Nobuaki Suzuki, Yoshitaro Shindo, Masao Nakajima, Ryouichi Tsunedomi, Hiroaki Nagano
Recent advances in tumor immunology and molecular drug development have ushered in a new era of cancer immunotherapy. Immunotherapy has shown promising results for several types of tumors, such as advanced melanoma, non-small cell lung cancer, renal cell carcinoma, bladder cancers, and refractory Hodgkin's lymphoma. Similarly, efforts have been made to develop immunotherapies such as adoptive T-cell transplantation, peptide vaccines, and dendritic cell vaccines, specifically for gastrointestinal tumors. However, before the advent of immune checkpoint inhibitors, immunotherapy did not work as well as expected...
December 3, 2023: Surgery Today
(no author information available yet)
No abstract text is available yet for this article.
November 29, 2023: Surgery Today
Assanee Tongyoo, Tuadpong Thangthong, Aekkaphod Liwattanakun, Ekkapak Sriussadaporn, Palin Limpavitayaporn, Chatchai Mingmalairak
PURPOSE: Nasogastric tube (NGT) insertion can be painful and distressing for the patient. Lidocaine nasal drops might be effective as a local anesthetic agent before the procedure. This study aimed to compare the effects of Lidocaine nasal drops versus placebo drops for reducing the discomfort of this procedure. METHODS: Patients indicated for NGT insertion were categorized into two groups randomly. The Lidocaine group had 2% Lidocaine instilled nasally 3 min before the procedure and the control group had normal saline drops instilled...
November 22, 2023: Surgery Today
Kota Sugiura, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Koji Shibata, Norihiro Yuasa, Masahiko Fujino
PURPOSE: Despite their similar clinical characteristics, appendiceal diverticulitis (AD) and acute appendicitis (AA) are pathologically distinct. This study compared the clinical features of AD and AA and identified relevant risk factors. METHODS: Patients who underwent appendectomy with a preoperative diagnosis of either AD or AA were categorized based on histopathological findings. The two groups were compared in terms of various clinical factors. RESULTS: Among the 854 patients included in the study, a histopathological evaluation revealed 49 and 805 cases of AD and AA, respectively...
November 21, 2023: Surgery Today
Yuuki Matsui, Takashi Kanou, Eriko Fukui, Toru Kimura, Naoko Ose, Soichiro Funaki, Yasushi Shintani
PURPOSES: Some predictive markers of death have been reported for patients on the waiting list for lung transplantation (LTx). We assessed whether or not the preoperative psoas muscle index (PMI) correlates with waitlist mortality. METHODS: In 81 patients with end-stage lung disease on the waiting list for LTx between 2011 and 2020 at Osaka University Hospital, we examined the association between baseline characteristics, including the diagnosis, respiratory function test results, blood collection items, steroid use, and psoas muscle mass on computed tomography, and survival during the waiting period using Kaplan-Meier curves and Cox proportional hazard regression models...
November 20, 2023: Surgery Today
Hiroyuki Yamamoto, Atsushi Nashimoto, Isao Miyashiro, Hiroaki Miyata, Yasushi Toh, Mitsukazu Gotoh, Yasuhiro Kodera, Yoshihiro Kakeji, Yasuyuki Seto
PURPOSE: The relationship between board certification, clinical guideline implementation, and quality of gastric cancer surgery remains unclear. METHODS: A web-based questionnaire survey was administered to departments registered in the National Clinical Database (NCD) of Japan between October 2014 and January 2015. Quality indicators (QIs) based on the Donabedian model were evaluated. Structural QIs (e.g., affiliations with academic societies and board certifications) and process QIs (adherence to clinical practice guidelines for gastric cancer) were assessed using risk-adjusted odds ratios (AORs) for surgical mortality...
November 18, 2023: Surgery Today
Akira Umemura, Akira Sasaki, Toshinari Takamura, Hiroaki Takayama, Yumie Takeshita, Yosuke Toya, Keisuke Kakisaka, Yutaka Hasegawa, Yasushi Ishigaki
PURPOSE: To clarify the relationships between the changes in hepatokines and weight loss, and between these changes and the metabolic effects, and the roles played by these changes, after laparoscopic sleeve gastrectomy (LSG). METHODS: We recruited 25 Japanese patients with severe obesity, who underwent LSG. We measured two hepatokines: selenoprotein P (SeP) and leukocyte cell-derived chemotaxin 2 (LECT2), at the baseline, and then 6 months and 1 year after LSG...
