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Elevated tryptase level in a child with idiopathic anaphylaxis: a case of hereditary alpha-tryptasemia.
Allergy, Asthma, and Clinical Immunology 2024 March 28
Hereditary alpha-tryptasemia (HαT) is an autosomal dominant disorder estimated to affect 5% of the population. High baseline tryptase level is a consistent finding, but there is a great variability of clinic manifestations, including no symptoms at all. We describe a case of HαT in a 5 years 8 months old girl manifesting with idiopathic anaphylaxis and elevated baseline tryptase level. As more cases of HαT are described, a better understanding of the clinical phenotype will be acquired.
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