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Journals Journal of Investigative Derma...

Journal of Investigative Dermatology

https://read.qxmd.com/read/38904567/challenging-the-lymph-node-progression-model-of-melanoma
#1
JOURNAL ARTICLE
Yung-Ching Kao, Mitchell S Stark
No abstract text is available yet for this article.
June 20, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38904568/young-esdr-engaging-and-nurturing-the-next-generation-skin-research-community
#2
JOURNAL ARTICLE
Clarisse Ganier, Chris Callewaert, Tiago R Matos, Enikö Sonkoly, Beatrice Dyring-Andersen, Neil Rajan
No abstract text is available yet for this article.
June 19, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38901775/standardized-protocols-for-clinical-and-histopathological-characterization-of-hidradenitis-suppurativa-tissue-specimens
#3
JOURNAL ARTICLE
Ashwath Jonathan Sampath, Linnea L Westerkam, Franklin R Blum, Raed Alhusayen, Falk G Bechara, Julie Caffrey, Carmelo Carmona-Rivera, Nisha Suyien Chandran, Ralph George, Stephanie R Goldberg, Johann E Gudjonsson, Scott L Hansen, John R Ingram, Brian Kirby, Angelo Valerio Marzano, Łukasz Matusiak, Dennis P Orgill, Errol Prens, Hessel H van der Zee, Kelsey R van Straalen, Christos C Zouboulis, Angel S Byrd, John W Frew, Michelle Anne Lowes, Haley B Naik, Olayemi Sokumbi, Qing-Sheng Mi, Jayson R Miedema, Paul B Googe, Christopher J Sayed
Methods for describing and reporting the clinical and histological characteristics of cutaneous tissue samples from patients with hidradenitis suppurativa (HS) are not currently standardized, limiting clinicians' and scientists' ability to uniformly record, report, and communicate about the characteristics of tissue used in translational experiments. A recently published consensus statement outlined morphological definitions of typical HS lesions, but no consensus has been reached regarding clinical characterization and examination of HS tissue samples...
June 18, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38888525/setting-the-stage-for-standardized-reporting-of-clinical-and-demographic-information-in-laboratory-based-studies-of-hidradenitis-suppurativa
#4
JOURNAL ARTICLE
Stephanie L Schell, Amanda M Nelson
Hidradenitis suppurativa (HS) is a complex inflammatory skin condition affecting 0.1-4% of the population that leads to permanent scarring in the axilla, inframammary region, groin, and buttocks. Its complex pathogenesis involves genetics, innate and adaptive immunity, microbiota, and environmental stimuli. Specific populations have a higher incidence of HS, including females and Black individuals and those with associated comorbidities. HS registries and biobanks have set standards for the documentation of clinical data in the context of clinical trials and outcomes research, but collection, documentation, and reporting of these important clinical and demographic variables are uncommon in HS laboratory research studies...
June 18, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38888524/a-review-of-atomic-force-microscopy-in-skin-barrier-function-assessment
#5
REVIEW
Jorge Pereda, Casper Milde Khatib, Sanja Kezic, Maria Oberländer Christensen, Sara Yang, Jacob P Thyssen, Chia-Yu Chu, Christoph Riethmüller, Hsien-Shun Liao, Imtisal Akhtar, Benjamin Ungar, Emma Guttman-Yassky, Merete Hædersdal, En-Te Hwu
Skin barrier function (SBF) disorders are a class of pathologies that affect a significant portion of the world population. These disorders cause skin lesions with intense itch, impacting patients' physical and psychological well-being as well as their social functioning. It is in the interest of patients that their disorder be monitored closely while under treatment to evaluate the effectiveness of the ongoing therapy and any potential adverse reactions. Symptom-based assessment techniques are widely used by clinicians; however, they carry some limitations...
June 18, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38897542/does-sex-matter-temporal-analyses-of-melanoma-trends-among-men-and-women-suggest-etiologic-heterogeneity
#6
JOURNAL ARTICLE
Catherine M Olsen, Nirmala Pandeya, Adalberto Miranda-Filho, Philip S Rosenberg, David C Whiteman
The incidence and distribution of cutaneous melanoma differs between the sexes, but it is unclear whether these differences have been constant through time or across generations. We compared incidence trends by age, sex, and anatomic site by analyzing long-term melanoma data (1982-2018) in three populations residing at high-, moderate- and low- ambient sun exposure: Queensland, Australia; United States White; Scotland. We fit age-period-cohort models and compared trends in the male-to-female incidence rate ratio (IRR) by site and sex...
June 17, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38885877/analysis-of-circadian-clock-gene-expression-in-epidermal-human-skin-indicates-that-body-location-impacts-rhythm-amplitude
#7
JOURNAL ARTICLE
William Cvammen, Stanley Dean Rider, Michael G Kemp
No abstract text is available yet for this article.