November 13, 2023: Surgery Today
Dai Yamanouchi
This study evaluated the safety and efficacy of a novel endovascular thrombectomy device in a swine model of deep vein thrombosis (DVT). The device has an over-the-wire configuration, a manually expandable catching basket, a funnel sheath with a covered stent to minimize the risk of microembolization, and an integrated delivery system. DVT was induced by occluding the right iliac vein with a balloon catheter and injecting thrombin. The novel device was inserted into the inferior vena cava through the right jugular vein access...
November 8, 2023: Surgery Today
Yukio Sato, Hiroyuki Yamamoto, Norihiko Ikeda, Hiroshi Konishi, Taizo Hibi, Shunsuke Endo, Masayoshi Inoue, Yoshinori Okada, Yashushi Shintani, Shinichi Toyooka, Hiroshige Nakamura, Yasushi Hoshikawa, Toyofumi Fengshi Chen-Yoshikawa, Hidetaka Uramoto, Yoshihiro Tsubochi, Tadao Kakizoe, Masayuki Chida, Ichiro Yoshino
PURPOSE: The current study was designed to analyze the impact of the COVID-19 pandemic on general thoracic surgeries in Japan. METHODS: Changes in surgeries for lung cancer and metastatic lung tumors were evaluated based on National Clinical Database data regarding cancer screening. RESULTS: In 2021, surgeries for primary lung cancer increased by 3.4% compared to 2020, which, given the increase from 2014 to 2019, indicates an overall 11.1% decrease...
November 7, 2023: Surgery Today
Shun Onishi, Genshiro Esumi, Masahiro Fukuhara, Tomoe Sato, Tomoko Izaki, Satoshi Ieiri, Noritoshi Handa
PURPOSE: To assess the long-term cosmetic outcomes of the "slit-slide procedure", designed to provide a more natural appearance for umbilical hernia repair, as perceived by the patients and their parents. METHODS: A total of 149 patients with umbilical hernia underwent the slit-slide procedure at our hospital. The slit-slide procedure allows for the creation of an umbilicus with a more natural and integrated appearance. The patient satisfaction survey questionnaire was mailed to the families (n = 139), and there were 74 (53...
November 7, 2023: Surgery Today
Takeshi Matsunaga, Kenji Suzuki, Aritoshi Hattori, Mariko Fukui, Kazuya Takamochi
PURPOSE: Bronchopleural fistula (BPF) is a lethal complication, even in the modern era. Therefore, we investigated the details of patients with BPF to select an appropriate surgical strategy. METHODS: This retrospective study included 4794 consecutive patients who underwent anatomical pulmonary resection between 2008 and 2022. We evaluated the predictors of BPF using a multivariable analysis and investigated the mortality and clinical course after BPF in detail...
November 4, 2023: Surgery Today
Jesse Y Tajima, Ryoma Yokoi, Shigeru Kiyama, Takao Takahashi, Hirokata Hayashi, Toshiya Higashi, Masahiro Fukada, Ryuichi Asai, Yuta Sato, Itaru Yasufuku, Yoshihiro Tanaka, Naoki Okumura, Katsutoshi Murase, Takuma Ishihara, Nobuhisa Matsuhashi
PURPOSE: Robot-assisted surgery has a multi-joint function, which improves manipulation of the deep pelvic region and contributes significantly to perioperative safety. However, the superiority of robot-assisted surgery to laparoscopic surgery remains controversial. This study compared the short-term outcomes of laparoscopic and robot-assisted surgery for rectal tumors. METHODS: This single-center, retrospective study included 273 patients with rectal tumors who underwent surgery with anastomosis between 2017 and 2021...
November 1, 2023: Surgery Today
Kotaro Yamashita, Kota Momose, Koji Tanaka, Tomoki Makino, Takuro Saito, Kazuyoshi Yamamoto, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki
PURPOSE: To investigate the indications for neoadjuvant chemotherapy (NAC) in esophageal cancer patients aged 75 years or older. METHODS: We analyzed data, retrospectively, from 155 patients over 75 years old, who underwent esophagectomy for esophageal cancer between 2010 and 2020. Forty-one patients underwent upfront surgery (US group) and 114 were treated with NAC followed by surgery (NAC group). We compared the patient backgrounds and perioperative outcomes including prognosis, between the two groups...
