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Journals Journal of Investigative Derma...

Journal of Investigative Dermatology

https://read.qxmd.com/read/38493933/efficacy-and-safety-of-rilzabrutinib-in-pemphigus-pegasus-phase-3-randomized-study
#1
JOURNAL ARTICLE
Dedee F Murrell, Frédéric Caux, Aikaterini Patsatsi, Owen Hagino, Lidia Rudnicka, Snejina Vassileva, Soner Uzun, Jenny Ye, Karl Yen, Puneet Arora, Steven G Gourlay, Pascal Joly, Victoria P Werth
TRIAL DESIGN: Pemphigus is a rare, but life-threatening autoimmune disease requiring long-term treatment that minimizes corticosteroid (CS) exposure while providing consistent disease control. The phase 2 pemphigus study of oral, reversible, covalent Bruton tyrosine kinase (BTK) inhibitor rilzabrutinib demonstrated rapid and sustained efficacy with well-tolerated safety. METHODS: Adults (18-80 y) were randomized 1:1 to rilzabrutinib 400 mg (n=65) or placebo (n=66) twice daily (with CS ≤0...
March 15, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38493385/endothelial-dysfunction-in-psoriasis-an-integrative-review
#2
REVIEW
Qingyang Li, Bingyu Pang, Erle Dang, Gang Wang
Vascular endothelial cells (ECs), the inner layer of blood vessels, were previously considered to be a passive lining that facilitates cellular and molecular exchange. However, recent studies have revealed that ECs can respond to various stimuli and actively regulate vascular function and skin inflammation. Specific subtypes of ECs are known to have significant roles in a diverse range of physiological and pathological processes in the skin. This review suggests that EC dysfunction is both causal and consequential in the pathogenesis of psoriasis...
March 15, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38493384/emerging-role-of-fibroblasts-in-vitiligo-a-formerly-underestimated-rising-star
#3
REVIEW
Yue Wu, Yiwen Yang, Yi Lin, Yuecen Ding, Ziqi Liu, Leihong Xiang, Mauro Picardo, Chengfeng Zhang
Vitiligo is a disfiguring depigmentation disorder characterized by loss of melanocytes. Although numerous studies have been conducted on the pathogenesis of vitiligo, the underlying mechanisms remain unclear. Although most studies have focused on melanocytes and keratinocytes, growing evidence suggests the involvement of dermal fibroblasts, residing deeper in the skin. This review aims to elucidate the role of fibroblasts in both the physiological regulation of skin pigmentation and their pathological contribution to depigmentation, with the goal of shedding light on the involvement of fibroblasts in vitiligo...
March 15, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38493383/advances-in-skin-on-a-chip-technologies-for-dermatological-disease-modeling
#4
REVIEW
Seo Won Cho, Hamza Malick, Soo Jung Kim, Alessandro Grattoni
Skin-on-a-chip (SoC) technologies are emerging as a paradigm shift in dermatology research by replicating human physiology in a dynamic manner not achievable by current animal models. Although animal models have contributed to successful clinical trials, their ability to predict human outcomes remains questionable, owing to inherent differences in skin anatomy and immune response. Covering areas including infectious diseases, autoimmune skin conditions, wound healing, drug toxicity, aging, and antiaging, SoC aims to circumvent the inherent disparities created by traditional models...
March 15, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38493382/time-is-running-out-the-circadian-clock-suggests-sex-and-aging-differences-in-human-epidermis
#5
JOURNAL ARTICLE
Rachel Bernstein, Shobhan Gaddameedhi
No abstract text is available yet for this article.
March 15, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38490440/calpain-inhibition-protects-against-uvb-induced-degradation-of-dermal-epidermal-junction-associated-proteins
#6
JOURNAL ARTICLE
Iva Doleckova, Tinka Vidovic, Lenka Jandova, Christine Gretzmeier, Alexander A Navarini, Michael R MacArthur, Orcun Goksel, Alexander Nyström, Collin Y Ewald
No abstract text is available yet for this article.
March 13, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38483357/modeling-wound-chronicity-in%C3%A2-vivo-the-translational-challenge-to-capture-the-complexity-of-chronic-wounds
#7
REVIEW
Anna-Lisa Pignet, Marlies Schellnegger, Andrzej Hecker, Lars-Peter Kamolz, Petra Kotzbeck
In an aging society with common lifestyle-associated health issues such as obesity and diabetes, chronic wounds pose a frequent challenge that physicians face in everyday clinical practice. Therefore, nonhealing wounds have attracted much scientific attention. Several in vitro and in vivo models have been introduced to deepen our understanding of chronic wound pathogenesis and amplify therapeutic strategies. Understanding how wounds become chronic will provide insights to reverse or avoid chronicity...
