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Kidney International

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https://read.qxmd.com/read/31248648/mitochondrial-dna-copy-number-is-associated-with-mortality-and-infections-in-a-large-cohort-of-patients-with-chronic-kidney-disease
#1
Federica Fazzini, Claudia Lamina, Liane Fendt, Ulla T Schultheiss, Fruzsina Kotsis, Andrew A Hicks, Heike Meiselbach, Hansi Weissensteiner, Lukas Forer, Vera Krane, Kai-Uwe Eckardt, Anna Köttgen, Florian Kronenberg
Damage of mitochondrial DNA (mtDNA) with reduction in copy number has been proposed as a biomarker for mitochondrial dysfunction and oxidative stress. Chronic kidney disease (CKD) is associated with increased mortality and risk of cardiovascular disease, but the underlying mechanisms remain incompletely understood. Here we investigated the prognostic role of mtDNA copy number for cause-specific mortality in 4812 patients from the German Chronic Kidney Disease study, an ongoing prospective observational national cohort study of patients with CKD stage G3 and A1-3 or G1-2 with overt proteinuria (A3) at enrollment...
May 10, 2019: Kidney International
https://read.qxmd.com/read/31248650/roscovitine-blocks-collecting-duct-cyst-growth-in-cep164-deficient-kidneys
#2
Rannar Airik, Merlin Airik, Markus Schueler, Carlton M Bates, Friedhelm Hildebrandt
Nephronophthisis is an autosomal recessive kidney disease with high genetic heterogeneity. Understanding the functions of the individual genes contributing to this disease is critical for delineating the pathomechanisms of this disorder. Here, we investigated kidney function of a novel gene associated with nephronophthisis, CEP164, coding a centriolar distal appendage protein, using a Cep164 knockout mouse model. Collecting duct-specific deletion of Cep164 abolished primary cilia from the collecting duct epithelium and led to rapid postnatal cyst growth in the kidneys...
May 8, 2019: Kidney International
https://read.qxmd.com/read/31285081/atypical-igm-on-t-cells-predict-relapse-and-steroid-dependence-in-idiopathic-nephrotic-syndrome
#3
Manuela Colucci, Rita Carsetti, Maria Manuela Rosado, Simona Cascioli, Maurizio Bruschi, Giovanni Candiano, Giorgia Corpetti, Laura Giardino, Jessica Serafinelli, Chiara Giannone, Gian Marco Ghiggeri, Maria Pia Rastaldi, Roberto Sitia, Francesco Emma, Marina Vivarelli
The clinical heterogeneity of idiopathic nephrotic syndrome (INS) in childhood may reflect different mechanisms of disease that are as yet unclear. Here, we evaluated the association between an atypical presence of IgM on the surface of T cells (T-cell IgM) and the response to steroid therapy in a total of 153 pediatric patients with INS in different phases of disease. At disease onset, T-cell IgM median levels were significantly elevated and predictive of risk of relapse in 47 patients. They were also significantly increased comparing 58 steroid-dependent (SD) to 8 infrequently relapsing and 14 frequently relapsing patients, especially during relapse, whereas they were within the normal range in 7 genetic steroid-resistant (SR) patients...
May 7, 2019: Kidney International
https://read.qxmd.com/read/31262489/the-sprint-trial-suggests-that-markers-of-tubule-cell-function-in-the-urine-associate-with-risk-of-subsequent-acute-kidney-injury-while-injury-markers-elevate-after-the-injury
#4
Alexander L Bullen, Ronit Katz, Alexandra K Lee, Cheryl A M Anderson, Alfred K Cheung, Pranav S Garimella, Vasantha Jotwani, William E Haley, Areef Ishani, James P Lash, Javier A Neyra, Henry Punzi, Anjay Rastogi, Erik Riessen, Rakesh Malhotra, Chirag R Parikh, Michael V Rocco, Barry M Wall, Udayan Y Bhatt, Michael G Shlipak, Joachim H Ix, Michelle M Estrella
Urine markers can quantify tubular function including reabsorption (α-1 microglobulin [α1m]) and β-2-microglobulin [β2m]) and protein synthesis (uromodulin). Individuals with tubular dysfunction may be less able to compensate to insults than those without, despite similar estimated glomerular filtration rate (eGFR) and albuminuria. Among Systolic Blood Pressure Intervention Trial (SPRINT) participants with an eGFR under 60 ml/min/1.73m2 , we measured urine markers of tubular function and injury (neutrophil gelatinase-associated lipocalin [NGAL], kidney injury molecule-1 [KIM-1], interleukin-18 [IL-18], monocyte chemoattractant protein-1, and chitinase-3-like protein [YKL-40]) at baseline...
