Kidney International

Benjamin A Vervaet, Cynthia C Nast, Channa Jayasumana, Gerd Schreurs, Frank Roels, Chula Herath, Nika Kojc, Vahid Samaee, Sonali Rodrigo, Swarnalata Gowrishankar, Christiane Mousson, Rajeewa Dassanayake, Carlos M Orantes, Vincent Vuiblet, Claire Rigothier, Patrick C D'Haese, Marc E De Broe
Almost 30 years after the detection of chronic interstitial nephritis in agricultural communities (CINAC) its etiology remains unknown. To help define this we examined 34 renal biopsies from Sri Lanka, El Salvador, India and France of patients with chronic kidney disease 2-3 and diagnosed with CINAC by light and electron microscopy. In addition to known histopathology, we identified a unique constellation of proximal tubular cell findings including large dysmorphic lysosomes with a light-medium electron-dense matrix containing dispersed dark electron-dense non-membrane bound "aggregates"...
November 23, 2019: Kidney International
Takao Saito, Akira Matsunaga, Megumu Fukunaga, Kiyotaka Nagahama, Shigeo Hara, Eri Muso
Of the glomerular disorders that occur due to apolipoprotein E (apoE) mutations, apoE2 homozygote glomerulopathy and lipoprotein glomerulopathy (LPG) have been characterized. ApoE2 homozygote glomerulopathy has been found in individuals expressing homozygous apoE2/2. This was characterized histologically by glomerulosclerosis with marked infiltration of foam cells derived from macrophages, and occasionally with non-lamellated lipoprotein thrombi. Recently, several cases of apoE Toyonaka (Ser197Cys) combined with homozygous apoE2/2 have been reported, in which non-immune membranous nephropathy-like features were observed in glomeruli...
November 22, 2019: Kidney International
Lili Chan, Kelly Beers, Amy A Yau, Kinsuk Chauhan, Áine Duffy, Kumardeep Chaudhary, Neha Debnath, Aparna Saha, Pattharawin Pattharanitima, Judy Cho, Peter Kotanko, Alex Federman, Steven G Coca, Tielman Van Vleck, Girish N Nadkarni
Symptoms are common in patients on maintenance hemodialysis but identification is challenging. New informatics approaches including natural language processing (NLP) can be utilized to identify symptoms from narrative clinical documentation. Here we utilized NLP to identify seven patient symptoms from notes of maintenance hemodialysis patients of the BioMe Biobank and validated our findings using a separate cohort and the MIMIC-III database. NLP performance was compared for symptom detection with International Classification of Diseases (ICD)-9/10 codes and the performance of both methods were validated against manual chart review...
November 9, 2019: Kidney International
Heng-Pin Chiang, Yi-Wen Chiu, Jia-Jung Lee, Chi-Chih Hung, Shang-Jyh Hwang, Hung-Chun Chen
Observational studies have demonstrated that low blood pressure is related to poor clinical outcomes in patients with chronic kidney disease (CKD). Subgroup analyses from the SPRINT trial showed that targeting systolic blood pressure under 120 mmHg is less beneficial for patients with CKD. Although malnutrition and inflammation are common in patients with advanced CKD, such patients are usually excluded from clinical trials. Therefore, we hypothesized that malnutrition-inflammation-cachexia syndrome could explain this J-shaped relationship...
November 7, 2019: Kidney International
Anique D Ter Braake, Anna E Smit, Caro Bos, Antonius E van Herwaarden, Wynand Alkema, Huib W van Essen, Nathalie Bravenboer, Marc G Vervloet, Joost G J Hoenderop, Jeroen H F de Baaij
Klotho knock-out mice are an important model for vascular calcification, which is associated with chronic kidney disease. In chronic kidney disease, serum magnesium inversely correlates with vascular calcification. Here we determine the effects of serum magnesium on aortic calcification in Klotho knock-out mice treated with a minimal or a high magnesium diet from birth. After eight weeks, serum biochemistry and aorta and bone tissues were studied. Protective effects of magnesium were characterized by RNA-sequencing of the aorta and micro-CT analysis was performed to study bone integrity...
