Kidney International

Catherine M Clase, Juan-Jesus Carrero, David H Ellison, Morgan E Grams, Brenda R Hemmelgarn, Meg J Jardine, Csaba P Kovesdy, Gregory A Kline, Gregor Lindner, Gregorio T Obrador, Biff F Palmer, Michael Cheung, David C Wheeler, Wolfgang C Winkelmayer, Roberto Pecoits-Filho
Potassium disorders are common in patients with kidney disease, particularly in patients with tubular disorders and low glomerular filtration rate. A multidisciplinary group of researchers and clinicians met in October 2018 to identify evidence and address controversies in potassium management. The issues discussed encompassed our latest understanding of the regulation of tubular potassium excretion in health and disease; the relationship of potassium intake to cardiovascular and kidney outcomes, with increasing evidence showing beneficial associations with plant-based diet and data to suggest a paradigm shift from the idea of dietary restriction toward fostering patterns of eating that are associated with better outcomes; the paucity of data on the effect of dietary modification in restoring abnormal serum potassium to the normal range; a novel diagnostic algorithm for hypokalemia that takes into account the ascendency of the clinical context in determining cause, aligning the educational strategy with a practical approach to diagnosis; and therapeutic approaches in managing hyperkalemia when chronic and in the emergency or hospital ward...
October 10, 2019: Kidney International
Kitty J Jager, Csaba Kovesdy, Robyn Langham, Mark Rosenberg, Vivekanand Jha, Carmine Zoccali
No abstract text is available yet for this article.
September 24, 2019: Kidney International
Marguerite Hureaux, Emma Ashton, Karin Dahan, Pascal Houillier, Anne Blanchard, Catherine Cormier, Eugenie Koumakis, Daniela Iancu, Hendrica Belge, Pascale Hilbert, Annelies Rotthier, Jurgen Del Favero, Franz Schaefer, Robert Kleta, Detlef Bockenhauer, Xavier Jeunemaitre, Olivier Devuyst, Stephen B Walsh, Rosa Vargas-Poussou
Hereditary tubulopathies are rare diseases with unknown prevalence in adults. Often diagnosed in childhood, hereditary tubulopathies can nevertheless be evoked in adults. Precise diagnosis can be difficult or delayed due to insidious development of symptoms, comorbidities and polypharmacy. Here we evaluated the diagnostic value of a specific panel of known genes implicated in tubulopathies in adult patients and compared to our data obtained in children. To do this we analyzed 1033 non-related adult patients of which 744 had a clinical diagnosis of tubulopathy and 289 had a diagnosis of familial hypercalcemia with hypocalciuria recruited by three European reference centers...
September 16, 2019: Kidney International
Zeljko Dvanajscak, Patrick D Walker, L Nicholas Cossey, Nidia C Messias, Christie L Boils, Michael B Kuperman, Christopher P Larsen
Intravascular hemolysis is relatively rare but can lead to acute kidney injury (AKI), from increased destruction of erythrocytes and release of free hemoglobin. Since hemolysis and hemoglobinuria are known causes of acute kidney injury we sought to define clinicopathologic findings and outcomes of patients with hemolysis-associated hemoglobin cast nephropathy through a retrospective analysis of 27 cases. The mean patient age was 47 years (range 19-79) and the female-to-male ratio was 1.3:1. All patients presented with AKI with a mean serum creatinine of 8...
September 16, 2019: Kidney International
Sander F Garrelfs, Gill Rumsby, Hessel Peters-Sengers, Florian Erger, Jaap W Groothoff, Bodo B Beck, Michiel J S Oosterveld, Alessandra Pelle, Thomas Neuhaus, Brigitte Adams, Pierre Cochat, Eduardo Salido, Graham W Lipkin, Bernd Hoppe, Sally-Anne Hulton
Primary hyperoxaluria type 2 is a rare inherited disorder of glyoxylate metabolism causing nephrocalcinosis, renal stone formation and ultimately kidney failure. Previously, primary hyperoxaluria type 2 was considered to have a more favorable prognosis than primary hyperoxaluria type 1, but earlier reports are limited by low patient numbers and short follow up periods. Here we report on the clinical, genetic, and biochemical findings from the largest cohort of patients with primary hyperoxaluria type 2, obtained by a retrospective record review of genetically confirmed cases in the OxalEurope registry, a dataset containing 101 patients from eleven countries...
