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Journal of Investigative Dermatology

Anita Y Voigt, Michael Michaud, Kenneth Y Tsai, Julia Oh, John P Sundberg
No abstract text is available yet for this article.
February 8, 2019: Journal of Investigative Dermatology
Jennifer Sand, Gabriele Fenini, Serena Grossi, Paulina Hennig, Michela Di Filippo, Mitchell Levesque, Sabine Werner, Lars E French, Hans-Dietmar Beer
The inflammasome protein NLRP1 is an important innate immune sensor in human keratinocytes and mediates, together with the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC) and caspase-1, the activation and secretion of the pro-inflammatory cytokines IL-1β and IL-18. These cytokines and inflammasomes can have in part opposing roles during tumorigenesis in mice. In contrast, ASC expression is impaired in different types of cancer in humans. In this study, we analyzed inflammasome activation and expression of inflammasome proteins including their downstream cytokines in squamous cell carcinomas (SCCs), a type of non-melanoma skin cancer derived from keratinocytes...
February 7, 2019: Journal of Investigative Dermatology
Xin Wang, Qing Zhang, Changji Li, Xiaoyan Qu, Peiwen Yang, Jinjing Jia, Liumei Song, Wenxin Fan, Huiling Jing, Yan Zheng
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancers. Several previous studies have shown that Fibulin-3 participates in the occurrence and development of various tumors; however, its role in cSCC remains unknown. In the present study, we observed that the expression of Fibulin-3 was down-regulated in cSCC tissues compared with normal skin tissues, which was due to Fibulin-3 promoter methylation. In vitro, knockdown of Fibulin-3 in cSCC cell lines A431 and SCL-1 cells promoted cell proliferation, protected cells against apoptosis and enhanced the migration and invasion abilities...
February 6, 2019: Journal of Investigative Dermatology
Luisa Senra, Alessio Mylonas, Ruairi D Kavanagh, Padraic G Fallon, Curdin Conrad, Julia Borowczyk-Michalowska, Ludovic Jean Wrobel, Guerkan Kaya, Nikhil Yawalkar, Wolf-Henning Boehncke, Nicolo Costantino Brembilla
IL-17E (IL-25) is a member of the IL-17 cytokine family involved in the promotion of type 2 immune responses. Recently, IL-17E has been reported to be upregulated in distinct skin inflammatory diseases such as psoriasis, atopic and contact dermatitis. We assessed the role played by IL-17E in skin inflammation. Here we show that IL-17E induces skin inflammation in vivo, characterized by the expression of innate immune response genes and the recruitment of innate immune cells, particularly neutrophils. Genetic deletion or IL-17E neutralization ameliorated skin inflammation induced by imiquimod application, or tape-stripping, with reductions in neutrophil and macrophage infiltration as assessed by t-SNE-guided multiparameter flow cytometry analysis, in mice...
February 6, 2019: Journal of Investigative Dermatology
Junko Takeshita, Whitney T Eriksen, Valerie T Raziano, Claire Bocage, Lynn Hur, Ruchi V Shah, Joel M Gelfand, Frances K Barg
In the U.S., black patients are less likely than whites to receive biologic treatment for their psoriasis. We conducted a qualitative freelisting study to identify patient-generated factors that may explain this apparent racial disparity in psoriasis treatment by comparing the perceptions of biologics and other psoriasis therapies between white and black adults with psoriasis. Participants included 68 white and black adults with moderate to severe psoriasis who had and had not received biologic treatment. Each participant was asked to list words in response to verbal probes querying five psoriasis treatments: self-injectable biologics, infliximab, methotrexate, apremilast, and phototherapy...
February 6, 2019: Journal of Investigative Dermatology
Ji Yeon Noh, Jung U Shin, Ji Hye Kim, Seo Hyeong Kim, Bo-Mi Kim, Young Hwan Kim, Semin Park, Tae-Gyun Kim, Kyong-Oh Shin, Kyungho Park, Kwang Hoon Lee
Adipokines modulate immune responses and lipid metabolism in allergic disease; however, little is known about its role in the skin barrier and atopic dermatitis (AD). We identified zinc-alpha-2 glycoprotein (ZAG), an adipokine that regulates lipid mobilization, as a biomarker for AD. ZAG levels were consistently decreased in sera, T cells, and skin in human AD patients compared with healthy controls. ZAG was primarily detected in the stratum corneum along with filaggrin (FLG) and loricrin (LOR). Knockdown of ZAG with shRNA resulted in decreased FLG and increased thymic stromal lymphopoietin (TSLP)...
