Journals Allergy, Asthma, and Clinical ...

Allergy, Asthma, and Clinical Immunology
Jared Silver, Elizabeth Packnett, Julie Park, Arijita Deb
BACKGROUND: Several biologics are now approved in the US as add-on treatments for chronic rhinosinusitus with nasal polyps (CRSwNP). This cross-sectional, retrospective, real-world study aimed to characterize treatment patterns and identify predictors of biologic use among patients with CRSwNP. METHODS: Adults in the Merative MarketScan Commercial and Medicare Supplemental Databases with medical claims for CRSwNP were identified June 2018-June 2019 (identification period [IP])...
December 8, 2023: Allergy, Asthma, and Clinical Immunology
Mitsuru Tsuge, Kenji Shigehara, Kazuhiro Uda, Seiji Kawano, Masaya Iwamuro, Yukie Saito, Masato Yashiro, Masanori Ikeda, Hirokazu Tsukahara
BACKGROUND: Non-esophageal eosinophilic gastrointestinal disorder (non-EoE-EGID) is a rare disease in which eosinophils infiltrate parts of the gastrointestinal tract other than the esophagus; however, the number of patients with non-EoE-EGID has been increasing in recent years. Owing to its chronic course with repeated relapses, it can lead to developmental delays due to malnutrition, especially in pediatric patients. No established treatment exists for non-EoE-EGID, necessitating long-term systemic corticosteroid administration...
December 5, 2023: Allergy, Asthma, and Clinical Immunology
Adrián Germán-Sánchez, Ana Alonso-Llamazares, Fernando García-González, Bakai Matala-Ahmed, Ceny Solani Melgar-Reyes, Ignacio Antepara-Ercoreca
BACKGROUND: The diagnosis of Alpha-gal Syndrome (AGS) is based on the presence of symptoms after being exposed to potential sources of alpha-gal together with values ​​of specific IgE (sIgE) to alpha-gal ≥ 0.1 kUA/L or ≥ 0.35 kUA/L. The aim of this study was to evaluate the diagnostic validity of sIgE levels to alpha-gal ≥ 0.1 kUA/L for identifying AGS. METHODS: This was a cross-sectional analysis of adult patients with available data on sIgE levels to alpha-gal, classified into two groups according to the presence (Group 1) or absence (Group 2) of symptoms after being exposed to potential sources of alpha-gal...
November 30, 2023: Allergy, Asthma, and Clinical Immunology
Zane Z Elfessi, Sarah Zavala, Israel Rubinstein
PURPOSE: Determine whether variable extrathoracic airflow limitation (VEAL) is observed in patients with negative methacholine challenge tests (MCT). METHODS: Electronic medical records of patients undergoing MCT at Jesse Brown VA Medical Center between January 2017 and December 2019 were reviewed. Only patients with negative MCT were selected. Pertinent demographic, clinical, and pulmonary function tests (PFT) and MCT data were abstracted from each record. Spirometric flow-volume loops recorded during each test were inspected by one co-author to determine the first inhaled methacholine concentration at which FEF50 /FIF50 was either > 1 or further increased if baseline FEF50 /FIF50 after nebulized saline (vehicle) already exceeded 1...
November 29, 2023: Allergy, Asthma, and Clinical Immunology
Ayel Luis R Batac, Kaitlyn A Merrill, Michael A Golding, Manvir Bhamra, Zoe Harbottle, Isac Kopsch, Erik Wilking, Marina Jonsson, Sandra Ekström, Elissa M Abrams, Michelle A Halbrich, Elinor Simons, Leslie E Roos, Jill A Keddy-Grant, Thomas V Gerstner, Jo-Anne St-Vincent, Jennifer L P Protudjer
BACKGROUND: Childhood atopic dermatitis can have a negative effect on caregivers' quality of life and stress levels due to the burdensome nature of its treatment. Given that the condition often emerges in infancy, atopic dermatitis-related stress also carries the potential to negatively affect the developing mother-infant bond. While it is plausible that atopic dermatitis has a negative impact on maternal-infant bonding, these relationships have not been studied directly. In light of this gap, the current study investigated the association between infantile atopic dermatitis and the maternal-infant bond using a mixed-method design...
November 29, 2023: Allergy, Asthma, and Clinical Immunology
Tongqian Wu, Jingjing He, Shirong Yan, Jing Li, Ke Chen, Dingshan Zhang, Mingliang Cheng, Zou Xiang, Yu Fang
BACKGROUND: Human placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. However, the effects of HPE on the functionality of mast cells, a critical cell type in allergic diseases, have not been reported. METHODS: To investigate the effects of HPE on the regulation of allergy with respect to the biological functions of mast cells, the mast cell line C57 or HMC-1 cells were treated with HPE followed by the assessment of cell proliferation, apoptosis, activation, chemotaxis and phagocytosis...
