journal
MENU ▼
Read by QxMD icon Read
search

International Journal of Pharmaceutical Compounding

journal
https://read.qxmd.com/read/30668540/stability-assessment-of-topical-amitriptyline-extemporaneously-compounded-with-lipoderm-base-plo-gel-mediflo-30-and-emollient-cream
#1
Ayah Shakshuki, Remigius U Agu
Extemporaneous topical compounds for neuropathic pain offers an alternative or adjunct approach to existing therapies for patients. Assigning evidence-based beyond-use dating prior to dispensing topical medications is a legal requirement by pharmacy governing bodies. The purpose of this study was to utilize a validated stability-indicating high-performance liquid chromatography assay to determine beyond-use dating of topical amitriptyline in three different bases (Lipoderm Base, PLO Gel Mediflo 30, Emollient Cream) at three different temperatures [room temperature (25°C), refrigeration (4°C), and high temperature (40°C)]...
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30668539/ex-vivo-evaluation-of-intravaginal-progesterone-and-testosterone-to-treat-the-luteal-phase-deficiency-and-vaginal-atrophy
#2
Larissa C Laque, Nádia Rb Raposo, Marcos Antônio F Brandão, Anderson O Ferreira, Hudson C Polonini
The purpose of this study was to evaluate the transmucosal permeation of progesterone and testosterone using Pentravan as its vehicle for vaginal delivery. Progesterone deficiency is a hormone imbalance that could lead to luteal-phase deficiency, which is a common problem in assisted reproductive technologies. Testosterone has been explored for treating postmenopausal symptoms, such as vaginal atrophy. The ex vivo experiments were performed using porcine vaginal mucosa and phosphate buffered saline + 0.5% 2-hydroxypropyl-ß-cyclodextrin as the receptor media, which was later quantified through high-performance liquid chromatography...
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30668538/stability-of-compounded-ursodiol-suspensions-in-pcca-base-suspendit
#3
Yashoda V Pramar, Tarun K Mandal, Levon A Bostanian, Anh Tq Nguyen, Valicia Miller, Tommy C Morris, Richard A Graves
Ursodiol (ursodeoxycholic acid) is a nontoxic, naturally occurring bile acid that constitutes 1% to 2% of human bile. It suppresses hepatic synthesis of cholesterol, aids in the desaturation of biliary cholesterol, and aids in the dissolution of cholesterol gallstones. Ursodiol is commercially available as a 300-mg capsule and a 250-mg tablet. However, no commercial liquid dosage form of ursodiol exists. An extemporaneously compounded suspension from pure drug powder or commercial tablets/capsules would provide an alternative option to meet unique patient needs...
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30668537/transdermal-delivery-of-metformin-hydrochloride-from-a-semisolid-vehicle
#4
Hudson Polonini, Paulo José Lopes Cândido, Junquiera Laura Andrade, Sharlene Loures, Nádia Rb Raposo, Marcos Antônio Fernandes Brandão, Anderson de Oliveira Ferreira
Metformin hydrochloride is a traditional, FDA-approved drug used as a first-line drug of choice to treat type 2 diabetes. Research has shown metformin hydrochloride effective in injuries, including age-related maladies. The purpose of this ex vivo study was to evaluate the use of a commercial transdermal vehicle as a semisolid, liposomal vanishing cream (Pentravan) to deliver metformin hydrochloride through the human skin. The experiments were conducted as percutaneous absorption assay in Franz Diffusion Cells, coupled with freshly excised human skin and analyzed by high-performance liquid chromatography...
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30668536/chemical-stability-of-progesterone-in-compounded-oral-rapid-dissolving-tablets
#5
Casey L Sayre, Christopher Cox, Gabriel Velazquez, Minh Thi Le, Amy Hong Nguyen, Marjorie Ramos, Anna Burrows, Venkata Kashyap Yellepeddi
Progesterone is a naturally occurring female sex hormone, which plays an important role in the female reproductive cycle. Progesterone supplementation is used to treat a variety of conditions. When commercial dosage strengths are unavailable, rapid-dissolving tablets may be compounded. The objective of this study was to evaluate the chemical stability of progesterone when compounded in a rapid-dissolving tablet formulation and to establish an evidence-based beyond-use date. Triplicate test samples were prepared by diluting the pulverized progesterone rapid-dissolving tablets with a portion of methanol to a final concentration of 100 µg/mL...
