The Principles of Biomedical Scientific Writing: Introduction.

A well-written introduction of a scientific paper provides relevant background knowledge to convince the readers about the rationale, importance, and novelty of the research. The introduction should inform the readers about the "problem", "existing solutions", and "main limitations or gaps of knowledge". The authors' hypothesis and methodological approach used to examine the research hypothesis should also be stated. After reading a good introduction, readers should be guided through "a general context" to "a specific area" and "a research question". Incomplete, inaccurate, or outdated reviews of the literature are the more common pitfalls of an introduction that may lead to rejection. This review focuses on the principles of writing the introduction of an article and provides a quick look at the essential points that should be considered for writing an optimal introduction.