June 15, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38885876/fcrn-inhibition-reduces-bullous-pemphigoid-anti-basement-membrane-zone-igg-deposition-and-blistering-in-3d-human-skin-equivalents
#8
JOURNAL ARTICLE
Lei Bao, Bethany E Perez White, Rachel C Chang, Jing Li, Katrien Vanderheyden, Peter Verheesen, Magdalena Sips, Maximilian Brinkhaus, Kyle T Amber
No abstract text is available yet for this article.
June 15, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38878050/infiltrating-basophils-tune-injured-skin-barrier-recovery
#9
JOURNAL ARTICLE
Ekaterini Tiligada, Francesca Levi-Schaffer
No abstract text is available yet for this article.
June 14, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38897541/rna-therapy-for-oncogenic-nras-driven-naevi-induces-apoptosis
#10
JOURNAL ARTICLE
Dale Bryant, Sara Barberan-Martin, Ruhina Maeshima, Ignacio Del Valle Torres, Mohammad Rabii, William Baird, Aimie Sauvadet, Charalambos Demetriou, Phoebe Jones, Nicole Knöpfel, Fanourios Michailidis, Melissa Riachi, Dorothy C Bennett, Davide Zecchin, Alan Pittman, Satyamaanasa Polubothu, Stephen Hart, Veronica A Kinsler
RAS proteins regulate cell division, differentiation and apoptosis via multiple downstream effector pathways. Oncogenic RAS variants are the commonest drivers in cancers, however they also drive many benign lesions predisposing to malignancy, such as melanocytic naevi, thyroid nodules, and colonic polyps. Reversal of these benign lesions could reduce cancer incidence, however the effects of oncogenic RAS have been notoriously difficult to target with downstream pathway inhibitors. Here we show effective suppression of oncogenic and currently undruggable NRASQ61K in primary cells from melanocytic naevi using siRNA targeted to the recurrent causal variant...
June 13, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38879155/retracing-from-outcomes-to-causes-nrf2-driven-gsta4-transcriptional-regulation-controls-chronic-inflammation-and-oxidative-stress-in-atopic-dermatitis-recurrence
#11
JOURNAL ARTICLE
Xin Ma, Hang Zhao, Jian-Kun Song, Zhan Zhang, Chun-Jie Gao, Ying Luo, Xiao-Jie Ding, Ting-Ting Xue, Ying Zhang, Meng-Jie Zhang, Mi Zhou, Rui-Ping Wang, Le Kuai, Bin Li
Atopic dermatitis (AD), a chronic and recurrent inflammatory skin disorder, presents a high incidence and imposes a substantial economic burden. Preventing its recurrence remains a significant challenge in dermatological therapy due to poorly understood underlying mechanisms. In our study, we adopted a strategy of tracing the mechanisms of recurrence from clinical outcomes. We developed a mouse model of recurrent AD and applied clinically validated treatment regimens. Transcriptomic analyses revealed a pronounced enrichment in the glutathione metabolic pathway in the treated group...
June 13, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38879154/breast-cancer-related-lymphedema-results-in-impaired-epidermal-differentiation-and-tight-junction-dysfunction
#12
JOURNAL ARTICLE
Adana-Christine Campbell, Jung Eun Baik, Ananta Sarker, Stav Brown, Hyeung Ju Park, Kevin G Kuonqui, Jinyeon Shin, Bracha L Pollack, Arielle Roberts, Gopika Ashokan, Jonathan Rubin, Raghu P Kataru, Joseph H Dayan, Andrea V Barrio, Babak J Mehrara
Breast cancer-related lymphedema (BCRL) is characterized by skin changes, swelling, fibrosis, and recurrent skin infections. Clinical studies have suggested that lymphedema results in skin barrier defects; however, the underlying cellular mechanisms and the effects of bacterial contamination on skin barrier function remain unknown. In matched biopsies from patients with unilateral BCRL, we observed decreased expression of filaggrin and the tight junction protein zona occludens-1 (ZO-1) in skin affected by moderate lymphedema, or by subclinical lymphedema in which dermal backflow of lymph was identified by indocyanine green lymphography, relative to controls (areas without backflow and from the unaffected arm)...
June 13, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38879153/the-prolyl-endopeptidase-prep-is-involved-in-filaggrinolysis-and-cornification
#13
JOURNAL ARTICLE
Julie Briot, Carole Pons, Aude Foucher, Dominique Goudounèche, Nicolas Gaudenzio, Mark Donovan, Dominique Bernard, Marie-Claire Méchin, Michel Simon
Filaggrin (FLG) is a well-known biomarker of atopic dermatitis and skin dryness. Its full proteolysis (or filaggrinolysis) produces the major constituents of the natural moisturizing factor. Some proteases/peptidases remain to be identified in this multistep process. Mining 16 omics analyses, we identified prolyl endopeptidase (PREP) as a candidate peptidase. Indirect immunofluorescence and confocal analysis demonstrated its localization in the granular and deep cornified layers, where it co-localized with FLG...
