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Biomarkers in Medicine

Yan Wang, Keke Liu, Qin Ma, Yongfei Tan, Wei Du, Yidan Lv, Yuan Tian, Hao Wang
AIM: Pancreatic cancer is one of the worst malignant tumors in prognosis. Therefore, to reduce the mortality rate of pancreatic cancer, early diagnosis and prompt treatment are particularly important. RESULTS: We put forward a new feature-selection method that was used to find clinical markers for pancreatic cancer by combination of Support Vector Machine Recursive Feature Elimination (SVM-RFE) and Large Margin Distribution Machine Recursive Feature Elimination (LDM-RFE) algorithms...
February 15, 2019: Biomarkers in Medicine
Wang Dazhi, Du Jing, Ren Chunling, Zhou Mi, Xia Zhixuan
AIM: To assess SLC6A6 expression in gastric cancer, its correlation with patients' clinicopathological features and survival, and the possible epigenetic regulation mechanism. METHODS: Expression profiles and methylation data were obtained from the Gene Expression Omnibus database and the Cancer Genome Atlas. The SLC6A6's protein level were obtained from the Human Protein Atlas. Correlations between SLC6A6 expression and clinicopathological features were assessed using the χ2 test, and survival by the Kaplan-Meier analysis...
February 15, 2019: Biomarkers in Medicine
Ozgul Duzgun, Inanc Samil Sarici
AIM: The difficulty of detecting lesions smaller than 1 cm in the preoperative period is still a continuing problem in peritoneal carcinomatosis. METHODS: The prospective data of 106 peritoneal carcinomatosis patients were included this study. Preoperative AFP, carcinoembryonic antigen, CA19.9, CA125, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet value, platelet distribution width, red cell distribution width and radiological findings compared according to Glisson capsule tumor involvement...
February 13, 2019: Biomarkers in Medicine
Piotr Duchnowski, Tomasz Hryniewiecki, Mariusz Kuśmierczyk, Piotr Szymanski
AIM: The usefulness of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) as a predictor of perioperative hemodynamic instability is not fully elucidated. METHODS: This prospective study was conducted on a group of 455 patients undergoing elective heart valve surgery. The primary end point at the 30-day follow-up was postoperative hemodynamic instability. The secondary end point was death from all causes in patients with postoperative hemodynamic instability...
February 13, 2019: Biomarkers in Medicine
Elif Hande Ozcan Cetin, Mehmet Serkan Cetin, Kumral Çağlı, Ahmet Temizhan, Mustafa Bilal Özbay, Emek Ediboglu, Özlem Özcan Çelebi, Dursun Aras, Serkan Topaloglu, Sinan Aydogdu
AIM: We aimed to investigate the association of estimated whole blood viscosity (WBV) with hemodynamic parameters and prognosis in patients with heart failure with reduced ejection fraction. MATERIALS & METHODS: Total of 542 patients were included and followed-up for median 13 months. RESULTS: The WBV parameters had negative relationship with right atrium pressure and positive correlation with cardiac index. The WBV parameters were found to be independent predictors of composite end point (CEP) and all-cause mortality...
January 23, 2019: Biomarkers in Medicine
Philippe Eggimann, Yok-Ai Que, Fabien Rebeaud
Sepsis is a life-threatening syndrome characterized by a dysregulated host response to an infection resulting in multiple organ dysfunctions. Early diagnosis and management of sepsis is key to improve patient outcome but remains challenging. Despite extensive research, only few biomarkers have so far proven to be helpful in the diagnosis of sepsis. A novel protein biomarker, the pancreatic stone protein (PSP), is showing great promises. Several lines of evidences suggest that PSP has a higher diagnostic performance for the identification of sepsis than procalcitonin and C-reactive protein, and a strong prognostic value to predict unfavorable outcome at admission to intensive care unit...
January 23, 2019: Biomarkers in Medicine
Devin M Parker, Jeremiah R Brown
No abstract text is available yet for this article.
