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Gynecologic and Obstetric Investigation

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https://read.qxmd.com/read/31055567/spontaneous-regression-of-cervical-intraepithelial-neoplasia-2-a-meta-analysis
#1
Jin Zhang, Chun-Xue Lu
BACKGROUND: Cervical intraepithelial neoplasia (CIN) is a precancerous condition that, if progresses, can cause cervical cancer. Less severe forms such as CIN1 regress spontaneously for most of the cases, but for high-grade CIN (CIN2 or CIN3), have higher potentials for progression. OBJECTIVE: Aim of the present study was to obtain reliable estimates of spontaneous regression and progression rates of CIN2. METHODS: Data were extracted from eligible studies identified after literature search in electronic databases, and meta-analyses were performed by pooling the regression and progression rates reported by these studies...
May 3, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/31039575/measurement-of-uterine-and-abdominal-muscle-electromyography-in-pregnant-women-for-estimation-of-expulsive-activities-during-the-2nd-stage-of-labor
#2
Xueya Qian, Pin Li, Shaoqing Shi, Robert E Garfield, Huishu Liu
BACKGROUND: The progression of labor and delivery of the fetus is dependent upon uterine contractions and the voluntary effort of abdominal muscle contractions. A good monitor of uterine contractions and pushing is necessary for obstetrical care. Electromyography (EMG) is the underlying basis for contractility of muscle including the myometrium. OBJECTIVES: The aim of this study was to determine the relationship between EMG activity of uterine and abdominal muscles and the duration of the 2nd stage of labor in pregnant women...
April 30, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/31039568/silencing-of-forkhead-box-m1-reverses-transforming-growth-factor-%C3%AE-1-induced-invasion-and-epithelial-mesenchymal-transition-of-endometriotic-epithelial-cells
#3
Jingjing Zhang, Zhiming Xu, Hongying Dai, Jing Zhao, Tingting Liu, Guiping Zhang
AIM: The aim of this study was to investigate the expression of Forkhead box M1 (FoxM1) in endometriosis and determine FoxM1's possible effects on endometriotic epithelial cells (EECs) invasion and epithelial-mesenchymal transition (EMT). METHODS: The expression of FoxM1 and E-cadherin in endometrium and ectopic tissues was analyzed by immunohistochemistry. The transforming growth factor-β1 (TGF-β1) was added to induce EMT of EECs, which were purified from ectopic tissues...
April 30, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30965339/maternal-anemia-and-coagulation-fibrinolysis-after-fetoscopic-laser-photocoagulation-for-twin-to-twin-transfusion-syndrome
#4
Mamoru Morikawa, Takashi Yamada, Kinuko Nakagawa, Ami Hosokawa-Miyanishi, Takeshi Umazume, Kentaro Chiba, Satoshi Kawaguchi, Kazutoshi Cho, Hidemichi Watari
AIM: This study was performed to evaluate maternal changes in laboratory characteristics after fetoscopic laser photocoagulation (FLP) for twin-to-twin transfusion syndrome (TTTS). METHODS: A retrospective review was conducted among 30 women with monochorionic diamniotic twin pregnancy with TTTS who underwent FLP at 16-26 weeks of gestation. Maternal laboratory parameters were measured before and after FLP. RESULTS: The pre-FLP mean hemoglobin level (10...
April 9, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30965333/familial-hydrocephalus-and-dysgenesis-of-the-corpus-callosum-associated-with-xp22-33-duplication-and-stenosis-of-the-aqueduct-of-sylvius-with-x-linked-recessive-inheritance-pattern
#5
Ali Alhousseini, Salam Zeineddine, Abraham Husseini, Heba Baddah, Homam Saker, Swati Mody, Salah A Ibrahim, Mili Thakur, Edgar Hernandez-Andrade, Ray Bahado-Singh
INTRODUCTION: X-linked recessive mutations predominantly affect male fetuses with milder or no abnormalities in female siblings. Most reports show only one affected member in the family. We are reporting a family affected with hydrocephalus, stenosis of the aqueduct of Sylvius, dysgenesis of the corpus callosum, and Xp22.33 microduplication. CASE PRESENTATION: Eighteen-year-old patient was evaluated for her 2 pregnancies; the first was a male fetus with severe hydrocephalus and the second a female fetus with mild hydrocephalus...