September 3, 2019: Kidney International
Rong Hu, Gupta Rohit, Zheyu Wang, Congzhou Wang, Hongcheng Sun, Srikanth Singamaneni, Evan D Kharasch, Jeremiah J Morrissey
Renal cell carcinoma (RCC) has poor survival prognosis because it is asymptomatic at an early, more curative stage. Recently, urine perilipin-2 (PLIN-2) was demonstrated to be a sensitive and specific biomarker for the noninvasive, early detection of RCC and an indispensable indicator to distinguish cancer from a benign renal mass. However, current Western blot or ELISA PLIN-2 assays are complicated, expensive, time-consuming or insensitive, making them unsuitable for routine analysis in clinical settings. Here we developed a plasmonic biosensor based on the high refractive index sensitivity of gold nanorattles for the rapid detection of PLIN-2 in patient urine...
September 3, 2019: Kidney International
Michael Kammer, Andreas Heinzel, Jill A Willency, Kevin L Duffin, Gert Mayer, Kai Simons, Mathias J Gerl, Christian Klose, Georg Heinze, Roman Reindl-Schwaighofer, Karin Hu, Paul Perco, Susanne Eder, Laszlo Rosivall, Patrick B Mark, Wenjun Ju, Matthias Kretzler, Mark I McCarthy, Hiddo L Heerspink, Andrzej Wiecek, Maria F Gomez, Rainer Oberbauer
Clinical risk factors explain only a fraction of the variability of estimated glomerular filtration rate (eGFR) decline in people with type 2 diabetes. Cross-omics technologies by virtue of a wide spectrum screening of plasma samples have the potential to identify biomarkers for the refinement of prognosis in addition to clinical variables. Here we utilized proteomics, metabolomics and lipidomics panel assay measurements in baseline plasma samples from the multinational PROVALID study (PROspective cohort study in patients with type 2 diabetes mellitus for VALIDation of biomarkers) of patients with incident or early chronic kidney disease (median follow-up 35 months, median baseline eGFR 84 mL/min/1...
August 30, 2019: Kidney International
Connor Francis, Guillaume Courbon, Claire Gerber, Samantha Neuburg, Xueyan Wang, Corey Dussold, Maralee Capella, Lixin Qi, Tamara Isakova, Rupal Mehta, Aline Martin, Myles Wolf, Valentin David
Iron deficiency, anemia, hyperphosphatemia, and increased fibroblast growth factor 23 (FGF23) are common and interrelated complications of chronic kidney disease (CKD) that are linked to CKD progression, cardiovascular disease and death. Ferric citrate is an oral phosphate binder that decreases dietary phosphate absorption and serum FGF23 concentrations while increasing iron stores and hemoglobin in patients with CKD. Here we compared the effects of ferric citrate administration versus a mineral sufficient control diet using the Col4a3 knockout mouse model of progressive CKD and age-matched wild-type mice...
August 30, 2019: Kidney International
Paula F Orlandi, Jing Huang, Masafumi Fukagawa, Wendy Hoy, Vivekanand Jha, Kook-Hwan Oh, Laura Sola, Paul Cockwell, Adeera Levin, Harold I Feldman
Rates of chronic kidney disease (CKD) progression, end stage kidney disease (ESKD), all-cause mortality, and cardiovascular (CVD) events among individuals with CKD vary widely across countries. Well-characterized demographic, comorbidity, and laboratory markers captured for prospective cohorts may explain, in part, such differences. To investigate whether core characteristics of individuals with CKD explain differences in rates of outcomes, we conducted an individual-level analysis of eight studies that are part of iNET-CKD, an international network of CKD cohort studies...
