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Journal of Cancer Research and Therapeutics

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https://read.qxmd.com/read/30539883/two-subsequent-metachronous-diseases-granuloma-annulare-and-colon-adenocarcinoma
#1
LETTER
Hatice Ataş, Fatma Aksoy Khurami, Müzeyyen Gönül, Murat Alper
No abstract text is available yet for this article.
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539882/severe-hypercalcemia-a-rare-and-unusual-presentation-of-acute-lymphoblastic-leukemia
#2
LETTER
Swaminathan Dhivyasree, Jeevarathnam Dhivyalakshmi, Shuba Sankaranarayanan, Julius Xavier Scott
Hypercalcemia is a rare and unusual complication of childhood malignancies. Acute lymphoblastic leukemia (ALL) presenting with hypercalcemia and lytic bone lesions is very rare in children. Here, we report a case of a 4-year-old girl with ALL who presented with severe hypercalcemia and radiological evidence of osteolytic lesions. Malignancies are the most common parathyroid hormone-independent cause of hypercalcemia. Severe hypercalcemia is a life-threatening emergency that should be addressed immediately. Effective treatment includes intense hydration, frusemide, calcitonin, and bisphosphonate in addition to the treatment of underlying cause...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539881/paratesticular-rhabdomyosarcoma-mimicking-complicated-epididymal-cyst
#3
LETTER
Mete Kilciler, Mustafa Kadihasanoglu, Ozcan Atahan
Paratesticular rhabdomyosarcoma (RMS) is a rare nongerm cell intrascrotal malignant tumor in children and young adult/teens resulting from the mesenchymal tissues of the tunica vaginalis, epididymis, spermatic cord, and testis. RMS accounts for approximately 7% of all genitourinary tract RMSs and 12% of all pediatric scrotal neoplasms. Patients usually present with a painless unilateral scrotal mass. We report a 16-year-old boy with a paratesticular RMS mimicking epididymal cyst. To our knowledge, this is the first case reported in the literature presenting as an epididymal cyst...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539880/ultrasonographic-diagnosis-of-benign-masseter-muscle-hypertrophy-a-case-report
#4
LETTER
Vihag Vinod Naphade, Sameer G Kedia, Pallavi Patil, Siddhant Khare
Masseter hypertrophy is a characteristic condition resulting from an increase in the size of the muscle mass. At times, it produces significant facial asymmetry and is an important finding in the differential diagnosis of similar located entities. A proper diagnosis of this condition would avoid more aggressive and unwarranted therapy by an inexperienced clinician who may mistake it for a more serious pathologic condition. This article reports two cases of bilateral masseter hypertrophy having characteristic diagnostic features, along with specialized imaging modalities and review of literature...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539879/treatment-strategy-for-huge-hepatocellular-carcinoma-with-intrahepatic-metastasis-and-macrovascular-invasion-a-case-report-and-literature-review
#5
LETTER
Chuanchao He, Zhenyu Zhou, Zhiyu Xiao, Jie Wang
Macrovascular invasion, such as tumor thrombus in the major portal vein (mPVTT) or major hepatic vein (mHVTT), is regarded as indicative of an advanced stage of hepatocellular carcinoma (HCC). To date, no effective treatment has been established for this kind of HCC. We herein present a case of huge HCC with intrahepatic metastasis, mPVTT, and mHVTT. The patient was successfully treated with surgical resection-based multidisciplinary treatment. The clinical presentation, treatment strategy, and outcome of this case were presented...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539878/gastric-metastasis-of-recurrent-hepatocellular-carcinoma-a-case-report-and-literature-review
#6
LETTER
Long Peng, Kehan Yu, Yong Li, Weidong Xiao
Hepatocellular carcinoma (HCC) with gastric metastasis is seldom reported. It is extremely easy to misdiagnose for primary gastric cancer with liver metastasis, especially gastric hepatoid adenocarcinoma. Here, we report a case of recurrent HCC with gastric metastasis in a 22-year-old man. He had a history of left side hepatic tumor local resection due to ruptured HCC 10 years ago. Computed tomography revealed tumors in the right liver and stomach. Endoscopy identified a massive protrusion-like malignant stromal tumor at the greater curvature of gastric body...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539877/fatal-interstitial-lung-disease-associated-with-azd9291
#7
LETTER
Sheng-Ming Deng, Jian-An Huang, Yan-Bin Chen
AZD9291 is one of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) for non-small cell lung cancer (NSCLC). Interstitial lung disease (ILD) induced by AZD9291 is very seldom. We provide a case of NSCLC treated with AZD9291 who developed ILD and died in order to improve the knowledge on AZD9291.
