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Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Cooling the Itch via TRPM8.
Journal of Investigative Dermatology 2018 June
Cooling is an effective temporary remedy for itch, bringing welcome relief to itchy insect bites, nettle stings, poison ivy, atopic dermatitis, and psoriasis. Menthol, causing a cooling sensation, has similar itch-relieving effects. Palkar et al. demonstrate that TRPM8, a menthol- and cold-activated ion channel, is essential for cooling to relieve itch, suggesting that pharmacologic TRPM8 activation should be explored further as an antipruritic strategy.
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