A proposal for standardized grading of chronic changes in native kidney biopsy specimens.

Sanjeev Sethi, Vivette D D'Agati, Cynthia C Nast, Agnes B Fogo, An S De Vriese, Glen S Markowitz, Richard J Glassock, Fernando C Fervenza, Surya V Seshan, Andrew Rule, Lorraine C Racusen, Jai Radhakrishnan, Christopher G Winearls, Gerald B Appel, Ingeborg M Bajema, Anthony Chang, Robert B Colvin, H Terence Cook, Sundaram Hariharan, Loren P Herrera Hernandez, Neeraja Kambham, Michael Mengel, Karl A Nath, Helmut G Rennke, Pierre Ronco, Brad H Rovin, Mark Haas

Kidney International 2017 April

Chronic changes represent an important component of native kidney biopsy evaluation and have a major bearing on predicting prognosis and guiding treatment. We propose here a uniform, semiquantitative approach to assessing such changes, which include glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis, and we report these findings as an overall chronicity grade.

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