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539876/symptomatic-treatment-of-brain-metastases-in-renal-cell-carcinoma-with-sorafenib
#8
LETTER
Dongyan Hu, Yu Hu, Jisheng Li, Xiuwen Wang
Brain metastasis is synchronous to the diagnosis of renal cell carcinoma (RCC). The prognosis of brain metastasis in RCC with the current treatment options is dismissal. Therefore, we present a case of an elderly female patient with RCC showing a partial response of brain metastasis after 18 months of 600 mg once daily sorafenib treatment who underwent right-sided nephrectomy. Further, withdrawal of sorafenib resulted in psychiatric changes along with increased metastasis lesions, which were recovered upon resuming the treatment, proposing that oral sorafenib can be used safely and efficiently for treatment of brain metastasis in advanced RCC...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539875/multiple-intercostal-neurilemmomas-in-a-chinese-woman
#9
LETTER
Wen-Kui Sun, Wen Yang, Chen-Hui Ma, Xin-Wu Xiao, Yi Shi, Yong Song
Neurilemmomas are rare tumors of neural crest cell origin that occur most commonly in the head and neck region. Intercostal neurilemmomas are extremely rare and are mostly seen as solitary tumors in the posterior mediastinum. Only one case report of multiple intercostal neurilemmomas has been documented previously. In this article, we report a case of multiple intercostal neurilemmomas in a 54-year-old woman who had initially presented with progressive dull left chest pain over a 1-year period. A computed tomography scan revealed three tumors in the left thoracic cavity which were distributed as a string of beads along the third intercostal nerve...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539874/malignant-solitary-fibrous-tumor-of-the-kidney-with-liver-metastasis-a-case-report-and-literature-review
#10
LETTER
Ning Zhang, Dongxiao Zhou, Kai Chen, Hongyan Zhang, Bingcang Huang
Solitary fibrous tumor (SFT) is a rare spindle cell soft tissue tumor which is rarely encountered in the clinical setting and imaging findings are nonspecific, mainly occurring in the tissue structure of the serosa. However, there is very little report on SFT originating in the kidney in the medical literature. We report a case of SFT with liver metastasis in an adult female and discuss the pathological features as it appears in our case.
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539873/cutaneous-metastasis-in-prostate-cancer-two-cases-with-similar-clinical-findings
#11
LETTER
Ayşe Kavak, Murat Yılmaz, Haydar Kamil Çam, Volkan Tuğcu, Hülya Albayrak, Damlanur Sakız, Ümran Yıldırım
Cutaneous metastasis of prostate cancer is rare. Lesions in this type of skin metastasis are usually seen as suprapubic nodules. Here, we presented two cases with skin metastases of prostate cancer characterized by grouped cutaneous and subcutaneous nodules.
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539872/uterine-tumors-resembling-ovarian-sex-cord-tumor-a-case-report-and-literature-review
#12
LETTER
Li-Li Fan, Yang Shen, Kenneth Chanda, Mu-Lan Ren
Uterine tumors resembling ovarian sex-cord tumor (UTROSCT) are a rare, multi-phenotype sex-cord tumors, containing a structure which is characteristic with the trabecular, cord, nests, and false adenoid arrangement. In addition, CD99-positive was a basis for diagnosis of the disease. With uncertain malignant potential and relapse, these patients should be closely followed up. This article is to summarize clinical and pathological features, diagnosis and differential diagnosis, treatment, and prognosis of UTROSCT...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539871/the-prognostic-role-of-thyroid-transcription-factor-1-in-lung-adenocarcinoma
#13
Esin Oktay, Utku Oflazoglu, Yelda Varol, Ozgur Tanriverdi, Necla Mermur, Hayri Ustun Arda, Lutfiye Demir, Ozge Keskin, Tural Ahmadli, Isil Somali, Ilhan Oztop, Nezih Meydan
Aims: In this study, we investigated the expression of thyroid transcription factor-1 (TTF-1) in lung adenocarcinoma patients' samples and analyzed the association of TTF-1 with clinicopathological parameters, prognosis, and treatment options in patients with lung adenocarcinoma. Subjects and Methods: This retrospective study enrolled 200 patients who were histologically confirmed lung adenocarcinoma with Stage I-IV disease, between 2008 and 2015 years. The cytological archive of these hospitals' Pathology Department was searched...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539870/combinatorial-effect-of-curcumin-and-tumor-necrosis-factor-%C3%AE-related-apoptosis-inducing-ligand-trail-in-induction-of-apoptosis-via-inhibition-of-nuclear-factor-kappa-activity-and-enhancement-of-caspase-3-activity-in-chronic-myeloid-cells-an-in-vitro-study
#14
Bushra Iqbal, Archna Ghildiyal, Shraddha Singh, Sahabjada Siddiqui, Pratibha Kumari, M Arshad, A A Mahdi