March 12, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38462125/spry1-deficiency-in-keratinocytes-induces-follicular-melanocyte-stem-cells-migration-to-epidermis-through-p53-scf-c-kit-signaling
#8
JOURNAL ARTICLE
Ying-Zhe Cui, Fan Xu, Yuan Zhou, Zhao-Yuan Wang, Xing-Yu Yang, Ni-Chang Fu, Xi-Bei Chen, Yu-Xin Zheng, Xue-Yan Chen, Li-Ran Ye, Ying-Ying Li, Xiao-Yong Man
The function and survival of melanocytes is regulated by an elaborate network of paracrine factors synthesized mainly by epidermal keratinocytes. Keratinocytes and melanocytes respond to UV exposure by eliciting a tanning response. However, how keratinocytes and melanocytes interact in the absence of UV exposure is unknown. Here, we demonstrate that after SPRY1 knockout in epidermal keratinocytes, melanocyte stem cells (McSCs) in the hair follicle exit the niche without depleting the pool of these cells. We also found that McSCs migrate to the epidermis in a p53/SCF/C-KIT-dependent manner induced by a tanning-like response resulting from SPRY1 loss in epidermal keratinocytes...
March 8, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38460809/genetic-analysis-of-perceived-youthfulness-reveals-differences-in-how-men-s-and-women-s-age-is-assessed
#9
JOURNAL ARTICLE
Nathan Ingold, Mathias Seviiri, Jue-Sheng Ong, Scott Gordon, Rachel E Neale, David C Whiteman, Catherine M Olsen, Stuart MacGregor, Matthew H Law
Skin aging is a natural process that occurs over time, but can be accelerated by sun exposure. Measuring skin age in a large population can provide insight into the extent of skin damage from sun exposure and skin cancer risk. Understanding the genetics of skin aging, within and across sexes, could improve our understanding of the genetic drivers of both skin aging and skin cancer. We used UK Biobank data to examine the genetic overlap between perceived youthfulness and traits relevant to actinic photoaging...
March 7, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38460808/monocyte-to-high-density-lipoprotein-ratio-is-associated-with-systemic-inflammation-insulin-resistance-and-coronary-subclinical-atherosclerosis-in-psoriasis-results-from-2-observational-cohorts
#10
JOURNAL ARTICLE
Emilio Berna-Rico, Carlota Abbad-Jaime de Aragon, Asuncion Ballester-Martinez, Javier Perez-Bootello, Jorge Solis, Leticia Fernandez-Friera, Mar Llamas-Velasco, Maria Castellanos-Gonzalez, Maria G Barderas, Carlos Azcarraga-Llobet, Emilio Garcia-Mouronte, Belen de Nicolas-Ruanes, Jorge Naharro-Rodriguez, Pedro Jaen-Olasolo, Joel M Gelfand, Nehal N Mehta, Alvaro Gonzalez-Cantero
Systemic inflammation or insulin resistance drive atherosclerosis. However, they are difficult to capture for assessing cardiovascular risk in clinical settings. The monocyte-to-HDL ratio (MHR) is an accessible biomarker that integrates inflammatory and metabolic information and which has been associated with poorer cardiovascular outcomes. Our aim was to evaluate the association of MHR with the presence of subclinical atherosclerosis in patients with psoriasis. The study involved a European and an American cohort including 405 patients with the disease...
March 7, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38458429/tumor-intrinsic-galectin-3-suppresses-melanoma-metastasis
#11
JOURNAL ARTICLE
Norhan B B Mohammed, Lee Seng Lau, Joseph Souchak, Shi Qiu, Manmeet S Ahluwalia, Iman Osman, Charles J Dimitroff
Melanoma poses a poor prognosis with high mortality rates upon metastasis. Exploring molecular mechanisms governing melanoma progression paves the way for developing novel approaches to control melanoma metastasis and ultimately enhance patient survival rates. Extracellular galectin-3 (Gal-3) has emerged as a pleiotropic promoter of melanoma metastasis, exerting varying activities depending on its interacting partner. However, whether intracellular Gal-3 promotes melanoma aggressive behavior remains unknown...
March 6, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38458428/casz1-is-essential-for-skin-epidermal-terminal-differentiation
#12
JOURNAL ARTICLE
Stephenie H Droll, Benny J Zhang, Maxwell C Levine, Celia Xue, Patric J Ho, Xiaomin Bao
The barrier function of skin epidermis is crucial for our bodies to interface with the environment. As epidermis continuously turns over throughout the lifetime, this barrier must be actively maintained by regeneration. Although several transcription factors have been established as essential activators in epidermal differentiation, it is unclear if additional factors remain to be identified. Here, we show that CASZ1, a multi-zinc-finger transcription factor previously characterized in non-epithelial cell types, shows highest expression in skin epidermis...
