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Journals International Journal of Clini...

International Journal of Clinical Practice

https://read.qxmd.com/read/38529258/knowledge-and-awareness-of-osteoporosis-a-survey-of-physical-therapy-providers-in-saudi-arabia
#1
JOURNAL ARTICLE
Muataz Almaddah, Fahad Alzahrani, RiziqAllah Gaowgzeh, Abdullah Alqarni, Rani Othman, Afnan Gmmash
BACKGROUND: Osteoporosis "OP" is classified as one of the most serious health conditions worldwide. OP increases the skeletal fracture risk by 35%, particularly at hip, spine, and wrist joints. Healthcare professionals should be aware of OP clinical signs and have good knowledge while managing all patients. OBJECTIVES: This study aims to investigate the current level of osteoporosis knowledge and awareness among physical therapy providers in Saudi Arabia. METHODS: One hundred and sixty-eight physical therapy providers participated in this cross-sectional electronic survey from February to July of 2021...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38510561/efficacy-and-safety-of-pericapsular-nerve-group-block-for-hip-fracture-surgery-under-spinal-anesthesia-a-meta-analysis
#2
JOURNAL ARTICLE
Shukai Li, Jing An, Chengyu Qian, Zhixue Wang
OBJECTIVE: To evaluate the effectiveness and safety of pericapsular nerve group (PENG) block for hip fracture surgery under spinal anesthesia. METHODS: This meta-analysis was registered on INPLASY (INPLASY202270005). PubMed, Embase, Cochrane, CNKI, and Wanfang databases were searched to collect the randomized controlled trials of the PENG block applied to hip fracture surgery in the setting of spinal anesthesia, with the search period from inception to 1 May 2023...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38505696/the-role-of-pharmaceutical-innovation-in-clinical-practice-guidelines-for-chronic-diseases
#3
JOURNAL ARTICLE
Meaghan Roach, Natalie Land, Jennifer Hernandez, Reina Rau, Jacquelyn W Chou, Stacey S Hickson, Danielle F Rollmann, J Ross Maclean
BACKGROUND: Over the last 25 years, clinical practice guidelines have emerged as a means to standardize and improve care. As pharmaceutical innovations develop, guidelines are updated to incorporate new interventions. However, the extent to which pharmacotherapies are represented as treatment options in guideline recommendations has not been well elucidated. This study aimed to quantify the role pharmacotherapy has played in clinical practice guidelines across a range of chronic diseases over the past 20 years...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38505695/blood-features-associated-with-viral-infection-severity-an-experience-from-covid-19-pandemic-patients-hospitalized-in-the-center-of-iran-yazd
#4
JOURNAL ARTICLE
Fatemeh Sadeghi-Nodoushan, Mohamad Reza Zare-Khormizi, Seyedhossein Hekmatimoghaddam, Fatemeh Pourrajab
Pandemics such as coronavirus disease 2019 (COVID-19) can manifest as systemic infections that affect multiple organs and show laboratory manifestations. We aimed to analyze laboratory findings to understand possible mechanisms of organ dysfunction and risk stratification of hospitalized patients in these epidemics. Methods . This retrospective study was conducted among patients admitted to COVID-19 referral treatment center, Shahid Sadoughi Hospital, Yazd, Iran, from April 21 to November 21, 2021. It was the fifth peak of COVID-19 in Iran, and Delta (VOC-21APR-02; B...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38495751/genetically-engineered-microorganisms-and-their-impact-on-human-health
#5
REVIEW
Marzie Mahdizade Ari, Leila Dadgar, Zahra Elahi, Roya Ghanavati, Behrouz Taheri
The emergence of antibiotic-resistant strains, the decreased effectiveness of conventional therapies, and the side effects have led researchers to seek a safer, more cost-effective, patient-friendly, and effective method that does not develop antibiotic resistance. With progress in synthetic biology and genetic engineering, genetically engineered microorganisms effective in treatment, prophylaxis, drug delivery, and diagnosis have been developed. The present study reviews the types of genetically engineered bacteria and phages, their impacts on diseases, cancer, and metabolic and inflammatory disorders, the biosynthesis of these modified strains, the route of administration, and their effects on the environment...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38495750/tumour-recurrence-depth-of-invasion-and-temple-location-as-independent-prognostic-parameters-of-lymph-node-metastases-of-head-and-neck-cutaneous-squamous-cell-carcinomas
