BASICS OF STERILE COMPOUNDING: Sterilization Methods in Sterile Product Manufacturing

Michael J Akers
International Journal of Pharmaceutical Compounding 2015, 19 (2): 127-38
Sterilization methods to produce sterile preparations include heat, gas, radiation, and filtration. This article focuses on heat, gas, and radiation sterilization, plus a brief introduction to bright-light sterilization. Microbiology basics and microbial death kinetics, key to understanding why these sterilization methods work, will also be briefly discussed. Filtration sterilization will be covered in a separate article.

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