Laura Mourino-Alvarez, Inés Perales-Sanchez, Emilio Berna-Rico, Carlota Abbad-Jaime de Aragon, Nerea Corbacho-Alonso, Tamara Sastre Oliva, Cristina Juarez-Alia, Asunción Ballester-Martinez, Maria Castellanos-Gonzalez, Mar Llamas-Velasco, Pedro Jaen, Jorge Solis, Leticia Fernandez-Friera, Neha N Mehta, Joel M Gelfand, Maria G Barderas, Alvaro Gonzalez-Cantero
Psoriasis is a chronic and inflammatory disease that affects the skin and joints, and is associated with multiple co-morbidities and cardiovascular risk factors. Consequently, patients with psoriasis have an increased risk of cardiovascular diseases like atherosclerosis, a chronic pathology that shares common inflammatory and immune-response mechanisms with psoriasis, including vascular inflammation and complement activation. To better understand the relationship between atherosclerosis and psoriasis, a proteomics study followed by a bioinformatics analysis was carried out, with a subsequent validation step using ELISA and western blotting...
November 28, 2023: Journal of Investigative Dermatology