October 31, 2023: Surgery Today
Imerio Angriman, Silvia Degasperi, Claudia Mescoli, Carmelo Lacognata, Claudia Armellin, Antonino Caruso, Federico Scognamiglio, Matteo Fassan, Renata D'Incà, Edoardo Savarino, Fabiana Zingone, Gaya Spolverato, Salvatore Pucciarelli, Romeo Bardini, Cesare Ruffolo, Marco Scarpa
PURPOSES: Stricture is a common complication of Crohn's disease (CD) and may be treated with bowel-sparing procedures. Our study analyzed what happens in terms of intestinal and systemic inflammation when the diseased bowel is left behind following surgery. METHODS: In this retrospective study, we enrolled 42 consecutive patients who underwent strictureplasty (alone or with resection) for stricturing CD. Control patients who underwent complete diseased bowel resection were identified and propensity score-matched for the sex, age, and history of abdominal surgery...
October 26, 2023: Surgery Today
Ryo Karita, Hidemi Suzuki, Yuki Onozato, Taisuke Kaiho, Terunaga Inage, Takamasa Ito, Kazuhisa Tanaka, Yuichi Sakairi, Ichiro Yoshino
No abstract text is available yet for this article.
October 25, 2023: Surgery Today
Yoshifumi Shimada, Toshihiro Ojima, Yutaka Takaoka, Aki Sugano, Yoshiaki Someya, Kenichi Hirabayashi, Takahiro Homma, Naoya Kitamura, Yushi Akemoto, Keitaro Tanabe, Fumitaka Sato, Naoki Yoshimura, Tomoshi Tsuchiya
PURPOSE: To develop deep learning models using thoracoscopic images to identify visceral pleural invasion (VPI) in patients with clinical stage I lung adenocarcinoma, and to verify if these models can be applied clinically. METHODS: Two deep learning models, one based on a convolutional neural network (CNN) and the other based on a vision transformer (ViT), were applied and trained via 463 images (VPI negative: 269 images, VPI positive: 194 images) captured from surgical videos of 81 patients...
October 20, 2023: Surgery Today
Mehmet Velidedeoglu, Veysel Umman, Fahrettin Kilic, Varol Celik, Ertugrul Gazioglu, Engin Hatipoglu, Tulin Ozturk, Birgul Mete
No abstract text is available yet for this article.
October 18, 2023: Surgery Today
Yousuke Gohda, Kazuki Yokota, Hiroo Uchida, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Satoshi Makita, Aitaro Takimoto, Shunya Takada, Yoichi Nakagawa, Takuya Maeda, Yaohui Guo, Akinari Hinoki
PURPOSE: The optimal surgical approach for recurrent congenital diaphragmatic hernia (CDH) remains controversial. We compared the surgical outcomes of a thoracoscopic approach versus an open abdominal approach for recurrent CDH after initial abdominal open repair. METHOD: The subjects of this comparative study were patients who underwent open abdominal or thoracoscopic surgery for recurrent CDH following an initial open abdominal repair. RESULTS: Among 166 patients with Bochdalek-type CDH, 15 underwent reoperation for recurrent CDH following an open abdominal repair...
October 13, 2023: Surgery Today
Ryo Oikawa, Kyoji Ito, Nobuyuki Takemura, Fuminori Mihara, Norihiro Kokudo
There are few reports on duct-to-duct biliary reconstruction for complex liver resection with limited bile duct resection. We performed duct-to-duct biliary reconstruction in two patients undergoing limited bile duct resection where Roux-en-Y hepaticojejunostomy (HJ) was difficult. An external biliary drainage tube was placed routinely at the anastomotic site to prevent stenosis. In case 1, the tumor-infiltrated part of the left hepatic duct (LHD) was resected and the LHD was repaired using duct-to-duct reconstruction with interrupted sutures...
October 10, 2023: Surgery Today
Hajime Ushigome, Hiroki Takahashi, Shinnosuke Harata, Yoshiaki Fujii, Kaori Watanabe, Takeshi Yanagita, Takuya Suzuki, Kazuyoshi Shiga, Ryo Ogawa, Yoichi Matsuo, Akira Mitsui, Masahiro Kimura, Shuji Takiguchi
It has been pointed out that robotic surgery is more time-consuming than laparoscopic surgery, and a major challenge for the future is educating young surgeons while maintaining the surgical quality. To solve these problems, we report a role-sharing surgery (RSS) approach in which the surgery is divided into several areas and timetabled, with roles shared by several operators. We performed RSS for 19 standard colorectal cancer surgeries. The surgery was completed within + 28 min of the scheduled operation time, and a beginner robotic surgeon (BRS) was able to perform approximately 66% of the total surgery...
September 30, 2023: Surgery Today
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