March 6, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38447867/s100a9-exacerbates-the-inflammation-in-rosacea-via-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling-pathway
#13
JOURNAL ARTICLE
Yan Le, Jiawen Zhang, Yi Lin, Jie Ren, Leihong Xiang, Chengfeng Zhang
Rosacea is a chronic inflammatory skin disorder characterized by immune response-dependent erythema and pustules. S100 calcium binding protein A9 (S100A9), a pro-inflammatory alarmin, has been associated with various inflammation-related diseases. However, the specific role of S100A9 in rosacea remains unexplored. Therefore, our objective was to unravel the role of S100A9 in the pathogenesis of rosacea and its underlying molecular mechanisms. Here, we show that expression levels of S100A9 were elevated in both the lesions and serum of PPR patients, as well as in lesions of the LL37-induced rosacea-like mouse model...
March 4, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38447866/epidemiology-and-co-morbidities-of-mucous-membrane-pemphigoid-a-national-cohort-study
#14
JOURNAL ARTICLE
Päivi Leisti, Laura Huilaja, Jari Jokelainen, Outi Varpuluoma, Kaisa Tasanen
No abstract text is available yet for this article.
March 4, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38447865/excoriation-disorder-is-characterized-by-systemic-glutamatergic-dysfunction
#15
JOURNAL ARTICLE
Zachary A Bordeaux, Sriya V Reddy, Emily Z Ma, Hannah Cornman, Thomas Pritchard, Melika Marani, Weiying Lu, Shenghao Guo, Cissy Zhang, Pratik Khare, Anne Le, Madan M Kwatra, Shawn G Kwatra
No abstract text is available yet for this article.
March 4, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38447864/similar-alterations-of-the-stratum-corneum-ceramide-profile-in-atopic-dermatitis-psoriasis-and-ichthyosis-results-from-a-systematic-review-and-meta-analysis
#16
JOURNAL ARTICLE
Jannik Rousel, Catherine Mergen, Jan W Schoones, Tessa Niemeyer-van der Kolk, Martijn B A van Doorn, Joke A Bouwstra, Jeroen van Smeden, Robert Rissmann
No abstract text is available yet for this article.
March 4, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38441507/the-promises-and-perils-of-foundation-models-in-dermatology
#17
REVIEW
Haiwen Gui, Jesutofunmi A Omiye, Crystal T Chang, Roxana Daneshjou
Foundation models (FM), which are large-scale artificial intelligence (AI) models that can complete a range of tasks, represent a paradigm shift in AI. These versatile models encompass large language models, vision-language models, and multimodal models. Although these models are often trained for broad tasks, they have been applied either out of the box or after additional fine tuning to tasks in medicine, including dermatology. From addressing administrative tasks to answering dermatology questions, these models are poised to have an impact on dermatology care delivery...
March 4, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38441508/phosphodiesterase-4-inhibitors-basophils-and-atopic-dermatitis
#18
JOURNAL ARTICLE
Mrinmoy Das, Saikat Mukherjee, Raif S Geha
No abstract text is available yet for this article.
March 3, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38431222/circulating-monocytes-are-predictive-and-responsive-in-moderate-to-severe-plaque-psoriasis-subjects-treated-with-apremilast
#19
JOURNAL ARTICLE
Emma L Larson, Dustin P DeMeo, Andrew B Young, Seunghee Margevicius, Joseph Rutter, Amanda L Davies, Craig A Rohan, Neil J Korman, Jeffrey B Travers, Thomas S McCormick, Kevin D Cooper
Monocytes play a critical role in the inflammation associated with psoriasis, and their abnormalities have been reported as biomarkers of cardiovascular event risk, a psoriasis comorbidity. Monocytic cells in chronic inflammatory disorders express elevated levels of cAMP phosphodiesterase. Restoring cAMP levels using the oral cAMP phosphodiesterase-4 inhibitor, apremilast, improves clinical outcomes for a subset of psoriasis patients. We asked whether aberrant monocyte subsets or transcriptomic pathways can function as biomarkers of psoriasis endotypes that can predict enhanced clinical responses to cAMP phosphodiesterase inhibition...
February 29, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38431221/somatic-loss-of-function-pik3r1-and-activating-non-hotspot-pik3ca-mutations-associated-with-capillary-malformation-with-dilated-veins-cmdv
#20
JOURNAL ARTICLE
Martina De Bortoli, Angela Queisser, Van Cuong Pham, Anne Dompmartin, Raphaël Helaers, Simon Boutry, Cathy Claus, An-Katrien De Roo, Frank Hammer, Pascal Brouillard, Salim Abdelilah-Seyfried, Laurence M Boon, Miikka Vikkula
Common capillary malformations (CMs) are red vascular skin lesions, most commonly associated with somatic activating GNAQ or GNA11 mutations. We focused on CMs lacking such a mutation to identify novel genetic causes. We used targeted next-generation-sequencing on 82 lesions. Bioinformatic analysis allowed the identification of 9 somatic pathogenic variants in PIK3R1 and PIK3CA, encoding for the regulatory and catalytic subunits of the PI3K kinase, respectively. Re-characterization of these lesions unraveled a common phenotype: a pale Capillary Malformation associated with visible Dilated Veins (CMDV)...
February 29, 2024: Journal of Investigative Dermatology
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