April 9, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30965324/laparoscopic-myomectomy-with-temporary-bilateral-uterine-artery-and-utero-ovarian-vessels-occlusion-compared-with-traditional-surgery-for-uterine-fibroids-blood-loss-and-recurrence
#6
Lanying Jin, Limei Ji, Mingjun Shao, Min Hu
AIM: To determine the optimal hemostatic technique for laparoscopic myomectomy (LM) by comparing temporary uterine artery blockage alone or combined with blockage of the utero-ovarian vessels. PATIENTS: Women with symptomatic uterine myoma attending the Department of Obstetrics and Gynecology in Jinhua Municipal Central Hospital. METHOD: A total of 200 patients with symptomatic uterine fibroids were randomly divided into Group A (n = 65), Group B (n = 67) and Group C (n = 68)...
April 9, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30897579/urodynamics-as-a-prognosticator-of-mirabegron-treatment-outcomes
#7
Helena Kopp Kallner, Caroline Elmér, Daniel Altman
AIMS: To determine if findings at urodynamics prognosticate improvements in overactive bladder symptoms among women receiving mirabegron treatment. METHODS: Before treatment, women completed a urodynamic investigation, a micturition diary and the Urinary Distress Inventory (UDI) with the irritative subscale UDIOAB. After 6 months mirabegron treatment, patients were clinically evaluated and completed the UDI. Associations were tested using regression analyses and nonparametric statistics...
March 21, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30889596/uncommon-mixed-endometrial-myometrial-benign-tumors-of-the-reproductive-tract-literature-review
#8
REVIEW
Marwan Habiba, Ivo Brosens, Gian Franco Zannoni, Giuseppe Benagiano
BACKGROUND: We reviewed published cases of uterus-like mass (U-LM), endomyometriosis, polypoid adenomyoma (PA), adenomyomatous polyp, atypical PA (APA), and adenomyoma. SEARCH METHODS: PubMed, Medline, and Scopus searches of all cases published in the databases till November 26, 2018. RESULTS: We identified 45 case reports of U-LM in the pelvis, 10 cases of endomyometriosis, 44 cases of adenomyomatous polyp, 466 cases of APA and case series of adenomyoma and PA...
March 19, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30844792/lack-of-survival-benefit-of-para-aortic-lymphadenectomy-in-advanced-cervical-cancer
#9
Cristina Gonzalez-Benitez, Patricia Salas, Jacek P Grabowski, Alicia Hernandez, Javier De Santiago, Ignacio Zapardiel
INTRODUCTION: The presence of positive para-aortic lymph nodes in advanced cervical cancer remains the most important prognostic factor for survival and also defines the treatment. Our aim was to define the influence of staging para-aortic lymphadenectomy in patients' survival. MATERIAL AND METHODS: The medical records of 74 patients with advanced cervical cancer (FIGO IIB-IVA) were reviewed. In 31 patients (41.9%), the assessment of lymph nodes was performed with imaging test (group 1) and in 43 (58...
March 7, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30836353/impact-of-metastatic-lymph-node-to-total-lymph-node-ratio-on-survival-of-endometrial-cancer-patients
#10
Siriwan Tangjitgamol, Thannaporn Kittisiam, Jittrind Sriraumpuch
OBJECTIVE: To evaluate the prognostic role of metastatic lymph node (MLN), total lymph nodes (TLN) and MLN to TLN ratio in advanced-stage endometrial cancer (EMC). -Methods: EMC patients who had complete surgical staging between January 1995 and May 2017 and were in stage IIIC-IVB with pelvic and/or para-aortic nodal metastasis were identified. Data collected were age, stage, histopathology, TLN and MLN numbers, adjuvant treatment, disease status, and living status. The association of lymph node ratio (LNR), presented as a percentage of MLN to TLN, and other clinicopathologic factors with progression-free survival (PFS) and cancer-specific survival (CSS) was studied...
