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JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL

The efficacy of pregabalin for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled double-blind study

Vinit K Srivastava, Sanjay Agrawal, Venkat N Kadiyala, Mukadder Ahmed, Sunil Sharma, Raj Kumar
Journal of Anesthesia 2015, 29 (2): 212-6
25200037

OBJECTIVE: The present study evaluated the efficacy of preoperative pregabalin for prevention of catheter-related bladder discomfort.

DESIGN: Prospective, randomized, placebo controlled, double blinded study.

MATERIALS AND METHODS: Sixty patients of either sex undergoing elective spine surgery and requiring urinary bladder catheterization were randomly assigned to two groups. The patients in Group P (pregabalin group) received 150 mg of pregabalin orally 1 h prior to induction of anesthesia with sips of water and the patients in Group C (control group) received placebo. Anesthesia technique was identical in both the groups. Catheter-related bladder discomfort (CRBD) was evaluated on a 4-point scale (1 = no discomfort, 2 = mild, 3 = moderate, 4 = severe), on arrival (0 h) and again at 1, 2, and 6 h postoperatively. Patients were provided patient-controlled analgesia with fentanyl for postoperative pain relief.

RESULTS: The incidence of CRBD was significantly less in the pregabalin group compared with the control group at all time intervals (P < 0.05). The severity of CRBD was reduced in the pregabalin group compared with the control group at all time intervals except 6 h. The postoperative consumption of fentanyl was significantly less in group P, while the sedation score was significantly higher in the group P compared to group C.

CONCLUSION: Pretreatment with pregabalin 150 mg prevents CRBD and also decreases postoperative fentanyl consumption. ClinicalTrials.gov identifier: (ref: CTRI/2013/11/004170).

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