Iridoid glycoside Cornuside alleviates the symptom of gestational diabetes mellitus by suppressing inflammation and regulating beta cell function.

OBJECTIVE: Gestational diabetes mellitus (GDM) is a frequently occurring complication during pregnancy and has adverse effects on both mother and off-spring. β-cell dysfunction and inflammation play important roles in GDM pathogenesis. Cornuside is an iridoid glycoside that exhibits anti-inflammation activities. In the present study, we explored the effects of Cornuside on β-cell and GDM. Design section: MIN6 β-cell line cells were treated with varying concentrations of Cornuside. The content and secretion of insulin were measured.

METHODS: The expression of Pdx1, Rac1, Piezo and NeuroD1, and cell proliferation in Cornuside-treated MIN6 cells were detected. Cornuside was administered to GDM mice, and the symptoms of GDM, expression of IL-6 and TNF-α, and activation of NF-κB in GDM mice were measured.

RESULTS: Cornuside promoted cell proliferation of MIN6 cells, enhanced insulin content and secretion, and expression of Pdx1, Rac1, Piezo and NeuroD1 in MIN6 cells. Cornuside alleviated symptoms of GDM mice and decreased serum levels of IL-6 and TNF-α in GDM mice. Cornuside suppressed the expression of IL-6 and TNF-α, as well as the activation of NF-κB in placenta of GDM mice.

CONCLUSION: Cornuside ameliorates GDM symptoms by suppressing inflammation and enhancing β-cell functions. Limitations subsection: Not applicable.