journal
https://read.qxmd.com/read/38652727/intravitreal-dexamethasone-for-the-treatment-of-macular-edema-secondary-to-hydroxychloroquine-toxicity
#1
JOURNAL ARTICLE
Mariam Mathai, Alexander Zeleny, Bradley H Jacobsen, Richard A Garfinkel, Reshma Katira, Jordana G Fein
PURPOSE: Cystoid macular edema is a vision-threatening complication infrequently associated with hydroxychloroquine retinal toxicity. There are limited data on the best treatment for this pathology. METHODS: A retrospective case series is presented. RESULTS: In this series, we present three cases of cystoid macular edema in patients with diagnosed hydroxychloroquine maculopathy successfully treated with intravitreal dexamethasone implantation...
May 1, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38569208/evolution-of-autoimmune-retinopathy-in-stiff-person-syndrome-a-case-report
#2
JOURNAL ARTICLE
Grace E Nipp, Richmond Woodward, Andrew Gross, Jordan Deaner, Dilraj S Grewal
PURPOSE: To report a case of autoimmune retinopathy (AIR) as the presenting feature of Stiff Person Syndrome (SPS) and assess its evolution. OBSERVATIONS: A 35-year-old man presented with progressive, chronic, vision loss. On initial examination, visual acuity measured 20/20 OD and 20/50 OS. Humphrey Visual Field testing (HVF) demonstrated decreased foveal threshold OU. Mild subfoveal ellipsoid zone loss was noted on Optical Coherence Tomography (OCT). Five years later the patient presented with painful lower extremity muscle spasms and stiffness and complained of increasing vision loss with difficulty distinguishing colors...
April 1, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38569205/a-case-of-alstr%C3%A3-m-syndrome-with-a-novel-variant-in-alms1-gene-presenting-with-cone-rod-dystrophy-as-first-finding
#3
JOURNAL ARTICLE
Busra Yen, Mukaddes Damla Ciftci, Filiz Afrashi, Huseyin Onay, Damla Goksen
PURPOSE: Alström Syndrome (AS) is a rare autosomal recessive monogenic ciliopathy which is caused by a mutation of the Alström syndrome 1 (ALMS1) gene. It is a multisystemic disorder characterized by insulin resistance, childhood obesity, cardiomyopathy, progressive hepatic and renal failure, sensorineural hearing loss and retinal degeneration. Herein, we aimed to report a novel variant in ALMS1 gene causing AS in a patient presenting with visual impairment. METHODS: Case report...
April 1, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38569172/en-face-depth-resolved-octa-monitoring-of-macular-outer-retinal-deposits-in-a-case-of-multifocal-choroiditis-mimicking-syphilitic-uveitis
#4
JOURNAL ARTICLE
Christian Akotoye, Sandra Hoyek, Itika Garg, Nakul Singh, John B Miller, Lucia Sobrin, Nimesh A Patel
PURPOSE: Multifocal choroiditis (MFC) is a rare inflammatory condition characterized by retinal and choroidal lesions that may present similarly to ocular pathology of various etiologies. Here we present a case of MFC mimicking syphilitic uveitis with unique en face optical coherence tomography angiography (OCTA) imaging characteristics. METHODS: Case report. RESULTS: A 61-year-old woman presented with blurry vision, floaters and multiple whitish subretinal deposits on en face swept-source OCTA in the left eye...
March 27, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38569170/the-accumulative-effect-of-intravenous-prostaglandin-e1-over-nineteen-years-to-treat-the-ocular-ischemia-in-high-myopia-keywords-ocular-ischemia-high-myopia-prostaglandin-e1-pge1-extreme-choroidal-thinning-prostaglandin-e1-in-high-myopia
#5
JOURNAL ARTICLE
Robert Davis Steigerwalt
PURPOSE: The purpose of this paper is to present the clinical history of the use of intrarvenous (IV) prostaglandin E1(PGE1), a potent vasodilator of the peripheral vascular system, to treat the ischemia in high myopia. This was originally reported in 2009. METHODS: Three patients with high myopia and progressive visual loss were seen. They all had documented ocular ischemia and were placed under treatment with IV PGE1 for the ischemia. RESULTS: All 3 had central and peripheral visual improvement which initially lasted from 10-14 days after each treatment...
