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JOURNAL ARTICLE

Oxaliplatin antagonizes HIV-1 latency by activating NF-κB without causing global T cell activation

Xiaoli Zhu, Sijie Liu, Pengfei Wang, Xiying Qu, Xiaohui Wang, Hanxian Zeng, Huabiao Chen, Huanzhang Zhu
Biochemical and Biophysical Research Communications 2014 July 18, 450 (1): 202-7
24878527
Reactivation of latent HIV-1 is a promising strategy for the clearance of the viral reservoirs. Because of the limitations of current agents, identification of new latency activators is urgently required. Using an established model of HIV-1 latency, we examined the effect of Oxaliplatin on latent HIV-1 reactivation. We showed that Oxaliplatin, alone or in combination with valproic acid (VPA), was able to reactivate HIV-1 without inducing global T cell activation. We also provided evidence that Oxaliplatin reactivated HIV-1 expression by inducing nuclear factor kappa B (NF-κB) nuclear translocation. Our results indicated that Oxaliplatin could be a potential drug candidate for anti-latency therapies.

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