Jessica K Fairley, José A Ferreira, Lucia A O Fraga, Sandra Lyon, Thales M Valadão Cardoso, Victor Campos Boson, Ana Carolina Madureira Nunes, Eloisa H Medeiros Cinha, Lorena B P de Oliveira, Erica B Magueta, Pedro H F Marçal, Alexandre C Branco, Maria Aparecida F Grossi, Dean P Jones, Thomas R Ziegler, Jeffrey M Collins
BACKGROUND: High resolution metabolomics (HRM) is an innovative tool to study challenging infectious diseases like leprosy, where the pathogen cannot be grown with standard methods. Here, we use HRM to better understand associations between disease manifestations, nutrition, and host metabolism. METHODS: From 2018-2019, adults with leprosy and controls were recruited in Minas Gerais, Brazil. Plasma metabolites were detected using an established HRM workflow and characterized by accurate mass m/z and retention time...
September 22, 2023: Journal of Infectious Diseases