March 27, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38546400/scleral-fixation-of-the-smaller-incision-new-generation-implantable-miniature-telescope-sing-imt-%C3%A2-using-goretex-suture
#6
JOURNAL ARTICLE
Alfonso Savastano, Leonardo Andrea Sammarco, Giuseppe Francione, Paola Sasso, Stanislao Rizzo
PURPOSE: In this case report we describe a surgical technique for scleral fixation of the Smaller-Incision New-Generation Implantable Miniature Telescope (SING-IMT). Using this surgical technique, patient's eye which receive surgery for the SING-IMT, could still have a safe SING IMT implant despite the anatomical conditions of the capsular bag or in cases of intraoperative complications. METHODS: The surgery was performed at Policlinico A. Gemelli, Rome, Italy. The patient's eye underwent a first surgery for artificial intraocular lens (IOL) explant and SING-IMT implant at the same time...
March 22, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38478907/central-retinal-artery-occlusion-after-cardioversion-of-atrial-fibrillation
#7
JOURNAL ARTICLE
Lilia Lagha, Dimitrios Kalogeropoulos, Srinivas Goverdhan, Andrew J Lotery
Central retinal artery occlusion (CRAO) is a vascular ophthalmic emergency. Often caused by a sudden interruption of blood flow to the eye, with profound and painless vision loss, resulting in irreversible cell damage. An impacted embolus at the narrowest part of the central retinal artery is the most common cause. Cardioversion is a medical procedure used to restore a normal heart rhythm in individuals with atrial fibrillation (AF). In some cases, cardioversion can lead to thromboembolic complications. If an embolus reaches the central retinal artery, it can block the blood flow to the retina, resulting in CRAO and subsequent vision loss...
March 12, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38470933/co-occurring-usher-syndrome-type-1-and-renal-failure
#8
JOURNAL ARTICLE
Hong Le, Helen Anderson, Glydel Lopez, Julie Bayer-Vile, Hind Al-Saif, Natario Couser
PURPOSE: To describe a patient with a rare co-occurrence of Usher syndrome type 1C (USH1C) and renal disease, suspected to be secondary to Alport syndrome. METHOD: Case report and literature review of cases with Usher syndrome and renal failure. Clinical examination, color fundus photography, visual field tests, electroretinography and whole exome sequencing were used to diagnose and document the patient's clinical presentation. RESULTS: An 18-year-old female with known history of congenital hearing loss and chronic renal failure, presents with progressive night and peripheral visual impairment suspicious for an inherited retinal disease...
March 8, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38470931/a-novel-rlbp1-gene-mutation-associated-to-a-flecked-retina-syndrome
#9
JOURNAL ARTICLE
Mohamad Issa, Georges Sukkarieh, Sebastien Bruneau, Ramin Tadayoni
PURPOSE: To present an unusual fleck retina condition associated to a novel RLBP1 gene mutation.Methods/Results: A 25-year old male presented flecks on fundoscopic examination. Clinical presentation, multimodal imaging and ERG were compatible with the diagnosis of benign familial fleck retina. Genetic analysis detected an RLBP1 gene, a gene commonly associated with more severe retinal disease. CONCLUSION: Flecked retina syndromes and other genetic retinal diseases have a complex genotype-phenotype relation and need further research for their pathophysiology to be fully understood...
March 8, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38471081/nonsurgical-closure-of-full-thickness-macular-hole-under-topical-therapy-in-two-eyes-with-pathologic-myopia
#10
JOURNAL ARTICLE
Mana Miyata, Takashi Ueta, Shuichiro Aoki, Kohdai Kitamoto, Keiko Azuma, Ryo Obata
PURPOSE: Non-surgical closure of a full-thickness macular hole (FTMH) with eye drops has recently been reported, but there are few similar reports in cases with pathologic myopia. CASE PRESENTATION: (Case 1) The right eye of a 75-year-old female with an axial length of 28.83 mm had undergone anti-vascular endothelial growth factor (VEGF) treatment for choroidal neovascularization presented with FTMH. Topical betamethasone, bromfenac, and blinzolamide treatments were started, and the FTMH was closed with visual improvement (20/32 to 20/20) after 5 weeks...
