We have located links that may give you full text access.
Prevalence and phylogenetic characterization of hepatitis C among men who have sex with men in India: limited evidence for sexual transmission.
Journal of Infectious Diseases 2020 January 10
BACKGROUND: Data from high-income countries suggest increasing hepatitis C virus (HCV) prevalence/incidence among HIV-infected men who have sex with men (MSM), but limited data derive from low-and-middle-income countries (LMICs).
METHODS: We recruited 4,994 MSM from 5 states across India using respondent-driven sampling (RDS). Logistic regression incorporating RDS weights and machine learning feature selection were used to identify correlates of prevalent HCV, and Bayesian phylogenetic analysis was used to examine genetic clustering.
RESULTS: Median age was 25, HIV prevalence was 7.2% and 49.3% reported recent unprotected anal intercourse. HCV prevalence was 1.3% (95% CI: 1.0 - 1.6%; site range: 0.2 - 3.4%) and was 3.1% in HIV-positive compared to 1.1% among HIV-negative. HCV infection was significantly associated with injection drug use (OR: 177.1; 95% CI: 72.7 - 431.5) and HIV (OR: 4.34; 95% CI: 1.88 - 10.05). Machine learning did not uncover any additional epidemiologic signal. Phylogenetic analysis revealed three clusters suggestive of linked transmission; each contained at least one individual reporting injection drug use.
CONCLUSIONS: We observed a low HCV prevalence in this large sample of MSM despite high prevalence of known risk factors, reflecting either the need for a threshold of HCV for sexual transmission and/or variability in sexual practices across settings.
METHODS: We recruited 4,994 MSM from 5 states across India using respondent-driven sampling (RDS). Logistic regression incorporating RDS weights and machine learning feature selection were used to identify correlates of prevalent HCV, and Bayesian phylogenetic analysis was used to examine genetic clustering.
RESULTS: Median age was 25, HIV prevalence was 7.2% and 49.3% reported recent unprotected anal intercourse. HCV prevalence was 1.3% (95% CI: 1.0 - 1.6%; site range: 0.2 - 3.4%) and was 3.1% in HIV-positive compared to 1.1% among HIV-negative. HCV infection was significantly associated with injection drug use (OR: 177.1; 95% CI: 72.7 - 431.5) and HIV (OR: 4.34; 95% CI: 1.88 - 10.05). Machine learning did not uncover any additional epidemiologic signal. Phylogenetic analysis revealed three clusters suggestive of linked transmission; each contained at least one individual reporting injection drug use.
CONCLUSIONS: We observed a low HCV prevalence in this large sample of MSM despite high prevalence of known risk factors, reflecting either the need for a threshold of HCV for sexual transmission and/or variability in sexual practices across settings.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app