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Journal Article
Review
The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition.
Microbes and Infection 2017 March
Mycobacterium tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding pathogenesis and thereby to derive new drug treatments and vaccines.
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