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International Journal of Clinical Pharmacology and Therapeutics

https://read.qxmd.com/read/38726563/risk-factors-for-infliximab-induced-infusion-reactions-based-on-a-retrospective-study-of-medical-information
#1
JOURNAL ARTICLE
Takahiro Amemiya, Hiroshi Suzuki
OBJECTIVE: Infliximab is indicated for a wide range of diseases, and infusion reactions (IRs) have been reported after infliximab administration in 17.6% of patients in clinical practice. This study aimed to identify the risk factors for IRs before the administration of infliximab based on available patient information. MATERIALS AND METHODS: We retrospectively analyzed patients treated with infliximab. Data were compared between patients with and without IRs immediately before initiation of infliximab...
May 10, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38726562/activated-charcoal-helps-in-the-diagnosis-of-dabigatran-overdose-a%C3%A2-case-study
#2
JOURNAL ARTICLE
Ning Zhang, Weihua Niu, Haiqing Zhang, Songsong Lu
The direct-acting oral anticoagulant dabigatran etexilate (DE) targets thrombin and is used widely to prevent thromboembolism. A 79-year-old man was admitted to the Emergency Department due to anuria for 2 days. An urgent laboratory examination revealed a serum creatinine concentration of 888 µmol/L. He was diagnosed with acute exacerbation of chronic renal insufficiency. During continuous renal replacement therapy (CRRT), the coagulation test showed a severe reduction in the fibrinogen level as well as a significantly prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT)...
May 10, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38699976/degree-of-serum-ldl-cholesterol-reduction-by-simvastatin-and-ezetimibe-is-dependent-on-baseline-ldl-cholesterol-concentration-but-not-on-baseline-values-and-changes-of-cholesterol-synthesis-and-absorption-parameters
#3
JOURNAL ARTICLE
Dieter Lütjohann, Frans Stellaard
OBJECTIVE: We questioned whether the baseline status of low-density lipoprotein cholesterol (LDL-C), cholesterol synthesis and absorption, and the changes in these parameters determine the change in serum LDL-C under statin or ezetimibe treatment or under combination treatment. MATERIALS AND METHODS: 37 mildly hypercholesterolemic healthy male subjects were studied under placebo, simvastatin (20 mg/d), ezetimibe (10 mg/d), and combination treatment. We correlated the change of LDL-C (ΔLDL-C) under treatment with the placebo end values of LDL-C (baseline), whole-body cholesterol synthesis, and hepatic cholesterol synthesis (serum lathosterol to cholesterol ratio) as well as fractional absorption rate (FAR) of cholesterol and serum campesterol to cholesterol ratio...
May 3, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38699975/pegylated-interferon-alpha-peg-ifn%C3%AE-induced-interstitial-lung-disease-in-a-patient-with-chronic-hepatitis-b-a%C3%A2-case-report-and-literature-review
#4
JOURNAL ARTICLE
Minghui Shi, Shiyao Wang, Yanhong Ren, Ling Zhao, Min Liu, Lulu Yang, Ting Yang
OBJECTIVES: Interferon (IFN)-induced lung injury is a rare but severe complication. Studies are needed to elucidate the demographic characteristics, clinical manifestations, and prognostic features of IFN-induced interstitial lung disease (ILD). CASE REPORT: We report a patient with chronic hepatitis who developed ILD after interferon monotherapy. To further clarify the clinical characteristics of such patients, we searched for cases in which lung injury was documented as a side effect of hepatitis treatment and systematically analyzed all case reports for clinical manifestations, type of treatment, and outcomes...
May 3, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38699974/palatability-evaluation-of-orally-disintegrating-tablets-using-a-visual-analog-scale-in-clinical-trials
#5
JOURNAL ARTICLE
Motoyasu Miura, Seiki Kojima, Shimako Tanaka, Yasuharu Kashiwagura, Noriyuki Namiki, Shinya Uchida
OBJECTIVE: Visual analog scale (VAS) can be used to evaluate multiple parameters. There have been no reports on the verification of order effects or reproducibility of the VAS method for overall palatability of oral dosage forms. The purpose of this study was to assess the validity of a method for evaluating the palatability of orally disintegrating tablets (ODTs) using a 100-mm VAS. MATERIALS AND METHODS: We conducted clinical trials to evaluate the overall palatability, taste, and scent of 3 ODTs (F1, F2, F3) that contained famotidine (20, 10, and 5 mg, respectively)...
