Effects of citalopram on blood pressure control in depressive patients with hypertension: A randomized clinical trial.

INTRODUCTION: Since there is a bi-directional interaction between hypertension and depression, we aimed to evaluate the effects of citalopram administration in the management of hypertension.

METHODS: A randomized clinical trial was conducted on 72 patients with concomitant depression and hypertension. The intervention group (n=41) received citalopram 20 mg daily plus anti-hypertensive standard treatment, while the control group (n=31) received only the standard treatment. The study's primary endpoint was in-office blood pressure (BP) measurement at baseline and home BP monitoring in the first and second months after entering the study.

RESULTS: There were no significant differences in baseline systolic BP (163.3±19.6 vs.164.2±20.3 mm Hg; P =0.910) and diastolic BP (94.5±13.8 vs. 88.2±14.4; P =0.071). After one month, diastolic BP (82.7±11.7 vs. 77.09±12.2; P =0.023) was significantly higher in the control group compared to the intervention group. Two months after the intervention, systolic BP (133.8±16.5 vs. 124.5±12.4; P =0.009) and diastolic BP (80.7±10.3 vs. 73.7±9.7; P =0.002) were significantly decreased in the intervention group compared to the control group.

CONCLUSION: This study supported the beneficial effects of citalopram in lowering BP in patients with concomitant depression and hypertension.