Michaël C J Van der Elst, Birgitte Schoenmakers, Jos M G A Schols, Nico De Witte, Jan De Lepeleire
no abstract required for a letter.
May 26, 2023: Gerontology
Sarah P Coundouris, Sylvain Hohn, Anup Basu, Uwe Dulleck, Julie D Henry, Nicolas Cherbuin
Introduction Age-related decline in executive functioning has been found to negatively impact one's capacity to make prudent financial decisions. The broader literature also speaks to the importance of considering interrelatedness in older spouses' functioning, as these individuals typically represent one's longest and closest relationship that involves an extended history of shared experiences. Accordingly, the aim of the present study was to provide the first examination of whether older adults' financial decision making capacity is impacted not only by their own, but also by their partner's, level of cognitive functioning...
May 24, 2023: Gerontology
Danya Pradeep Kumar, Bijan Najafi, Kaveh Laksari, Nima Toosizadeh
INTRODUCTION: Frailty is a common geriatric syndrome associated with decline in physiological reserve. While several digital biomarkers of daily physical activity (DPA) have been used in frailty assessment, the association between DPA variability and frailty is still not clear. The goal of this study was to determine the association between frailty and DPA variability. METHODS: This is an observational cross-sectional study conducted between September 2012 and November 2013...
May 10, 2023: Gerontology
Frederico Pieruccini-Faria, Seyyed Mohammad Hassan, Nickolas W Bray, Yanina Sarquis-Adamson, Robert Bartha, Manuel Montero-Odasso
Introduction- Mild Cognitive Impairment (MCI) affects obstacle negotiation capabilities, potentially increasing the risk of falls in older adults. However, it is unclear whether smaller brain volumes typically observed in older individuals with MCI are related to the observed hazardous obstacle negotiation in this population. Methods- A total of 93 participants (71.9±5.36years of age; MCI=53 / Control=40) from the Gait and Brain Study were analyzed. Gray matter (GM) volumes from the frontal, temporal and parietal lobes were entered in the analysis...
April 25, 2023: Gerontology
Ceereena Ubaida-Mohien, Toshiko Tanaka, Qu Tian, Zenobia Moore, Ruin Moaddel, Nathan Basisty, Eleanor M Simonsick, Luigi Ferrucci
Measuring the abundance of biological molecules and their chemical modifications in blood and tissues has been the cornerstone of research and medical diagnoses for decades. Although the number and variety of molecules that can be measured have expanded exponentially, the blood biomarkers routinely assessed in medical practice remain limited to a few dozen, which have not substantially changed over the last 30-40 years. The discovery of novel biomarkers would allow, for example, risk stratification or monitoring of disease progression or the effectiveness of treatments and interventions, improving clinical practice in myriad ways...
April 25, 2023: Gerontology
Eun-Jeong Han, Myonghwa Park, Thi-Thanh-Tinh Giap
INTRODUCTION: The number of older adults requiring long-term care (LTC) is increasing rapidly worldwide. The primary family caregivers of LTC recipients experience ongoing burdens and various challenges in their caregiving that adversely affect their own health and also the quality of caring that they provide to their loved ones. As a country becoming a super-aged society, South Korea has been making considerable efforts to improve the long-term effects on caregivers by providing them with support intervention programs...
April 25, 2023: Gerontology
Jinhui Zhou, Xinwei Li, Xiang Gao, Yuan Wei, Lihong Ye, Sixin Liu, Jiaming Ye, Yidan Qiu, Xulin Zheng, Chen Chen, Jun Wang, Virginia Byers Kraus, Yuebin Lv, Chen Mao, Xiaoming Shi
INTRODUCTION: About half of adults aged ≥ 80 years suffer from frailty. Exercise is considered effective in preventing frailty but may be inapplicable to adults aged ≥ 80 years due to physical limitations. As an alternative, we aimed to explore the association of leisure activities with frailty and identify potential interaction with established polygenic risk score (PRS) among adults aged ≥ 80 years. METHODS: Analyses were performed in a prospective cohort study of 7471 community-living older adults aged ≥ 80 years who were recruited between 2002 and 2014 from 23 provinces in China...
