journal
https://read.qxmd.com/read/37263354/iga-nephropathy-the-lectin-pathway-and-implications-for-targeted-therapy
#1
REVIEW
Jonathan Barratt, Richard A Lafayette, Hong Zhang, Vladimir Tesar, Brad H Rovin, James A Tumlin, Heather N Reich, Jürgen Floege
Many patients with IgA nephropathy (IgAN) progress to end-stage kidney disease even with optimal supportive care. An improved understanding of the pathophysiology of IgAN in recent years has led to the investigation of targeted therapies with acceptable tolerability that may address the underlying causes of IgAN or the pathogenesis of kidney injury. The complement system - particularly the lectin and alternative pathways of complement - have emerged as key mediators of kidney injury in IgAN and possible targets for investigational therapy...
May 30, 2023: Kidney International
https://read.qxmd.com/read/37263353/bio-impedance-spectroscopy-added-to-a-fluid-management-protocol-does-not-improve-preservation-of-residual-kidney-function-in-incident-hemodialysis-patients-in-a-randomized-controlled-trial
#2
JOURNAL ARTICLE
Simon J Davies, David Coyle, Elizabeth J Lindley, David Keane, John Belcher, Fergus J Caskey, Indranil Dasgupta, Andrew Davenport, Ken Farrington, Sandip Mitra, Paula Ormandy, Martin Wilkie, Jamie Macdonald, Mandana Zanganeh, Lazaros Andronis, Ivonne Solis-Trapala, Julius Sim
Avoiding excessive dialysis-associated volume depletion may help preserve residual kidney function (RKF). To establish whether knowledge of the estimated normally hydrated weight from bioimpedance measurements (BI-NHW) when setting the post-hemodialysis target weight (TW) might mitigate rate of loss of RKF, we undertook an open label, randomized controlled trial in incident patients receiving HD, with clinicians and patients blinded to bioimpedance readings in controls. A total of 439 patients with over 500 ml urine/day or residual GFR exceeding 3 ml/min/1...
May 30, 2023: Kidney International
https://read.qxmd.com/read/37245565/trends-and-perspectives-for-improving-quality-of-chronic-kidney-disease-care-conclusions-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#3
Kai-Uwe Eckardt, Cynthia Delgado, Hiddo J L Heerspink, Roberto Pecoits-Filho, Ana C Ricardo, Bénédicte Stengel, Marcello Tonelli, Michael Cheung, Michel Jadoul, Wolfgang C Winkelmayer, Holly Kramer
Chronic kidney disease (CKD) affects over 850 million people globally, and there is an urgent need to prevent its development and progression. During the last decade, new perspectives have arisen related to the quality and precision of care for CKD due to the development of new tools and interventions to diagnose and manage CKD. New biomarkers, imaging methods, artificial intelligence techniques, and approaches to organizing and delivering health care may help clinicians to recognize CKD, determine its etiology, assess the dominant mechanisms at given time points, and identify patients at high risk for progression of kidney disease or related events...
May 26, 2023: Kidney International
https://read.qxmd.com/read/37244474/age-related-changes-in-nephrosclerosis-in-a-multiethnic-living-kidney-donor-cohort
#4
JOURNAL ARTICLE
Brendan R Emmons, Ibrahim Batal, Jai Radhakrishnan, S Ali Husain
No abstract text is available yet for this article.
May 25, 2023: Kidney International
https://read.qxmd.com/read/37244473/repurposing-small-molecules-for-nephronophthisis-and-related-renal-ciliopathies
#5
REVIEW
Alexandre Benmerah, Luis Briseño-Roa, Jean-Philippe Annereau, Sophie Saunier
Nephronophthisis is an autosomal recessive tubulo-interstitial nephropathy, belonging to the ciliopathy disorders, characterized by fibrosis and/or cysts. It is the most common genetic cause of renal failure in children and young adults. Clinically and genetically heterogeneous, it is caused by variants in ciliary genes resulting in either an isolated kidney disease or syndromic forms in association with other manifestations of ciliopathy disorders. No curative treatment is currently available. Over the past two decades, advances in understanding disease mechanisms have identified several dysregulated signaling pathways, some shared with other cystic kidney diseases...
