Early Experience with an Occupational JYNNEOS (Orthopoxvirus) Vaccination Program.

OBJECTIVE: To identify lessons learned implementing JYNNEOS vaccination for laboratory workers exposed to orthopoxviruses such as mpox.

METHODS: Workers at risk of laboratory exposure were offered vaccine in a carefully planned occupational health program. Vaccine was procured from the CDC Drug Service which has special requirements. Reasons for accepting or declining vaccine, and side effects were obtained by survey.

RESULTS: Most workers accepted JYNNEOS, and occupational risk was the most commonly cited reason for acceptance. Most experienced mild local side effects. The administrative requirements of the CDC Drug Service are documented.

CONCLUSIONS: Occupational health programs caring for laboratory workers handling unusual biological agents require careful planning and coordination to facilitate access to vaccines that are not commercially available, anticipate and mitigate barriers to vaccination, and comply with special CDC requirements.