March 5, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30808843/antidiabetic-medications-and-the-risk-of-endometrial-cancer-in-patients
#11
Jing Tian, Yuan Liang, Pengpeng Qu
BACKGROUND: Recent epidemiological studies suggest that antidiabetic medications (ADMs) may reduce the risks of cancer and cancer mortality among patients with type 2 diabetes. However, data on its effect on endometrial cancer (EC) are unclear. In this systematic review and meta-analysis, we evaluated the association between metformin, sulfonylureas (SUs), insulin, and the risk of EC in patients with diabetes mellitus (DM). METHODS: Studies were identified from PubMed and EMBASE database through October 2017...
February 26, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30799426/live-births-after-in-vitro-fertilization-with-fertility-sparing-surgery-for-borderline-ovarian-tumors-a-case-series-and-literature-review
#12
Song Li, Haiyan Lin, Yanqiu Xie, Xuedan Jiao, Qi Qiu, Qingxue Zhang
This is a case series reporting live births following in vitro fertilization (IVF) after fertility-sparing surgery in patients with borderline ovarian tumors (BOTs). Seventeen patients, in whom fertility-sparing surgery for BOTs followed by IVF was performed from July 1, 2011 to September 30, 2017, in our IVF center, were included. Here we retrospectively present their BOT characteristics and clinical outcomes of assisted reproduction technology (ART) and then discuss the literature on management of patients with BOTs after fertility-sparing surgery...
February 21, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30759440/possible-association-between-cathepsin-v-and-the-development-of-placenta-accreta-spectrum-disorders
#13
Satoshi Matsukawa, Seiji Sumigama, Tomomi Kotani, Jingwen Wang, Rika Miki, Yoshinori Moriyama, Tomoko Nakano, Yukio Mano, Hiroyuki Tsuda, Koji Tamakoshi, Fumitaka Kikkawa
BACKGROUND/AIMS: The study aimed to evaluate molecular changes related to trophoblast adhesion in placenta accreta spectrum (PAS) disorders. METHODS: A retrospective analysis of 10 PAS cases in which both the trophoblast adherent site and the non-adherent site were identified was performed in April 2010 and March 2013. Microarray analysis and reverse transcription polymerase chain reaction (RT-PCR) analyses were performed to extract upregulated genes in the adherent site...
February 13, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30712043/interleukin-15-and-interleukin-7-are-the-major-cytokines-to-maintain-endometriosis
#14
Patrick Bellelis, Denise Frediani Barbeiro, Bárbara Yasmin Gueuvoghlanian-Silva, Jorge Kalil, Mauricio Simões Abrão, Sergio Podgaec
OBJECTIVE: The objective of this study was to evaluate cytokines related to natural killer and T-regulatory cells in endometriotic lesions, peritoneal fluid (PF) and the peripheral blood (PB) of patients with deep infiltrative endometriosis. STUDY DESIGN: A case-control study was conducted in a tertiary referral hospital. Sixty-four consecutive patients after laparoscopy were divided into 2 groups: with endometriosis (Group A - n = 32) and without endometriosis (Group B - n = 32)...
February 1, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30712041/reported-outcomes-in-perinatal-iron-deficiency-anemia-trials-a-systematic-review
#15
REVIEW
Ann Kinga Malinowski, Rohan D'Souza, Khalid S Khan, Nadine Shehata, Marcin Malinowski, Jahnavi Daru
BACKGROUND/AIMS: Iron deficiency (ID) and iron deficiency anemia (IDA) are global health concerns associated with adverse perinatal effects. Despite efforts taken at the international level, there is no consensus on unified prevention/treatment strategies, largely stemming from inconsistencies of outcome reporting. Our objective was to comprehensively assess outcome reporting perinatal iron intervention trials as Phase 1 of core outcome set (COS) development to inform future research...