May 25, 2023: Kidney International
https://read.qxmd.com/read/37244472/mutant-phosphodiesterase-3a-protects-the-kidney-from-hypertension-induced-damage
#6
JOURNAL ARTICLE
Anastasiia Sholokh, Stephan Walter, Lajos Markó, Brandon J McMurray, Daniele Yumi Sunaga-Franze, Minze Xu, Kerstin Zühlke, Michael Russwurm, Theda U P Bartolomaeus, Reika Langanki, Fatimunnisa Qadri, Arnd Heuser, Andreas Patzak, Sofia K Forslund, Sylvia Bähring, Tatiana Borodina, Pontus B Persson, Philipp G Maass, Michael Bader, Enno Klussmann
No abstract text is available yet for this article.
May 25, 2023: Kidney International
https://read.qxmd.com/read/37244471/tolerogenic-dendritic-cells-protect-against-acute-kidney-injury
#7
JOURNAL ARTICLE
Jennifer S Y Li, Harry Robertson, Katie Trinh, Arti M Raghubar, Quan Nguyen, Nicholas Matigian, Ellis Patrick, Angus W Thomson, Andrew J Mallett, Natasha M Rogers
Ischemia reperfusion injury is a common precipitant of acute kidney injury that occurs following disrupted perfusion to the kidney. This includes blood loss and hemodynamic shock, as well as during retrieval for deceased donor kidney transplantation. Acute kidney injury is associated with adverse long-term clinical outcomes and requires effective interventions that can modify the disease process. Immunomodulatory cell therapies such as tolerogenic dendritic cells remain a promising tool, and here we tested the hypothesis that adoptively transferred tolerogenic dendritic cells can limit kidney injury...
May 25, 2023: Kidney International
https://read.qxmd.com/read/37236424/novel-anemia-therapies-in-ckd-conclusions-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#8
Elaine Ku, Lucia Del Vecchio, Kai-Uwe Eckardt, Volker H Haase, Kirsten L Johansen, Masaomi Nangaku, Navdeep Tangri, Sushrut S Waikar, Andrzej Więcek, Michael Cheung, Michel Jadoul, Wolfgang C Winkelmayer, David C Wheeler
Anemia is common in patients with chronic kidney disease (CKD) and is associated with a high burden of morbidity and adverse clinical outcomes. In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline for the diagnosis and management of anemia in CKD. Since then, new data from studies assessing established and emerging therapies for the treatment of anemia and iron deficiency have become available. Beginning in 2019, KDIGO planned two Controversies Conferences to review the new evidence and its potential impact on the management of anemia in clinical practice...
May 24, 2023: Kidney International
https://read.qxmd.com/read/37236423/challenges-in-the-management-of-the-kidney-allograft-from-decline-to-failure-conclusions-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#9
Michelle A Josephson, Yolanda Becker, Klemens Budde, Bertram L Kasiske, Bryce Kiberd, Alexandre Loupy, Jolanta Małyszko, Roslyn B Mannon, Burkhard Tönshoff, Michael Cheung, Michel Jadoul, Wolfgang C Winkelmayer, Martin Zeier
In March 2022, KDIGO held a virtual controversies conference to address the important but rarely examined phase during which the kidney transplant is failing or has failed. In addition to discussing the definition of the failing allograft, four broad areas were considered in the context of a declining functioning graft: prognosis and kidney failure trajectory; immunosuppression strategies; management of medical and psychological complications, patient factors; and choice of kidney replacement therapy or supportive care following graft loss...
May 24, 2023: Kidney International
https://read.qxmd.com/read/37236422/a-novel-role-for-the-histone-modifier-prdm6-and-an-opportunity-to-understand-hypertension
#10
JOURNAL ARTICLE
Jason P Smith, Maria Luisa S Sequeira-Lopez, R Ariel Gomez
No abstract text is available yet for this article.
May 24, 2023: Kidney International
https://read.qxmd.com/read/37230224/a-wave-of-deep-intronic-mutations-in-x-linked-alport-syndrome
#11
JOURNAL ARTICLE
Marie Boisson, Christelle Arrondel, Nicolas Cagnard, Vincent Morinière, Zaïna Aït Arkoub, Hassan Saei, Laurence Heidet, Jessica Kachmar, Aurélie Hummel, Bertrand Knebelmann, Marie-Noëlle Bonnet-Dupeyron, Bertrand Isidor, Hassane Izzedine, Eric Legrand, Philippe Couarch, Olivier Gribouval, Christine Bole-Feysot, Mélanie Parisot, Patrick Nitschké, Corinne Antignac, Guillaume Dorval
X-linked Alport syndrome (XLAS) is an inherited kidney disease caused exclusively by pathogenic variants in the COL4A5 gene. In 10-20% of cases, DNA sequencing of COL4A5 exons or flanking regions cannot identify molecular causes. Here, our objective was to use a transcriptomic approach to identify causative events in a group of 19 patients with XLAS without identified mutation by Alport gene panel sequencing. Bulk RNAseq and/or targeted RNAseq using a capture panel of kidney genes was performed. Alternative splicing events were compared to those of 15 controls by a developed bioinformatic score...
