Impact of first wave of COVID-19 pandemic on mortality at emergency department in elderly patients with covid and non-covid diagnoses.

INTRODUCTION: Mortality in emergency departments (ED) is not well known. This study aimed to assess the impact of the first-wave pandemic on deaths accounted in the ED of older patients with COVID and non-covid diseases.

METHODS: We used data from the EDEN (Emergency Department and Elderly Needs) cohort (preCOVID period) and from the EDEN-Covid cohort (COVID period) that included all patients ≥65 years seen in 52 Spanish EDs from April 1 to 7, 2019, and March 30 to April 5, 2020, respectively. We recorded patient characteristics and final destination at ED. We compared older patients in the pre-COVID period, with older patients with non-covid and with covid-19. ED-Mortality (before discharge or hospitalization) is the prior outcome and was expressed as an adjusted Odds Ratio (aOR) with 95% interval confidence (IC).

RESULTS: We included 23,338 older patients from the preCOVID period (aged 78.3 (8.1) years), 6,715 patients with non-covid conditions (aged 78.9 (8.2) years) and 3,055 with covid (aged 78.3 (8.3) years) from the COVID period. Compared to the older patients preCOVID period, patients with non-covid and with COVID-19 were more often male, referred by a doctor and by ambulance, with more comorbidity and disability, dementia, nursing-home and more risk according to qSOFA, respectively (p<0.001). Compared to the preCOVID period, patients with non-covid and with covid-19 were more often to be hospitalized from ED (24.8% vs 44.3% vs 79.1%) and were more often to die in ED (0.6% vs 1.2% vs 2.2%), respectively (p<0.001). Compared to the pre-covid period, aOR for age, sex, comorbidity and disability, ED mortality in elderly patients cared in ED during the COVID period was 2.31 (95% CI 1,76-3,06), and 3.75 (95% CI 2.77-5.07) for patients with COVID. By adding the variable qSOFA to the model, such OR were 1.59 (95% CI 1,11-2.30) and 2.16 (95% CI 1,47-3,17), respectively.

CONCLUSIONS: During the early first pandemic wave of COVID-19, more complex and life-threatening older with COVID and non-covid diseases were seen compared to the pre-covid period. In addition, the need for hospitalization and the ED-mortality doubled in non-covid and tripled in COVID diagnosis. This increase in ED mortality is not only explained by the complexity or severity of the elderly patients but also because of the system's overload.