August 30, 2019: Kidney International
Mark A Perazella, Anushree C Shirali
Immune checkpoint inhibitors have dramatically improved cancer therapy for many patients. These humanized monoclonal antibodies against various immune checkpoints (receptors and ligands) effectively treat a number of malignancies by unleashing the immune system to destroy cancer cells. These drugs are not excreted by the kidneys or liver, have a long half-life, and undergo receptor-mediated clearance. Although these agents have greatly improved the prognosis of many cancers, immune-related end organ injury is a complication that has come to light in clinical practice...
August 23, 2019: Kidney International
Qi Cao, Ruifeng Wang, Yiping Wang, Zhiguo Niu, Titi Chen, Chengshi Wang, Li Jin, Qingsong Huang, Qing Li, Xin Maggie Wang, Farhana Azmi, Vincent W S Lee, Yuan Min Wang, Guoping Zheng, Stephen I Alexander, David C H Harris
Innate lymphoid cells are a recently recognized group of immune cells with critical roles in tissue homeostasis and inflammation. Regulatory innate lymphoid cells are a newly identified subset of innate lymphoid cells, which play a suppressive role in the innate immune response, favoring the resolution of intestinal inflammation. However, the expression and role of regulatory innate lymphoid cells in kidney has not been reported. Here, we show that regulatory innate lymphoid cells are present in both human and mouse kidney, express similar surface markers and form a similar proportion of total kidney innate lymphoid cells...
August 23, 2019: Kidney International
Christina M Wyatt, Tilman B Drüeke
No abstract text is available yet for this article.
August 23, 2019: Kidney International
Ana Malvar, Valeria Alberton, Bruno Lococo, Matias Ferrari, Pamela Delgado, Haikady N Nagaraja, Brad H Rovin
The optimal duration of maintenance immunosuppressive therapy for patients with lupus nephritis who have achieved clinical remission has not been established. Furthermore, clinical and histologic remissions are often discordant. We postulated that continuing therapy for patients with persistent histologic activity on kidney biopsies done during maintenance and discontinuing therapy only for patients without histologic activity would minimize subsequent lupus nephritis flares. To test this, a cohort of 75 prospectively-followed patients with proliferative lupus nephritis was managed using kidney biopsies performed during maintenance therapy...
August 20, 2019: Kidney International
Mark R Paterson, Aron M Geurts, Alison J Kriegel
Chronic kidney disease presents a complex and distinct pathological landscape in men and women, yet this difference is poorly understood. microRNAs are powerful molecular regulators of pathophysiology in the kidney and other organs. We previously reported a significant upregulation of miR-146b-5p in the 5/6 nephrectomy rat model of chronic kidney disease. Here we investigated the sex-specific contribution of miR-146b-5p to renocardiac pathology by generating a novel miR-146b-/- rat and characterized the expression of miR-146b-5p in both wild-type and knockout animals...
August 16, 2019: Kidney International
Ewout J Hoorn, Anela Blazevic, Jorie Versmissen, Noortje M Rabelink
No abstract text is available yet for this article.
November 2019: Kidney International
Christian Schmidt-Lauber, Maike Büttner-Herold, Mario Schiffer, Michael S Wiesener
No abstract text is available yet for this article.
November 2019: Kidney International
Enrique Montagud-Marrahí, Pedro Ventura-Aguiar, Fritz Diekmann
No abstract text is available yet for this article.
November 2019: Kidney International
Marcus J Moeller, Christoph Kuppe, Vivette D D'Agati
No abstract text is available yet for this article.
November 2019: Kidney International
Alexander J Howie
No abstract text is available yet for this article.
November 2019: Kidney International
Khalil El Karoui, Idris Boudhabhay, Véronique Frémeaux-Bacchi
No abstract text is available yet for this article.
November 2019: Kidney International
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