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Journals Pakistan Journal of Pharmaceut...

Pakistan Journal of Pharmaceutical Sciences

https://read.qxmd.com/read/38264897/prevalence-of-plasmid-mediated-quinolone-resistance-and-16s-rrna-methylase-genes-among-escherichia-coli-clinical-isolates-in-a-hospital-in-saudi-arabia
#1
JOURNAL ARTICLE
Mutasim E Ibrahim
The plasmid-mediated quinolone resistance (PMQR) and 16S ribosomal RNA (rRNA) methylase genes can lead to high-level bacterial resistance to various antibiotics, including quinolones and aminoglycosides. This study determined the prevalence of PMQR and 16S rRNA methylase determinants in clinical Escherichia coli. Non-duplicate E. coli resistant to quinolones (nalidixic acid, ciprofloxacin, or norfloxacin) and/or aminoglycosides (amikacin or gentamicin) were collected from patients at King Abdullah Hospital, Bisha, Saudi Arabia...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38264896/the-role-of-vitamin-d-supplementation-in-augmenting-ifn-%C3%AE-production-in-response-to-mycobacterium-tuberculosis-infection-a-randomized-controlled-trial
#2
RANDOMIZED CONTROLLED TRIAL
Muhammad Imran Hussain, Ramisha Ibtisam, Tayyaba Fatima, Huba Khalid, Ayesha Aziz, - Khansa, Adan Sitara, Anam Shahzad, Aymen Jabeen
Vitamin D supports the immune system fight TB by inhibiting Interferon-gamma (IFN-γ) and lowering host inflammation. The purpose of the research was to see if giving the vitamin D supplements to TB patients affected their prognosis. A randomized placebo control study of 200 TB patients was performed among which 106 received 400,000 IU of injectable vitamin D3 and 94 received placebo for 2 doses. Assessment was carried out at the end of every month for 3 months. IFN-γ responses to whole blood stimulation generated by the Mycobacterium tuberculosis sonicate (MTBs) antigen and early secreted and T cell activated 6 kDa (ESAT6) were assessed at 0 and 12 weeks...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38264895/guizhi-longgu-muli-decoction-ameliorates-pathological-changes-in-heart-and-bone-in-ovariectomized-rats
#3
JOURNAL ARTICLE
Yuhan Wang, Pei Li, Jing Hu, Ying Yang, Qiqi Yan, Haixia Liu, Yanjing Chen, Zhiguo Zhang
The aim of this study is to investigate the pathological changes in cardiac function, blood pressure, blood lipids and bone metabolism in ovariectomized (OVX) rats, as well as the intervention effect of Guizhi Longgu Muli decoction (GZLM). Bilateral oophorectomy was used to establish an OVX menopausal model. Four groups of rats were randomly selected: Sham surgery group, OVX group, estradiol (0.018g/L) and GZLM group (20g/kg). Cardiac function was assessed using ultrasound, blood pressure was measured using the tail cuff method...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38264894/antioxidant-effects-of-rosemary-oil-in-streptozotocin-induced-diabetic-rats
#4
JOURNAL ARTICLE
Deniz Uluışık
This study designed to investigate the potential effects of rosemary oil on oxidative stress markers in streptozotocin-induced diabetic rats. The rats divided into four groups such as control group, rosemary group, diabetes group and diabetes + rosemary group. Blood samples were analyzed to assess with enzyme-linked immunosorbent assay various parameters including malondialdehyde (MDA), glutathione (GSH), super oxide dismutase (SOD). Insulin and glucose levels were also determined through autoanalyzer. The results indicated significant increase in MDA levels and significant decrease in GSH and SOD levels in the diabetes group...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38264893/moringa-oleifera-mediated-iron-oxide-nanoparticles-characterization-and-their-anti-proliferative-potential-on-mda-mb-231-human-breast-cancer-cells
#5
JOURNAL ARTICLE
Huzaifa Umar, Maryam Rabiu Aliyu
Iron oxide nanoparticles (Fe2 O3 NPs) stabilized with Moringa oleifera (M.O.) were successfully synthesized. The study aimed to explore the cytotoxic, anti-proliferative and anti-microbial potential of Fe2 O3 NPs through various assays, including trypan blue, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT), wound healing and disc diffusion assay. The Moringa oleifera-mediated Fe2 O3 NPs (M O Fe2 O3 NPs) underwent analysis using various techniques, including Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), UV-vis spectroscopy (UV-vis), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX)...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38264892/centratherum-anthelminticum-seeds-administration-improved-risk-factor-markers-in-metformin-treated-type-2-diabetic-patients
