Kitty J Jager, Anneke Kramer, Nicholas C Chesnaye, Cécile Couchoud, J Emilio Sánchez-Álvarez, Liliana Garneata, Fréderic Collart, Marc H Hemmelder, Patrice Ambühl, Julia Kerschbaum, Camille Legeai, María Dolores Del Pino Y Pino, Gabriel Mircescu, Lionel Mazzoleni, Tiny Hoekstra, Rebecca Winzeler, Gert Mayer, Vianda S Stel, Christoph Wanner, Carmine Zoccali, Ziad A Massy
The aim of this study was to investigate 28-day mortality after COVID-19 diagnosis in the European kidney replacement therapy population. In addition, we determined the role of patient characteristics, treatment factors, and country on mortality risk using ERA-EDTA Registry data on patients receiving kidney replacement therapy in Europe between February 1, 2020 and April 30, 2020. Additional data on all patients with a diagnosis of COVID-19 were collected from seven European countries encompassing 4298 patients...
September 23, 2020: Kidney International
Nuri Baris Hasbal
No abstract text is available yet for this article.
September 22, 2020: Kidney International
Rimda Wanchoo, Maria Louise Barilla-LaBarca, Kenar D Jhaveri
No abstract text is available yet for this article.
September 22, 2020: Kidney International
Manuel A Anderegg, Giuseppe Albano, Daniela Hanke, Christine Deisl, Dominik E Uehlinger, Simone Brandt, Rajesh Bhardwaj, Matthias A Hediger, Daniel G Fuster
NHA2 is a sodium/proton exchanger associated with arterial hypertension in humans, but the role of NHA2 in kidney function and blood pressure homeostasis is currently unknown. Here we show that NHA2 localizes almost exclusively to distal convoluted tubules in the kidney. NHA2 knock-out mice displayed reduced blood pressure, normocalcemic hypocalciuria and an attenuated response to the thiazide diuretic hydrochlorothiazide. Phosphorylation of the thiazide-sensitive sodium/chloride cotransporter NCC and its upstream activating kinase Ste20/SPS1-related proline/alanine rich kinase (SPAK), as well as the abundance of with no lysine kinase 4 (WNK4), were significantly reduced in the kidneys of NHA2 knock-out mice...
September 18, 2020: Kidney International
Xiaoyang Wang, Robert Lopez, Rebecca A Luchtel, Sassan Hafizi, Benjamin Gartrell, Niraj Shenoy
Targeted therapies and immune checkpoint inhibitors have advanced the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade. While checkpoint inhibitors have demonstrated survival benefit and are currently approved in the front-line and second-line settings, primary and secondary resistance is common. A comprehensive understanding of the mechanisms of immune evasion in RCC is therefore critical to the development of effective combination treatment strategies. This article reviews the current understanding of the different, yet coordinated, mechanisms adopted by RCC cells to evade immune killing; summarizes various aspects of clinical translation thus far, including the currently registered RCC clinical trials exploring agents in combination with checkpoint inhibitors; and provides perspectives on the current landscape and future directions for the field...
September 16, 2020: Kidney International
Neeraj Singh, Srijan Tandukar, Gazi Zibari, Muhammad Saad Naseer, Hosein S Amiri, Millie Samaniego
No abstract text is available yet for this article.
September 15, 2020: Kidney International
Camilo G Sotomayor, Dion Groothof, Joppe J Vodegel, Michele F Eisenga, Tim J Knobbe, Jan IJmker, Rosa G M Lammerts, Martin H de Borst, Stefan P Berger, Ilja M Nolte, Ramón Rodrigo, Riemer H J A Slart, Gerjan J Navis, Daan J Touw, Stephan J L Bakker
The kidney is one of the most sensitive organs to cadmium-induced toxicity, particularly in conditions of long-term oxidative stress. We hypothesized that, in kidney transplant recipients, nephrotoxic exposure to cadmium represents an overlooked hazard for optimal graft function. To test this, we performed a prospective cohort study and included 672 outpatient kidney transplant recipients with a functioning graft of beyond one year. The median plasma cadmium was 58 ng/L. During a median 4.9 years of follow-up, 78 kidney transplant recipients developed graft failure with a significantly different distribution across tertiles of plasma cadmium (13, 26, and 39 events, respectively)...
September 14, 2020: Kidney International
Berenice Gitomer, Renata Pereira, Isidro B Salusky, Jason W Stoneback, Tamara Isakova, Xuan Cai, Lorien S Dalrymple, Norma Ofsthun, Zhiying You, Harmut H Malluche, Franklin Maddux, Diana George, Vicente Torres, Arlene Chapman, Theodore I Steinman, Myles Wolf, Michel Chonchol
Mice with disruption of Pkd1 in osteoblasts demonstrate reduced bone mineral density, trabecular bone volume and cortical thickness. To date, the bone phenotype in adult patients with autosomal dominant polycystic kidney disease (ADPKD) with stage I and II chronic kidney disease has not been investigated. To examine this, we characterized biochemical markers of mineral metabolism, examined bone turnover and biology, and estimated risk of fracture in patients with ADPKD. Markers of mineral metabolism were measured in 944 patients with ADPKD and other causes of kidney disease...
