Atsushi Sawada, Gen Ochiai, Michiaki Yamakage
PURPOSE: Immobilization of the cervical spine after trauma is recommended as standard care to prevent secondary injury. We tested the hypothesis that a two-handed airway maneuver, consisting of mandibular advancement and mouth opening in the neutral neck position, would minimize changes in the angle of the cervical vertebrae at the C0/4 level and tidal volume in non-obese patients under anesthesia with neuromuscular blockade. METHODS: Twenty consecutive patients without cervical spine injury undergoing general anesthesia were enrolled and evaluated...
July 28, 2021: Journal of Anesthesia
Tatsuo Horiuchi, Tomonori Takazawa, Shigeru Saito
No abstract text is available yet for this article.
July 28, 2021: Journal of Anesthesia
Reecha Panghal, Sukanya Mitra, Jasveer Singh, Rashi Sarna, Bharti Goel
BACKGROUND: Intravenous acetaminophen is safe and effective as an adjunct to labor analgesia with combined spinal-epidural (CSE) analgesia and patient-controlled epidural analgesia (PCEA). Oral acetaminophen is a much cheaper and safe option but has not been studied as an adjunct to labor analgesia till date. The aim of the present study is to evaluate the effect of oral acetaminophen as an adjunct in patients receiving local anesthetic-opioid combination using CSE analgesia. METHOD: In this ethically approved randomized double-blind placebo-controlled trial, 60 consenting parturients were randomly allocated to two groups of 30 each: acetaminophen (who received oral acetaminophen 1 g) or placebo, 45 min before the procedure...
July 27, 2021: Journal of Anesthesia
Greet Van den Berghe
The "fight or flight" response to critical illness relies on increased cortisol availability, traditionally attributed to several-fold-increased cortisol production via hypothalamus-pituitary-adrenal-axis activation. Recent studies provided evidence against this concept with clinical implications. First, high cortisol availability during critical illness is driven by suppressed cortisol binding and reduced cortisol breakdown rather than increased cortisol production. This implies reduction of hydrocortisone doses when prescribed in ICU...
July 24, 2021: Journal of Anesthesia
Feng-He Cui, Jie Li, Ke-Zhong Li, Yong-Gang Xie, Xiao-Ling Zhao
OBJECTIVE: This study explored the effects of sevoflurane exposure during different stages of pregnancy on the brain development of offspring. METHODS: Thirty-six pregnant SD rats were randomly divided into 4 groups: control, sevoflurane exposure in early (S1) pregnancy, sevoflurane exposure in middle (S2) pregnancy, and sevoflurane exposure in late (S3) pregnancy. After natural birth, the learning and memory capacity of offspring rats was analyzed using the Morris water maze experiment...
July 19, 2021: Journal of Anesthesia
Andreas Koster, Nikolai Hulde, Armin Zittermann
No abstract text is available yet for this article.
July 16, 2021: Journal of Anesthesia
Hideki Kuniyoshi, Yu Yamamoto, Shohei Kimura, Takanori Hiroe, Takako Terui, Yoichi Kase
PURPOSE: We investigated the non-inferiority of continuous rectus sheath block to continuous epidural anesthesia for postoperative analgesia of gynecological cancer patients. METHODS: One hundred ASA-PS 1-2 patients via a median incision up to 5 cm above the navel were randomized into a continuous epidural anesthesia (CEA) group and a continuous rectus sheath block (CRSB) group. Following surgery, they have controlled with intravenous patient-controlled analgesia (IV-PCA) as basal postoperative analgesia...
July 15, 2021: Journal of Anesthesia
Hyun-Jung Shin, Gihong Boo, Hyo-Seok Na
PURPOSE: To assess the effects of various concentrations of dexmedetomidine on the human blood coagulation profile using rotational thromboelastometry (ROTEM). METHODS: Venous blood samples were collected from 11 healthy volunteers and divided into four specimen bottles; dexmedetomidine was added to attain final sample concentrations of 0, 0.5, 1.0, and 1.5 ng/mL. ROTEM was performed on each study sample. RESULTS: The concentration of dexmedetomidine increased, and the ROTEM values showed a hypercoagulable state...
July 15, 2021: Journal of Anesthesia
Ahmed Hasanin, Maha Mostafa
Tocilizumab (TCZ) is a recombinant anti-interleukin-6 monoclonal antibody which showed uprising evidence as an anti-inflammatory agent which modulates the cytokine storm in patients with COVID-19. However, proper use of the drug requires selection of the appropriate patient and timing. The two main factors which might improve patient selection are the degree of respiratory failure and systemic inflammation. TCZ can decrease the mortality and progression to invasive mechanical ventilation in patients with severe COVID-19 who are not yet invasively ventilated...
