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Gerontology

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https://read.qxmd.com/read/31096217/low-intensity-exercise-suppresses-ccaat-enhancer-binding-protein-%C3%AE-myostatin-pathway-through-androgen-receptor-in-muscle-cells
#1
Bo-Kyung Son, Masato Eto, Miya Oura, Yuki Ishida, Sakiko Taniguchi, Koichi Ito, Yumi Umeda-Kameyama, Taro Kojima, Masahiro Akishita
BACKGROUND: Androgen production following exercise has been suggested to contribute anabolic actions of muscle. However, the underlying mechanisms of the androgen receptor (AR) in androgen's action are still unclear. OBJECTIVE: In the present study, we examined androgen/AR-mediated action in exercise, especially for the suppression of myostatin, a potent negative regulator of muscle mass. METHODS: To examine the effects of exercise, we employed low-intensity exercise in mice and electric pulse stimulation (EPS) in C2C12 myotubes...
May 16, 2019: Gerontology
https://read.qxmd.com/read/31085916/effects-of-age-on-obstacle-avoidance-while-walking-and-deciphering-text-versus-audio-phone-messages
#2
Wagner Souza Silva, Bradford McFadyen, Joyce Fung, Anouk Lamontagne
BACKGROUND: Widely popular among young, and more recently older adults, mobile phones are increasingly used while walking. Knowledge of the impact of phone message modality (e.g., text vs. audio) on the ability to avoid collisions with other pedestrians, however, remains limited. OBJECTIVES: This study aimed to investigate the extent to which the circumvention of an approaching pedestrian is affected by text versus audio phone messages in healthy young and older adults...
May 14, 2019: Gerontology
https://read.qxmd.com/read/31071713/examining-relationships-between-multiple-self-reported-sleep-measures-and-gait-domains-in-cognitively-healthy-older-adults
#3
John P K Bernstein, Alyssa De Vito, Daniel S Weitzner, Rebecca MacAulay, Matthew Calamia, Robert Brouillette, Heather Foil, Owen T Carmichael, Jeffrey N Keller
BACKGROUND: Gait-related changes in older adulthood may be related to changes in cognition (e.g., executive functioning), and recent work suggests that different self-reported measures of sleep may be tied to contrasting aspects of executive functioning. However, the relationship between these self-reported sleep measures and gait domains has not been explored. Such an investigation would be useful in helping to determine which older adults might exhibit changes in gait as well as experience other gait-associated changes (e...
May 9, 2019: Gerontology
https://read.qxmd.com/read/31055579/effect-of-creative-dance-on-fitness-functional-balance-and-mobility-control-in-the-elderly
#4
Hee Joung Joung, Yongho Lee
BACKGROUND: In the literature on creativity in older adults, creative activities have been found to be an effective way of adapting to age-related psychological and physical changes, providing older adults with opportunities to think differently and be open to new ideas. On the other hand, physical activities play an important role in the prevention of physical decline. Thus, combining physical activity and certain creative activities, such as creative dance (CD), might help facilitate successful aging...
May 3, 2019: Gerontology
https://read.qxmd.com/read/31055573/human-inflammaging
#5
Tamàs Fülöp, Anis Larbi, Jacek M Witkowski
Human aging is a very complex process that occurs in an intricate biological and physiological setting. Many changes occur with aging and among the most important are changes in immune reactivity associated with cell differentiation stages and the phenomenon of inflammaging, understood as subclinical inflammatory readiness, manifested by elevated levels of proinflammatory factors. It was stated for a long time that this tandem occurs in parallel or eventually sequentially. However, recent evidence points to the fact that, as both originate from chronic antigen stimulation, they mutually drive each other...
May 3, 2019: Gerontology
https://read.qxmd.com/read/31048587/prediction-model-of-cardiac-risk-for-dental-extraction-in-elderly-patients-with-cardiovascular-diseases
#6
Min Tang, Ping Hu, Cao-Feng Wang, Chuang-Qi Yu, Jing Sheng, Shao-Jun Ma
BACKGROUND: With the rapidly increasing population of elderly people, dental extraction in elderly individuals with cardiovascular diseases (CVDs) has become quite common. The issue of how to assure the safety of elderly patients with CVDs undergoing dental extraction has perplexed dentists and internists for many years. And it is important to derive an appropriate risk prediction tool for this population. OBJECTIVES: The aim of this retrospective, observational study was to establish and validate a prediction model based on the random forest (RF) algorithm for the risk of cardiac complications of dental extraction in elderly patients with CVDs...