March 6, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38452267/mound-like-epiretinal-material-its-short-term-changes-and-association-with-posterior-vitreous-detachment
#11
JOURNAL ARTICLE
Issei Tetsumura, Shuichiro Aoki, Tatsuya Inoue, Kohdai Kitamoto, Takahiro Arai, Keiko Azuma, Ryo Obata
PURPOSE: To describe clinical characteristics of a retinal finding termed mound-like epiretinal material (MOLEM), and distinguish it from epiretinal proliferation, a similar epiretinal finding previously described in various pathologies. METHODS: Five eyes from five patients were retrospectively identified from medical records. Clinical findings and images, including fundus photographs and optical coherence tomography (OCT), were reviewed. RESULTS: All eyes displayed mound-like material with uniform and low-to-moderate reflectivity on an otherwise intact retinal surface detected on OCT...
March 6, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38452261/pembrolizumab-related-bilateral-ocular-hypotony-associated-with-ciliary-detachments-and-macula-oedema-a-treatment-resistant-side-effect
#12
JOURNAL ARTICLE
Louise Bec, Charles Khouri, Christophe Chiquet
PURPOSE: To report of a case of bilateral ocular hypotony associated with ciliary detachments and macula edema as an uncommon troublesome side-effect of pembrolizumab (an immune checkpoint inhibitor) treatment. METHODS: A 56-year-old man with a history of metastatic axillary melanoma (bone, lung, spleen and lymph node lesions) treated with pembrolizumab complained of visual deterioration at his first-year anti-PD1 follow-up visit. Visual acuity in both eyes was 20/32...
March 6, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38452245/a-rare-presentation-of-nocardia-choroidal-abscess-after-glioblastoma-surgery
#13
JOURNAL ARTICLE
Giacomo Visioli, Alessandro Beccia, Luca Lucchino, Davide Mastromarino, Maria Pia Pirraglia
PURPOSE: to report the natural history of a rare ocular manifestation of endogenous Nocardia farcinica infection in an immunocompromised patient, with involvement observed in both the anterior and posterior segments of the eye. METHODS AND RESULTS: Given the patient's limited mobility, a handheld fundus camera was utilized for bedside anterior segment and ocular fundus examinations. The findings included visual acuity of hand motion, posterior synechiae, vitreal opacity, and a large choroidal abscess...
March 6, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38447053/boucher-neuhauser-syndrome-chorioretinal-changes-in-a-single-case-over-time
#14
JOURNAL ARTICLE
Jennifer O Adeghate, Jerome Sherman, Sherry Bass, James Liu, Robert B Hufnagel, Lawrence A Yannuzzi
To describe chorioretinal changes in a single case of Boucher-Neuhauser Syndrome (BNHS) over 45 years of follow-up. Methods: Retrospective chart review was performed. Color fundus photography from 1977 to 2003 was obtained and digitized. Current fundus photography was obtained with widefield imaging. High-resolution spectral-domain optical coherence tomography (OCT) was performed. Genetic analysis was performed using an inherited retinal disorders panel. Results: Fundus examination demonstrated central chorioretinal atrophy with sclerotic choroidal vessels...
March 6, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38447130/retinal-vasculitis-in-a-patient-with-hansen-s-disease
#15
JOURNAL ARTICLE
Shravan V Savant, Sarkis H Soukiasian, Richard F Spaide, Kendra A Klein-Mascia
PURPOSE: Hansen's disease is endemic in over 140 countries worldwide and a potentially blinding condition. We describe a case of retinal vasculitis in a patient with Hansen's disease with concomitant positive antiphospholipid antibody serology, a potentially under-reported complication in this setting. METHODS: A 37-year-old Brazilian man systemically stable on triple therapy (clofazimine, rifampin, dapsone) for Hansen's disease presented for a comprehensive ophthalmic evaluation...