February 1, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30712040/normality-ranges-of-menstrual-fluid-volume-during-reproductive-life-using-direct-quantification-of-menses-with-vaginal-cups
#16
Manuel B Donoso, Ramón Serra, Gregory E Rice, María Teresa Gana, Carolina Rojas, Maroun Khoury, José Antonio Arraztoa, Lara J Monteiro, Stephanie Acuña, Sebastián E Illanes
OBJECTIVE: To determine the normal limits of menstrual fluid volume during reproductive life, quantified by direct measurement. METHODS: This was an observational, prospective clinical trial of healthy women aged 20-49 years old, with normal menstrual periods, recruited in a Natural Family Planning Unit. Women collected their menstrual fluid for at least 3 menstrual periods using a vaginal cup. Menstrual volume and different covariables were evaluated using a multilevel mixed-effects linear regression...
February 1, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30661071/sentinel-lymph-node-biopsy-in-the-treatment-of-endometrial-cancer-why-we-fail-results-of-a-prospective-multicenter-study-on-the-factors-associated-with-failure-of-node-mapping-with-indocyanine-green
#17
Manuel Maria Ianieri, Andrea Puppo, Antonia Novelli, Federica Campolo, Tommaso Staniscia, Giuseppe Di Martino, Elisa Piovano, Francesco Bruni, Giovanni Roviglione, Daniele Mautone, Marcello Ceccaroni
BACKGROUND: The sentinel lymph node (SLN) mapping for endometrial cancer staging is gaining wide diffusion, but there is no definitive evidence on the factors associated with the failure of mapping. OBJECTIVES: To analyze the factors associated with the possible failure of bilateral SLN mapping with indocyanine green (ICG). METHODS: A prospective observational study without control on 110 patients with endometrial cancer apparently confined to the uterus, underwent laparoscopic surgical staging with SLN mapping with ICG...
January 18, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30654361/the-effect-of-preoperative-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-on-predicting-rupture-risk-in-tubal-ectopic-pregnancies
#18
Özgür Kan, Ali Gemici, Aysegul Alkilic, Elif Nazli Cetindag, Caner Cakir, Riza Dur, Metin Altay
BACKGROUND: Consecutive measurements of β-hCG levels and sonographic evaluation of adnexae are critical for choosing the optimal management in ampullar tubal ectopic pregnancies (EP). To select suitable patients for conservative approach, there is a need for an affordable and reliable marker for determining rupture risk. Evaluation of systemic inflammatory markers in combination with serum β-hCG levels and ultrasound might help to decide the appropriate treatment option. OBJECTIVE: The purpose of the present study was to evaluate the diagnostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in determining the rupture risk in ampullar tubal EPs and to compare with intraoperative findings...
January 17, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30650411/deregulated-micrornas-and-adiponectin-in-postmenopausal-women-with-breast-cancer
#19
María Isabel Peña-Cano, Renata Saucedo, Enrique Morales-Avila, Jorge Valencia, Jose A Zavala-Moha, Adriana López
BACKGROUND: Obesity is a risk factor for breast cancer (BC). Some mechanisms through which obesity can lead to cancer development are insulin-like growth factors (IGFs), adipokines, and microRNAs (miRs). The objective of the study was to determine whether miR-17-5p, miR-195-5p, and miR-221-3p expressions were deregulated in serum samples of obese and nonobese postmenopausal women with BC. In addition, insulin, adiponectin, leptin and IGFs were analyzed. METHODS: Fifty postmenopausal women with newly diagnosed BC and 50 postmenopausal healthy women were evaluated...
January 16, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30636254/morphological-and-functional-changes-in-the-vagina-following-critical-lifespan-events-in-the-ewe
#20
Lucie Hympanova, Rita Rynkevic, Iva Urbankova, Silvia Blacher, Laurent de Landsheere, Katerina Mackova, Ladislav Krofta, Jan Deprest
BACKGROUND/AIMS: The ewe is increasingly being used as an animal model for pelvic floor disorders. The aim was to further characterize changes in the vaginal properties during its entire lifespan. METHODS: Vaginal tissues were collected at different stages of reproductive life (neonatal, prepubescence, nulliparous, primiparous, multiparous, and menopausal; ≥6 ewes/group). Vaginal size, as well as active and passive biomechanics, was measured. Microscopy included thickness of glycogen, epithelium, lamina propria and muscularis thickness, densities of collagen, elastin, smooth muscle, and nerves...
January 11, 2019: Gynecologic and Obstetric Investigation
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