May 3, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38660886/pharmacokinetics-of-apixaban-in-patients-undergoing-pancreaticoduodenectomy-pap-up
#6
JOURNAL ARTICLE
Richard Zheng, Edwin Lam, Peter Altshuler, Madison Crutcher, Harish Lavu, Charles J Yeo, Douglas Stickle, Benjamin Leiby, Walter K Kraft
OBJECTIVE: The impact of pancreaticoduodenectomy on absorption of drugs in the duodenum remains largely unknown. We aim to characterize the pharmacokinetics of apixaban in patients who had previously undergone pancreaticoduodenectomy. MATERIALS AND METHODS: A single 10-mg dose of apixaban was administered to 4 volunteers who underwent pancreaticoduodenectomy at least 6 months prior. The maximum plasma apixaban concentration (Cmax ) and area under the plasma concentration time-curve (AUC0-24 , AUC0-inf ) were compared against healthy historical control subjects (N = 12)...
April 25, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38660885/a-cross-sectional-study-on-the-potential-drug-drug-interaction-risk-of%C3%A2-covid-19-patients-in-hospital
#7
JOURNAL ARTICLE
Liu-Lyu Huang, Bo Jiang, Yong-Long Han, Ying Liu
OBJECTIVE: To investigate the incidence of and risk factors for potential drug-drug interactions (DDIs) among elderly patients with corona virus disease 2019 (-COVID-19) in hospital and to explore management strategies to reduce the occurrence of potential DDIs and ensure patient medication safety. MATERIALS AND METHODS: This was a descriptive, retrospective cross-sectional study among patients aged 65 years and older who were hospitalized with COVID-19. Potential DDIs associated with prescriptions containing two or more medicines were analyzed with Lexicomp software, the incidence of DDIs was calculated, recommendations for medication adjustment were formulated, and the χ2 -test and binary logistic regression were used to analyze related risk factors...
April 25, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38606856/acute-liver-failure-caused-by-high-dose-tigecycline-a-case-report
#8
JOURNAL ARTICLE
Yingpei Zhang, Jiajun Wang, Yibin Tan, Jianhua Wu
High-dose tigecycline is gradually being introduced for the treatment of serious infectious diseases due to the increasing difficulty in treating pan-resistant bacterial infections. However, the safety of high-dose tigecycline is controversial. We report the case of a 76-year-old female patient with cerebral hemorrhage who received high-dose tigecycline (100 mg q12h) with other drugs for ventilator-associated pneumonia. 25 days after admission, she developed acute liver failure, mainly manifested by abnormally high bilirubin, coagulation dysfunction, and gastrointestinal hemorrhage with hemorrhagic shock...
April 12, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38606855/calcineurin-inhibitors-experience-in-unplanned-pregnancies-with-active-lupus-disease-a-retrospective-observational-study
#9
JOURNAL ARTICLE
İbrahim Vasi, Derya Yıldırım, Rıza Can Kardaş, Burcugül Kaya, Rahime Duran, Gizem Tuğçe Alp, Hazan Karadeniz, Aslıhan Avanoğlu Güler, Hamit Küçük, Berna Göker, Abdurrahman Tufan, Mehmet Akif Öztürk, Abdulsamet Erden
OBJECTIVES: To evaluate the use of calcineurin inhibitors (CNIs), specifically tacrolimus, in unplanned pregnancies with active lupus disease among patients with systemic lupus erythematosus (SLE). MATERIALS AND METHODS: The study includes data from pregnancies in women diagnosed with SLE at Gazi University Hospital in Ankara, Türkiye, between January 2010 and July 2022. The study categorized pregnancies into planned and unplanned groups based on lupus nephritis presence, emphasizing the need for inactive lupus disease for at least 6 months before attempting conception in planned pregnancies...
April 12, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38577753/effectiveness-of-atropine-in-managing-sialorrhea-a-systematic-review-and-meta-analysis
#10
JOURNAL ARTICLE
Venkata K Yellepeddi, Jonathan A Race, Mary M McFarland, Jonathan E Constance, Elika Fanaeian, Nancy A Murphy
OBJECTIVES: To describe the efficacy of atropine in controlling salivary flow in patients with sialorrhea or drooling. MATERIALS AND METHODS: We included randomized controlled studies, quasi-randomized trials, case reports, clinical trials, systematic reviews, and meta-analyses assessing the use of atropine in patients with sialorrhea or drooling. The endpoints were reduction in salivary flow rate, amount of saliva secreted, reduction in clinical symptoms of sialorrhea, death rattle intensity, or reduction in drooling intensity as measured by an objective scale such as the drooling intensity scale...
