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Risk factors for amiodarone-induced liver injury: A retrospective analysis of medical records.
OBJECTIVE: This study identified risk factors for drug-induced liver injury (DILI) based on patient information before the administration of amiodarone.
MATERIALS AND METHODS: A retrospective analysis was performed on patients who had received amiodarone treatment. Data from patients with and without DILI were compared immediately before the start of amiodarone treatment.
RESULTS: An elevated C-reactive protein level (odds ratio (OR) 1.119; 95% confidence interval (CI) 1.009 - 1.241; p = 0.033) before amiodarone administration was a significant risk factor for DILI.
CONCLUSION: Possible treatment with alternative drugs should be considered in patients with elevated C-reactive protein levels. Moreover, close monitoring of liver function when amiodarone is administered may prevent the onset and exacerbation of DILI.
MATERIALS AND METHODS: A retrospective analysis was performed on patients who had received amiodarone treatment. Data from patients with and without DILI were compared immediately before the start of amiodarone treatment.
RESULTS: An elevated C-reactive protein level (odds ratio (OR) 1.119; 95% confidence interval (CI) 1.009 - 1.241; p = 0.033) before amiodarone administration was a significant risk factor for DILI.
CONCLUSION: Possible treatment with alternative drugs should be considered in patients with elevated C-reactive protein levels. Moreover, close monitoring of liver function when amiodarone is administered may prevent the onset and exacerbation of DILI.
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