journal
https://read.qxmd.com/read/34310988/vitamin-k-and-cardiovascular-complications-in-ckd-patients
#1
REVIEW
N Kaesler, L J Schurgers, J Floege
Vitamin K, well known for its role in coagulation, encompasses two major subgroups: Vitamin K1 is exclusively synthesized by plants, whereas vitamin K2 mostly originates from bacterial synthesis. Vitamin K serves as a cofactor for the enzyme γ-glutamyl carboxylase, which carboxylates and thereby activates various vitamin K dependent proteins. Several vitamin K-dependent proteins are synthesized in bone but the role of vitamin K for bone health in CKD patients, in particular the prevention of osteoporosis is still not firmly established...
July 23, 2021: Kidney International
https://read.qxmd.com/read/34302849/chronic-kidney-disease-rescuing-kidney-patients-from-early-demise-role-of-anti-cytokine-therapies
#2
T Alp Ikizler, Jonathan Himmelfarb
No abstract text is available yet for this article.
July 21, 2021: Kidney International
https://read.qxmd.com/read/34298034/skimming-the-fat-in-diabetic-kidney-disease-kim-1-and-tubular-fatty-acid-uptake
#3
Huihui Huang, Samir M Parikh
No abstract text is available yet for this article.
July 20, 2021: Kidney International
https://read.qxmd.com/read/34284044/the-romanov-study-found-impaired-humoral-and-cellular-immune-responses-to-sarscov-2-mrna-vaccine-in-virus-unexposed-patients-receiving-maintenance-hemodialysis
#4
Maxime Espi, Xavier Charmetant, Thomas Barba, Laetitia Koppe, Caroline Pelletier, Emilie Kalbacher, Elodie Chalencon, Virginie Mathias, Anne Ovize, Emmanuelle Cart-Tanneur, Christine Bouz, Laurence Pellegrina, Emmanuel Morelon, Denis Fouque, Laurent Juillard, Olivier Thaunat
Patients on maintenance hemodialysis (MHD), which are at high risk of infection by SARS-CoV-2 virus and death due to COVID-19, have been prioritized for vaccination. However, because they were excluded from pivotal studies and have weakened immune responses, it is not known whether these patients are protected after the "standard" two doses of mRNA vaccines. To answer this, anti-spike receptor binding domain (RBD) IgG and interferon gamma-producing CD4+ and CD8+ specific-T cells were measured in the circulation 10-14 days after the second injection of BNT162b2 vaccine in 106 patients receiving MHD (14 with history of COVID-19) and compared to 30 healthy volunteers (four with history of COVID-19)...
July 17, 2021: Kidney International
https://read.qxmd.com/read/34284043/how-cyclosporin-reduces-mycophenolic-acid-exposure-by-40-while-other-calcineurin-inhibitors-do-not
#5
Teun van Gelder
The most frequently used immunosuppressive treatment in kidney transplant recipients is the combination therapy of a calcineurin inhibitor and mycophenolate mofetil (MMF), with or without corticosteroids. Cyclosporin and tacrolimus are the two calcineurin inhibitors registered for this indication. Also in the treatment of glomerular diseases calcineurin inhibitors and mycophenolic acid are being used on a worldwide scale, either alone or as combined treatment. In January 2021 the U.S. Food and Drug Administration (FDA) has approved voclosporin, a novel calcineurin inhibitor for the treatment of adult patients with active lupus nephritis...
July 17, 2021: Kidney International
https://read.qxmd.com/read/34280456/a-team-based-approach-for-testing-biomarkers-of-kidney-disease-progression
#6
Javier A Neyra
No abstract text is available yet for this article.
July 16, 2021: Kidney International
https://read.qxmd.com/read/34273381/superior-cellular-and-humoral-immunity-towards-sars-cov-2-reference-and-alpha-and-beta-voc-strains-in-covid-19-convalescent-as-compared-to-the-prime-boost-bnt162b2-vaccinated-dialysis-patients
#7
LETTER
Arturo Blazquez-Navarro, Lema Safi, Toni L Meister, Constantin J Thieme, Sviatlana Kaliszczyk, Krystallenia Paniskaki, Mara Stockhausen, Jan Hörstrup, Okan Cinkilic, Linus Flitsch-Kiefner, Corinna Marheinecke, Eike Steinmann, Felix S Seibert, Ulrik Stervbo, Timm H Westhoff, Stephanie Pfaender, Toralf Roch, Nina Babel
No abstract text is available yet for this article.
July 14, 2021: Kidney International
https://read.qxmd.com/read/34270945/comparison-of-bnt162b2-biontech-pfizer-and-mrna-1273-moderna-sars-cov-2-mrna-vaccine-immunogenicity-in-dialysis-patients
#8
LETTER
Robert A Kaiser, Maria C Haller, Petra Apfalter, Heidrun Kerschner, Daniel Cejka
No abstract text is available yet for this article.