May 7, 2019: Kidney International
https://read.qxmd.com/read/31262488/mitochondrial-biogenesis-induced-by-the-%C3%AE-2-adrenergic-receptor-agonist-formoterol-accelerates-podocyte-recovery-from-glomerular-injury
#5
Ehtesham Arif, Ashish K Solanki, Pankaj Srivastava, Bushra Rahman, Wayne R Fitzgibbon, Peifeng Deng, Milos N Budisavljevic, Catalin F Baicu, Michael R Zile, Judit Megyesi, Michael G Janech, Sang-Ho Kwon, Justin Collier, Rick G Schnellmann, Deepak Nihalani
Podocytes have limited ability to recover from injury. Here, we demonstrate that increased mitochondrial biogenesis, to meet the metabolic and energy demand of a cell, accelerates podocyte recovery from injury. Analysis of events induced during podocyte injury and recovery showed marked upregulation of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), a transcriptional co-activator of mitochondrial biogenesis, and key components of the mitochondrial electron transport chain. To evaluate our hypothesis that increasing mitochondrial biogenesis enhanced podocyte recovery from injury, we treated injured podocytes with formoterol, a potent, specific, and long-acting β2-adrenergic receptor agonist that induces mitochondrial biogenesis in vitro and in vivo...
May 6, 2019: Kidney International
https://read.qxmd.com/read/31053387/heart-failure-in-chronic-kidney-disease-conclusions-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#6
Andrew A House, Christoph Wanner, Mark J Sarnak, Ileana L Piña, Christopher W McIntyre, Paul Komenda, Bertram L Kasiske, Anita Deswal, Christopher R deFilippi, John G F Cleland, Stefan D Anker, Charles A Herzog, Michael Cheung, David C Wheeler, Wolfgang C Winkelmayer, Peter A McCullough
The incidence and prevalence of heart failure (HF) and chronic kidney disease (CKD) are increasing, and as such a better understanding of the interface between both conditions is imperative for developing optimal strategies for their detection, prevention, diagnosis, and management. To this end, Kidney Disease: Improving Global Outcomes (KDIGO) convened an international, multidisciplinary Controversies Conference titled Heart Failure in CKD. Breakout group discussions included (i) HF with preserved ejection fraction (HFpEF) and nondialysis CKD, (ii) HF with reduced ejection fraction (HFrEF) and nondialysis CKD, (iii) HFpEF and dialysis-dependent CKD, (iv) HFrEF and dialysis-dependent CKD, and (v) HF in kidney transplant patients...
April 30, 2019: Kidney International
https://read.qxmd.com/read/31229049/are-sglt2-inhibitors-a-targeted-treatment-for-diabetic-kidney-disease
#7
Eiichiro Kanda, Masaomi Nangaku
No abstract text is available yet for this article.
July 2019: Kidney International
https://read.qxmd.com/read/31229048/blood-pressure-measurement-in-mice-tail-cuff-or-telemetry
#8
Tilman B Drüeke, Olivier Devuyst
No abstract text is available yet for this article.
July 2019: Kidney International
https://read.qxmd.com/read/31229047/under-pressure-how-to-assess-blood-pressure-in-rodents-tail-cuff
#9
James Matthew Luther, Agnes B Fogo
No abstract text is available yet for this article.
July 2019: Kidney International
https://read.qxmd.com/read/31229046/men-mice-and-blood-pressure-telemetry
#10
Friedrich C Luft
No abstract text is available yet for this article.
