Piyarat Suntarattiwong, Joshua A Mott, Sarita Mohanty, Chalinthorn Sinthuwattanawibool, Nattinee Srisantiroj, Orada Patamasingh Na Ayudhaya, Chonticha Klungthong, Stefan Fernandez, Lindsay Kim, Danielle Hunt, Danielle Hombroek, Tana Brummer, Tawee Chotpitayasunondh, Fatimah S Dawood, Wanitchaya Kittikraisak
BACKGROUND: We assessed performance of participant-collected mid-turbinate nasal swabs compared to study staff-collected mid-turbinate nasal swabs for the detection of respiratory viruses among pregnant women in Bangkok, Thailand. METHODS: We enrolled pregnant women aged ≥18 years and followed them throughout the 2018 influenza season. Women with acute respiratory illness (ARI) self-collected mid-turbinate nasal swabs at homes for influenza viruses, RSV, and hMPV real-time RT-PCR testing while the study nurse collected a second mid-turbinate nasal swab during home visits...
January 18, 2021: Journal of Infectious Diseases
Jean-Pierre Routy, Stephane Isnard
No abstract text is available yet for this article.
January 18, 2021: Journal of Infectious Diseases
Omid Rezahosseini, Christina Ekenberg, Dina Leth Møller, Søren Schwartz Sørensen, Neval Ete Wareham, Michael Perch, Finn Gustafsson, Allan Rasmussen, Nikolai Kirkby, Joanne Reekie, Jens Lundgren, Susanne Dam Nielsen
Routine monitoring of Parvovirus B19 (B19V) the first six months post-transplantation was performed in 241 seronegative solid organ transplant (SOT) recipients. Incidence rates (IR) during the 1st month and the 2nd to 6th months post-transplantation were 1.2 (95% CI, 0.33-3.2) and 0.21 (95% CI, 0.06-0.57) per 100 recipients per-month, respectively. Of the 6 SOT recipients with positive B19V PCR, 3 (50%) were admitted to hospital and 2 (33%) were treated with intravenous immunoglobulin. Thus, routine monitoring of B19V in seronegative SOT recipients may not be necessary...
January 18, 2021: Journal of Infectious Diseases
Zhengguo Zhang, Ming Wang, Yu Zhang, Yiming Zhang, Marek Bartkuhn, Melanie Markmann, Hamid Hossain, Trinad Chakraborty, Sandra B Hake, Zhankui Jia, Andreas Meinhardt, Sudhanshu Bhushan
Urinary tract infections are common and costly diseases affecting millions of people. Uropathogenic Escherichia coli (UPEC) is a primary cause of these infections and has developed multiple strategies to avoid the host immune response. Here, we dissected the molecular mechanisms underpinning UPEC inhibition of inflammatory cytokine in vitro and in vivo. We found that UPEC infection simulates NFkB activation but does not result in transcription of cytokine genes. Instead, UPEC-mediated suppression of the metabolic enzyme ATP citrate lyase (ACLY) results in decreased acetyl-CoA level, leading to reduced H3K9 histone acetylation in the promotor region of CXCL8...
January 16, 2021: Journal of Infectious Diseases
Yiwang Chen, Lecai Ji, Qingyun Liu, Jinli Li, Chuangyue Hong, Qi Jiang, Mingyu Gan, Howard E Takiff, Weiye Yu, Weiguo Tan, Qian Gao
Tuberculosis (TB) heteroresistance, in which only a fraction of the bacteria in a TB patient contains drug-resistant mutations, has been a rising concern. However, its origins and prevalence remain elusive. Here, whole-genome sequencing was performed on 83 serial isolates from 31 MDR-TB patients and heteroresistance was detected in isolates from 21 (67.74%) patients. Heteroresistance persisted in the host for long periods, spanning months to years, and was associated with having multiple tubercular lesions...
January 12, 2021: Journal of Infectious Diseases
Purbita Bandopadhyay, Ranit D' Rozario, Abhishake Lahiri, Jafar Sarif, Yogiraj Ray, Shekhar Ranjan Paul, Rammohan Roy, Rajshekhar Maiti, Kausik Chaudhuri, Saugata Bagchi, Ayan Maiti, Md Masoom Perwez, Biswanath Sharma Sarkar, Devlina Roy, Rahul Chakraborty, Janani Srinivasa Vasudevan, Sachin Sharma, Durba Biswas, Chikam Maiti, Bibhuti Saha, Prasun Bhattacharya, Rajesh Pandey, Shilpak Chatterjee, Sandip Paul, Dipyaman Ganguly
Novel coronavirus SARS-CoV2, causing coronavirus disease 2019 or COVID-19, led to significant morbidity and mortality. While most suffer from mild symptoms, some patients progress to a severe disease with acute respiratory distress syndrome (ARDS) and an associated systemic hyper-inflammation. First to characterize key cytokines and their dynamics in this hyper-inflammatory condition, we assessed abundance and correlative expression of a panel of forty eight cytokines in patients progressing to ARDS, as compared to patients with mild disease...