April 19, 2023: Gerontology
Mark Brennan-Ing, Eleni Mattas
Due to effective anti-retroviral therapy (ART), the people with HIV are aging, and this is observed globally wherever ART is readily available. While this represents the success of HIV treatment, those aging with HIV face several health challenges that emphasize the importance of access to health care and health equity. These challenges include changes to the immune system, chronic inflammation, and higher rates of multimorbidity at younger ages compared to people without HIV. Intersectional identities impact health care access and health equity and include age, sexual orientation, gender identity, race/ethnicity, socioeconomic position, and HIV serostatus...
April 18, 2023: Gerontology
Anders Rydström, Ruth Stephen, Ingemar Kåreholt, Alexander Darin Mattsson, Tiia Ngandu, Jenni Lehtisalo, Lars Bäckman, Nina Kemppainen, Juha Rinne, Shireen Sindi, Hilkka Soininen, Ritva Vanninen, Alina Solomon, Francesca Mangialasche
INTRODUCTION: Mechanisms underlying the positive association between occupational mental demands and late-life cognition are poorly understood. The objective of this study was to assess whether the association between occupational complexity and cognition is related to and moderated by brain integrity in individuals at-risk for dementia. Brain integrity was appraised throughout structural measures (Magnetic Resonance Imaging, MRI) and amyloid accumulation (Pittsburgh Compound B (PiB)-positron emission tomography, PiB-PET)...
April 18, 2023: Gerontology
Matthias Hoben, Wenshan Li, Hana Dampf, David B Hogan, Kyle Corbett, Stephanie A Chamberlain, Kim McGrail, Lauren E Griffith, Andrea Gruneir, Natasha E Lane, Jennifer Baumbusch, Colleen Maxwell
Introduction Family/friend caregivers play an essential role in promoting the physical and mental health of older adults in need of care - especially during the COVID-19 pandemic and especially in assisted living (AL) homes, were resident care needs are similarly complex as in long-term care homes but fewer staffing resources and services are available. However, little research is available on caregiver involvement and concerns with care of AL residents prior to and during waves 1 and 2 of the COVID-19 pandemic...
April 17, 2023: Gerontology
Jiraporn Sri-On, Kwannapa Thong-On, Thiti Kredarunsooksree, Thitiwan Paksopis, Rasida Ruangsiri
INTRODUCTION: Dehydration is associated with morbidity, and many factors affect dehydration in older adults including age and medication use. This study determined the prevalence of hypertonic dehydration (HD) and factors affecting HD in older adults and developed a risk score (a set of consistent weights that assign a numerical value to each risk factor) which are potentially useful in predicting HD among community-dwelling Thai older adults. METHODS: Data were obtained from a cohort study of community-dwelling older adults aged ≥60 years in Bangkok, Thailand between October 1, 2019, and September 30, 2021...
April 3, 2023: Gerontology
Ollie Fegter, Haylie Santos, Alfred Rademaker, Angela C Roberts, Emily Rogalski
INTRODUCTION: Identifying responsive outcome measures for assessing functional change related to cognition, communication, and quality of life for individuals with neurodegenerative disease is important for intervention design and clinical care. Goal Attainment Scaling (GAS) has been used as an outcome measure to formally develop and systematically measure incremental progress towards functional, patient-centered goals in clinical settings. Evidence suggests that GAS is reliable and feasible for use in older adult populations and in adult populations with cognitive impairment, but no review has assessed the suitability of GAS in older adults with neurodegenerative disease experiencing dementia or cognitive impairment, based on responsiveness...
March 24, 2023: Gerontology
Zheran Liu, Yonglin Su, Rendong Huang, Ruidan Li, Zhigong Wei, Ling He, Yiyan Pei, Yu Min, Xiaolin Hu, Xingchen Peng
BACKGROUND: Cognitive performance in older ages is strongly affected by individuals' genetic predispositions. We investigated whether depression trajectories were associated with subsequent cognitive performance independent of participants' genetic predispositions. METHODS: Participants from the Health and Retirement Study with European ancestry and aged over 50 were included in the analysis. Depressive symptoms were evaluated using the Center for Epidemiologic Studies Depression Scale, and the 6-year trajectories were fitted using latent class linear mixed models...
March 21, 2023: Gerontology
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No abstract text is available yet for this article.
