JOURNAL ARTICLE

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

Rebekah M Dedrick, Carlos A Guerrero-Bustamante, Rebecca A Garlena, Daniel A Russell, Katrina Ford, Kathryn Harris, Kimberly C Gilmour, James Soothill, Deborah Jacobs-Sera, Robert T Schooley, Graham F Hatfull, Helen Spencer
Nature Medicine 2019, 25 (5): 730-733
31068712
A 15-year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineering and forward genetics. Intravenous phage treatment was well tolerated and associated with objective clinical improvement, including sternal wound closure, improved liver function, and substantial resolution of infected skin nodules.

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