July 13, 2021: Kidney International
https://read.qxmd.com/read/34265359/neutralizing-antibody-response-against-variants-of-concern-after-vaccination-of-dialysis-patients-with-bnt162b2
#9
LETTER
Claudius Speer, Louise Benning, Maximilian Töllner, Christian Nusshag, Florian Kälble, Paula Reichel, Matthias Schaier, Marie Bartenschlager, Paul Schnitzler, Martin Zeier, Caner Süsal, Christian Morath, Ralf Bartenschlager
No abstract text is available yet for this article.
July 12, 2021: Kidney International
https://read.qxmd.com/read/34256055/reasons-for-covid-19-vaccination-hesitancy-in-hemodialysis-patients
#10
LETTER
Sunil Bhandari
No abstract text is available yet for this article.
July 10, 2021: Kidney International
https://read.qxmd.com/read/34252450/harmonizing-acute-and-chronic-kidney-disease-definition-and-classification-report-of-a-kidney-disease-improving-global-outcomes-kdigo-consensus-conference
#11
Norbert Lameire, Adeera Levin, John A Kellum, Michael Cheung, Michel Jadoul, Wolfgang C Winkelmayer, Paul E Stevens
Kidney disease is an important public health problem. Both acute kidney injury (AKI) and chronic kidney disease have been well defined and classified, leading to improved research efforts and subsequent management strategies and recommendations. For those patients with abnormalities in kidney function and/or structure who meet neither the definition of AKI nor chronic kidney disease, there remains a gap in research, care, and guidance. The term acute kidney diseases and disorders, abbreviated to acute kidney disease (AKD), has been introduced as an important construct to address this...
July 9, 2021: Kidney International
https://read.qxmd.com/read/34252449/specific-disruption-of-calcineurin-signaling-in-the-distal-convoluted-tubule-impacts-the-transcriptome-and-proteome-and-causes-hypomagnesemia-and-metabolic-acidosis
#12
Eszter Banki, Viktoria Fisi, Sandra Moser, Agnieszka Wengi, Monique Carrel, Dominique Loffing-Cueni, David Penton, Denise V Kratschmar, Ludovica Rizzo, Soeren Lienkamp, Alex Odermatt, Markus M Rinschen, Johannes Loffing
Adverse effects of calcineurin inhibitors (CNI), such as hypertension, hyperkalemia, acidosis, hypomagnesemia and hypercalciuria, have been linked to dysfunction of the distal convoluted tubule (DCT). To test this, we generated a mouse model with an inducible DCT-specific deletion of the calcineurin regulatory subunit B alpha (CnB1-KO). Three weeks after CnB1 deletion, these mice exhibited hypomagnesemia and acidosis, but no hypertension, hyperkalemia or hypercalciuria. Consistent with the hypomagnesemia, CnB1-KO mice showed a downregulation of proteins implicated in DCT magnesium transport, including TRPM6, CNNM2, SLC41A3 and parvalbumin but expression of calcium channel TRPV5 in the kidney was unchanged...
July 9, 2021: Kidney International
https://read.qxmd.com/read/34246657/the-ketone-body-%C3%AE-hydroxybutyrate-mitigates-the-senescence-response-of-glomerular-podocytes-to-diabetic-insults
#13
Yudong Fang, Bohan Chen, Athena Y Gong, Deepak Malhotra, Rajesh Gupta, Lance D Dworkin, Rujun Gong
Diabetic kidney disease (DKD) is one of the most common complications of diabetes and clinically featured by progressive albuminuria, consequent to glomerular destruction that involves podocyte senescence. Burgeoning evidence suggests that ketosis, in particular β-hydroxybutyrate, exerts a beneficial effect on aging and on myriad metabolic or chronic diseases, including obesity, diabetes and chronic kidney diseases. Its effect on DKD is largely unknown. In vitro in podocytes exposed to a diabetic milieu, β-hydroxybutyrate treatment substantially mitigated cellular senescence and injury, as evidenced by reduced formation of γH2AX foci, reduced staining for senescence-associated-β-galactosidase activity, diminished expression of key mediators of senescence signaling like p16INK4A and p21, and preserved expression of synaptopodin...
July 8, 2021: Kidney International
https://read.qxmd.com/read/34246656/significance-of-hla-dq-in-kidney-transplantation-time-to-re-evaluate-hla-matching-priorities-to-improve-transplant-outcomes-an-expert-review-and-recommendations
#14
REVIEW
Anat R Tambur, Vasilis Kosmoliaptsis, Frans Hj Claas, Roslyn B Mannon, Peter Nickerson, Maarten Naesens
The weight of HLA matching in kidney allocation algorithms, especially in the US, has been devalued in a stepwise fashion, supported by the introduction of modern immunosuppression. The intent was further to reduce the observed ethnic/racial disparity, as data emerged associating HLA matching with decreased access to transplantation for African American patients. In recent years, it has been increasingly recognized that a leading cause of graft loss is chronic antibody mediated rejection attributed to the development of de novo antibodies against mismatched donor HLA expressed on the graft...
