We have located links that may give you full text access.
The antioxidant and anti-inflammatory effects of astaxanthin supplementation on the expression of miR-146a and miR-126 in patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled clinical trial.
International Journal of Clinical Practice 2021 January 15
BACKGROUND: The pathogenesis of type 2 diabetes mellitus (T2DM) is associated with chronic oxidative stress and inflammation. It is well known that the expression of some miRNAs such as miRNA-146a is upregulated in diabetic and hyperglycemic patients, whereas circulating miRNA-126 is reduced. Therefore, we aimed to determine the effects of astaxanthin (AST) supplementation on the circulating malondialdehyde (MDA) and interleukin 6 (IL-6) levels, and the expression of miR-146a and miR-126 in patients with T2DM.
METHODS: This randomized, double-blind, placebo-controlled clinical trial was conducted on 44 patients with T2DM randomly receiving 8 mg/day of oral AST (n=22) or placebo (n=22) for eight weeks.
RESULTS: We observed that AST supplementation could decrease plasma levels of MDA and IL-6 (P < 0.05) and decrease the expression level of miR-146a over time (fold change: -1/388) (P < 0.05).
CONCLUSION: AST supplementation might be beneficial for improving circulating MDA and IL-6 and the down-regulation of miR-146a. However, future investigations are suggested to confirm these results.
METHODS: This randomized, double-blind, placebo-controlled clinical trial was conducted on 44 patients with T2DM randomly receiving 8 mg/day of oral AST (n=22) or placebo (n=22) for eight weeks.
RESULTS: We observed that AST supplementation could decrease plasma levels of MDA and IL-6 (P < 0.05) and decrease the expression level of miR-146a over time (fold change: -1/388) (P < 0.05).
CONCLUSION: AST supplementation might be beneficial for improving circulating MDA and IL-6 and the down-regulation of miR-146a. However, future investigations are suggested to confirm these results.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app