Packing procedure effective for liver transplantation in hemophilic patients with HIV/HCV coinfection

Susumu Eguchi, Akihiko Soyama, Takanobu Hara, Masaaki Hidaka, Shinichiro Ono, Tomohiko Adachi, Takashi Hamada, Tota Kugiyama, Sinichiro Ito, Kengo Kanetaka, Takuji Maekawa, Motohiro Sekino, Tetsuya Hara, Kazuhiro Nagai, Yasushi Miyazaki
Surgery Today 2020 June 22
We herein report an effective procedure for liver transplantation (LT) for severe cirrhotic patients with hemophilia. Three hemophilic patients suffering from liver cirrhosis due to human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfection underwent deceased donor LT in our institute. Basic clotting parameters were measured and evaluated during LT to determine the optimal packing procedure. All patients were treated with a gauze packing procedure to ensure stable hemostasis in relation to hemophilia during the peri-transplant period. The graft function of all patients recovered well upon gauze removal (depacking) procedure and the patients were finally discharged to home. The administration of clotting factor was discontinued on day 3 after deceased donor LT. No infectious complications occurred in any of the 3 patients. This technique could be an option for achieving successful LT in these patients. Cooperation between transplant surgeons and anesthesiologists can make this challenging operation possible.

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