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30668535/quality-control-and-basics-of-sterile-compounding-attempting-to-avoid-out-of-specification-results-and-patient-harm-in-sterile-compounding
#6
Matt Martin
What do you do when something goes wrong in your cleanroom? What do you do when a sterility test fails and what are the implications of such a failure? What should you do when your environmental monitoring or personnel monitoring provides results that exceed your action levels? A root cause analysis is needed in any situation where action levels are exceeded or tests are out of specification. However, should the questions be what can be done to prevent these occurrences, and how can the development be noticed before they occur? In this article, we will discuss going beyond the recommendations of United States Pharmacopeia Chapter <797> to attempt to build a program that limits the possibility of contamination through monitoring of the facility, personnel, and procedures in aseptic processing...
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30668534/basics-of-compounding-standardization-of-compounded-medications
#7
Loyd V Allen
The feasibility of standardizing concentrations of compounded drug preparations to attempt to minimize adverse events of both nonsterile and sterile compounded preparations has been discussed. It is critical that a wide variety of opinions and potential "unintended consequences" be aired in the public before an issue like this is recommended to become a standard. In this article, we combine the thoughts and recommendations of many practicing compounding pharmacists from both community and hospital practice sites that have contributed to this topic through the International Journal of Pharmaceutical Compounding's Compounders' Network List, a complimentary listserve for our subscribers to share information; ask questions; and provide answers, comments, and opinions...
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30668533/u-s-food-and-drug-administration-inspection-authority-how-to-know-whether-u-s-food-and-drug-administration-inspectors-are-crossing-the-line
#8
Stephen T Snow, Robert W Stannard, Jennifer Bellis, Carrie A Moss
No abstract text is available yet for this article.
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30668532/topical-treatment-of-primary-focal-hyperhidrosis-part-1
#9
Eyal Zur
Primary focal hyperhidrosis is idiopathic, localized, uncontrollable, excessive, and unpredictable sweating beyond what is necessary to regulate body temperature. Primary hyperhidrosis is thought to affect approximately 2% to 3% of the population, and its effect on a patient's quality of life is very significant. Primary focal hyperhidrosis can be managed using various therapeutic options, including drugs (topical and systemic), nonsurgical interventions (e.g., iontophoresis, botulinum toxin injections), and surgery...
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30668531/the-history-symptoms-causes-risk-factors-types-diagnosis-treatments-and-prevention-of-gout-part-2
#10
LaVonn A Williams
Gout, a common and complex form of inflammatory arthritis, is characterized by abnormally elevated levels of uric acid in the blood. The most current estimate from the Centers for Disease Control and Prevention shows an increase from 52.5 million to 54.4 million people in the U.S. have arthritis or one of the rheumatic diseases. There are over 100 rheumatic diseases and conditions. In the U.S., the most common types of arthritis or rheumatic diseases are osteoarthritis, gout, fibromyalgia, and rheumatoid arthritis, in that order according to prevalence...
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30668530/an-outlook-on-the-european-and-italian-rules-to-guarantee-magistral-formulas
#11
Francesca Selmin, Antonella Casiraghi, Umberto M Musazzi, Marco Fortini, Paola Minghetti
Pharmaceutical compounded medicinal preparations are aimed to fulfill the special needs of a subpopulation of patients for whom a medicinal product is not commercially available. Nowadays, this activity remains an important component of pharmacy practice and an integral part of the modern healthcare system. In 2011, the Committee of Ministers of the Council of Europe adopted a resolution to harmonize quality assurance and safety standards for medicinal products prepared in pharmacies for the special needs of patients in European countries...
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30668529/prescription-the-cost-of-information
#12
EDITORIAL
Loyd V Allen
No abstract text is available yet for this article.
January 2019: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30384354/errata
#13
Loyd V Allen
Ketamine 50-mg/mL Injection, IJPC Jul/Aug 2013 pg 331. "Evaluation of the Stability of Ketoprofen in Pluronic Lecithin Organogel and the Determination of an Appropriate Beyond-use Date" IJPC Jul/Aug 2014 pg 348-350. "Rolapitant Injectable Emulsion with Palonosetron Hydrochloride Admixture" IJPC May/Jun 2018 pg 237.
November 2018: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30384353/compatibility-of-baclofen-carvedilol-hydrochlorothiazide-mercaptopurine-methadone-hydrochloride-oseltamivir-phosphate-phenobarbital-propranolol-hydrochloride-pyrazinamide-sotalol-hydrochloride-spironolactone-tacrolimus-monohydrate-ursodeoxycholic-acid-and-vancomycin
#14
Hudson Polonini, Sharlene Loures da Silva, Marcos Antônio Fernandes Brandão, Tiene Bauters, Barbara De Moerloose, Anderson de Oliveira Ferreira
Compounded liquid medication is frequently required in children to allow easy dose adjustment and overcome swallowing difficulties. The objective of this study was to evaluate the stability of oral suspensions compounded with SyrSpend SF PH4 and the commonly used active pharmaceutical ingredients baclofen 2.0 mg/mL, carvedilol 5.0 mg/mL, hydrochlorothiazide 2.0 mg/mL, mercaptopurine 10.0 mg/mL, methadone hydrochloride 10.0 mg/mL, oseltamivir phosphate 6.0 mg/mL, phenobarbital 9.0 mg/mL and 15.0 mg/mL, propranolol hydrochloride 0...