#6
JOURNAL ARTICLE
Zuzana Horakova, Ivo Starek, Jana Zapletalova, Richard Salzman
The excellent survival rate of cutaneous squamous cell carcinoma (cSCC) exceeding 90% is reduced by the presence of nodal metastases by over 50%. We analysed various risk parameters of cSCC to predict the incidence of nodal metastases. A total of 118 patients with the head cSCC were included in a single-institution retrospective study covering the period from 2008 to 2020. Tumour recurrence, temple location, and tumour infiltration depth were found to be independent predictors of nodal metastases (increasing the probability of metastases by 8...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38481823/pharmacokinetics-safety-and-tolerability-of-tenapanor-in-healthy-chinese-and-caucasian-volunteers-a-randomized-open-label-single-center-placebo-controlled-phase-1-study
#7
JOURNAL ARTICLE
Gang Yuan, Yili Chen, Li Li, Xin Wang, Gang Wei, Jiawei Zeng, Ai-Min Hui, Yueyun Jiang, Han Zhao, Lei Diao, Yongchun Zhou, Yinglian Xiao, Minhu Chen
BACKGROUND: Tenapanor is a locally acting selective sodium-hydrogen exchanger 3 inhibitor with the potential to treat sodium/phosphorus and fluid overload in various cardiac-renal diseases, which has been approved for constipation-predominant irritable bowel syndrome in the US. The pharmacokinetics (PK) of tenapanor and its metabolite tenapanor-M1 (AZ13792925), as well as the safety and tolerability of tenapanor, were investigated in healthy Chinese and Caucasian subjects. METHODS: This randomized, open-label, single-center, placebo-controlled phase 1 study (https://www...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38469171/the-effect-of-a-combination-of-vibration-and-external-cold-on-pain-caused-during-vaccine-injection-in-infants-a-randomized-clinical-trial
#8
JOURNAL ARTICLE
Zahra Unesi, Zahra Amouzeshi, Javad Jamavar, Fatemeh Mahmoudzadeh Zarandi
AIM: This study was conducted to determine the effect of combining vibration and external cold on pain caused by vaccine injection among six-month-old infants. DESIGN: Randomized controlled trial. METHODS: In this clinical trial, 80 eligible infants were selected from the infants referred to a health center as per the inclusion criteria. The infants were assigned to either a control group or an intervention group by block randomization. In the intervention group, a vibrating and cold device was placed above the injection site from one minute before to 15 seconds after the pentavalent vaccine injection...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38454935/a-nomogram-to-predict-benign-malignant-mediastinal-lymph-nodes-based-on-ebus-sonographic-features
#9
JOURNAL ARTICLE
Bingchao Ling, Weishun Xie, Yi Zhong, Taowen Feng, Yueli Huang, Lianying Ge, Aiqun Liu
BACKGROUND: Endobronchial ultrasound (EBUS) sonographic features help identify benign/malignant lymph nodes while conducting transbronchial needle aspiration (TBNA). This study aims to identify risk factors for malignancy based on EBUS sonographic features and to estimate the risk of malignancy in lymph nodes by constructing a nomogram. METHODS: 1082 lymph nodes from 625 patients were randomly enrolled in training ( n  = 760) and validation ( n  = 322) sets...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38450292/cocktail-of-ropivacaine-morphine-and-diprospan-reduces-pain-and-prolongs-analgesic-effects-after-total-knee-arthroplasty-a-prospective-randomized-controlled-trial
#10
JOURNAL ARTICLE
Zhenyu Luo, Weinan Zeng, Xi Chen, Qiang Xiao, Anjing Chen, Jiali Chen, Haoyang Wang, Zongke Zhou
BACKGROUND: Local infiltration analgesia (LIA) provides postoperative analgesia for total knee arthroplasty (TKA). The purpose of this study was to evaluate the analgesic effect of a cocktail of ropivacaine, morphine, and Diprospan for TKA. METHODS: A total of 100 patients from September 2018 to February 2019 were randomized into 2 groups. Group A (control group, 50 patients) received LIA of ropivacaine alone (80 ml, 0.25% ropivacaine). Group B (LIA group, 50 patients) received an LIA cocktail of ropivacaine, morphine, and Diprospan (80 ml, 0...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38420595/unveiling-the-influence-of-the-curve-of-spee-on-bite-force-and-chewing-ability-a-comparative-study