#6
JOURNAL ARTICLE
Hina Akram Mudassir, Rukhsana Rubeen, Shamim Akhter Qureshi, Rizwan Ashraf, Syed Muhammed Talha Arshad, Munazzah Naheed, Sadia Anwer
This study was designed to assess the effect of Centratherum anthelminticum seeds administration on blood and serum risk factor markers in type 2 diabetic (T2D) patients using metformin. It was a randomized non-blinded, controlled, 3month trial. T2D patients were registered from Sindh Government Hospital New Karachi, Karachi. There were 3 groups, DT (Diabetic Test, n=20), DC (Diabetic Control, n=20) HC (Healthy Control n=20, healthy individuals of similar age were selected). DC (metformin 500mg), DT (capsule of C...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38264891/effect-of-bushen-tongluo-decoction-on-the-erk-c-fos-signal-transduction-pathway-in-rats-with-bone-cancer-pain
#7
JOURNAL ARTICLE
Xinchao Jiang, Yi Song, Mei Fang, Biao Zhang, Yinyin Guo, Zhijun Fang, Jianxue Qian
Bone cancer pain could lead to pain sensitization. Traditional Chinese Medicine could relieve bone cancer pain (BCP). This study aimed to investigate the analgesic effect of Bushen Tongluo decoction on rats with BCP and its impact on ERK/c-fos pathway in spinal dorsal horn. Cancer cells were injected to induce bone cancer pain rats. Inflammatory factors in serum were determined using enzyme-linked immunosorbent. ERK/c-Fos in the spinal dorsal horn were detected using western blotting and RT-qPCR. Thermal hyperalgesia and mechanical allodynia were observed in BCP rats...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38264890/synthesis-characterization-and-in-vitro-cytotoxic-potential-of-sitagliptin-phosphate-nanoparticles-against-advanced-breast-cancer-cell-line-mcf-7
#8
JOURNAL ARTICLE
Muhammad Abdullah, Azra Rafiq, Nariman Shahid, Muhammad Nasir Kalam, Yusra Munir, Muhammad Daoud Butt, Hamid Saeed
Pharmaceutical substance sitagliptin has long been used to treat diabetes. However, subsequent researches have shown that sitagliptin has additional therapeutic effects. Anti-inflammatory effects are observed. Combining sitagliptin with biodegradable polymers like nanoparticles for chemotherapy may be effective. This method enhances therapeutic agent pharmacokinetics. This study tests sitagliptin (SIT) chitosan base nanoparticles against MCF-7 cancer cell lines for anti-cancer effects. Sitagliptin chitosan-based nanoparticles are tested for their ability to suppress MCF-7 cancer cell proliferation...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38264889/biological-activities-of-crude-leaf-extract-and-fractions-of-scutellaria-sibthorpii-benth-hal%C3%A3-csy-an-endemic-plant-of-north-cyprus
#9
JOURNAL ARTICLE
Cagin Korkmazer, Emmanuel Mshelia Halilu
Scutellaria sibthorpii is used in treatment of bacterial infections, pains and inflammations. The leaf was extracted by maceration and then partitioned with hexane, ethyl acetate and n-butanol. The extract was screened for phytochemicals. The antioxidant activity was assayed using DPPH, H2 O2 and β-carotene. The total phenolic and flavonoid contents were estimated using Folin-Ciocalteu's and AlCl3 . The crude extract/fractions were tested on E. coli, S. typhi, B. subtilis and S. aureus using agar disk diffusion...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38264888/comparison-of-intralesional-5-fluorouracil-and-intralesional-triamcinolone-acetonide-in-the-treatment-of-localized-vitiligo
#10
JOURNAL ARTICLE
Maryam Tahir, Muhammad Khurram Shahzad, Tahir Hassan, Naima Aliya, Nazia Hanif, Asma Naz, Muhammad Irfan Jamil
The objective of this study was to compare the efficacy and safety of intralesional 5-fluorouracil (5-FU) and triamcinolone acetonide (TA) in the treatment of localized vitiligo. the A non-randomized control trial conducted at Sheikh Zayed Hospital, RYK, from January to June 2022 included sixty patients, aged 18-60 years, with stable vitiligo. Patients were divided into two groups: Group A received 5-FU and Group B received TA. The outcome was assessed using the Vitiligo Area Scoring Index (VASI). There were 58...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124423/anxiolytic-interventions-of-extracts-and-pure-compounds-from-adenanthera-pavonina-and-peltophorum-pterocarpum-leaves-to-treat-acute-anxiety-and-depression-symptoms-in-mice
