Mutsumi Suganuma, Motoki Furutani, Tohru Hosoyama, Risa Mitsumori, Rei Otsuka, Marie Takemura, Yasumoto Matsui, Yukiko Nakano, Shumpei Niida, Kouichi Ozaki, Shosuke Satake, Daichi Shigemizu
INTRODUCTION: Although frailty is a geriatric syndrome that is associated with disability, hospitalization, and mortality, it can be reversible and preventable with the appropriate interventions. Additionally, as the current diagnostic criteria for frailty include only physical, psychological, cognitive and social measurements, there is a need for promising blood-based molecular biomarkers to aid in the diagnosis of frailty. METHODS: To identify candidate blood-based biomarkers that can enhance current diagnosis of frailty, we conducted a comprehensive analysis of clinical data, messenger RNA sequencing (RNA-seq), and aging-related factors using a total of 104 older adults aged 65-90 years (61 frail subjects and 43 robust subjects) in a cross-sectional case-control study...
March 14, 2024: Gerontology