April 5, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38577752/association-between-serum-igg-concentrations-and-the-incidence-of-infections-in-patients-with-chronic-lymphocytic-leukemia-and-secondary-immunodeficiency-under-treatment-with-privigen
#11
JOURNAL ARTICLE
Burkhard Otremba, Ferdinand Haslbauer, Marcel Reiser, Rudolf Weide, Michael Obermeier, Dietmar Pfründer
OBJECTIVE: To investigate the association between serum immunoglobulin G (IgG) concentrations and the incidence of infections in patients with chronic lymphocytic leukemia (CLL) and secondary immunodeficiency receiving treatment with Privigen. MATERIALS AND METHODS: Data was analyzed from a non-interventional study conducted in 31 centers in Germany and 1 in Austria. Adult CLL patients with hypogammaglobulinemia and recurrent infections were allowed to enter the study upon signing informed consent, if a prior decision for treatment with Privigen had been made...
April 5, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38577751/a-crossover-study-to-evaluate-the-pharmacokinetics-and-bioequivalence-of-hydroxychloroquine-tablets-in-healthy-chinese-subjects
#12
JOURNAL ARTICLE
Jie Feng, Shuang-Yu Kuang, Jun-Han Wan, Rong Li, Yi-Jie Zhu, Bei-Lei Cai, Lei Guan, Zheng Zhang
AIMS: Hydroxychloroquine (HCQ) has a high variability and a long half-life in the human body. The purpose of this study was to evaluate the bioequivalence of a generic HCQ tablet (test preparation) versus a brand HCQ tablet (reference preparation) under fasting and fed conditions in a crossover design. MATERIALS AND METHODS: This was an open-label, two-period randomized, single-dose, crossover study in 47 healthy Chinese subjects who were sequentially and randomly allocated either to the fed group (high-fat meal; n = 23) or the fasting group (n = 24)...
April 5, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38529928/therapeutic-drug-monitoring-of-vancomycin-in-surgical-patients-through-a-validated-hplc-method
#13
JOURNAL ARTICLE
Muhammad Noman Akram, Muhammad Imran Khokhar, Mateen Abbas, Muhammad Khurram Waqas, Mian Waqar Mustafa, Abdulhakeem S Alamri, Majid Alhomrani, Walaa F Alsanie, Muhammad Usman
BACKGROUND: Vancomycin is being used for the treatment of a variety of infections caused by methicillin resistant Staphylococcus aureus and methicillin susceptible Staphylococcus aureus . Therapeutic drug monitoring (TDM) is highly recommended for ensuring the safe and effective therapy with vancomycin. A reliable and cost-effective bioanalytical method is required for TDM as well as pharmacokinetic studies of vancomycin. MATERIALS AND METHODS: A selective, sensitive, and cost effective HPLC method was developed and validated for quantification of vancomycin concentrations in human plasma...
March 26, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38529927/primary-and-secondary-prevention-of-stroke-and-cardiovascular-events-using-evolocumab-and-alirocumab-meta-analysis-of-randomized-controlled-trials
#14
JOURNAL ARTICLE
Kwang-Hee Shin, Hye Duck Choi
OBJECTIVES: Although the clinical role of protein convertase subtilisin kexin type 9 (PCSK9) inhibitors for cholesterol management is increasing, the post-marketing period of use is short compared to other lipid-lowering drugs, so there is still insufficient evidence for their efficacy and safety. In this meta-analysis, we evaluated preventive effects of stroke and cardiovascular (CV) events using evolocumab and alirocumab. MATERIALS AND METHODS: We assessed the relative risk of stroke and CV events after alirocumab or evolocumab treatment in individuals with or without clinical CV diseases compared with that in controls...
March 26, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38469705/efficacy-and-safety-of-antiplatelet-therapy-in-covid-19-insights-from-a%C3%A2-meta-analysis-of-randomized-controlled-trials
#15
JOURNAL ARTICLE
Guoying Kao, Yunlin Chen, Jinqi Fan
BACKGROUND: COVID-19 induces a pro-coagulant state with thrombotic events. This meta-analysis explores the efficacy and safety of antiplatelet-based therapy in COVID-19 patients through randomized controlled trials (RCTs). MATERIALS AND METHODS: A systematic literature search until March 10, 2023, identified 7 RCTs involving 23,415 inpatients. Of these, 11,891 received antiplatelet-based treatment, and 11,524 received placebo/other drugs. Statistical analysis was performed using Review Manager 5...