September 11, 2020: Kidney International
John A Kellum, Mitra K Nadim, Lui G Forni
No abstract text is available yet for this article.
September 10, 2020: Kidney International
Rory Wolfe, James B Wetmore, Robyn L Woods, John J McNeil, Hugh Gallagher, Paul Roderick, Rowan Walker, Mark R Nelson, Christopher M Reid, Raj C Shah, Michael E Ernst, Jessica E Lockery, Andrew M Tonkin, Walter P Abhayaratna, Peter Gibbs, Erica M Wood, Suzanne E Mahady, Jeff D Williamson, Geoffrey A Donnan, Geoffrey C Cloud, Anne M Murray, Kevan R Polkinghorne
The role of aspirin for primary prevention in older adults with chronic kidney disease (CKD) is unclear. Therefore, post hoc analysis of the randomized controlled trial ASPirin in Reducing Events in the Elderly (ASPREE) was undertaken comparing 100 mg of enteric-coated aspirin daily against matching placebo. Participants were community dwelling adults aged 70 years and older in Australia, 65 years and older in the United States, all free of a history of dementia or cardiovascular disease and of any disease expected to lead to death within five years...
September 10, 2020: Kidney International
Anusha S Shankar, Zhaoyu Du, Hector Tejeda Mora, Thierry P P van den Bosch, Sander S Korevaar, Ingrid M Van den Berg-Garrelds, Eric Bindels, Carmen Lopez-Iglesias, Marian Clahsen-van Groningen, Joost Gribnau, Carla C Baan, A H Jan Danser, Ewout J Hoorn, Martin J Hoogduijn
Renin production by the kidney is of vital importance for salt, volume, and blood pressure homeostasis. The lack of human models hampers investigation into the regulation of renin and its relevance for kidney physiology. To develop such a model, we used human induced pluripotent stem cell derived kidney organoids to study the role of renin and the renin-angiotensin system in the kidney. Extensive characterization of the kidney organoids revealed kidney-specific cell populations consisting of podocytes, proximal and distal tubular cells, stromal cells and endothelial cells...
September 9, 2020: Kidney International
Aude Servais, Kay Thomas, Luca Dello Strologo, John A Sayer, Soumeya Bekri, Aurelia Bertholet-Thomas, Matthew Bultitude, Giovanna Capolongo, Rimante Cerkauskiene, Michel Daudon, Steeve Doizi, Valentine Gillion, Silvia Gràcia-Garcia, Jan Halbritter, Laurence Heidet, Marleen van den Heijkant, Sandrine Lemoine, Bertrand Knebelmann, Francesco Emma, Elena Levtchenko
Cystinuria (OMIM 220100) is an autosomal recessive hereditary disorder in which high urinary cystine excretion leads to formation of cystine stones due to its low solubility at normal urinary pH. We developed clinical practice recommendation for diagnosis, surgical and medical treatment, and follow up of cystinuria patients. Elaboration of these Clinical Practice Recommendations spanned from June 2018 until December 2019 with a consensus conference in January 2019. Selected topic areas were chosen by the co-chairs of the conference...
September 9, 2020: Kidney International
Jennifer R Charlton, Yanzhe Xu, Teresa Wu, Kim A deRonde, Jillian L Hughes, Shourik Dutta, Gavin T Oxley, Aleksandra Cwiek, Helen P Cathro, Nathan P Charlton, Mark R Conaway, Edwin J Baldelomar, Neda Parvin, Kevin M Bennett
Acute kidney injury (AKI) increases the risk for chronic kidney disease (CKD). However, there are few tools to detect microstructural changes after AKI. Here, cationic ferritin-enhanced magnetic resonance imaging (CFE-MRI) was applied to examine the heterogeneity of kidney pathology in the transition from AKI to CKD. Adult male mice received folic acid followed by cationic ferritin and were euthanized at four days (AKI), four weeks (CKD-4) or 12 weeks (CKD-12). Kidneys were examined by histologic methods and CFE-MRI...
September 8, 2020: Kidney International
Craig Peter Coorey, Ankit Sharma, Samuel Mueller, Jean Yang
Kidney transplant recipients and transplant physicians face important clinical questions where machine learning methods may help improve the decision-making process. This mini-review explores potential applications of machine learning methods to key stages of a kidney transplant recipient's journey, from initial waitlisting and donor selection, to personalization of immunosuppression and prediction of post-transplantation events. Both unsupervised and supervised machine learning methods are presented, including k-means clustering, principal components analysis, k-nearest neighbors and random forests...
