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Is mitochondrial dysfunction a common root of noncommunicable chronic diseases?

Alexis Diaz-Vegas, Pablo Sanchez-Aguilera, James R Krycer, Pablo E Morales, Matías Monsalves-Alvarez, Mariana Cifuentes, Beverly A Rothermel, Sergio Lavandero
Endocrine Reviews 2020 March 16
32179913
Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss the role of mitochondria in maintaining cellular and whole-organism homeostasis, the mechanisms that promote mitochondrial dysfunction and the role of this phenomenon in noncommunicable chronic diseases. We also review the state of the art regarding the pre-clinical evidence associated with the regulation of the mitochondrial function and the development of current mitochondrial-targeted therapeutics to treat non communicable chronic diseases. Finally; we give an integrated vision of how the mitochondrial damage is implicated in these metabolic diseases.

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