Journal of Anesthesia

Shoichiro Sazuka, Toshiya Koitabashi
PURPOSE: Tapentadol is a dual-acting mu-opioid receptor agonist and noradrenaline reuptake inhibitor with non-inferior analgesic efficacy to oxycodone and better gastrointestinal tolerability than full mu-opioid receptor agonists. Tapentadol is approved for cancer pain in Japan; however, real-world evidence on tapentadol's effectiveness and safety for cancer-related pain in Japan is limited. METHODS: This retrospective study evaluated the effectiveness, safety, and tolerability of tapentadol (by patient type-opioid-naïve and opioid-tolerant) in 84 patients with moderate-to-severe cancer pain at Ichikawa General Hospital between September 2014 and August 2016...
July 9, 2020: Journal of Anesthesia
Patrick Wong, Wan Yen Lim
The coronavirus disease 2019 (COVID-19) pandemic is caused by a coronavirus that is transmitted primarily via aerosol, droplets or direct contact. This may place anesthetists at higher risk of infection due to their frequent involvement in aerosol-generating airway interventions. Many anesthethetic COVID-19 guidelines have emerged, whose underlying management principles include minimizing aerosol contamination and protecting healthcare workers. These guidelines originate from Australia and New Zealand, Canada, China, India, Italy, Korea, Singapore, the United States and the United Kingdom...
July 8, 2020: Journal of Anesthesia
Narinder P Singh, Jeetinder K Makkar, Anuradha Borle, David Monks, Basavana Gouda Goudra, Andres Zorrilla-Vaca, Preet Mohinder Singh
PURPOSE: Quadratus lumborum block (QLB) has recently gained popularity for postoperative analgesia after cesarean delivery (CD) as it provides both visceral and somato-sensory blockade of the abdomen. Aim of this meta-analysis was to evaluate the analgesic potential of QLB after CD. METHODS: Electronic database from inception to December 2019 was searched systematically for randomized-controlled trials comparing QLB with injection of inactive solution in women undergoing CD...
July 8, 2020: Journal of Anesthesia
Qin Cai, Hanlin Gong, Mingbo Fan, Wen Chen, Lun Cai
PURPOSE: This study aimed to explore the effect of patient-controlled intravenous analgesia (PCIA) using tramadol combined with butorphanol on uterine cramping pain in women undergoing repeat caesarean section. METHODS: A total of 126 patients, who were scheduled to undergo repeat caesarean section under spinal anesthesia, were included. PCIA using tramadol combined with butorphanol or sufentanil was randomly performed for postoperative pain control. Postoperative uterine cramping pain and wound pain within 48 h after surgery were evaluated...
July 5, 2020: Journal of Anesthesia
Xinyue Liu, Jing Ji, Guo-Qing Zhao
As the recent update of General anaesthesia compared to spinal anaesthesia (GAS) studies has been published in 2019, together with other clinical evidence, the human studies provided an overwhelming mixed evidence of an association between anaesthesia exposure in early childhood and later neurodevelopment changes in children. Pre-clinical studies in animals provided strong evidence on how anaesthetic and sedative agents (ASAs) causing neurotoxicity in developing brain and deficits in long-term cognitive functions...
June 29, 2020: Journal of Anesthesia
Tomoyuki Saito, Takashi Asai
No abstract text is available yet for this article.
June 29, 2020: Journal of Anesthesia
Yoshikazu Inoue, Takahiko Katoh, Shota Masuda, Xi Lu, Tadashi Koga, Tomohiro Sadohara, Michiaki Sadanaga, Eiji Tanaka
PURPOSE: This study examined the association between smoking and perioperative complications of laparoscopic abdominal surgery and whether these complications were reduced with ≥ 4 weeks of preoperative smoking cessation. METHODS: A total of 555 patients who underwent gastric and colorectal cancer surgeries under general anesthesia were divided into the following groups retrospectively: 290 individuals without smoking history (NS group), 144 previous smokers (stopped smoking more than 8 weeks before surgery, PS group), and 121 current smokers (CS group) divided to two groups according to preoperative smoking cessation for < 4 (CS1, n = 76) and 4-8 weeks (CS2, n = 45)...