July 2019: Kidney International
https://read.qxmd.com/read/31229045/athena-wisdom-and-warfare-in-defining-the-role-of-de-novo-mtor-inhibition-in-kidney-transplantation
#11
Steve Chadban, Helio Tedesco-Silva
ATHENA, published in this edition of Kidney International, is the third contemporary, multicenter, randomized, controlled trial to compare de novo use of everolimus, calcineurin inhibitor, and steroids to our current standard of care, mycophenolate, tacrolimus, and steroids, in kidney transplant recipients. This commentary highlights the strengths and significant weaknesses of ATHENA. It then seeks to distill the key messages from the 3 trials, ATHENA, TRANSFORM, and US92, and considers the role of everolimus in kidney transplantation today...
July 2019: Kidney International
https://read.qxmd.com/read/31229044/the-case-an-unusual-cause-of-renal-impairment-and-hematuria-in-aortic-dissection
#12
Cynthia C Lim, Jia Liang Kwek, Jason C J Choo, Alwin Loh
No abstract text is available yet for this article.
July 2019: Kidney International
https://read.qxmd.com/read/31229043/the-case-acute-kidney-injury-in-an-african-woman-with-microangiopathic-hemolytic-anemia-and-hiv
#13
Hatem Elabd, Tarek Rashid, Mennallah Elkholi, M Barry Stokes
No abstract text is available yet for this article.
July 2019: Kidney International
https://read.qxmd.com/read/31229042/interstitial-nephritis-in-immune-checkpoint-inhibitor-therapy
#14
Sandhya Manohar, Robert C Albright
No abstract text is available yet for this article.
July 2019: Kidney International
https://read.qxmd.com/read/31229041/acth-corticotrophin-therapy-in-resistant-primary-membranous-nephropathy
#15
LETTER
Soumita Bagchi, Vineet Behera, Sanjay Kumar Agarwal
No abstract text is available yet for this article.
July 2019: Kidney International
https://read.qxmd.com/read/31229040/gut-microbiome-and-kidney-stone-disease-not-just-an-oxalobacter-story
#16
Andrea Ticinesi, Antonio Nouvenne, Tiziana Meschi
Intestinal regulation of oxalate absorption is a complex mechanism, not exclusively reliant on the oxalate-degrading anaerobe Oxalobacter formigenes. Using metagenomics, Miller et al. were able to describe a network of bacterial taxa co-occurring with Oxalobacter formigenes in fecal samples from non-stone forming controls and less represented in stone formers. These findings may help to illuminate why previous intervention studies with probiotics have failed to reduce the risk of hyperoxaluria, opening new possibilities for future research...
July 2019: Kidney International
https://read.qxmd.com/read/31229039/the-authors-reply
#17
LETTER
Anne-Els van de Logt, Sanna R Rijpma, Coralien H Vink, Elma Prudon-Rosmulder, Jack F Wetzels, Miranda van Berkel
No abstract text is available yet for this article.
July 2019: Kidney International
https://read.qxmd.com/read/31229038/b-cells-a-new-player-in-mesenchymal-stromal-cell-mediated-immune-modulation-in-renal-transplant-patients
#18
LETTER
Urvashi Kaundal, Raja Ramachandran, Amit Arora, Deepesh B Kenwar, Ratti Ram Sharma, Mukut Minz, Vivekanand Jha, Aruna Rakha
No abstract text is available yet for this article.
July 2019: Kidney International
https://read.qxmd.com/read/31229037/albumin-assays-and-clinical-decision-making-in-nephrotic-syndrome-patients
#19
LETTER
Joris R Delanghe, Marijn M Speeckaert, Sigurd E Delanghe, Marc L De Buyzere
No abstract text is available yet for this article.
July 2019: Kidney International
https://read.qxmd.com/read/31229036/the-choice-of-the-assay-for-measuring-albumin-has-a-major-impact-on-routine-laboratory-values
#20
LETTER
Laura Labriola, Michel Jadoul
No abstract text is available yet for this article.
July 2019: Kidney International
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