March 4, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38437821/bilateral-choroidal-detachments-following-novel-car-t-cell-immunotherapy-regimen
#16
JOURNAL ARTICLE
Timothy J Goblirsch, Vincent Huang, Albert Maguire, Apoorv P Chebolu
PURPOSE: To describe a vision-threatening adverse event of a novel CAR T-cell immunotherapy for metastatic prostate cancer. METHODS: Observational Case Report. PATIENT: 77-year-old male with history of metastatic prostate cancer and pulmonary embolism enrolled in a clinical trial investigating the use of CAR T-cell immunotherapy for treatment of metastatic prostate cancer presented with a subjective left temporal visual disturbance. RESULTS: The patient was found to have bilateral extensive choroidal detachments on examination...
March 4, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38437813/severe-recurrence-and-retinal-inflammatory-infiltration-after-cessation-of-immunosuppression-for-multifocal-choroiditis-and-panuveitis
#17
JOURNAL ARTICLE
Jeannette Ossewaarde-van Norel, Richard F Spaide
PURPOSE: To describe a severe recurrence of intraocular inflammation following the cessation of immunosuppression, previously administered for multifocal choroiditis and panuveitis (MCP). METHODS: Retrospective chart review. RESULTS: A 27-year-old woman with MCP initially was treated with intravenous and oral corticosteroids and photodynamic therapy because of an active macular neovascularization in both eyes. Mycophenolate was soon started and the recurrences during tapering of the oral corticosteroids in the first months were treated with periocular corticosteroids and anti-vascular endothelial growth factor injections as they became available...
March 4, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38437797/a-case-of-rhegmatogenous-retinal-detachment-in-chronic-myeloid-leukemia
#18
JOURNAL ARTICLE
Nenita Maganti, Gordon S Crabtree, Jonathan S Chang, Kathleen R Schildroth
PURPOSE: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by uncontrolled proliferation of granulocytes, caused the BCR-ABL1 fusion gene. While ocular manifestations of CML are rare, the presentations can range from asymptomatic to sudden vision loss. CML associated ocular findings that have been reported include retinal hemorrhages, leukemic infiltrates, and optic disc edema, but a rhegmatogenous retinal detachment (RRD) in the setting of CML has not been described...
March 4, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38437796/shwachman-diamond-syndrome-associated-with-rod-cone-dystrophy
#19
JOURNAL ARTICLE
Jingwen Zhang, Thales A C de Guimaraes, Dorothy Thompson, Michel Michaelides
PURPOSE: To report a patient with Shwachman-Diamond syndrome and concomitant rod-cone dystrophy who underwent bone marrow transplantation. METHODS: Retrospective single case report. RESULTS: A female patient with Shwachman-Diamond syndrome was referred to a tertiary hospital to investigate possible pigmentary retinopathy at the age of 16. She described poor night vision and was found to have reduced visual acuity (6/20 right, 6/38 left). Over the ten-year follow-up period, her visual acuity remained relatively stable with no new visual symptoms...
March 4, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38437795/rahnella-aquatilis-endophthalmitis-after-intravitreal-injection-in-an-immunocompetent-patient
#20
JOURNAL ARTICLE
Parker J Williams, Gilbert Xue, Bing X Ross, Erika White, Lisa Shammas, Pradeepa Yoganathan, Christopher Chapman, Xihui Lin
PURPOSE: To present a novel case of exogenous Rahnella aquatilis endophthalmitis following an intravitreal injection. METHODS: Case report. RESULTS: A 74-year-old male presented with acute progressive vision loss and pain in the left eye, 5 days after an intravitreal injection for diabetic macular edema. The patient was diagnosed with exogenous endophthalmitis and empirically treated with intravitreal injections of vancomycin and ceftazidime as well as topical and oral ciprofloxacin...
March 4, 2024: Retinal Cases & Brief Reports
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