#11
JOURNAL ARTICLE
Farhana Tasleem, Syed Sabir Hassan, Safia Abidi, Saima Zahid, Zafar Alam Mahmood
Anxiolytic effect of ethanol, hexane extracts and pure compounds β- sito sterol glucoside and bergenin isolated from Adenanthera pavonina AP (Fabaceae) and Peltophorum pterocarpum PP (Fabaceae) leaves were monitored in this study. Mice were treated with dose of 125mg/kg body weight of ethanol and hexane leaves extracts of both tested plants while, 5mg/kg body weight of β-sito sterol glucoside and 25mg/kg body weight of bergenin. The effect was monitored by hole board test, forced swimming test, open field apparatus and stationary rod test...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124422/anti-inflammatory-effects-of-weiyan-i-decoction-against-gastric-ulcers-in-a-rat-model-via-inhibition-of-p38-mitogen-activated-protein-kinases-signaling
#12
JOURNAL ARTICLE
Xu Yifei, Hong Xinxin, Luo Liuru, Lin Yandan, Li Jingwei, Li Haiwen, Guo Shaoju, Huang Bin
Gastric ulcer (GU) is a common gastrointestinal disease that can lead to complications such as bleeding, perforation and even cancer. Weiyan I Decoction (WYI) is an effective Chinese medicine prescription against GU. This study aimed to explore the therapeutic mechanism of WYI in GU. WYI constituents were analyzed via ultra-high-performance liquid chromatography-mass spectrometry. SD rats were divided into control, model, lansoprazole (30mg/kg), SB203580 (2mg/kg), WYI (10.8g/kg, 5.4g/kg and 2.7g/kg) groups...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124421/antileishmaniasis-effects-of-monoherbal-skin-ointment-made-from-bark-and-leaf-of-holoptelea-integrifolia-roxb-planch-in-patients-of-cutaneous-leishmaniasis
#13
JOURNAL ARTICLE
Darshna Kumari, Ghazala H Rizwani, Bushra Hina, Ishrat Younus, Maryam Ahmed, Huma Shareef
Prevalence of parasitic skin diseases, cutaneous leishmaniasis is very frequent in Pakistan, especially in Baluchistan where occurrence of phelbotomine sand flies (vector of protozoan parasite of genus Leishmania) is very common. This study was conducted to assess the antileishmaniasis activity of Intericutol plus ointment (2% and 3%) made with ethanolic extract of bark and leaves of Holoptelea integrifolia (Roxb.)Planch. The antileishmaniasis effect was observed by applying the ointments on the lesions of leishmaniasis patients...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124420/preparation-of-lamivudinyl-palmitate-nanoemulsome-for-liver-targeting-delivery
#14
JOURNAL ARTICLE
Chang Liu, Tao Xu, Xiaoyu Sui, Jing Wang, Cuiyan Han, Xiaoxing Ma, Jiayi Qian, Wenquan Zhu
The water solubility and side effects of lamivudine limit its application for the treatment of viral hepatitis type B and human immunodeficiency virus. In order to increase the solubility of LA and improve the in vivo membrane permeability of the drug, LA was modified with hexadecane acid to prepare the prodrug lamivudine palmitic acid (LAP) and loaded into nanoemulsome (NES). LAP-NES was prepared by the thin film dispersion method. The LAP-NES showed the sustained release performance up to 72h in pH 7.4 PBS...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124419/the-need-for-valproic-acid-as-prophylaxis-in-neurosurgery-patients
#15
JOURNAL ARTICLE
Shaharyar Sheikh, Kamran Hussain, Saman Shahid, Rana Aatif Siddique, Mehreen Kamran
Using anti-epileptic drugs in neurosurgery patients is a routine practice. This controlled trial aimed to assess whether prophylaxis with Valproate in brain surgery patients is justified or not. Group A (n=50; controls) patients received valproic acid postoperatively for three months, while group B (n=50; subjects) received a placebo. Serum valproic acid levels between 50-125g/ml were required. Kendall's Tau was applied to see the correlation between the 'frequency of seizures' between different surgical procedures performed and the extent of manipulations-EOMs...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124418/effect-of-multicomponent-crystal-of-piperine-nicotinic-acid-on-antihyperlipidemic-activity-in-rats