September 8, 2020: Kidney International
Fabian Braun, Tobias B Huber, Victor G Puelles
Recent studies have reported a variety of urine abnormalities in patients hospitalized due to SARS-CoV-2 infection. In a single center study from Belgium, Werion et al., now present a concise investigation of tubular dysfunction in COVID-19 patients identifying potential risk factors for increased disease severity. These data complement current evidence regarding SARS-CoV-2 presence and potential infection in the kidney.
September 8, 2020: Kidney International
Edward D Siew, Sharidan K Parr, Khaled Abdel-Kader, Amy M Perkins, Robert A Greevy, Andrew J Vincz, Jason Denton, Otis D Wilson, Adriana M Hung, T Alp Ikizler, Cassianne Robinson-Cohen, Michael E Matheny
Recurrent episodes of acute kidney injury (AKI) are common among AKI survivors. Renin-angiotensin aldosterone inhibitors (RAASi) are often indicated for these patients but may increase the risk for recurrent AKI. Here, we examined whether RAASi associates with a higher risk for recurrent AKI and mortality among survivors of moderate to severe AKI in a retrospective cohort of Veterans who survived Stage II or III AKI. The primary exposure was RAASi at hospital discharge and the primary endpoint was recurrent AKI within 12 months...
September 8, 2020: Kidney International
Marine Berquez, Jonathan R Gadsby, Beatrice Paola Festa, Richard Butler, Stephen P Jackson, Valeria Berno, Alessandro Luciani, Olivier Devuyst, Jennifer L Gallop
Loss-of-function mutations in the OCRL gene, which encodes the phosphatidylinositol [PI] 4,5-bisphosphate [PI(4,5)P2 ] 5-phosphatase OCRL, cause defective endocytosis and proximal tubule dysfunction in Lowe syndrome and Dent disease 2. The defect is due to increased levels of PI(4,5)P2 and aberrant actin polymerization, blocking endosomal trafficking. PI 3-phosphate [PI(3)P] has been recently identified as a coactivator with PI(4,5)P2 in the actin pathway. Here, we tested the hypothesis that phosphoinositide 3-kinase (PI3K) inhibitors may rescue the endocytic defect imparted by OCRL loss, by rebalancing phosphoinositide signals to the actin machinery...
September 5, 2020: Kidney International
Thomas Bardin, Quang D Nguyen, Khoy M Tran, Nghia H Le, Minh D Do, Pascal Richette, Emmanuel Letavernier, Jean-Michel Correas, Mathieu Resche-Rigon
We have previously shown that ultrasonography can detect hyperechogenic crystal deposits in the kidney medulla of patients with gout. In this cross-sectional study we investigated the frequency and clinical correlates of hyperechogenic kidney medulla in 502 consecutive primary consultants for gout (ACR/EULAR criteria) at the Vien Gut medical center in Ho Chi Minh City, Vietnam. None of these patients received urate-lowering drugs. Kidney medulla echogenicity on B-mode ultrasonography was compared to that of the kidney cortex...
September 5, 2020: Kidney International
Paul M Schroder, Robin Schmitz, Zachary W Fitch, Brian Ezekian, Janghoon Yoon, Ashley Y Choi, Miriam Manook, Andrew Barbas, Frank Leopardi, Mingqing Song, Alton B Farris, Bradley Collins, Jean Kwun, Stuart J Knechtle
Sensitized patients are difficult to transplant due to pre-formed anti-donor immunity. We have previously reported successful desensitization using carfilzomib and belatacept in a non-human primate (NHP) model. Here we evaluated selective blockade of the co-stimulatory signal (CD28-B7) with Lulizumab, which preserves the co-inhibitory signal (CTLA4-B7). Five maximally MHC-mismatched pairs of NHPs were sensitized to each other with two sequential skin transplants. Individuals from each pair were randomized to either desensitization with once-weekly Carfilzomib (27mg/m2 IV) and Lulizumab (12...
September 5, 2020: Kidney International
Amaury Dujardin, Marine Lorent, Yohann Foucher, Christophe Legendre, Clarisse Kerleau, Sophie Brouard, Magali Giral
The transplantation field requires the identification of specific risk factors associated with the level of immunosuppression. Here, our aim was to analyze the association between the number of circulating lymphocytes, monitored routinely by complete blood cell counts during outpatient visits, and patient and graft survival. In total, 2,999 kidney or combined kidney-pancreas recipients transplanted between 2000 and 2016, from two University hospitals, were enrolled. We investigated the etiological relationship between time-dependent lymphocyte count beyond one year after transplantation and patient and graft survival, viral infection and cancer risk using time-dependent multivariate Cox models...
September 3, 2020: Kidney International
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