Bruno Marcel Silva de Melo, Flávio Protásio Veras, Pascale Zwicky, Diógenes Lima, Florian Ingelfinger, Timna Varela, Douglas da Silva Prado, Stefanie Schärli, Gabriel Publio, Carlos Hiroji Hiroki, Paulo Henrique Melo, André Saraiva, Thainá Norbiato, Leonardo Lima, Bernhard Ryffel, Thomas Vogl, Johannes Roth, Ari Waisman, Helder I Nakaya, Cacilda da Silva Souza, Fernando Q Cunha, Thiago M Cunha, Burkhard Becher, José C Alves-Filho
Psoriasis is a chronic inflammatory skin disorder driven by IL-23/type-3 immune response. However, molecular mechanisms sustaining the chronicity of inflammation and psoriatic lesions remain elusive. Combining systematic analyses of several transcriptomic datasets, we delineated gene signatures across human psoriatic skin, identifying S100A9 as one of the most up-regulated genes, confirmed in lesioned skin from psoriasis patients and preclinical psoriasiform skin inflammation models. Genetic ablation or pharmacological inhibition of S100A9 alleviated Aldara-induced skin inflammation...
March 13, 2023: Journal of Investigative Dermatology