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"An Unusual Case of Primary Vitreoretinal Lymphoma: A Transformed Lymphoma".
Retinal Cases & Brief Reports 2022 October 25
PURPOSE: To report a case of primary vitreoretinal lymphoma (VRL) presenting as diffuse large b-cell lymphoma (DLBCL) 19 years after initial systemic follicular lymphoma.
METHOD: A case report.
RESULTS: An 81-year-old male patient presented with a 1-month history of floaters and blurry vision in the left eye. He had a history of follicular non-Hodgkin lymphoma treated with systemic chemotherapy in 2002 and prostate cancer treated surgically in 2004. Ophthalmic examination revealed vitritis, retinal whitening, perivascular sheathing, and a vascularized cream-colored retinal mass in the superonasal periphery of the left eye. Diagnostic vitrectomy with retina and vitreous biopsies demonstrated DLBCL. Positron emission tomography/computed tomography confirmed the isolated lesion in the left eye without systemic involvement. Treatment with systemic and intraocular chemotherapy was planned.
CONCLUSION: To the best of our knowledge, this is the first reported case of primary VRL of DLBCL transformed from follicular lymphoma. Intravitreal and systemic chemotherapy, including rituximab, should be consideered in the management of patients with transformed VRL.
METHOD: A case report.
RESULTS: An 81-year-old male patient presented with a 1-month history of floaters and blurry vision in the left eye. He had a history of follicular non-Hodgkin lymphoma treated with systemic chemotherapy in 2002 and prostate cancer treated surgically in 2004. Ophthalmic examination revealed vitritis, retinal whitening, perivascular sheathing, and a vascularized cream-colored retinal mass in the superonasal periphery of the left eye. Diagnostic vitrectomy with retina and vitreous biopsies demonstrated DLBCL. Positron emission tomography/computed tomography confirmed the isolated lesion in the left eye without systemic involvement. Treatment with systemic and intraocular chemotherapy was planned.
CONCLUSION: To the best of our knowledge, this is the first reported case of primary VRL of DLBCL transformed from follicular lymphoma. Intravitreal and systemic chemotherapy, including rituximab, should be consideered in the management of patients with transformed VRL.
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