May 23, 2023: Kidney International
https://read.qxmd.com/read/37230223/the-genetic-landscape-and-clinical-spectrum-of-nephronophthisis-and-related-ciliopathies
#12
JOURNAL ARTICLE
Friederike Petzold, Katy Billot, Xiaoyi Chen, Charline Henry, Emilie Filhol, Yoann Martin, Marina Avramescu, Maxime Douillet, Vincent Morinière, Pauline Krug, Cécile Jeanpierre, Kalman Tory, Olivia Boyer, Anita Burgun, Aude Servais, Remi Salomon, Alexandre Benmerah, Laurence Heidet, Nicolas Garcelon, Corinne Antignac, Mohamad Zaidan, Sophie Saunier
Nephronophthisis (NPH) is an autosomal-recessive ciliopathy representing one of the most frequent causes of kidney failure in childhood characterized by a broad clinical and genetic heterogeneity. Applied to one of the worldwide largest cohorts of patients with NPH, genetic analysis encompassing targeted and whole exome sequencing identified disease-causing variants in 600 patients from 496 families with a detection rate of 71%. Of 788 pathogenic variants, 40 known ciliopathy genes were identified. However, the majority of patients (53%) bore biallelic pathogenic variants in NPHP1...
May 23, 2023: Kidney International
https://read.qxmd.com/read/37224919/editing-of-apol1-mrna-reduces-apol1-expression-and-activation-of-innate-immunity
#13
JOURNAL ARTICLE
Heidi Karttunen, Michael J Ross
No abstract text is available yet for this article.
May 22, 2023: Kidney International
https://read.qxmd.com/read/37224918/apol1-channel-blocker-reduces-proteinuria-in-fsgs
#14
JOURNAL ARTICLE
Opeyemi A Olabisi
No abstract text is available yet for this article.
May 22, 2023: Kidney International
https://read.qxmd.com/read/37224917/self-maintaining-macrophages-within-the-kidney-contribute-to-salt-and-water-balance-by-modulating-kidney-sympathetic-nerve-activity
#15
JOURNAL ARTICLE
Qian Zhu, Liang Xiao, Guo Cheng, Jian He, Chunyou Yin, Liang Wang, Qiang Wang, Li Li, Bo Wei, Yuancheng Weng, Fei Geng, Xiao Z Shen, Peng Shi
The kidney is critical in controlling salt and water balance, with the interstitium involved with a variety of components including immune cells in steady state. However, the roles of resident immune cells in kidney physiology are largely unknown. To help unravel some of these unknowns, we employed cell fate mapping, and identified a population of embryo-derived self-maintaining macrophages (SM-MØ) that were independent of the bone marrow in adult mouse kidneys. This kidney-specific SM-MØ population was distinctive from the kidney monocyte-derived macrophages in transcriptome and in their distribution...
May 22, 2023: Kidney International
https://read.qxmd.com/read/37220805/interleukin-21-promotes-type-1-activation-and-cytotoxicity-of-cd56-dim-cd16-bright-natural-killer-cells-during-kidney-allograft-antibody-mediated-rejection-showing-a-new-link-between-adaptive-and-innate-humoral-allo-immunity
#16
JOURNAL ARTICLE
Elodie Bailly, Camila Macedo, Jason Ossart, Kevin Louis, Xinyan Gu, Bala Ramaswami, Carol Bentlejewski, Adriana Zeevi, Parmjeet Randhawa, Carmen Lefaucheur, Diana Metes
The role of Natural killer (NK) cells during kidney allograft antibody-mediated rejection (ABMR) is increasingly recognized, but an in-depth characterization of mechanisms that contribute to such immune response is still under investigation. Here, we characterized phenotypic, functional, and transcriptomic profiles of peripheral blood circulating and allograft infiltrating CD56dim CD16bright NK cells during anti-HLA donor-specific antibody (DSA)+ ABMR. Cross- sectional analyses performed in 71 kidney transplant recipients identified a unique phenotypic circulating CD56dim CD16bright NK cell cluster expanded in DSA+ ABMR...