#11
JOURNAL ARTICLE
Zainab Ali Alkhalaf, Mohammed Ghazi Sghaireen, Kiran Kumar Ganji, Mohammad Khursheed Alam, Rakhi Issrani, Raghad Mohammed Alsaleh, Sultana Zamil Almegren, Mahmoud Gamal Salloum
AIM: To investigate the impact of the curve of Spee (CS) accentuation on bite force, chewing ability, and additionally, other factors that influence chewing ability and bite force such as restorations, caries, gender, habits, and TMJ problems. MATERIALS AND METHODS: 231 participants (118 male and 113 female, mean age = ±27.96 years) were recruited for this cross-section study. Participants completed a data collection sheet in which age, gender, Angle's classification of malocclusion, overjet, overbite, TMJ problems, habits, restorations, and caries experience were recorded...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38414580/takotsubo-cardiomyopathy-and-autoimmune-disorders-a-systematic-scoping-review-of-published-cases
#12
REVIEW
Mohsen Farjoud Kouhanjani, Seyed Ali Hosseini, Seyedeh Maryam Mousavi, Zahra Noroozi, Paniz Sadeghi, Armita Jokar-Derisi, Mohammad Saleh Jamshidi Mouselou, Meysam Ahmadi, Armin Attar
INTRODUCTION: Takotsubo cardiomyopathy (TCM) features transient left ventricular apical dysfunction or ballooning. The underlying mechanism remains elusive; however, evidence suggests the role of different physical and psychological stressors. We systematically reviewed patients presenting with TCM and autoimmunity to explore the link between the two conditions. METHODS: We applied the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) to report this review...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38410673/parotid-gland-metastases-of-cutaneous-squamous-cell-carcinoma-of-the-head-occult-metastases-occurrence-and-their-late-manifestation
#13
JOURNAL ARTICLE
Zuzana Horakova, Ivo Starek, Jana Zapletalova, Richard Salzman
Cutaneous squamous cell carcinomas (cSCC) are malignant tumours with excellent prognosis unless nodal metastases develop. The aim of our study is to determine the prognostic significance of the clinical stage of parotid gland metastases and the incidence of occult cervical lymph node involvement in cSCC of the head. Our retrospective analysis includes 39 patients with cSCC parotid gland metastases, 15 of whom had concurrent cervical node involvement. In 32 patients, the lymph nodes manifested at stage N3b. A total of 26 patients were treated with parotidectomy, 9 patients received radiotherapy alone, and 4 received symptomatic therapy...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38390376/percutaneous-coronary-intervention-with-procedural-unfractionated-heparin-without-activated-clotting-time-guidance-a-unique-opportunity-to-assess-thrombotic-and-bleeding-events
#14
JOURNAL ARTICLE
Ali Z Zgheib, Jennifer Jdaidani, Elie Akl, Suzan Khalil, Omar Chaabo, Nicolo Piazza, Fadi J Sawaya, Abdallah G Rebeiz
BACKGROUND: Rates of major bleeding and intraprocedural thrombotic events (IPTE) in the setting of percutaneous coronary intervention (PCI) using weight-adjusted unfractionated heparin (UFH) without activated clotting time (ACT) monitoring are not known. METHODS: We reviewed 2,748 consecutive patients who underwent coronary angiography at our tertiary care university hospital between January 2017 and December 2020. All patients who underwent PCI with weight-adjusted UFH without ACT guidance were considered for further analysis...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38380128/a-psychometric-study-of-the-student-evidence-based-practice-scale-s-ebpq-arabic-version-for-use-among-undergraduate-nursing-students
#15
JOURNAL ARTICLE
Basmah F Alharbi
BACKGROUND: Previous studies have demonstrated the significance of evidence-based practice in improving patient care and outcomes. Therefore, integrating evidence-based practice into the health professions' education curriculum has become a pedagogical priority. However, there is a lack of reliable and valid scales to measure students' evidence-based practice usage, attitudes, knowledge, and skills in Arab countries. AIM: This study aims to examine the adapted Student Evidence-Based Practice Scale Questionnaire (S-EBPQ) validity at logical statistical level and reliability for use among students in Arabic context...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38375028/comparison-of-efficacy-and-safety-of-first-line-treatment-options-for-unresectable-stage-iii-non-small-cell-lung-cancer-a-retrospective-analysis