February 6, 2019: Journal of Investigative Dermatology
Yi-Giien Tsai, Jia-Hung Liou, Shuen-Iu Hung, Chun-Bing Chen, Tsu-Man Chiu, Chuang-Wei Wang, Wen-Hung Chung
Drug reaction with eosinophilia and systemic symptom (DRESS) is life-threatening disorder with an estimated mortality of 2%. Recently, type II innate lymphoid cells (ILC2s) has been implicated as an important contributor to the pathogenesis of allergic disorders. However, whether the roles of ILC2s and ILC2-associated cytokines in DRESS remain unclear. Herein, we enrolled 54 participants (including 24 DRESS patients and 30 healthy controls), and identified the increased ST2+ ILC2s population in skin lesions/blood...
February 5, 2019: Journal of Investigative Dermatology
Xiannian Zhang, Yang Peng, Chunmei Li, Qianxi Li, Zhilong Yu, Yuhong Pang, Angela Ruohao Wu, Yanyi Huang, Hang Li
Acral melanoma (AM) is an extremely aggressive subtype of melanoma that is prevalent in east Asia. AM exhibits high intertumoral and intratumoral heterogeneities with poor prognosis. To associate the genomic heterogeneities with phenotypic traits and efficacy of treatments, a method is needed to recover genomic information from limited samples with high specificity and sensitivity from early stage AM specimens. We performed laser capture microdissection (LCM) to isolate single micro-tumor-nests, containing only dozens of cells, from stained tissue slices and then applied multiple annealing and looping based amplification cycles (MALBAC), a highly efficient whole genome amplification methods originally developed for single cells, to amplify the whole genome of each tumor nest for sequencing...
January 30, 2019: Journal of Investigative Dermatology
Deborah J Robinson, Ankit Patel, Karin J Purdie, Jun Wang, Hasan Rizvi, Martin Hufbauer, Paola Ostano, Baki Akgül, Giovanna Chiorino, Catherine Harwood, Daniele Bergamaschi
Keratinocyte skin cancer, comprising cutaneous squamous (cSCC) and basal cell carcinoma, is the most common malignancy in the UK. P53 is frequently mutated in cSCC. iASPP is a key inhibitor of p53 and NF-kB signalling pathways and has been documented as highly expressed in several types of human cancer. We have previously identified an autoregulatory feedback loop between iASPP and p63, which is critical in epidermal homeostasis. We hypothesised a potential role for dysregulation of this axis in the pathogenesis of keratinocyte malignancies...
January 30, 2019: Journal of Investigative Dermatology
Matthias Van Gils, Olivier M Vanakker
No abstract text is available yet for this article.
January 29, 2019: Journal of Investigative Dermatology
François Kuonen, Noelle E Huskey, Gautam Shankar, Prajakta Jaju, Ramon J Whitson, Kerri E Rieger, Scott X Atwood, Kavita Y Sarin, Anthony E Oro
Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the microtubule-based organelle, the primary cilium. Despite naïve tumors responsiveness to Smoothened inhibitors (Smoi ), resistance in advanced tumors remains frequent. While the resistant BCCs usually maintain HH pathway activation, squamous cell carcinomas with Ras/MAPK pathway activation also arise, with the molecular basis of tumor type and pathway selection still obscure. Here we identify the primary cilium as a critical determinant controlling tumor pathway switching...
January 29, 2019: Journal of Investigative Dermatology
Neda Nikbakht, Manoela Tiago, Dan A Erkes, Inna Chervoneva, Andrew E Aplin
No abstract text is available yet for this article.
January 28, 2019: Journal of Investigative Dermatology
Tanja Torbica, Kate Wicks, Takahiro Umehara, Lale Gungordu, Salma Alrdahe, Kelly Wemyss, John R Grainger, Kimberly A Mace
Chronic inflammation is a hallmark of impaired healing in a plethora of tissues, including skin, and is associated with aging and diseases such as diabetes. Diabetic chronic skin wounds are characterized by excessive myeloid cells that display an aberrant phenotype, partially mediated by stable intrinsic changes induced during hematopoietic development. However, the relative contribution of myeloid cell-intrinsic factors to chronic inflammation versus aberrant signals from the local environmental was unknown...