January 12, 2021: Journal of Infectious Diseases
Drishya Kurup, Christine R Fisher, Gabrielle Scher, Catherine Yankowski, AnnaMarie Testa, Rohan Keshwara, Tiago Abreu-Mota, Rachael Lambert, Melissa Ferguson, William Rinaldi, Leonard Ruiz, Christoph Wirblich, Matthias J Schnell
BACKGROUND: The objective of this study is to evaluate the immunogenicity of adjuvanted monovalent rabies virus-based vaccine candidates against Ebola virus (FILORAB1), Sudan virus (FILORAB2), Marburg virus (FILORAB3), Lassa virus (LASSARAB1), and combined trivalent vaccine candidate (FILORAB1-3) and tetravalent vaccine candidate (FILORAB1-3 and LASSARAB) in nonhuman primates. METHODS: Twenty-four Macaca fascicularis were randomly assigned into six groups of four animals...
January 9, 2021: Journal of Infectious Diseases
Lars H Omland, Hanne T Vestergaard, Ram B Dessau, Jacob Bodilsen, Nanna S Andersen, Claus B Christiansen, Svend Ellermann-Eriksen, Lene Nielsen, Christian Ø Andersen, Anne-Mette Lebech, Niels Obel
BACKGROUND: Risk factors for and long-term outcomes following detection of varicella zoster virus (VZV) DNA in the cerebrospinal fluid (CSF) are unknown. METHODS: We performed a nationwide population-based cohort study of all Danish residents who had VZV DNA detected in the CSF by polymerase chain reaction (PCR) between 1 January 1997 and 1 March 2016 (VZV cohort; n = 517) and an age- and sex- matched comparison cohort from the general Danish population (n = 9823)...
January 8, 2021: Journal of Infectious Diseases
Roxie C Girardin, Alan P Dupuis, Anne F Payne, Timothy J Sullivan, Donna Strauss, Monica M Parker, Kathleen A McDonough
BACKGROUND: COVID-19 convalescent plasma (CCP) received an Emergency Use Authorization by the FDA. CCP with a signal-to-cutoff ratio of ≥12 using the Ortho VITROS SARS-CoV-2 IgG test (OVSARS2IgG) is permitted to be labeled "high titer". Little is known about the relationship between OVSARS2IgG ratio and neutralizing capacity of plasma/sera against genuine SARS-CoV-2 virus. METHODS: 981 samples from 196 repeat CCP donors 0-119 days post initial donation (DPID) were analyzed...
January 8, 2021: Journal of Infectious Diseases
Xin Fan, Ning Li, Meiyi Xu, Decheng Yang, Beinan Wang
BACKGROUND: Staphylococcus aureus (S. aureus) causes community- and hospital-acquired pneumonia linked to a high mortality rate. The emergence and rapid transmission of multidrug-resistant S. aureus strains have become a serious health concern, and highlight the challenges associated with the development of a vaccine to combat S. aureus pneumonia. METHODS: This study evaluated the effects of intrapulmonary (i.pulmon.) immunization on the immune response and protection against S...
January 8, 2021: Journal of Infectious Diseases
Nicolas Barros, Natalie Alexander, Adam Viens, Kyle Timmer, Natalie Atallah, Sally A I Knooihuizen, Alex Hopke, Allison Scherer, Zeina Dagher, Daniel Irimia, Michael K Mansour
BACKGROUND: Solid organ (SOT) and stem cell transplant (SCT) recipients are at increased risk of invasive fungal disease despite normal neutrophil counts. Here, we measure neutrophil anti-Candida activity. METHODS: Twenty-one SOT and 19 SCT recipients were enrolled 2-4 months post-transplant and compared to 23 healthy control patients (HC). Neutrophils were co-incubated with C. albicans and percent killing, and swarming responses were measured. RESULTS: Neutrophils from transplant patients had decreased fungicidal capacity compared to HC (42%, 43%, 72%; SCT, SOT, and HC respectively; SCT vs...
January 8, 2021: Journal of Infectious Diseases
Evan M Bloch, Elizabeth P Crowe, Aaron A R Tobian
No abstract text is available yet for this article.
January 7, 2021: Journal of Infectious Diseases
Lidya Handayani Tjan, Koichi Furukawa, Tatsuya Nagano, Tatsunori Kiriu, Mitsuhiro Nishimura, Jun Arii, Yasuhisa Hino, Sachiyo Iwata, Yoshihiro Nishimura, Yasuko Mori
Most COVID-19 patients experience asymptomatic/mild symptoms, but some suffer critical symptoms requiring intensive care. It is important to determine how asymptomatic/mild patients react to SARS-CoV-2 infection and suppress virus spread. Innate immunity is important for evasion from the first virus attack, and it may play an important role in the pathogenesis in these patients. We measured serum cytokine levels of 95 COVID-19 patients during the infection's acute phase and are first to report that significantly higher IL-12 and IL-2 levels were induced in asymptomatic/mild patients versus those in the moderate/severe patients, indicating these cytokines' key roles in asymptomatic/mild infections' pathogenesis...