January 23, 2019: Biomarkers in Medicine
Mustafa Zafer Temiz, Omer Onur Cakir, Serdar Aykan, Suat Hayri Kucuk, Necip Ozan Tiryakioglu, Gunal Bilek, Nagehan Ersoy Tunali, Engin Kandirali, Atilla Semercioz
AIM: To generate a combination of serum zinc (Zn) and prostate-specific antigen (PSA) in an attempt to provide better prediction of prostate biopsy outcomes with Zn/PSA ratios. MATERIALS & METHODS: Diagnostic performances of PSA and Zn/PSA were investigated using receiver operating characteristic and the area under the curve analysis and McNemar test in 480 men. Decision curve analysis was also used to determine the net clinical benefits of the two parameters...
January 23, 2019: Biomarkers in Medicine
Ziba Nariman-Saleh-Fam, Zahra Saadatian, Abdolreza Daraei, Yaser Mansoori, Milad Bastami, Javad Tavakkoli-Bazzaz
MiRNAs have immerged as essential modulators of key cellular procuresses involved in post-transcriptional regulation of the human transcriptome. They are essential components of complex regulatory networks that modulate most important physiological functions of cells. MicroRNA-155 (miR-155) is a multifaceted regulator of cell proliferation, cell cycle, development, immunity and inflammation that plays pivotal, and sometimes contradictory, roles in numerous cancers including esophageal cancer. Here, we review the intricate role of miR-155 in cancer by exemplifying carcinogenesis of various tumors, focusing on recent findings that may provide a link between miR-155 and esophageal cancer-related pathways...
January 23, 2019: Biomarkers in Medicine
Hyo Jung An, Dae Hyun Song, Hyun Min Koh, Gyung Hyuck Ko, Jeong-Hee Lee, Dong Chul Kim, Jung Wook Yang, Min Hye Kim, Deok Ha Seo, Se Min Jang, Jong Sil Lee
AIM: To examine the expression of RAB27A and RAB27B in clear cell renal cell carcinoma (CCRCC). MATERIALS & METHODS: The intensity and proportion of tumor cells staining positive for RAB27A and RAB27B in a total of 304 cores were evaluated. RESULTS: The T stage showed a significant correlation with RAB27A intensity (p < 0.001). In multivariate analysis, CCRCC with negative intensity of RAB27A expression demonstrated poor disease-specific survival (hazard ratio: 6...
January 21, 2019: Biomarkers in Medicine
Jennifer Creed, Andrea Maggrah, Brian Reguly, Andrew Harbottle
AIM: Accurate noninvasive diagnostic aids for endometriosis are needed. We evaluated mitochondrial DNA deletions as potential biomarkers for endometriosis. METHODS: The diagnostic accuracy of deletions was evaluated by quantitative polymerase chain reaction (QPCR) using well-characterized clinical specimens from all subtypes and stages of endometriosis in a case-control format (n = 182). RESULTS: Deletions (1.2 and 3.7 kb) detected in blood differentiated between endometriosis and controls (area under the curve [AUC] 0...
January 15, 2019: Biomarkers in Medicine
Qing Zhang, Yanli Qu, Hangyu Liu, Hongying Jia, Fengyun Wen, Shengnan Pei, Hong Yu
AIM: To assessed the prognostic significance of pretreatment platelet-to-lymphocyte ratio (PLR) in patients with limited-stage small cell lung cancer (LS-SCLC). METHODS: We retrospectively analyzed 286 patients with LS-SCLC. RESULTS: Sixty received chemotherapy alone, 158 sequential chemo- and radiotherapy, 38 concurrent chemo- and radiotherapy and 30 surgery combined with therapy. The cut-off value of pretreatment PLR was 152.1. The median progression free survival (PFS) and overall survival (OS) in the low and high PLR groups were 27...
January 9, 2019: Biomarkers in Medicine
Xiufang Wang, Juyi Li, Zhongjing Wang, Aiping Deng
AIM: The aim of this study was to investigate the relationship between CXCL-6 levels in wound exudates and healing of diabetic foot ulcers (DFU). MATERIALS & METHODS: One hundred patients with neuropathic DFU were recruited. Wound exudate CXCL-6 levels were measured by enzyme-linked immunosorbent assay. Patients were followed for 24 weeks and divided into rapidly healing and nonhealing groups. RESULTS: Compared with the NH group, the mean CXCL-6 levels in the wound exudates of the rapidly healing group were significantly higher...
