We have located links that may give you full text access.
Moringa oleifera-mediated iron oxide nanoparticles, characterization and their anti-proliferative potential on MDA-MB 231 human breast cancer cells.
Pakistan Journal of Pharmaceutical Sciences 2023 November
Iron oxide nanoparticles (Fe2 O3 NPs) stabilized with Moringa oleifera (M.O.) were successfully synthesized. The study aimed to explore the cytotoxic, anti-proliferative and anti-microbial potential of Fe2 O3 NPs through various assays, including trypan blue, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT), wound healing and disc diffusion assay. The Moringa oleifera-mediated Fe2 O3 NPs (M O Fe2 O3 NPs) underwent analysis using various techniques, including Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), UV-vis spectroscopy (UV-vis), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). FTIR, XRD and SEM-EDX results confirmed the successful synthesis of Fe2 O3 NPs. The UV-Vis spectra analysis indicated an absorption peak at 314 nm, ensuring both the successful synthesis and remarkable stability of the nanoparticles. The nanoparticles displayed a uniform spherical morphology and contained Fe, O, confirming the formation of M O Fe2 O3 NPs. Cytotoxic and anti-proliferative potential on MDA-MB 231 human breast cancer cells were observed with various concentrations of M O Fe2 O3 NPs and the cytotoxicity result revealed an IC50 of 69.7μg/mL. In conclusion, stable Fe2 O3 NPs were synthesized using a methanolic extract of M.O. and they demonstrated antimicrobial activity against both gram-negative and gram-positive bacteria. The nanoparticles exhibited cytotoxicity and anti-proliferative activity on MDA-MB 231 human breast cancer cell lines.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app