January 7, 2021: Journal of Infectious Diseases
Hesham Abboud
No abstract text is available yet for this article.
January 7, 2021: Journal of Infectious Diseases
Andrea Pilotto, Stefano Masciocchi, Sergio Ferrari, Alessandro Padovani
No abstract text is available yet for this article.
January 7, 2021: Journal of Infectious Diseases
Shelly Bolotin, Vanessa Tran, Selma Osman, Kevin A Brown, Sarah A Buchan, Eugene Joh, Shelley L Deeks, Vanessa G Allen
We analyzed 21,676 residual specimens from Ontario, Canada collected between March-August, 2020 to investigate the effect of antibody decline on SARS-CoV-2 seroprevalence estimates. Testing specimens orthogonally using the Abbott (anti-nucleocapsid) and then the Ortho (anti-spike) assays, seroprevalence estimates ranged from 0.4%-1.4%, despite ongoing disease activity. The geometric mean concentration (GMC) of antibody-positive specimens decreased over time (p=0.015), and the GMC of antibody-negative specimens increased over time (p=0...
January 5, 2021: Journal of Infectious Diseases
Jerald Sadoff, Els De Paepe, John DeVincenzo, Efi Gymnopoulou, Joris Menten, Bryan Murray, Arangassery Rosemary Bastian, An Vandebosch, Wouter Haazen, Nicolas Noulin, Christy Comeaux, Esther Heijnen, Kingsley Eze, Anthony Gilbert, Rob Lambkin-Williams, Hanneke Schuitemaker, Benoit Callendret
BACKGROUND: Respiratory syncytial virus (RSV) is a significant cause of severe lower respiratory tract disease in children and older adults, but has no approved vaccine. This study assessed the potential of Ad26.RSV.preF to protect against RSV infection and disease in an RSV human challenge model. METHODS: In this double-blind, placebo-controlled study, healthy adults aged 18-50 years were randomized 1:1 to receive 1x1011 vp Ad26.RSV.preF or placebo intramuscularly...
January 5, 2021: Journal of Infectious Diseases
Catherine M Stein, Penelope Benchek, Jacquelaine Bartlett, Robert P Igo, Rafal S Sobota, Keith Chervenak, Harriet Mayanja-Kizza, C Fordham von Reyn, Timothy Lahey, William S Bush, W Henry Boom, William K Scott, Carmen Marsit, Giorgio Sirugo, Scott M Williams
BACKGROUND: Tuberculosis (TB) is the most deadly infectious disease globally and highly prevalent in the developing world. For individuals infected with both Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV), the risk of active TB is 10% or more annually. Previously, we identified in a genome-wide association study (GWAS) a region on chromosome 5 associated with resistance to TB, which included epigenetic marks that could influence gene regulation. We hypothesized that HIV-infected individuals exposed to Mtb, who remain disease free, carry epigenetic changes that strongly protect them from active TB...
January 5, 2021: Journal of Infectious Diseases
Juan P Aguilar Ticona, Huma Baig, Nivison Nery, Simon Doss-Gollin, Gielson A Sacramento, Haritha Adhikarla, M Catherine Muenker, Elsio A Wunder, Eduardo J M Nascimento, Ernesto T A Marques, Mitermayer G Reis, Albert I Ko, Federico Costa
In order to understand the disease burden of sexually transmitted Zika virus (ZIKV), we prospectively followed a cohort of 359 adult and adolescent residents of an urban community in Salvador, Brazil through the 2015 ZIKV epidemic. Later, in 2017, we used a retrospective survey to associate sexual behavior during the epidemic with ZIKV infection as defined by IgG3-NS1 ELISA. We found that males who engaged in casual sexual encounters during the epidemic were more likely (ORa=6.2; 95%CI 1.2-64.1) to be ZIKV positive, suggesting that specific groups may be at increased risk of sexually transmitted infections...
January 4, 2021: Journal of Infectious Diseases
Christine H T Bui, H W Yeung, John C W Ho, Connie Y H Leung, Kenrie P Y Hui, Ranawaka A P M Perera, Richard J Webby, Stacey L Schultz-Cherry, John M Nicholls, J S Malik Peiris, Michael C W Chan
BACKGROUND: Human spillovers of SARS-CoV-2 to dogs and the emergence of a highly contagious avian-origin H3N2 canine influenza virus have raised concerns towards the role of dogs in the spread of SARS-CoV-2 and their susceptibility to existing human and avian influenza viruses which might result in further reassortment. METHODS: We systematically studied the replication kinetics of SARS-CoV-2, SARS-CoV, influenza A viruses of H1, H3, H5, H7 and H9 subtypes and influenza B viruses of Yamagata-like and Victoria-like lineages in ex-vivo canine nasal cavity (NC), soft palate (SP), trachea (T) and lung (L) tissue explant cultures and examined ACE2 and sialic acid (SA) receptor distribution in these tissues...
January 4, 2021: Journal of Infectious Diseases
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