Background: Nuclear factor kappa B (NFkB-light-chain-enhancer of activated B-cells) expression and its regulation is a key role in the development of number of malignancies, as NFkB mediates the balance between cell death and its survival. Therefore, NFkB regulation constitutes an attractive target to overcome the resistance to chemotherapeutic agents in anticancer therapy. Curcumin, as a chemopreventive agent, has a potential role in inhibiting cell growth in a variety of malignancies...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539869/expression-of-programmed-death-ligand-1-and-programmed-death-1-in-hepatocellular-carcinoma-and-its-clinical-significance
#15
J Long, Tao Qu, X F Pan, X Tang, H H Wan, P Qiu, Yan-Hua Xu
Objective: To investigate the correlation between the expression of programmed death 1 (PD-1) and PD ligand-1 (PD-L1) in hepatocellular carcinoma (HCC) and clinical parameters. Materials and Methods: The study comprised tumor sections from 45 HCC patients treated with curative resection, which were evaluated for PD-1 and PD-L1 protein expression by immunohistochemistry. Results: PD-1 and PD-L1 expression was increased in cancers compared to adjacent normal tissues, with a positive rate of 37...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539868/influence-of-pharmorubicin-on-the-left-ventricular-ejection-fraction-of-patients-with-breast-cancer-a-mechanism-study
#16
Hu Liu, Ming-Rui Xie, Hui Gao, Jian Li
Aims: Breast cancer is a great public health problem. It remains unclear how pharmorubicin induces cardiac dysfunction in patients with breast cancer. Our study was aimed to explore the influence of pharmorubicin on the left ventricular ejection fraction (EF) of patients with breast cancer and its potential mechanism. Materials and Methods: Patients with breast cancer were enrolled at the same hospital. Group I consisted of 135 samples, who were under treatment of pharmorubicin (200 mg/m2 )...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539867/association-of-x-ray-cross-complementing-group-3-thr241met-gene-polymorphism-with-osteosarcoma-risk-and-its-development-and-prognosis
#17
Yanwei Wang, Guanliang Wang, Zhiyong Dong
Aim of Study: The relationship between X-ray cross-complementing group 3 (XRCC3) Thr241Met gene polymorphism and osteosarcoma risk and its development and prognosis is still debated. This meta-analysis was performed to assess these associations. Materials and Methods: The association studies were identified from PubMed, and eligible reports were included and calculated using meta-analysis method. Results: Interestingly, all the included studies were from Asian population...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539866/meta-analysis-on-the-association-between-xeroderma-pigmentosum-group-a-a23g-polymorphism-and-esophageal-cancer-in-a-chinese-population
#18
Jiang-Lan Xu, Jing Bai, Jian-Feng Jiao, Li Ding, Li Lei, Xiao-Ping Bai, Yu-Feng Cheng
Aim of the Study: Several studies have evaluated the correlation between xeroderma pigmentosum Group A (XPA) A23G polymorphism (rs 1800975) and esophageal cancer in Chinese people. However, the results are inconsistent. To assess the effects of XPA A23G variants on the risk for development of esophageal cancer in the Chinese population, a meta-analysis was performed. Materials and Methods: Studies were identified using PubMed and Chinese databases through December 2015...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539865/laminin-is-over-expressed-in-breast-cancer-and-facilitate-cancer-cell-metastasis
#19
Xia Qiu, Haosheng Tan, Deyuan Fu, Yuxiang Zhu, Jiaxin Zhang
Aim of Study: Breast cancer invasion and metastasis is the main reason for the failure, and laminin is involved in it. This study intends to explore the expression of laminin in breast cancer and normal breast tissue and its clinical significance. Materials and Methods: We use immunohistochemical assay for the detection of breast infiltrating ductal cancer tissues and normal breast tissues of laminin expression and discuss their role in breast cancer invasion and metastasis...
December 2018: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30539864/concurrent-computed-tomography-guided-radioactive-iodine-125-seeds-percutaneous-interstitial-implantation-and-chemotherapy-for-treatment-of-cervical-lymph-node-metastases
#20
Zhaodong Li, Xiangguo Wang, Kexia Fang, Jian Shi, Xiangjie Qi, Runming Sun
Aim: The study aimed to evaluate the effect of concurrent computed tomography (CT)-guided percutaneous interstitial implantation of iodine-125 (125 I) seeds and chemotherapy on cervical lymph nodes metastasis. Methods: The prospective randomized study included 82 cases with cervical lymph nodes metastasis who were admitted to our hospital from January 2010 to June 2012. All the subjects were randomly divided into the concurrent 125 I implantation and chemotherapy group (n = 48) and chemotherapy-only group (n = 34) according to the treatment strategy...
December 2018: Journal of Cancer Research and Therapeutics
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