May 2, 2019: Gerontology
https://read.qxmd.com/read/31018201/implementing-accessibility-settings-in-touchscreen-apps-for-people-living-with-dementia
#7
Phil Joddrell, Arlene J Astell
BACKGROUND: Accessibility options within apps can enable customisation and improve usability. The consideration of accessibility for people living with dementia has not been explored but is necessary to prevent a "digital divide" in our society. This study set out to examine whether the introduction of accessibility settings for people with dementia in two mainstream gaming apps (Solitaire and Bubble Explode) could improve the user experience. OBJECTIVES: To evaluate the effectiveness of tailored accessibility settings for people living with dementia by comparing the gameplay experience with and without the settings and measure the impact on their ability to initiate gameplay, play independently and experience enjoyment...
April 24, 2019: Gerontology
https://read.qxmd.com/read/30970348/epigenetic-mechanisms-underlying-the-aging-of-articular-cartilage-and-osteoarthritis
#8
REVIEW
Mingcai Zhang, Justin L Theleman, Katherine A Lygrisse, Jinxi Wang
Aging is a progressive and complicated bioprocess with overall decline in physiological function. Osteoarthritis (OA) is the most common joint disease in middle-aged and older populations. Since the prevalence of OA increases with age and breakdown of articular cartilage is its major hallmark, OA has long been thought of as "wear and tear" of joint cartilage. Nevertheless, recent studies have revealed that changes in the chondrocyte function and matrix components may reduce the material properties of articular cartilage and predispose the joint to OA...
April 10, 2019: Gerontology
https://read.qxmd.com/read/30943489/pathophysiology-of-benign-prostatic-hyperplasia-and-benign-prostatic-enlargement-a-mini-review
#9
Stephan Madersbacher, Natalie Sampson, Zoran Culig
Benign prostatic hyperplasia (BPH), benign prostatic enlargement (BPE) and lower urinary tract symptoms (LUTS) belong to the most frequent diseases in ageing men. Beyond the 6th decade of life, more than 30% of men suffer from moderate to severe LUTS requiring intervention. The pathophysiology of BPH/BPE is still incompletely understood. The dominant role of the androgen system and the androgen receptor is well defined. Androgen receptors are expressed in BPH tissue in which they are activated by the potent androgen dihydrotestosterone...
April 3, 2019: Gerontology
https://read.qxmd.com/read/30921803/association-between-adverse-childhood-experiences-and-muscle-strength-in-older-age
#10
Boris Cheval, Clovis Chabert, Stefan Sieber, Dan Orsholits, Rachel Cooper, Idris Guessous, David Blane, Matthias Kliegel, Delphine S Courvoisier, Michelle Kelly-Irving, Matthieu P Boisgontier, Stéphane Cullati
BACKGROUND: Muscle weakness - a biomarker of health - may have its origins in early life and be related to factors such as adverse childhood experiences (ACE), which refer to a set of early-life traumatic and stressful psychosocial events out of the child's control. To date, evidence of an association between ACE and muscle strength in older age is lacking. -Objective: Here, we assessed the associations between ACE during the first 15 years of life and the risk of low muscle strength (LMS) later in life...
March 28, 2019: Gerontology
https://read.qxmd.com/read/30909272/physical-activity-and-mobility-differentially-predict-nondemented-executive-function-trajectories-do-sex-and-apoe-moderate-these-associations
#11
Sherilyn Thibeau, G Peggy McFall, Richard Camicioli, Roger A Dixon
BACKGROUND: In nondemented aging, higher levels of everyday physical activity (EPA) and mobility performance are associated with better executive function (EF) trajectories. However, these associations may be moderated by both sex and Alzheimer's disease (AD) genetic risk. OBJECTIVES: In a longitudinal study, we investigate sex differences in (a) EPA and mobility effects on EF performance (level) and change (slope) and (b) AD genetic risk moderation of these associations...
March 25, 2019: Gerontology
https://read.qxmd.com/read/30904915/oral-health-and-cognitive-function-in-older-adults-a-systematic-review
#12
Matthew R Nangle, Julia Riches, Sarah A Grainger, Nithin Manchery, Perminder S Sachdev, Julie D Henry
BACKGROUND: It has often been argued that there is a relationship between oral health and cognitive decline in late adulthood, but a recent systematic review concluded that it was unclear "how or whether" any relationship exists. However, most of the studies that contributed to this review operationalised cognitive function using a brief cognitive screen and/or dementia status. OBJECTIVE: An updated systematic review was conducted that focused on how oral health relates to specific cognitive abilities in older adults (specifically, the neurocognitive domains specified in the DSM-5: learning and memory, perceptual motor function, language, executive function, complex attention, and social cognition)...