November 27, 2023: Allergy, Asthma, and Clinical Immunology
Diem-Tran I Nguyen, Kathleen Pitts, Kristen A Staggers, Carla M Davis
INTRODUCTION: Food allergies (FA) can detrimentally impact physical, emotional, and psychological quality of life (QoL) among pediatric patients. Given the changes from childhood into adolescence, the impact of FA on QoL likely evolves with age. The purpose of this study was to determine whether QoL differed between adolescents and children with FA who participated in a Food Allergy Symposium (FAS). METHODS: Patients with confirmed FA were recruited at an educational community symposium in September 2018 and September 2019...
November 27, 2023: Allergy, Asthma, and Clinical Immunology
Shuxian Wang, Xiaokang Wang, Jiaqi Liu, Yaqian Li, Minghui Sun, Guoqiang Zhu, Xiaofang Zhu
BACKGROUND: Although numerous studies have suggested a negative correlation between Helicobacter pylori (H. pylori) infection and allergies, there has been limited research on the relationship between H. pylori infections and atopic dermatitis (AD). The present study aimed to investigate the effects of H. pylori infection in an AD mouse model and identify potential mechanisms related to type 2 immunity, skin barrier defects, and pruritus. METHODS: A model of AD-like symptoms was established with 2,4-dinitrochlorobenzene (DNCB) after infection of the gastric cavity with H...
November 17, 2023: Allergy, Asthma, and Clinical Immunology
Silvia Sánchez-Díez, Xavier Muñoz, Tomás Montalvo, Iñigo Ojanguren, Christian Romero-Mesones, Juan Carlos Senar, Victor Peracho-Tobeña, María-Jesús Cruz
INTRODUCTION: Hypersensitivity pneumonitis (HP) is usually caused by the inhalation of avian and fungal proteins. The present study assesses a cohort of Urban Pest Surveillance and Control Service (UPSCS) workers with high exposure to avian and fungal antigens, in order to identify their degree of sensitization and the potential risk of developing HP. METHODS: Workers were divided according to their work activity into Nest pruners (Group 1) and Others (Group 2)...
November 13, 2023: Allergy, Asthma, and Clinical Immunology
Max Moloney, Alison Morra, Rachael Morkem, John Queenan, Samir Gupta, Teresa To, Geneviève Digby, David Barber, M Diane Lougheed
BACKGROUND: Most asthma diagnoses and patient care take place in primary care settings. Electronic medical records (EMRs) offer an opportunity to utilize technology to improve asthma diagnosis and care. The purpose of this study was to create and validate separate case definitions for suspected and confirmed asthma in primary care EMRs, to enable surveillance, benchmarking, and quality improvement in primary care settings. The objective of this study was to develop a case definition for suspected and confirmed asthma for use in a primary care sentinel surveillance system...
November 13, 2023: Allergy, Asthma, and Clinical Immunology
Alanna Chomyn, Edmond S Chan, Joanne Yeung, Scott Cameron, Gilbert T Chua, Timothy K Vander Leek, Brock A Williams, Lianne Soller, Elissa M Abrams, Raymond Mak, Tiffany Wong
BACKGROUND: Food ladders are tools designed to facilitate home-based dietary advancement in children with food allergies through stepwise exposures to increasingly allergenic forms of milk and egg. Several studies have now documented safety and efficacy of food ladders. In 2021, we published a Canadian adaptation of the previously existing milk and egg ladders originating in Europe using foods more readily available/consumed in Canada. Our study adds to the growing body of evidence supporting food ladder use and provides safety and effectiveness data for our Canadian adaptation of the milk and egg ladders...
November 6, 2023: Allergy, Asthma, and Clinical Immunology
Michael Lopez, Garo Hagopian, Linda Doan, Benjamin J Lee, Nathan W Rojek, Janellen Smith, Sai-Hong Ignatius Ou, Yesim Yilmaz Demirdag, Misako Nagasaka
BACKGROUND: Osimertinib has emerged as an important tool in the treatment of non-small cell lung cancers (NSCLC) with certain activating mutations of epidermal growth factor receptor (EGFR). However, Osimertinib may cause adverse effects, including severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The risk of certain adverse effects may be increased in the setting of recent use of immune checkpoint inhibitor (ICI) therapy, although it is unclear whether recent use of ICI therapy is a risk factor for Osimertinib-induced SJS specifically...
October 28, 2023: Allergy, Asthma, and Clinical Immunology
Khanh Duy Doan, Adeyinka Akinsanya, Matthew Kuhar, Hector Mesa
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare but severe and sometimes fatal adverse drug reaction that is known to occur with a number of antiepileptic drugs. It often follows a prolonged clinical course, which can worsen even after discontinuing the causative drug and administering steroid treatment. Failure to promptly identify the delayed involvement of vital organs, such as the heart and liver, may result in irreversible organ failure and death. We report a case of a presumed sudden death of a young woman who had a documented history of a protracted intermittent hypersensitivity reaction to lamotrigine...
