simultaneous resistance to bamlanivimab and etesivimab. This mutation was isolated from a patient who had coronavirus disease and was treated with these drugs.
July 27, 2021: Emerging Infectious Diseases
Seth A Hoffman, Cristina Costales, Malaya K Sahoo, Srikanth Palanisamy, Fumiko Yamamoto, ChunHong Huang, Michelle Verghese, Daniel C Solis, Mamdouh Sibai, Aruna Subramanian, Lucy S Tompkins, Philip Grant, Robert W Shafer, Benjamin A Pinsky
We report persistent severe acute respiratory syndrome coronavirus 2 infection in a patient with HIV/AIDS; the virus developed spike N terminal domain and receptor binding domain neutralization resistance mutations. Our findings suggest that immunocompromised patients can harbor emerging variants of severe acute respiratory syndrome coronavirus 2.
July 23, 2021: Emerging Infectious Diseases
Nicolas Vignier, Vincent Bérot, Nathalie Bonnave, Sandrine Peugny, Mathilde Ballet, Estelle Jacoud, Céline Michaud, Mélanie Gaillet, Félix Djossou, Denis Blanchet, Anne Lavergne, Magalie Demar, Mathieu Nacher, Dominique Rousset, Loïc Epelboin
An outbreak of severe acute respiratory syndrome coronavirus 2 caused by the Gamma variant of concern infected 24/44 (55%) employees of a gold mine in French Guiana (87% symptomatic, no severe forms). The attack rate was 60% (15/25) among fully vaccinated miners and 75% (3/4) among unvaccinated miners without a history of infection.
July 21, 2021: Emerging Infectious Diseases
Aubrey Brown, Leilani Schwarcz, Catherine R Counts, Leslie M Barnard, Betty Y Yang, Jamie M Emert, Andrew Latimer, Christopher Drucker, John Lynch, Peter J Kudenchuk, Michael R Sayre, Thomas Rea
We investigated the risk of coronavirus disease (COVID-19)- patients transmitting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to emergency medical service (EMS) providers, stratified by aerosol-generating procedures (AGP), in King County, Washington, USA, during February 16-July 31, 2020. We conducted a retrospective cohort investigation using a statewide COVID-19 registry and identified 1,115 encounters, 182 with ≥1 AGP. Overall, COVID-19 incidence among EMS personnel was 0.57 infections/10,000 person-days...
July 1, 2021: Emerging Infectious Diseases
Weimin Liu, Ronnie M Russell, Frederic Bibollet-Ruche, Ashwin N Skelly, Scott Sherrill-Mix, Drew A Freeman, Regina Stoltz, Emily Lindemuth, Fang-Hua Lee, Sarah Sterrett, Katharine J Bar, Nathaniel Erdmann, Sigrid Gouma, Scott E Hensley, Thomas Ketas, Albert Cupo, Victor M Cruz Portillo, John P Moore, Paul D Bieniasz, Theodora Hatziioannou, Greer Massey, Mary-Beth Minyard, Michael S Saag, Randall S Davis, George M Shaw, William J Britt, Sixto M Leal, Paul Goepfert, Beatrice H Hahn
Not all persons recovering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection develop SARS-CoV-2-specific antibodies. We show that nonseroconversion is associated with younger age and higher reverse transcription PCR cycle threshold values and identify SARS-CoV-2 viral loads in the nasopharynx as a major correlate of the systemic antibody response.
June 30, 2021: Emerging Infectious Diseases
Nancy A Otieno, Eduardo Azziz-Baumgartner, Bryan O Nyawanda, Eunice Oreri, Sascha Ellington, Clayton Onyango, Gideon O Emukule
We determined incidence of severe acute respiratory syndrome coronavirus 2 and influenza virus infections among pregnant and postpartum women and their infants in Kenya during 2020-2021. Incidence of severe acute respiratory syndrome coronavirus 2 was highest among pregnant women, followed by postpartum women and infants. No influenza virus infections were identified.