March 22, 2019: Gerontology
https://read.qxmd.com/read/30897578/cell-therapy-for-knee-osteoarthritis-mesenchymal-stromal-cells
#13
REVIEW
Christopher Kim, Armand Keating
Osteoarthritis (OA) is designated the 11th highest contributor of 291 diseases of global disability and the most common cause of chronic disability in elderly people. OA has a devastating impact on quality of life and represents an enormous socio-economic burden. Currently, OA is incurable, and no approved medications, biological therapy, or procedure prevents the progressive destruction of the osteoarthritic knee joint. All current treatments provide symptomatic relief rather than preventative or regenerative results...
March 21, 2019: Gerontology
https://read.qxmd.com/read/30897570/is-life-expectancy-of-french-women-going-to-plateau-and-oscillate
#14
Eric Le Bourg
Some authors have hypothesised that life expectancy at birth could reach 100 years in developed countries in the next decades. Using recent data for French women, it is shown that life expectancy changes from 1993 to 2016 are mainly linked to mortality rates of oldest women. In recent years, it happened that life expectancy of French women oscillated, because of for instance influenza epidemics killing mainly oldest frail people. It is hypothesised that in coming years, life expectancy of French women (and one day of men?) will only very slightly increase and will show oscillations because of increased mortality the years of severe influenza, heatwave and other events threatening the life of frail oldest people...
March 21, 2019: Gerontology
https://read.qxmd.com/read/30870838/myostatin-a-powerful-biomarker-for-sarcopenia-and-frailty
#15
LETTER
Michaël R Laurent, Jolan Dupont, Marian Dejaeger, Evelien Gielen
No abstract text is available yet for this article.
March 14, 2019: Gerontology
https://read.qxmd.com/read/30844813/identifying-features-that-enhance-older-adults-acceptance-of-robots-a-mixed-methods-study
#16
Li Chu, Hung-Wen Chen, Pei-Yi Cheng, Pokuan Ho, I-Tan Weng, Pei-Ling Yang, Sung-En Chien, Yun-Chen Tu, Chien-Chun Yang, Te-Mei Wang, Helene H Fung, Su-Ling Yeh
BACKGROUND: With global aging, robots are considered a promising solution for handling the shortage of aged care and companionships. However, these technologies would serve little purpose if their intended users do not accept them. While the socioemotional selectivity theory predicts that older adults would accept robots that offer emotionally meaningful relationships, selective optimization with compensation model predicts that older adults would accept robots that compensate for their functional losses...
March 7, 2019: Gerontology
https://read.qxmd.com/read/30826811/iridescent-life-course-lgbtq-aging-research-and-blueprint-for-the-future-a-systematic-review
#17
Karen I Fredriksen Goldsen, Sarah Jen, Anna Muraco
BACKGROUND: LGBTQ* (lesbian, gay, bisexual, trans, and queer) older adults are demographically diverse and growing populations. In an earlier 25-year review of the literature on sexual orientation and aging, we identified four waves of research that addressed dispelling negative stereotypes, psychosocial adjustment to aging, identity development, and social and community-based support in the lives of LGBTQ older adults. OBJECTIVES: The current review was designed to develop an evidence base for the field of LGBTQ aging as well as to assess the strengths and limitations of the existing research and to articulate a blueprint for future research...
March 1, 2019: Gerontology
https://read.qxmd.com/read/30820018/myostatin-as-a-biomarker-for-diagnosis-or-prognosis-of-frailty-and-sarcopenia-current-knowledge
#18
LETTER
Haritz Arrieta, Ana Rodriguez-Larrad, Jon Irazusta
No abstract text is available yet for this article.
March 1, 2019: Gerontology
https://read.qxmd.com/read/30814472/loneliness-shapes-the-relationship-between-information-and-communications-technology-use-and-psychological-adjustment-among-older-adults
#19
Yang Fang, Anson K C Chau, Helene H Fung, Jean Woo
BACKGROUND: Given findings that generally support the benefits of information and communication technology (ICT) for older adults' psychosocial adjustment, one might surmise that lonely older adults, who have a stronger need for psychological support, would reap more psychosocial benefits from ICT use. However, scant research has examined this view, much less the likelihood that ICT use might worsen the psychological well-being of lonely older adults, as has been shown to be the case in younger adults...
February 27, 2019: Gerontology
https://read.qxmd.com/read/30783068/performance-of-e-health-devices-for-frailty-evaluation-in-real-life-settings-is-far-from-being-demonstrated
#20
LETTER
Antoine Piau, Katherine Wild
No abstract text is available yet for this article.
February 18, 2019: Gerontology
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