May 21, 2023: Kidney International
https://read.qxmd.com/read/37187288/dealing-with-dramatic-health-care-problems-during-times-of-natural-disaster-and-armed-conflict
#17
EDITORIAL
Sami Alasfar, Wasim Zakaria, Khaled Haj Nasan, Abdul R Zanabli, Fahd Al-Saghir, Ahmad Oussama Rifai, Valerie Luycks, Lina Murad, Saleh Kaysi, Akram Al-Makki, Mohamed Sekkarie
No abstract text is available yet for this article.
May 13, 2023: Kidney International
https://read.qxmd.com/read/37172690/application-of-the-banff-human-organ-transplant-panel-to-kidney-transplant-biopsies-with-features-suspicious-for-antibody-mediated-rejection
#18
JOURNAL ARTICLE
Jack Beadle, Artemis Papadaki, Frederic Toulza, Eva Santos, Michelle Willicombe, Adam McLean, James Peters, Candice Roufosse
The Banff Classification for Allograft Pathology includes the use of gene expression in the diagnosis of antibody-mediated rejection (AMR) of kidney transplants, but a predictive set of genes for classifying biopsies with 'incomplete' phenotypes has not yet been studied. Here, we developed and assessed a gene score that, when applied to biopsies with features of AMR, would identify cases with a higher risk of allograft loss. To do this, RNA was extracted from a continuous retrospective cohort of 349 biopsies randomized 2:1 to include 220 biopsies in a discovery cohort and 129 biopsies in a validation cohort...
May 10, 2023: Kidney International
https://read.qxmd.com/read/37164260/hemolysis-is-associated-with-altered-heparan-sulfate-of-the-endothelial-glycocalyx-and-with-local-complement-activation-in-thrombotic-microangiopathies
#19
JOURNAL ARTICLE
Timothée Laboux, Mehdi Maanaoui, Fabrice Allain, Eric Boulanger, Agnès Denys, Jean-Baptiste Gibier, François Glowacki, Gaëlle Grolaux, Anne Grunenwald, Mike Howsam, Steve Lancel, Céline Lebas, Benjamin Lopez, Lubka Roumenina, François Provôt, Viviane Gnemmi, Marie Frimat
The complement system plays a key role in the pathophysiology of kidney thrombotic microangiopathies (TMA), as illustrated by atypical hemolytic uremic syndrome. But complement abnormalities are not the only drivers of TMA lesions. Among other potential pathophysiological actors, we hypothesized that alteration of heparan sulfate (HS) in the endothelial glycocalyx could be important. To evaluate this, we analyzed clinical and histological features of kidney biopsies from a monocentric, retrospective cohort of 72 patients with TMA, particularly for HS integrity and markers of local complement activation...
May 9, 2023: Kidney International
https://read.qxmd.com/read/37164261/peroxiredoxin-1-aggravates-acute-kidney-injury-by-promoting-inflammation-through-mincle-syk-nf-%C3%AE%C2%BAb-signaling
#20
JOURNAL ARTICLE
Shenglan Li, Yan Zhang, Rong Lu, Xin Lv, Qunjuan Lei, Damu Tang, Qin Dai, Zhenghao Deng, Xiaohua Liao, Sha Tu, Huixiang Yang, Yanyun Xie, Jie Meng, Qiongjing Yuan, Jiao Qin, Jiaxi Pu, Zhangzhe Peng, Lijian Tao
Damage-associated molecular patterns (DAMPs) are a cause of acute kidney injury (AKI). Our knowledge of these DAMPs remains incomplete. Here, we report serum peroxiredoxin 1 (Prdx1) as a novel DAMP for AKI. Lipopolysaccharide (LPS) and kidney ischemia/reperfusion injury instigated AKI with concurrent increases in serum Prdx1 and reductions of Prdx1 expression in kidney tubular epithelial cells. Genetic knockout of Prdx1 or use of a Prdx1-neutralizing antibody protected mice from AKI and this protection was impaired by introduction of recombinant Prdx1 (rPrdx1)...
May 8, 2023: Kidney International
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