June 30, 2021: Emerging Infectious Diseases
Rachel M Burke, Laura Calderwood, Marie E Killerby, Candace E Ashworth, Abby L Berns, Skyler Brennan, Jonathan M Bressler, Laurel Harduar Morano, Nathaniel M Lewis, Tiffanie M Markus, Suzanne Newton, Jennifer S Read, Tamara Rissman, Joanne Taylor, Jacqueline E Tate, Claire M Midgley
We characterized common exposures reported by a convenience sample of 202 US patients with coronavirus disease during January-April 2020 and identified factors associated with presumed household transmission. The most commonly reported settings of known exposure were households and healthcare facilities; among case-patients who had known contact with a confirmed case-patient compared with those who did not, healthcare occupations were more common. Among case-patients without known contact, use of public transportation was more common...
June 30, 2021: Emerging Infectious Diseases
Linsey C Marr
No abstract text is available yet for this article.
June 30, 2021: Emerging Infectious Diseases
Sathyavani Subbarao, Helen Campbell, Sonia Ribeiro, Stephen A Clark, Jay Lucidarme, Mary Ramsay, Ray Borrow, Shamez Ladhani
Invasive meningococcal disease incidence in England declined from 1.93/100,000 persons (1,016 cases) in 2010-11 to 0.95/100,000 (530 cases) in 2018-19 and 0.74/100,000 in 2019-20 (419 cases). During national lockdown for the coronavirus disease pandemic (April-August 2020), incidence was 75% lower than during April-August 2019.
June 30, 2021: Emerging Infectious Diseases
Andrea G Buchwald, Jude Bayham, Jimi Adams, David Bortz, Katie Colborn, Olivia Zarella, Meghan Buran, Jonathan Samet, Debashis Ghosh, Rachel Herlihy, Elizabeth J Carlton
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic necessitated rapid local public health response, but studies examining the impact of social distancing policies on SARS-CoV-2 transmission have struggled to capture regional-level dynamics. We developed a susceptible-exposed-infected-recovered transmission model, parameterized to Colorado, USA‒specific data, to estimate the impact of coronavirus disease‒related policy measures on mobility and SARS-CoV-2 transmission in real time. During March‒June 2020, we estimated unknown parameter values and generated scenario-based projections of future clinical care needs...
June 30, 2021: Emerging Infectious Diseases
Maureen Lynch, Guerrino Macori, Séamus Fanning, Edel O'Regan, Eoin Hunt, Dermot O'Callaghan, Brian McCullagh, Cormac Jennings, Anne Fortune
We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants.
June 23, 2021: Emerging Infectious Diseases
Nicholas B Lehnertz, Xiong Wang, Jacob Garfin, Joanne Taylor, Jennifer Zipprich, Brittany VonBank, Karen Martin, Dana Eikmeier, Carlota Medus, Brooke Wiedinmyer, Carmen Bernu, Matthew Plumb, Kelly Pung, Margaret A Honein, Rosalind Carter, Duncan MacCannell, Kirk E Smith, Kathryn Como-Sabetti, Kris Ehresmann, Richard Danila, Ruth Lynfield
Coronavirus disease has disproportionately affected persons in congregate settings and high-density workplaces. To determine more about the transmission patterns of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in these settings, we performed whole-genome sequencing and phylogenetic analysis on 319 (14.4%) samples from 2,222 SARS-CoV-2-positive persons associated with 8 outbreaks in Minnesota, USA, during March-June 2020. Sequencing indicated that virus spread in 3 long-term care facilities and 2 correctional facilities was associated with a single genetic sequence and that in a fourth long-term care facility, outbreak cases were associated with 2 distinct sequences...
June 17, 2021: Emerging Infectious Diseases
Victor Williams, Bassey Edem, Marianne Calnan, Kennedy Otwombe, Charles Okeahalam
The accelerated development of coronavirus disease (COVID-19) candidate vaccines is intended to achieve worldwide immunity. Ensuring COVID-19 vaccination is crucial to stemming the pandemic, reclaiming everyday life, and helping restore economies. However, challenges exist to deploying these vaccines, especially in resource-limited sub-Saharan Africa. In this article, we highlight lessons learned from previous efforts to scale up vaccine distribution and offer considerations for policymakers and key stakeholders to use for successful COVID-19 vaccination rollout in Africa...
