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Significance of lncRNA MIR31HG in predicting the prognosis for Chinese patients with cancer: a meta-analysis.
Biomarkers in Medicine 2020 March 6
It is important to clarify the significance of long noncoding RNA MIR31 host gene (lncRNA MIR31HG ) in predicting the prognosis for malignant tumors through meta-analysis. Electronic databases were systemically searched, from inception until 2 January 2019, to identify related articles. Meanwhile, the hazard ratios (odds ratios) and 95% CIs were computed for exploring the association between the expression of lncRNA MIR31HG and the survival (pathological variables). Eleven studies with 1041 cases were enrolled into the current meta-analysis. Low expression of lncRNA MIR31HG showed correlation with the dismal overall survival, disease-free survival, high tumor stage and lymph node metastasis among patients with digestive system cancers. Low expression of lncRNA MIR31HG may serve as a potential novel factor to indicate the dismal prognosis and metastasis in patients with digestive system cancers.
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