July 8, 2021: Kidney International
https://read.qxmd.com/read/34246655/shared-decision-making-in-hemodialysis-vascular-access-practice
#15
REVIEW
Mariana Murea, Carl R Grey, Charmaine E Lok
Shared decision making (SDM) is a process of collaborative deliberation in the dyadic patient-physician interaction whereby physicians inform the patients about the pros and cons of all available treatment options and reach an agreement with the patients on their preferred treatment plan. In hemodialysis vascular access practice, SDM advocates a deliberative approach based on the existence of reasonable alternatives-i.e., arteriovenous fistula, arteriovenous graft, and central venous catheter-so that patients are able to form and share preferences about access options...
July 8, 2021: Kidney International
https://read.qxmd.com/read/34237327/a-review-of-kidney-transplantation-from-hcv-viremic-donors-into-negative-recipients
#16
REVIEW
Reem Daloul, Todd Pesavento, David S Goldberg, Peter P Reese
The safety and efficacy of direct acting antiviral therapies have allowed the transplantation of organs from hepatitis C virus (HCV)-viremic donors into uninfected recipients. This novel strategy contrasts with the previous standard-of-care practice of limiting the transplantation of HCV infected donor organs to HCV infected recipients, or all too often, discarding viable organs. In this review, we summarize the published literature about the safety and feasibility of transplanting organs from HCV-viremic donors, the challenges that hinder wider adoption of this strategy, and future research needs...
July 5, 2021: Kidney International
https://read.qxmd.com/read/34237326/an-international-cohort-study-spanning-five-decades-assessed-outcomes-of-nephropathic-cystinosis
#17
Francesco Emma, William Van't Hoff, Katharina Hohenfellner, Rezan Topaloglu, Marcella Greco, Gema Ariceta, Chiara Bettini, Detlef Bockenhauer, Koenraad Veys, Lars Pape, Sally Hulton, Suzanne Collin, Fatih Ozaltin, Aude Servais, Georges Deschênes, Robert Novo, Aurélia Bertholet-Thomas, Jun Oh, Elisabeth Cornelissen, Mirian Janssen, Dieter Haffner, Lucilla Ravà, Corinne Antignac, Olivier Devuyst, Patrick Niaudet, Elena Levtchenko
Nephropathic cystinosis is a rare disease secondary to recessive mutations of the CTNS gene encoding the lysosomal cystine transporter cystinosin, causing accumulation of cystine in multiple organs. Over the years, the disease has evolved from being a fatal condition during early childhood into a treatable condition, with patients surviving into adulthood. Data on cystinosis are limited by the rarity of the disease. Here, we have investigated factors associated with kidney and growth outcome in a very large cohort of 453 patients born between 1964 and 2016 and followed in Belgium, Germany, Austria, France, Italy, Spain, The Netherlands, Turkey and United Kingdom...
July 5, 2021: Kidney International
https://read.qxmd.com/read/34237325/measurement-of-urinary-dickkopf-3-uncovered-silent-progressive-kidney-injury-in-patients-with-chronic-obstructive-pulmonary-disease
#18
Stefan J Schunk, Christoph Beisswenger, Felix Ritzmann, Christian Herr, Martina Wagner, Sarah Triem, Gregor Hütter, David Schmit, Stephen Zewinger, Tamim Sarakpi, Anja Honecker, Peer Mahadevan, Peter Boor, Stefan Wagenpfeil, Rudolf Jörres, Henrik Watz, Tobias Welte, Claus F Vogelmeier, Hermann-Josef Gröne, Danilo Fliser, Thimoteus Speer, Robert Bals
Chronic kidney disease (CKD) represents a global public health problem with high disease related morbidity and mortality. Since CKD etiology is heterogeneous, early recognition of patients at risk for progressive kidney injury is important. Here, we evaluated the tubular epithelial derived glycoprotein dickkopf-3 (DKK3) as a urinary marker for the identification of progressive kidney injury in a non-CKD cohort of patients with chronic obstructive pulmonary disease (COPD) and in an experimental model. In COSYCONET, a prospective multicenter trial comprising 2,314 patients with stable COPD (follow-up 37...
July 5, 2021: Kidney International
https://read.qxmd.com/read/34237324/iga-nephropathy-presenting-as-macroscopic-hematuria-in-2-pediatric-patients-after-receiving-the-pfizer-covid-19-vaccine
#19
LETTER
Christian Hanna, Loren P Herrera Hernandez, Lihong Bu, Sarah Kizilbash, Lydia Najera, Michelle N Rheault, Jan Czyzyk, Anne M Kouri
No abstract text is available yet for this article.
July 5, 2021: Kidney International
https://read.qxmd.com/read/34237323/granulomatous-vasculitis-after-the-astra-zeneca-anti-sars-cov-2-vaccine
#20
LETTER
Valentine Gillion, Michel Jadoul, Nathalie Demoulin, Selda Aydin, Arnaud Devresse
No abstract text is available yet for this article.
July 5, 2021: Kidney International
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