June 23, 2020: Journal of Anesthesia
Yao Zhou, Weimin Tao, Xuewei Qin, Rong Lin, Zhiqiang Liu, Zhendong Xu
This study presents the case of a pregnant woman with antiphospholipid syndrome (APS) who developed septic shock after labor induction. Prolonged coagulation times suggested a hypocoagulable state and contraindication to anticoagulation. Thromboelastography (TEG) similarly indicated hypocoagulation. To exclude the impact of lupus anticoagulant on the coagulation assays, a mixing test of prolonged activated partial thromboplastin times was conducted. The mixing test confirmed that prolongation of coagulation times in vitro was affected by antiphospholipid antibodies (aPL), such as lupus anticoagulant...
June 21, 2020: Journal of Anesthesia
Kazuyoshi Hirota
Angiotensin converting enzyme 2 (ACE2) is a target cell receptor for internalization and proliferation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). When ACE2-highly expressed tissues are manipulated, SARS-CoV-2 containing aerosols may be generated. Normal breathing and speaking are capable of producing aerosols so mask ventilation, suction of airway tract and bucking during tracheal intubation and extubation are clinical procedures capable of significant aerosol production. Whilst no data have been reported on the distribution of SARS-CoV-2 in the operating room (OR), contamination in the OR can be estimated from the intensive care unit (ICU) data...
June 19, 2020: Journal of Anesthesia
Yasutomo Kumakura, Tadahiko Ishiyama, Toru Matsuoka, Tetsuya Iijima, Takashi Matsukawa
PURPOSE: To evaluate changes in cerebral regional oxygen saturation (rSO2 ) after spinal anesthesia and compare the changes in rSO2 and systemic oxygenation between dexmedetomidine sedation and propofol sedation. METHODS: Thirty-six patients scheduled to undergo transurethral surgery under spinal anesthesia were randomly assigned to the dexmedetomidine (n = 18) and propofol groups (n = 18). We used near-infrared spectroscopy sensors to measure rSO2 , and obtained data from each side were averaged...
June 18, 2020: Journal of Anesthesia
Mitsuharu Kodaka, Junko Ichikawa, Kazuyoshi Ando, Makiko Komori
PURPOSE: We evaluated the efficacy of hemostatic therapy based on point-of-care (POC) testing in patients undergoing cardiac surgery. METHODS: This was a single-institution, prospective, randomized, double-blinded study. In step 1, 90 patients scheduled for elective cardiac surgery underwent complete blood count and fibrinogen measurements at baseline, after cardiopulmonary bypass (CPB) initiation (CPB start), just after CPB end, and in the intensive care unit (ICU)...
June 17, 2020: Journal of Anesthesia
Kayo Hirose, Kanji Uchida, Shinjiro Umezu
No abstract text is available yet for this article.
June 14, 2020: Journal of Anesthesia
Yuko Noda, Toshimichi Yasuda, Rieko Kanzaki, Hirotsugu Miyoshi, Keiko Mukaida, Satoshi Kamiya, Atsushi Morio, Hiroshi Hamada, Masashi Kawamoto, Yasuo M Tsutsumi
PURPOSE: This study aimed to evaluate whether the three ryanodine receptor type 1 (RYR1) variants (p.Ser2345Thr, p.Ser2345Arg, and p.Lys3367Arg) which we identified in Japanese malignant hyperthermia (MH) patients with a clinical grading scale rank of 6 were causative for MH. METHODS: We prepared human embryonic kidney (HEK)-293 cells transfected with wild-type RYR1 or one of the RYR1 variants, along with myotubes cultured from muscle pieces. Calcium kinetics were examined by calculating the 340/380-nm ratio under various caffeine and 4-chloro-m-cresol (4CmC) concentrations with the ratiometric dye Fura-2 AM...