October 25, 2023: Allergy, Asthma, and Clinical Immunology
Shima Shahbaz, Wendy Sligl, Mohammed Osman, Shokrollah Elahi
BACKGROUND: There is an urgent need to understand the interplay between SARS-CoV-2 and HIV to inform risk-mitigation approaches for HIV-infected individuals. OBJECTIVES: We conclude that people living with HIV (PLWH) who are antiretroviral therapy (ART) naïve could be at a greater risk of morbidity or mortality once co-infected with SARS-CoV-2. METHODS: Here, we performed extensive immune phenotyping using flow cytometry. Moreover, to compare the range of values observed in the co-infected case, we have included a larger number of mono-infected cases with SARS-CoV-2...
October 17, 2023: Allergy, Asthma, and Clinical Immunology
Michael Yong, Keshinisuthan Kirubalingam, Martin Y Desrosiers, Shaun J Kilty, Andrew Thamboo
BACKGROUND: Dupilumab, omalizumab, and mepolizumab are the three biologics currently approved for use in CRSwNP in Canada. Despite evidence of efficacy, their cost-effectiveness, which is a key factor influencing prescribing patterns, has not yet been compared to each other. METHODS: A cost-effectiveness model using quality-adjusted life years (QALYs) was constructed using a Decision Tree Markov analysis. A third-party healthcare payer perspective and a 10-year time horizon was used...
October 14, 2023: Allergy, Asthma, and Clinical Immunology
Bethany Wilken, M Zaman, Y Asai
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects children and adults. Poor treatment adherence in AD requires interventions to promote self-management; patient education in chronic diseases is key to self-management. Many international AD management guidelines published to date include a recommendation for educating patients as part of their treatment but there are no formal recommendations on how to deliver this knowledge. MAIN: We performed a scoping review to map the existing literature on patient education practices in AD and to highlight the clinical need for improved patient education in AD...
October 13, 2023: Allergy, Asthma, and Clinical Immunology
Esra Alagoz, Megan Saucke, Prakash Balasubramanian, Paul Lata, Tyler Liebenstein, Sujani Kakumanu
BACKGROUND: Penicillin allergy is the most commonly reported drug allergy in the US. Despite evidence demonstrating that up to 90% of labels are incorrect, scalable interventions are not well established. As part of a larger mixed methods investigation, we conducted a qualitative study to describe the barriers to implementing a risk-based penicillin de-labeling protocol within a single site Veteran's hospital. METHODS: We conducted individual and group interviews with multidisciplinary inpatient and outpatient healthcare teams...
October 11, 2023: Allergy, Asthma, and Clinical Immunology
Linlei Ye, Tiffany Wong, Elana Lavine, Victoria E Cook, Stephanie C Erdle
BACKGROUND: Current management of food protein-induced enterocolitis syndrome (FPIES) involves strict avoidance of the offending food for 12-18 months, followed by oral food challenge (OFC) under physician supervision. OFCs are resource-intensive and there is a lack of a universal standardized protocol for FPIES. Prolonged avoidance may increase the risk of IgE-mediated allergy, particularly in atopic patients. Food ladders have shown success in promoting accelerated tolerance in patients with IgE-mediated allergy...
October 6, 2023: Allergy, Asthma, and Clinical Immunology
Lu Jiang, Xiaohan Hu, Qiang Lin, Ruyue Chen, Yunyan Shen, Yun Zhu, Qinying Xu, Xiaozhong Li
BACKGROUND: Activated phosphoinositide3-kinase (PI3K) δ syndrome 1 (APDS1) is a novel inborn errors of immunity (IEIs) caused by heterozygous gain of function mutations in PI3Kδ catalytic p110δ (PIK3CD). APDS1 has a spectrum of clinical manifestations. Recurrent respiratory infections, lymphoproliferation, hepatosplenomegaly, hyper-IgM syndrome and autoimmunity are the common symptoms of this disease. CASE PRESENTATION: Patient 1 presented with recurrent respiratory infections, hepatosplenomegaly and hyper-IgM syndrome...
September 23, 2023: Allergy, Asthma, and Clinical Immunology
Megan Harmon, Kiarash Riazi, Jeannie Callum, Donald M Arnold, Rebecca Barty, Davinder Sidhu, Nancy M Heddle, Laurie MacLeod, Na Li
BACKGROUND: Canada has high immunoglobulin (IG) product utilization, raising concerns about appropriate utilization, cost and risk of shortages. Currently, there is no national set of standardized IG guidelines, and considerable variations exist among the existing provincial guidelines. The aims of this study were: (1) to compare the existing Canadian provincial guidelines on the use of IG products to identify their consistencies and differences and (2) to examine the existing research in Canada on IG supply and utilization following the establishment of IG guidelines to understand the scope of research and pinpoint the gaps...
September 16, 2023: Allergy, Asthma, and Clinical Immunology
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.