November 2018: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30384352/compounded-orodispersible-films-with-natural-ingredients-for-halitosis-a-clinical-experience
#15
Régis De Souza Apolinário, Maria Das Graças Afonso Miranda Chaves, Hanny Reis Mockdeci Gonçalves, Isadora Conde Ferreria Martins, Renée Mazilão De Paula, Ana Paula Alves Granato, Hudson Caetano Polonini, Marcos Antônio Fernandes Brandão, Anderson De Oliveira Ferreira, Nádia Rezende Barbosa Raposo
Halitosis can be described as unpleasant odors emanating from the oral cavity. It is usually associated with decomposition action of bacteria present mainly on the back of the tongue and periodontal pockets, and able to produce volatile sulfur compounds. We conducted a study at the Faculty of Dentistry, Federal University of Juiz de Fora and evaluated the therapeutic effect of two natural extracts, Camellia sinensis (green tea) and resveratrol in the form of oral polymer films, to control halitosis. Fifty volunteers (students of health courses) participated in the research after orientation and signing the informed consent form...
November 2018: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30384351/physical-and-chemical-stability-of-estriol-0-025-to-1-vaginal-creams-versabase
#16
Kendice Ip, Ashley Shan, Wei Yan, Daniel Banov
Estrogen replacement therapy is often recommended when female patients present with lower than normal physiologic levels, such as patients going through menopause. The physical and chemical stability of estriol 0.25 mg/g and 10 mg/g vaginal creams (VersaBase) was tested over a period of 182 days, at room temperature and refrigerated conditions, in order to determine the corresponding beyond-use date. The physical characterization consisted in observing all samples for color/appearance and odor, and testing for pH, whereas the chemical characterization consisted in ultra-performance liquid chromatography assay testing...
November 2018: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30384350/gabapentin-in-elastic-liposomes-preparation-characterization-drug-release-and-penetration-through-porcine-skin
#17
Uyen Minh Le, Sarah Baltzley, Abeer AlGhananeem
In the outpatient pharmacy compounding, gabapentin, an anti-epileptic agent, has been commonly prescribed to be prepared alone or in combination with other agents in Pluronic lecithin organogel for transdermal pain management and palliative care. The objective of this study was to formulate and characterize gabapentin encapsulated elastic liposomes and then compare the gabapentin-based liposomes with compounded gabapentin-based Pluronic lecithin organogel regarding their efficiency in transdermal delivery of gabapentin...
November 2018: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30384349/basics-of-compounding-vehicles-for-compounded-oral-liquid-medications-a-review
#18
Kara Cutaia, Lipika Chablani, Fang Zhao
Compounded oral liquid medications play an important role in addressing the unmet needs of special patient populations, including pediatric, geriatric, and tube fed patients. The use of manufactured vehicles can streamline the compounding activities for pharmacists. In recent years, there is an increase in the availability of manufactured vehicles with various promotional features. This article uses the general formulation principles as a guide to compare and contrast the manufactured vehicles regarding their physicochemical properties, presence of preservatives and dyes, organoleptic properties, and ease of use...
November 2018: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30384348/basics-of-sterile-compounding-quality-assurance-and-quality-control-being-prepared-for-u-s-food-and-drug-administration-inspections-and-staying-in-compliance-with-united-states-pharmacopeia-chapter-797-part-2
#19
Matt Martin
Compounders engaged in making sterile preparations need to employ a quality-assurance system of documented policies and procedures to attempt to reduce the possibility of contamination. The quality-assurance program will be monitored through the facility's quality-control system. Compounders should be aware of the requirements of each state they are licensed in as well as the inspection observations commonly noted in 483s issued by the U.S. Food and Drug Administration. Part 1 of this 2-part article discussed the currently evolving regulatory environment and why sterile compounding requires planning and monitoring to deliver quality compounds to patients...
November 2018: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/30384347/compounding-from-a-pharmacy-student-s-perspective-staying-competitive-as-a-compounding-pharmacy
#20
Ryan Waldschmidt
The International Academy of Compounding Pharmacists Foundation held a student essay contest in the Spring of 2018. Two great submissions were chosen to receive an award. This article features one of the chosen essays, which discusses some of the challenges that compounding pharmacies face in the competitive profession of pharmacy.
November 2018: International Journal of Pharmaceutical Compounding
journal
journal
32731
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"