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Combining Alginate/PVPI-Based Film with Frequency Rhythmic Electrical Modulation System (FREMS™) Technology as An Advanced Strategy for Diabetic Wounds.
Macromolecular Bioscience 2023 October 7
Diabetes is rising as one of the most diffused diseases of our century with the related urgent necessity to face its systemic and local effects on the patients, such as cardiovascular problems, degeneration of limbs, and dysfunction of the wound healing process. The diffusion of leg ulcers has been estimated to be 1.51 for 1,000 population, and these non-resolved wounds can produce several social, economic, and mental health issues in diabetic patients. At the same time, these people experience neuropathic pain that causes morbidity and a further decrease in their quality of life. Here, we present a new study where an Alginate/PVPI-based wound dressing is combined with the Frequency Rhythmic Electrical Modulation System (FREMS™) technology, an established medical device for the treatment of neuropathic pain and diabetic ulcers. The produced Alginate/PVPI-based films were characterized in terms of morphology, chemistry, wettability, bio-/hemo-compatibility, and clotting capacity. Next, the Alginate/PVPI-based films were used together with FREMSTM technology in diabetic mice models, and synergism of their action in the wound closure rate and anti-inflammatory properties was found. Hence, we want to demonstrate how the combination of electrical neurostimulation devices and advanced wound dressings can be a new approach to improve chronic wound treatment. This article is protected by copyright. All rights reserved.
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