GSTM1 null genotype and susceptibility to cervical cancer in the Chinese population: An updated meta-analysis.

AIM OF STUDY: To clarify the effects of glutathione S-transferases mu-1. (GSTM1) null genotype on the risk of CC, an updated meta-analysis. was performed in Chinese populations.

MATERIALS AND METHODS: An extensive literature search for relevant studies was conducted on Pub Med, Springer Link, Ovid SP, Chinese Biomedical (CBM), Chinese National Knowledge Infrastructure (CNKI), VIP, and Wan fang Database from their inception through 22 October, 2014. This meta-analysis was performed using the STATA 10.0 software. The crude odds ratio (OR) with 95% confidence interval (CI) was calculated.

RESULTS: A total of four studies including 364 cervical cancer cases and 378 controls were involved in this meta-analysis. Overall, significant association was found between GSTM1 null genotype and CC risk when all studies in the Chinese population pooled into the meta--analysis. In subgroup analyses stratified by geographical location, ethnicity, and source of controls; the same results were observed.

CONCLUSION: This meta-analysis provides the evidence that GSTM1 null genotype may contribute to the CC development in Chinese and studies with large sample size and wider spectrum of population are warranted to verify this finding.