January 28, 2019: Journal of Investigative Dermatology
Fuduan Peng, Gu Zhu, Pirro G Hysi, Ryan J Eller, Yan Chen, Yi Li, Merel A Hamer, Changqing Zeng, Racquel L Hopkins, Case L Jacobus, Paige L Wallace, André G Uitterlinden, M Arfan Ikram, Tamar Nijsten, David L Duffy, Sarah E Medland, Timothy D Spector, Susan Walsh, Nicholas G Martin, Fan Liu, Manfred Kayser
No abstract text is available yet for this article.
January 28, 2019: Journal of Investigative Dermatology
Kosuke Shido, Kaname Kojima, Kenshi Yamasaki, Atsushi Hozawa, Gen Tamiya, Soichi Ogishima, Naoko Minegishi, Yosuke Kawai, Kozo Tanno, Yoichi Suzuki, Masao Nagasaki, Setsuya Aiba
No abstract text is available yet for this article.
January 25, 2019: Journal of Investigative Dermatology
Shuang Chen, Kaiwen Zhuang, Kaiyi Sun, Qin Yang, Xin Ran, Xiaoxi Xu, Chan Mu, Bin Zheng, Yanrong Lu, Jun Zeng, Yalin Dai, Pradhan Sushmita, Yuping Ran
Infantile hemangioma (IH) is the most common benign vascular tumor of infancy. We have previously reported that itraconazole, a common anti-fungal agent, can clinically improve or cure IH; however, the underlying molecular mechanisms are still unclear. Here, we show that itraconazole treatment significantly inhibits the proliferation and promotes apoptosis of the endothelial cells of mouse hemangioma (EOMA) cell line and infantile primary hemangioma endothelial cell (HemEC). Itraconazole also remarkably reduced angiogenesis of HemEC in vitro...
January 25, 2019: Journal of Investigative Dermatology
Rebecca Kohnken, Anjali Mishra
MicroRNAs (miRs) are small, noncoding RNAs with numerous cellular functions. With advancing knowledge of the many functions of miRs in cancer pathogenesis, there is emerging interest in miRs as therapeutic targets in cancers. One disease that poses an intriguing model for miR therapy is cutaneous T-cell lymphoma, a rare disease featuring malignant CD4+ T cells that proliferate in the skin. The hallmark of cutaneous T-cell lymphoma progression is epigenetic dysregulation, with aberrant miR levels being a common feature...
January 24, 2019: Journal of Investigative Dermatology
Takashi Inozume, Tomonori Yaguchi, Ryo Ariyasu, Yosuke Togashi, Takehiro Ohnuma, Akiko Honobe, Hiroyoshi Nishikawa, Yutaka Kawakami, Tatsuyoshi Kawamura
MHC class I loss due to the abnormality of β2-microgloburin (B2M) gene is one of the mechanism underlying delayed relapses in melanoma patients long after the initial positive responses to anti-PD-1 therapy. However, the tumor-specific reactivity of tumor-infiltrating lymphocytes (TILs) in tumor lesions that lost MHC class I expression has not been well evaluated. We report the case of a 55-year-old woman with two metastatic melanoma lesions. After a 12-month period of successful tumor suppression by anti-PD-1 antibody therapy, one lesion started to grow again...
January 23, 2019: Journal of Investigative Dermatology
John T O'Malley, Rachael A Clark, Hans R Widlund
No abstract text is available yet for this article.
January 23, 2019: Journal of Investigative Dermatology
Megumi Saito, Kazuhiro Okumura, Eriko Isogai, Kimi Araki, Chizu Tanikawa, Koichi Matsuda, Takehiko Kamijo, Ryo Kominami, Yuichi Wakabayashi
Identification of the specific genetic variants responsible for the increased susceptibility to familial or sporadic cancers is important. Using a forward genetics approach to map such loci in a mouse skin cancer model, we previously identified a strong genetic locus, Stmm3 (skin tumor modifier of MSM 3), conferring resistance to chemically-induced skin papillomas on chromosome 4. Here, we report the cyclin-dependent kinase inhibitor gene Cdkn2a/p19Arf as a major responsible gene for the Stmm3 locus. We provide evidence that the function of Stmm3 is dependent on p53 and that p19ArfMSM confers stronger resistance to papillomas than p16Ink4aMSM in vivo...
January 23, 2019: Journal of Investigative Dermatology
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