#16
JOURNAL ARTICLE
Maria D Octavia, Hasmiwati Hasmiwati, Gusti Revilla, Erizal Zaini
The alkaloid piperine is the main bioactive compound in black pepper (Piper nigrum L) and exhibits antihyperlipidemic activity. Piperine is a Biopharmaceutical Classification System (BCS) Class II compound, which has low water solubility, resulting in low bioavailability. This study aims to examine the effects of multicomponent nicotinic acid-piperine crystals on antihyperlipidemic activity in rats fed a high-fat diet. To increase the effectiveness of piperine, we prepared multicomponent crystals by the solvent-drop grinding method, using nicotinic acid as a co-former...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124417/pre-and-post-characterization-of-odts-with-emphasis-on-compression-force-and-quality-of-super-disintegrants-in-vivo-analysis-in-healthy-volunteers
#17
JOURNAL ARTICLE
Shagufta Ayub, Sana Hanif, Umar Inzamam Ul Huq, Muhammad Irfan, Ijaz Ali, Osama A Madkhali, Kalsom Farzana, Muhammad Ali Syed, Nariman Shahid, Tayyaba Aftab, Maliha Asmatullah
Oral dispersible tablets (ODTs) are patient compliant dosage forms which rapidly disintegrate in the mouth following active absorption with rapid onset of action. The current study was designed to resolve compression problems used for ODTs, as high compression force exhibited hardness and drug release problems. Formulations, F1-F9 were compressed at three different forces 44, 54 and 64 kN using cross-carmellose sodium (CCS) and sodium starch glycolate (SSG) and evaluated for pre and post compression. Formulations F1, F4 and F7 which were compressed at 44 kN showed hardness ranges between 5...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124416/huangjinshuangshen-granules-can-improve-immunity-and-enhance-the-ability-of-5-fluorouracil-to-induce-apoptosis-of-gastric-cancer-cells
#18
JOURNAL ARTICLE
Xuefei Xu, Chuqi Yang, Mengting Wu, Qingwen An, Tao Jiang, Guangji Zhang
In recent years, Chinese herbal compounds have gained significant prominence in the treatment of gastric cancer. The goal of this study was to investigate the antitumor effect of HuangJinShuangShen granules (HJSS) combined with 5-fluorouracil on MFC gastric cancer mice. In this study, the MFC model with gastric cancer was successfully established. After continuous administration for 14 d, the body weight, tumor volume and weight and spleen mass of mice in each group were recorded. The levels of IFN-γ and TGF-β1 in serum were detected by ELISA...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124415/revealing-analgesic-and-anxiolytic-potentials-of-synthetic-benzimidazole-analogues-an-in-vivo-and-in-silico-study
#19
JOURNAL ARTICLE
Shamim Akhtar, Sabahat Naeem, Nadia Asghar, Faisal Muhammad Khan, Moona Mehboob Khan, Arfa Akram, Imran Suheryani
Certain drugs have potential to affect and alter individual's behavior. On the other hand, pain is a complex phenomenon with various treatment options; analgesic medicines are the primary source. Therefore, this study was based on examining some of the benzimidazole analogues for their analgesic as well as behavioral potential following Tail immersion test and Open field test respectively. In addition, molecular docking was performed to find the interaction of these compounds with the active site using AutoDock Vina which was further visualized through Discovery Studio Visualizer...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38124414/simultaneous-determination-of-seven-toxic-components-in-shenfutuodu-capsules-by-hplc-ms-ms
#20
JOURNAL ARTICLE
Zhigang Zhou, Lanjun Zheng
An accurate and reliable HPLC-MS/MS method has been established for the simultaneous determination of seven toxic components in the Chinese medicine ShenFuTuoDu capsules. The seven toxic components were separated on a Shimadzu Shim-pack GIST C18 column (3.0 mm×50 mm, 3.0 μm) with methanol and water (containing 0.1% formic acid) as the mobile phase by gradient elution. The flow rate was 0.5 mL•min-1 . The column temperature was 25° C and the injection volume was 5μL. An ESI+ scan combined with MRM was adopted and the instrument parameters were as follows: ion source voltage, 5...
November 2023: Pakistan Journal of Pharmaceutical Sciences
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