November 2, 2019: Kidney International
Eugene Yu-Hin Chan, Hazel Webb, Ellen Yu, Gian Marco Ghiggeri, Markus J Kemper, Alison Lap-Tak Ma, Tomohiko Yamamura, Aditi Sinha, Arvind Bagga, Julien Hogan, Claire Dossier, Marina Vivarelli, Isaac Desheng Liu, Koichi Kamei, Kenji Ishikura, Priya Sharma, Kjell Tullus
Rituximab is an effective treatment for steroid-dependent/ frequently-relapsing nephrotic syndrome (SDFRNS) in children. However, the optimal rituximab regimen remains unknown. To help determine this we conducted an international, multicenter retrospective study at 11 tertiary pediatric nephrology centers in Asia, Europe and North America of children 1-18 years of age with complicated SDFRNS receiving rituximab between 2005-2016 for 18 or more months follow-up. The effect of rituximab prescribed at three dosing levels: low (375mg/m2 ), medium (750mg/m2 ) and high (1125-1500mg/m2 ), with or without maintenance immunosuppression (defined as concurrent use of corticosteroids, mycophenolate motile or calcineurin inhibition at first relapse or for at least six months following the rituximab treatment) was examined...
October 31, 2019: Kidney International
Joshua A Walker, Sean Richards, Mostafa E Belghasem, Nkiruka Arinze, Sung Bok Yoo, Joseph Y Tashjian, Stephen A Whelan, Norman Lee, Vijaya B Kolachalama, Jean Francis, Katya Ravid, David Sherr, Vipul C Chitalia
Emerging evidence in animal models of chronic kidney disease (CKD) implicates Aryl Hydrocarbon Receptor (AHR) signaling as a mediator of uremic toxicity. However, details about its tissue-specific and time-dependent activation in response to various renal pathologies remain poorly defined. Here, a comprehensive analysis of AHR induction was conducted in response to discrete models of kidney diseases using a transgenic mouse line expressing the AHR responsive-promoter tethered to a β-galactosidase reporter gene...
October 30, 2019: Kidney International
Daniel M Breitkopf, Vera Jankowski, Kim Ohl, Juliane Hermann, Daniela Hermert, Klaus Tenbrock, Xiyang Liu, Ina V Martin, Jialin Wang, Fabian Groll, Elisabeth Gröne, Jürgen Floege, Tammo Ostendorf, Thomas Rauen, Ute Raffetseder
Systemic lupus erythematosus (SLE) is an autoimmune disease and lupus nephritis is a major risk factor for morbidity and mortality. Notch-3 signaling induced by membrane-bound or soluble ligands such as YB-1 constitutes an evolutionarily conserved pathway that determines major decisions in cell fate. Mass spectrometry of extracellular YB-1 in sera from patients with SLE and lupus-prone mice revealed specific post-translational guanidinylation of two lysine residues within the highly conserved cold-shock domain of YB-1 (YB-1-G)...
October 30, 2019: Kidney International
Octavia Bane, Stefanie J Hectors, Sonja Gordic, Paul Kennedy, Mathilde Wagner, Amanda Weiss, Rafael Khaim, Zhengzi Yi, Weijia Zhang, Veronica Delaney, Fadi Salem, Cijiang He, Madhav C Menon, Sara Lewis, Bachir Taouli
Here we assessed the diagnostic value of a quantitative multiparametric magnetic resonance imaging (mpMRI) protocol for evaluation of renal allograft dysfunction with fibrosis. Twenty-seven renal transplant patients, including 15 with stable functional allografts (eGFR mean 71.5 ml/min/1.73m2 ), and 12 with chronic dysfunction/established fibrosis (eGFR mean 30.1 ml/min/1.73m2 ), were enrolled in this prospective single-center study. Sixteen of the patients had renal biopsy (mean 150 days) before the MRI. All patients underwent mpMRI at 1...
