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Journal Article
Review
The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control.
Exercise and Sport Sciences Reviews 2019 January
The mechanistic target of rapamycin (mTOR) is a central regulator of muscle protein synthesis, and its activation has long been attributed to its translocation to the lysosome. Here, we present a novel model of mTOR activation in skeletal muscle where the translocation of mTOR and the lysosome toward the cell membrane is a key process in mTOR activation.
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