#16
JOURNAL ARTICLE
Luqing Zhao, Zhiting Zhao, Xiaoqi Yan, Fei Wu, Ning Sun, Renhong Guo, Shaorong Yu, Xiao Hu, Jifeng Feng
BACKGROUND: Based on PACIFIC trial, durvalumab as consolidation therapy following concurrent chemoradiotherapy (cCRT) has been a new standard treatment for unresectable stage III non-small cell lung cancer (NSCLC). In clinical applications, there are heterogeneous adjustments or novel strategies following specialized discussions in experienced multidisciplinary teams. This study retrospectively compared the efficacy and safety of different first-line treatments for unresectable stage III NSCLC...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38352962/network-pharmacology-analysis-of-the-therapeutic-potential-of-colchicine-in-acute-lung-injury
#17
JOURNAL ARTICLE
Fei Sun, Lijuan Zhang, Lulu Shen, Chunman Wang
BACKGROUND: This study employed integrated network pharmacology approach to explore the mechanisms underlying the protective effect of colchicine against acute lung injury (ALI). METHODS: We analyzed the expression profiles from 13 patients with sepsis-related ALI and 21 controls to identify differentially expressed genes and key modules. ALI-related genes were curated using databases such as DisGeNET, Therapeutic Target, and Comparative Toxicogenomics Database to curate ALI-related genes...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38344141/effects-of-different-inspiratory-muscle-training-protocols-on-exercise-capacity-respiratory-muscle-strength-and-health-related-quality-of-life-in-patients-with-hypertension
#18
JOURNAL ARTICLE
İrem Hüzmeli, Nihan Katayıfçı, Fatih Yalçın, Esra Doğru Hüzmeli
AIM: This study aimed to explore how varying inspiratory muscle training workloads affect exercise capacity, health-related quality of life (HrQoL), depression, peripheral and respiratory muscle strength, pulmonary function, dyspnea, fatigue, and physical activity levels in hypertension (HT) patients. METHODS: A randomized, controlled three-arm study. Forty-five patients (58.37 ± 8.53 y, 7F/38M) with HT received IMT (7 days/8 weeks) by POWERbreathe® Classic LR device and were randomized to control group (CG, 10% maximal inspiratory pressure (MIP), n : 15), low-load group (LLG, 30% MIP), and high-load group (HLG, %50 MIP)...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38328797/community-pharmacists-knowledge-and-perception-towards-telepharmacy-services-and-willingness-to-practice-it-in-light-of-covid-19
#19
JOURNAL ARTICLE
Ayesha Siddiqua, Soha Makki, Sazada Siddiqui, Randa A Abdelkarim, Tahani Jubran, Wejdan Nwar, Ahlam Alqahtani, Maryam Alshehri, Maram Saeed, Arwa Khaled
BACKGROUND: During the COVID-19 pandemic, there was increased adoption of telepharmacy, which has proven benefits. This study was conducted to assess the knowledge and perception of the community pharmacists of Aseer region, Saudi Arabia, towards telepharmacy services and evaluate their willingness to adopt telepharmacy in clinical practice during the COVID-19 pandemic. MATERIALS AND METHODS: A cross-sectional study was conducted using an online self-administered structured anonymous questionnaire on the community pharmacists of Aseer region, Saudi Arabia...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38322113/gpx3-mediated-oxidative-stress-affects-pyrimidine-metabolism-levels-in-stomach-adenocarcinoma-via-the-ampk-mtor-pathway
#20
JOURNAL ARTICLE
Yaowen Zhang, Yixin Yang, Shanshan Kuang, Yang Zhang, Hancheng Qin, Jisheng Xie
BACKGROUND: Amino acid metabolism, including ATP production, nucleotide synthesis, and redox homeostatic processes, are associated with proliferation and differentiation of tumor cells. This study aimed to identify novel prognostic biomarkers and potential therapeutic targets of amino acid metabolism-related genes for stomach adenocarcinoma (STAD). METHODS: RNA sequencing transcriptome data in the TCGA-STAD (training set) and GTEx datasets (validation set) were used...
2024: International Journal of Clinical Practice
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