March 17, 2023: Gerontology
Leon Brüll, Natalie Hezel, Adamantios Arampatzis, Michael Schwenk
Introduction There is increasing evidence that perturbation-based balance training (PBT) is highly effective in preventing falls at older age. Different PBT paradigms have been presented so far, yet a systematic comparison of PBT approaches with respect to feasibility and effectiveness is missing. Two different paradigms of PBT seem to be promising for clinical implementation: 1. Technology-supported training on a perturbation treadmill (PBTtreadmill); 2. Training of dynamic stability mechanisms in the presence of perturbations induced by unstable surfaces (PBTstability)...
March 15, 2023: Gerontology
Tingting Liu, Zhengjia Yang, Shufen Liu, Jianshe Wei
INTRODUCTION: Cancer and neurodegeneration are two major leading causes of morbidity and death worldwide. Neurodegeneration results in excessive neuronal cell death, and cancer emerges from increased proliferation and resistance to cell death. Although most epidemiological studies support an inverse association between the risk for the development of neurodegenerative diseases and cancer, increasing evidence points to a positive correlation between specific types of cancer, like prostate adenocarcinoma (PRAD), and neurodegenerative diseases, like Parkinson's disease (PD)...
March 15, 2023: Gerontology
Yi Xu, Chuan Chen, Yanpeng Yang, Shanmu Ai, Wei Ao, Lingwen Kong, Ying Zhang, Jun Li, Jun Xiao
BACKGROUND: Hypertension is the most common cardiovascular disease, and its main harmful effect is chronic damage to target organs. In some patients with well-controlled blood pressure, target organ damage still occurs. GLP-1 agonists have significant cardiovascular benefits, but their antihypertensive effect is limited. The cardiovascular protective effect of GLP-1 is worth studying. METHODS: The ambulatory blood pressure of spontaneously hypertensive rats (SHRs) was detected by ambulatory blood pressure monitoring, and the characteristics of blood pressure and the effect of subcutaneous intervention with a GLP-1R agonist on blood pressure were observed...
March 7, 2023: Gerontology
Chia Jung Hsieh, Pei-Shan Li, Chia-Hui Wang, Shu-Ling Lin, Tzu-Chi Hsu, Chia-Mei Tsai Tsai
BACKGROUND AND OBJECTIVE: The purpose of our study was to explore the immediate and long-term effects of socially assistive robots (SARs) on neuropsychiatric symptoms (NPS), behavioral and psychological symptoms of dementia (BPSD), positive emotional experiences, and social interaction in older people living with dementia. METHODS: We set keywords and used Boolean operators to search the CINAHL, Cochrane Library, EMBASE, IEEE Digital Library, MEDLINE, PsycINFO, PubMed, Web of Science, Scopus, and Chinese Electronic Periodical Service from inception to February 2022 for randomized controlled trials...
March 3, 2023: Gerontology
Emilia Frangos, Armando Barriguete Melendez, Patrice Debré, Luis Miguel Gutierrez Robledo, André-Laurent Parodi, Jean-Pierre Michel
After the first wave of the COVID 19 pandemic, the severity of the disease in certain countries was attributed to a lack of basic education among the inhabitants. We therefore sought to elucidate the role of education and health literacy in health behaviours. This work demonstrates that, alongside genetics, the affective and educational family environment as well as general education, has a strong influence on health starting from the very first days of life. Epigenetics plays a major role in the determination of health and disease (DOHAD), as well as in the characterization of gender...
March 2, 2023: Gerontology
Anda Botoseneanu, Sheila Markwardt, Ana R Quiñones
INTRODUCTION: Specific multimorbidity combinations, in particular those including arthritis, stroke, and cognitive impairment, have been associated with high burden of ADL-IADL disability in older adults. The biologic underpinnings of these associations are still unclear. METHODS: Observational longitudinal study using data from the Health & Retirement Study (N=8,618, mean age=74 years, 58% female, 25% non-White) and negative binomial regression models stratified by sex to evaluate the role of inflammatory and glycemic biomarkers (high-sensitivity C-reactive protein (hs-CRP) and HbA1c) in the association between specific multimorbidity combinations (grouped around one of eight index diseases: arthritis, cancer, cognitive impairment, diabetes, heart disease, hypertension, lung disease, and stroke; assessed between 2006-2014) and prospective ADL-IADL disability (2 years later, 2008-2016)...
March 1, 2023: Gerontology
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