June 13, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38871024/faulty-gap-filling-in-nucleotide-excision-repair-leads-to-double-strand-break-formation-in-senescent-cells
#14
JOURNAL ARTICLE
Takashi Suzuki, Yukako Komaki, Momoka Amano, Satoko Ando, Kosuke Shobu, Yuko Ibuki
The change of repair efficiency of UV-induced pyrimidine dimers due to aging was examined in replicatively senesced fibroblasts. The fibroblasts with repeated passages showed the characteristics of cellular senescence including irreversible cell cycle arrest, elevated β-galactosidase activity and senescence-associated secretory phenotype. The incision efficiency of oligonucleotide containing UV lesions was similar regardless of cell doubling levels, but the gap filling process was impaired in replicatively senescent cells...
June 11, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38871023/autoimmune-connective-tissue-and-dermatological-diseases-in-children-with-autism-spectrum-disorder
#15
JOURNAL ARTICLE
Sang-Hoon Lee, Jae Joon Jeon, Won-Soo Lee, Solam Lee
No abstract text is available yet for this article.
June 11, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38848988/identification-of-small-molecule-inhibitors-targeting-different-signaling-pathways-in-cancer-associated-fibroblast-reprogramming-under-tumor-stroma-interaction
#16
JOURNAL ARTICLE
Shidi Wu, Rui Fang, Marion H Rietveld, Jeroen R G Torremans, Yang Liu, Zili Gu, Jan N Bouwes Bavinck, Maarten H Vermeer, Abdoelwaheb El Ghalbzouri
Cancer-associated fibroblasts (CAFs) interact reciprocally with tumor cells through various signaling pathways in many cancer types including cutaneous squamous cell carcinoma (cSCC). Among normal fibroblast (NF) subtypes, papillary fibroblasts (PFs) and reticular fibroblasts (RFs) respond distinctly to tumor cell signaling, eventuating the differentiation of RFs, rather than PFs, into CAFs. The regulation of subtype differentiation in fibroblasts remains poorly explored. In this study, we assessed the differences between PFs, RFs, and CAFs, and examined the effects of small-molecule inhibitors targeting the TGFβ, PI3K/AKT/mTOR, and NOTCH pathways on the tumor-promoting property of CAFs and CAF reprogramming in 2D and 3D cultures...
June 5, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38848987/pemphigus-associated-desmoglein-specific-igg1-and-igg4-have-a-dominant-agalactosylated-glycan-modification
#17
JOURNAL ARTICLE
Armin Oloumi, Stephanie T Le, Yiyun Liu, Samantha Herbert, Antonio Ji-Xu, Alexander A Merleev, Olga Kruglinskaya, Kimberly Artounian, Dayoung Park, Alina I Marusina, John J Zone, Ron Feldman, Carlito B Lebrilla, Emanual Maverakis
No abstract text is available yet for this article.
June 5, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38848986/sash1-s519n-variant-links-skin-hyperpigmentation-and-premature-hair-graying-to-dysfunction-of-melanocyte-lineage
#18
JOURNAL ARTICLE
Karoline A Lambert, Christopher M Clements, Nabanita Mukherjee, Theresa R Pacheco, Samantha X Shellman, Morkos A Henen, Beat Vögeli, Nathaniel B Goldstein, Stanca Birlea, Jennifer Hintzsche, Griffin Caryotakis, Aik-Choon Tan, Rui Zhao, David A Norris, William A Robinson, Yizhou Wang, Jillian G VanTreeck, Yiqun G Shellman
A better understanding of human melanocyte (MC) and melanocyte stem cell (McSC) biology is essential for treating melanocyte-related diseases. This study employed an inherited pigmentation disorder carrying the SASH1S519N variant in a Hispanic family to investigate the SASH1 function in the MC lineage and the underlying mechanism for this disorder. We used a multidisciplinary approach, including clinical exams, human cell assays, yeast two-hybrid screening, and biochemical techniques. Results linked early hair graying to the SASH1S519N variant, a previously unrecognized clinical phenotype in hyperpigmentation disorders...
June 5, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38844128/granuloma-annulare-exhibits-mixed-immune-and-macrophage-polarization-profiles-with-spatial-transcriptomics
#19
JOURNAL ARTICLE
Chitrasen Mohanty, Chandra K Singh, Joseph A Daccache, William Damsky, Christina Kendziorski, Di Yan, Aman Prasad, Donglin Zhang, Tom Keenan, Beth Drolet, Nihal Ahmad, Bridget E Shields
Granuloma annulare (GA) is an idiopathic condition characterized by granulomatous inflammation in the skin. Prior studies have suggested that GA develops from various triggers, leading to a complex interplay involving innate and adaptive immunity, tissue remodeling, and fibrosis. Macrophages are the major immune cells comprising GA granulomas, however, the molecular drivers and inflammatory signaling cascade behind macrophage activation is poorly understood. Histologically, GA exhibits both palisaded and interstitial patterns on histology, however the molecular composition of GA at the spatial level remains unexplored...
June 4, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38842990/much-more-than-just-diabetes-the-pivotal-role-of-dipeptidyl-peptidase-4-in-skin-fibrosis
#20
JOURNAL ARTICLE
Vera Vorstandlechner, Michael Mildner
No abstract text is available yet for this article.
June 4, 2024: Journal of Investigative Dermatology
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