March 12, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38431833/low-albumin-combined-with-low-molecular-weight-heparin-as-risk-factors-for-liver-injury-using-azvudine-evidence-from-an-analysis-of-covid-19-patients-in-a-national-prospective-pharmacovigilance-database
#16
JOURNAL ARTICLE
Hong Lu, Ying Zeng, Qun-Zhi Shi, Lin Liu, Yong-Qing Gong, Sen Li, Pan Yan
OBJECTIVE: Azvudine is an effective treatment for patients infected with common COVID-19. However, physicians have reported a series of adverse reactions, including multiple cases of liver injury, caused by azvudine in clinical practice. This study assessed the incidence, clinical features, and associated risk factors of liver injury induced by azvudine in real-world settings, offering guidance for safe clinical use. MATERIALS AND METHODS: This study utilized the Chinese Hospital Pharmacovigilance System (CHPS) to retrospectively analyze the treatment of COVID-19 patients with azvudine at Changsha Central Hospital from December 19, 2022, to June 6, 2023...
March 3, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38431832/evaluation-of-the-risk-factors-for-the-failure-of-a-single-prophylactic-dose-of-anticholinergic-drugs-for-irinotecan-induced-cholinergic-symptoms
#17
JOURNAL ARTICLE
Takuya Watanabe, Yoshitaka Saito, Yoh Takekuma, Yasushi Shimizu, Ichiro Kinoshita, Yoshito Komatsu, Mitsuru Sugawara
OBJECTIVE: Irinotecan (IRI) is an anticancer drug that is frequently used to treat colorectal, gastric, and pancreatic cancers. Its side effects include cholinergic symptoms, such as diarrhea, abdominal pain, nausea, and hyperhidrosis. Anticholinergic medicines are frequently used for treatment or prophylaxis; however, the risk factors for the failure of a single prophylactic anticholinergic administration remain unclear. Moreover, an appropriate anticholinergic drug for prophylaxis remains unknown...
March 3, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38431831/clinical-and-research-implications-of-uricase-knockout-and-renal-injury
#18
JOURNAL ARTICLE
ShaoJun Zheng
No abstract text is available yet for this article.
March 3, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38431829/network-pharmacology-analysis-and-clinical-efficacy-of-the-traditional-chinese-medicine-bu-shen-jian-pi-part%C3%A2-2-modulation-of-hypoxia-redox-status-and-mitochondrial-protection-in%C3%A2-a-neuroblastoma-cell-line-sh-sy5y
#19
JOURNAL ARTICLE
Wenli Yuan, Jiacheng Lin, Jun Wang, Chenghui Wang, Yuetong Shan, Wei Jing, Zhimin Fei, Weidong Pan
OBJECTIVE: To examine the mitochondrial protective effects of icariin, naringenin, kaempferol, and formononetin, potentially active agents in Bu-Shen-Jian-Pi formula (BSJP) identified using network pharmacology analysis. MATERIALS AND METHODS: Mitochondrial protection activity was determined using a hypoxia-reoxygenation in vitro model based on the neuroblastoma cell line SH-SY5Y and measurements of anti-ferroptotic activity. RESULTS: Icariin, naringenin, kaempferol, and formononetin showed mitochondrial protective activity involving diverse signaling pathways...
March 3, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38431828/balancing-efficacy-and-adverse-reactions-using-everolimus-in-a-patient-with-metastatic-malignant-insulinoma-case-report
#20
JOURNAL ARTICLE
Siham Rouf, Khadija Boujtat, Tijani El Harroudi, Hanane Latrech
INTRODUCTION: Malignant insulinoma is a rare neuroendocrine tumor responsible for excessive insulin secretion and life-threatening hypoglycemia episodes. Computed tomography (CT) of the abdomen can identify a pancreatic tumor corresponding to insulinoma. Loco-regional metastases define the metastatic cases. The first-line therapeutic approach is surgery, while other medical treatments like diazoxide and everolimus play also a role. These treatments have shown efficacy in regulating blood glucose and, to some extent, controlling tumor progression...
March 3, 2024: International Journal of Clinical Pharmacology and Therapeutics
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