July 15, 2021: Journal of Anesthesia
Naoyuki Hirata, Dong Tien Ngo, Phuc Huu Phan, Akira Ainai, Thuy Thi Bich Phung, Tuan Anh Ta, Jin Takasaki, Shoji Kawachi, Hiroyuki Nunoi, Noriko Nakajima, Tran Minh Dien
PURPOSE: Recombinant human soluble thrombomodulin (rTM) has been used to treat disseminated intravascular coagulation (DIC). Recent studies have shown the efficacy of rTM through its anti-inflammatory effects for treatment of adults with acute respiratory distress syndrome (ARDS). However, the safety and efficacy of rTM in children with severe ARDS complicated by DIC have not been reported. In this preliminary study, we reported the feasibility of using rTM for the treatment of pneumonia-induced severe ARDS complicated by DIC in children...
July 14, 2021: Journal of Anesthesia
Claudia Avalos, Guilia Dula Razzolini, Sarah Crimmins, Katrina Mark
OBJECTIVE: To evaluate current opioid prescription practices following a cesarean delivery. METHODS: Women were asked to participate in a prospective observational cohort study following a cesarean delivery. Participants were asked about their opioid use after discharge, amount leftover, subjective pain score, and satisfaction. RESULTS: A total of 344 women had cesarean deliveries during the study period, 242 were approached, 171 met eligibility criteria, and 109 were included in the analysis...
July 12, 2021: Journal of Anesthesia
Hyub Huh, Suk Woo Lee, Jang Eun Cho, Hyun-Chang Kim
PURPOSE: Catheter-related bladder discomfort (CRBD) is postoperative distress caused by a urinary catheter. CRBD is related to muscarinic receptor activation. Chlorpheniramine has antimuscarinic properties. Hence, this investigation was undertaken to evaluate the efficacy of chlorpheniramine in preventing CRBD in patients undergoing transurethral resection of bladder tumor (TURBT). METHODS: Seventy-six patients scheduled for TURBT under general anesthesia were assigned into two groups...
July 10, 2021: Journal of Anesthesia
Michiaki Yamakage
No abstract text is available yet for this article.
July 8, 2021: Journal of Anesthesia
Berrin Gunaydin, Irfan Gungor, Gozde Inan
No abstract text is available yet for this article.
July 2, 2021: Journal of Anesthesia
Azzeddine Kermad, Jacques Speltz, Guy Danziger, Thilo Mertke, Robert Bals, Thomas Volk, Philipp M Lepper, Andreas Meiser
PURPOSE: In this retrospective study, we compared inhaled sedation with isoflurane to intravenous propofol in invasively ventilated COVID-19 patients with ARDS (Acute Respiratory Distress Syndrome). METHODS: Charts of all 20 patients with COVID-19 ARDS admitted to the ICU of a German University Hospital during the first wave of the pandemic between 22/03/2020 and 21/04/2020 were reviewed. Among screened 333 days, isoflurane was used in 97 days, while in 187 days, propofol was used for 12 h or more...
June 25, 2021: Journal of Anesthesia
Takuya Hinoue, Tomoaki Yatabe, Himuro Fujiwara, Osamu Nishida
The usefulness and safety of continuous glucose monitoring (CGM) systems in adult patients with severe coronavirus disease (COVID-19) have been reported. Using CGM might reduce the exposure patients and healthcare workers to COVID-19 and limit the use of personal protective equipment during the pandemic. CGM devices measure glucose in the subcutaneous interstitial fluid, but the accuracy of this technique has not been established in critically ill patients. The artificial pancreas, STG-55 (Nikkiso, Tokyo), is a closed-loop device that conducts continuous blood glucose monitoring using a peripheral vein...
June 24, 2021: Journal of Anesthesia
Yuan Sun, Xiao Huang
No abstract text is available yet for this article.
June 23, 2021: Journal of Anesthesia
Hans-Joachim Priebe
No abstract text is available yet for this article.
June 14, 2021: Journal of Anesthesia
Liu-Jia-Zi Shao, Shao-Hua Liu, Fu-Shan Xue
No abstract text is available yet for this article.
June 11, 2021: Journal of Anesthesia
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