January 3, 2019: Biomarkers in Medicine
Enver Yalnız, Gülistan Karadeniz, Fatma Demirci Üçsular, Gülru Erbay Polat, Görkem Vayısoğlu Şahin
AIM: We aimed to evaluate platelet-to-lymphocyte ratio (PLR) in patients with sarcoidosis. METHODS: A total of 310 sarcoidosis patients and 220 healthy controls retrospectively were recorded in this study. RESULTS: PLR was significantly higher in patients with sarcoidosis than in the control group, and was also significantly higher in patients with pulmonary involvement in stage 2-3-4 than in stage 1. PLR were significantly positive correlated with erythrocyte sedimentation rate...
January 3, 2019: Biomarkers in Medicine
Xiang-Hong Chen, Wen-Wen Zhang, Jun Wang, Jia-Yuan Sun, Feng-Yan Li, Zhen-Yu He, San-Gang Wu
AIM: To determine the effect of the 21-gene recurrence score (RS) on outcome and chemotherapy decision in breast invasive lobular carcinoma (ILC). MATERIALS & METHODS: We included 6467 patients with early stage and estrogen receptor-positive ILC from the Surveillance, epidemiology, and end results database. RESULTS: A total of 9.1, 31.4, and 70.1% of patients with low-, intermediate-, and high-risk RS groups received chemotherapy, respectively...
December 19, 2018: Biomarkers in Medicine
Xian-Wen Yang, Fei Wang, Ru-Zi Qin, Qin-Lin Zhou, Hong-Xing Huang
AIM: To investigate if the serum CC motif ligand 4 (CCL4) levels are linked to disease severity in patients with postmenopausal osteoporosis (PMOP). PATIENTS & METHODS: We enrolled 66 PMOP females, 68 postmenopausal nonosteoporotic women and 67 healthy women of childbearing age. Bone mineral densities were assessed with dual x-ray absorptiometry scans. The Oswestry disability index and the visual analog scale were employed to quantify functional ability and severity of symptoms...
December 18, 2018: Biomarkers in Medicine
Hongbing Mei, Yuhan Liu, Qun Zhou, Kun Hu, Yuchen Liu
AIM: it has been reported that metastasis-associated lung adenocarcinoma transcript 1 is abnormally expressed in various cancers. METHODS: eligible studies fulfilling the search criteria were selected from the online databases. Statistical analysis was performed based on the platforms of STATA 14.0. RESULTS:  12 studies were included in this study comprising 741 cases and 794 controls. The pooled results were shown as follows: sensitivity, 0...
December 18, 2018: Biomarkers in Medicine
Hemant Vira, Vandana Pradhan, Vinod Umare, Ajay Chaudhary, Anjali Rajadhyksha, Milind Nadkar, Kanjaksha Ghosh, Anita Nadkarni
AIM: To investigate the possible association between MMP-9 (-1562 C/T) and TIMP-1 (372 T/C) polymorphism and inflammatory markers with disease activity in systemic lupus erythematosus (SLE) patients. MATERIALS & METHODS: 150 SLE patients were recruited. Disease severity was assessed by SLEDAI (SLE disease activity index). The polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and serum levels by ELISA...
December 18, 2018: Biomarkers in Medicine
Ebony Torrington
No abstract text is available yet for this article.
December 18, 2018: Biomarkers in Medicine
Makbule K Karadağ, Ersin Yıldırım
AIM: Our aim was to evaluate the relationship and diagnostic value of atherogenic index of plasma (AIP) and mean platelet volume (MPV) for heart failure (HF) and ejection fraction (EF). MATERIALS AND METHODS: In the present study, AIP and MPV were studied in 114 stable HF patients (48 ischemic [42.1%], 66 nonischemic [57.9%]) and 69 controls. RESULTS: Mean AIP and MPV were significantly higher in HF compared with controls (p = 0.002; p = 0...
December 18, 2018: Biomarkers in Medicine
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