June 13, 2020: Journal of Anesthesia
Linlin Song, Yuting Li, Zhenzhen Xu, Zhi-Yu Geng, Dong-Xin Wang
PURPOSE: The aim of the study is to compare the femoral triangle (FT) and adductor canal (AC) blocks in terms of the analgesic efficacy and ambulatory outcomes in the context of multimodal analgesia following total knee arthroplasty (TKA). METHODS: Patients presenting for TKA were assigned to a preoperative ultrasound-guided single-injection FT or AC block. Combined spinal and epidural anesthesia with bupivacaine was administered for TKA. Perioperatively a multimodal analgesic regimen was applied up to 48 h after surgery...
June 12, 2020: Journal of Anesthesia
Shuguang Yang, Kun Chen, Li Wan
It was widely recognized that the procedure of ultrasound-guided lumbar and sacral plexus block is required to be performed in a lateral decubitus position that patients' hips and knees were bended. It is difficult, however, for patients with hip fractures to change position because of severe pain and confined movements. We here reported a new modified combination of ultrasound-guided lumbosacral plexus block with anterior quadratus lumborum block in supine position that had been successfully applied in one elderly patient who underwent hip surgery...
June 12, 2020: Journal of Anesthesia
Shinnosuke Shiono, Sho C Shibata, Daijiro Kabata, Ayumi Shintani, Takehiko Ikeda, Yuji Fujino
PURPOSE: We evaluated the influence of anesthetic management with sevoflurane or propofol on recurrence in patients undergoing breast cancer surgery. METHODS: This single center, retrospective study, included patients who received either sevoflurane or propofol during primary breast cancer surgery between 2008 and 2012. Our primary outcome was recurrence-free survival (RFS) at 1 year. Recurrence was defined as locoregional recurrence and distal metastasis. Propensity scores were calculated using seven variables (age, sex, body mass index, cancer stage, tumor size, intrinsic subtype, and deviation from standard therapy), and Kaplan-Meier survival curves were constructed from the date of diagnosis of recurrence...
June 10, 2020: Journal of Anesthesia
Marguerite M Hoyler, Briana S Lui, Robert S White
No abstract text is available yet for this article.
June 8, 2020: Journal of Anesthesia
Yan Zhang, Shu-Ting He, Bin Nie, Xue-Ying Li, Dong-Xin Wang
BACKGROUND: The clinical significance of emergence delirium remains unclear. The purpose of this study was to investigate the association between emergence delirium and postoperative delirium in elderly after general anesthesia and surgery. METHODS: This prospective observational study was done in a tertiary hospital in Beijing, China. Elderly patients (65-90 years) who underwent major noncardiac surgery under general anesthesia and admitted to the postanesthesia care unit (PACU) after surgery were enrolled...
June 7, 2020: Journal of Anesthesia
Hiroshi Hoshijima, Risa Takeuchi, Kimiharu Kikuchi, Kentaro Mizuta
Monoamine oxidase (MAO) deficiency is an X-linked hereditary disease characterized by spontaneous deletion of MAO-A and/or MAO-B on the X chromosome. Here, we describe the first reported case of a patient with MAO-A and MAO-B deficiency managed under general anesthesia in dental treatment. The patient was aged 11 years old when he was scheduled for dental treatment. He was diagnosed with MAO-A and MAO-B deficiency on genetic testing at 2 years of age. He was not given premedication, and standard monitoring with noninvasive blood pressure monitoring, pulse oximetry, and ECG was instituted...
June 5, 2020: Journal of Anesthesia
Hidekazu Imai, Yutaka Seino, Hiroshi Baba
PURPOSE: The NMOC-3WAY catheter® is a novel urinary catheter for men that can be used to inject a local anesthetic into the urethra. We sought to assess whether the injection of a local anesthetic into the urethra via the NMOC-3WAY catheter® would reduce catheter-related bladder discomfort (CRBD) after endovascular aneurysm repair (EVAR). METHODS: Adult male patients who underwent elective EVAR for abdominal aortic aneurysms were randomly assigned to the 2% lidocaine group and the normal saline group (control group)...
June 4, 2020: Journal of Anesthesia
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