October 30, 2019: Kidney International
Christina M Wyatt, Tilman B Drueke
No abstract text is available yet for this article.
October 25, 2019: Kidney International
Anna Caroli, Andrea Remuzzi, Giuseppe Remuzzi
No abstract text is available yet for this article.
October 25, 2019: Kidney International
Yohan Bignon, Laurent Pinelli, Nadia Frachon, Olivier Lahuna, Lucile Figueres, Pascal Houillier, Stéphane Lourdel, Jacques Teulon, Marc Paulais
The kidneys excrete the daily acid load mainly by generating and excreting ammonia but the underlying molecular mechanisms are not fully understood. Here we evaluated the role of the inwardly rectifying potassium channel subunit Kir4.2 (Kcnj15 gene product) in this process. In mice, Kir4.2 was present exclusively at the basolateral membrane of proximal tubular cells and disruption of Kcnj15 caused a hyperchloremic metabolic acidosis associated with a reduced threshold for bicarbonate in the absence of a generalized proximal tubule dysfunction...
October 24, 2019: Kidney International
Wenguang Feng, Zhengrong Guan, Dongqi Xing, Xingsheng Li, Wei-Zhong Ying, Colton E Remedies, Edward W Inscho, Paul W Sanders
Prior studies reported that haploinsufficiency of the transcription factor ETS-1 is renoprotective in Dahl salt-sensitive rats, but the mechanism is unclear. Here, we tested whether ETS-1 is involved in hypertension-induced renal microvascular pathology and autoregulatory impairment. Hypertension was induced in salt-sensitive rats and salt-sensitive rats that are heterozygous with 1 wild-type or reference allele of Ets1 (SSEts1+/- ) by feeding a diet containing 4% sodium chloride for 1 week. Increases in blood pressure did not differ...
October 22, 2019: Kidney International
Pierre Ronco
No abstract text is available yet for this article.
January 2020: Kidney International
Brad H Rovin
No abstract text is available yet for this article.
January 2020: Kidney International
Andrew S Levey, Lesley A Inker, Josef Coresh
No abstract text is available yet for this article.
January 2020: Kidney International
Richard J Glassock, Pierre Delanaye, Andrew D Rule
No abstract text is available yet for this article.
January 2020: Kidney International
Petter Bjornstad, Robert G Nelson, Meda E Pavkov
Cardiovascular and renal outcome trials demonstrate nephroprotection with sodium-glucose cotransporter-2 inhibitors in people with type 2 diabetes. Attenuation of hyperfiltration is believed to be responsible for the nephroprotection, and studies in young adults with type 1 diabetes suggest that afferent arteriolar vasoconstriction induced by a tubuloglomerular feedback mechanism may be responsible for this effect. The study by van Bommel et al. suggests that this mechanism may not hold true in older adults with type 2 diabetes, who instead attenuate elevated glomerular filtration rate via post-glomerular vasodilation...
January 2020: Kidney International
Syeda Behjat Ahmad, Gerald B Appel
Membranous nephropathy (MN) is either primary or associated with various etiologies, each with unique glomerular antigens. The discovery of the phospholipase A2 receptor (PLA2R) antigen in primary MN revolutionized our understanding of MN and led to major clinical progress. Other recently discovered antigens in MN include the THSD7A antigen and exostosin. Sethi et al. have now identified a new antigen, NELL-1, in primary MN, again decreasing the number of patients whose antigen remains unknown.
January 2020: Kidney International
David Jayne, Ingeborg M Bajema
Malvar et al. report the results of a study on protocolized repeat renal biopsies in 76 patients with class III or IV (± class V) lupus nephritis. They show that managing maintenance therapy in patients with lupus nephritis through protocolized repeat kidney biopsies results in a lower flare rate. Provided that these results can be replicated in other studies, there is an argument for protocolized repeat kidney biopsies to become the standard of care.
January 2020: Kidney International
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