Zhengzi Yi, Caixia Xi, Madhav C Menon, Paolo Cravedi, Fasika Tedla, Alan Soto, Zeguo Sun, Keyu Liu, Jason Zhang, Chengguo Wei, Man Chen, Wenlin Wang, Brandon Veremis, Monica Garcia-Barros, Abhishek Kumar, Danielle Haakinson, Rachel Brody, Evren U Azeloglu, Lorenzo Gallon, Philip O'Connell, Maarten Naesens, Ron Shapiro, Robert Colvin, Stephen Ward, Fadi Salem, Weijia Zhang
Lesion scores on procurement donor biopsies are commonly used to guide organ utilization for deceased-donor kidneys. However, frozen sections present challenges for histological scoring, leading to inter- and intra-observer variability and inappropriate discard. Therefore, we constructed deep-learning based models to recognize kidney tissue compartments in hematoxylin &eosin-stained sections from procurement needle biopsies performed nationwide in years 2011-2020. To do this, we extracted whole-slide abnormality features from 2431 kidneys and correlated with pathologists' scores and transplant outcomes...
November 3, 2023: Kidney International