June 17, 2021: Emerging Infectious Diseases
Pinkus Tober-Lau, Tatjana Schwarz, David Hillus, Jana Spieckermann, Elisa T Helbig, Lena J Lippert, Charlotte Thibeault, Willi Koch, Leon Bergfeld, Daniela Niemeyer, Barbara Mühlemann, Claudia Conrad, Stefanie Kasper, Friederike Münn, Frank Kunitz, Terry C Jones, Norbert Suttorp, Christian Drosten, Leif Erik Sander, Florian Kurth, Victor M Corman
One week after second vaccinations were administered, an outbreak of B.1.1.7 lineage severe acute respiratory syndrome coronavirus 2 infections occurred in a long-term care facility in Berlin, Germany, affecting 16/20 vaccinated and 4/4 unvaccinated residents. Despite considerable viral loads, vaccinated residents experienced mild symptoms and faster time to negative test results.
June 8, 2021: Emerging Infectious Diseases
Tatjana Schwarz, Pinkus Tober-Lau, David Hillus, Elisa T Helbig, Lena J Lippert, Charlotte Thibeault, Willi Koch, Irmgard Landgraf, Janine Michel, Leon Bergfeld, Daniela Niemeyer, Barbara Mühlemann, Claudia Conrad, Chantip Dang-Heine, Stefanie Kasper, Friederike Münn, Kai Kappert, Andreas Nitsche, Rudolf Tauber, Sein Schmidt, Piotr Kopankiewicz, Harald Bias, Joachim Seybold, Christof von Kalle, Terry C Jones, Norbert Suttorp, Christian Drosten, Leif Erik Sander, Victor M Corman, Florian Kurth
We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary.
June 8, 2021: Emerging Infectious Diseases
Marcelo Rodrigues Gonçalves, Rodrigo Citton Padilha Dos Reis, Rodrigo Pedroso Tólio, Lucia Campos Pellanda, Maria Inês Schmidt, Natan Katz, Sotero Serrate Mengue, Pedro C Hallal, Bernardo L Horta, Mariangela Freitas Silveira, Roberto Nunes Umpierre, Cynthia Goulart Bastos-Molina, Rodolfo Souza da Silva, Bruce B Duncan
We assessed the associations of social distancing and mask use with symptomatic, laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection in Porto Alegre, Brazil. We conducted a population-based case-control study during April-June 2020. Municipal authorities furnished case-patients, and controls were taken from representative household surveys. In adjusted logistic regression analyses of 271 case-patients and 1,396 controls, those reporting moderate to greatest adherence to social distancing had 59% (odds ratio [OR] 0...
June 4, 2021: Emerging Infectious Diseases
Atul Patel, Ritesh Agarwal, Shivaprakash M Rudramurthy, Manoj Shevkani, Immaculata Xess, Ratna Sharma, Jayanthi Savio, Nandini Sethuraman, Surabhi Madan, Prakash Shastri, Deepak Thangaraju, Rungmei Marak, Karuna Tadepalli, Pratik Savaj, Ayesha Sunavala, Neha Gupta, Tanu Singhal, Valliappan Muthu, Arunaloke Chakrabarti
During September-December 2020, we conducted a multicenter retrospective study across India to compare epidemiology and outcomes among cases of coronavirus disease (COVID-19)-associated mucormycosis (CAM). Among 287 mucormycosis patients, 187 (65.2%) had CAM; CAM prevalence was 0.27% among hospitalized COVID-19 patients. We noted a 2.1-fold rise in mucormycosis during the study period compared with September-December 2019. Uncontrolled diabetes mellitus was the most common underlying disease among CAM and non-CAM patients...
June 4, 2021: Emerging Infectious Diseases
Martin Hoch, Sebastian Vogel, Laura Kolberg, Elisabeth Dick, Volker Fingerle, Ute Eberle, Nikolaus Ackermann, Andreas Sing, Johannes Huebner, Anita Rack-Hoch, Tilmann Schober, Ulrich von Both
We investigated severe acute respiratory syndrome coronavirus 2 infections in primary schools, kindergartens, and nurseries in Germany. Of 3,169 oropharyngeal swab specimens, only 2 were positive by real-time reverse transcription PCR. Asymptomatic children attending these institutions do not appear to be driving the pandemic when appropriate infection control measures are used.
June 4, 2021: Emerging Infectious Diseases
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